9月
UBE2T/FANCL-IN-1；UBE2T/FANCL-IN-1UBE2T/FANCL-IN-1；UBE2T/FANCL-IN-1 (2024/9/8)
簡介：ube2t/fancl-in-1 is a highly effective inhibitor of ube2t/fancl-mediated fancd2 monoubiquitylation. it greatly enhances the sensitivity of cells to carboplatin, a dna cross-linking agent.
Amylin (8-37), human；Amylin (8-37), humanAmylin (8-37), human (2024/9/8)
簡介：amylin (8-37), human, derived from human amylin, possesses direct vasodilator effects in isolated mesenteric resistance arteries of rats. human amylin is a small pancreatic β-cell hormone that forms aggregates in the absence of insulin and is a key pathological feature of type ii diabetes mellitus.
Mefenpyr-diethyl；Mefenpyr-diethylMefenpyr-diethyl (2024/9/8)
簡介：mefenpyr-diethyl is an herbicide safener, which protects crops against herbicide injury.
Bromochloronitromethane；BromochloronitromethaneBromochloronitromethane (2024/9/8)
簡介：bromochloronitromethane is a member of halonitromethanes, a newly discovered group of disinfection by-products (dbps) found in drinking water.
GS-443902 trisodium；瑞德西韋代謝物三鈉鹽GS-441524triphosphatetrisodium|||Remdesivirmetabolitetrisodium；GS-4415 (2024/9/8)
簡介：gs-443902 trisodium (gs-441524 triphosphate trisodium), the active triphosphate metabolite of remdesivir (gs-5734), serves as a potent inhibitor of viral rna-dependent rna-polymerases (rdrp), displaying inhibitory concentrations (ic50) of 1.1 μm and 5 μm for rsv rdrp and hcv rdrp, respectively.
Desmethyl-WEHI-345 analog；Desmethyl-WEHI-345 analogDesmethyl-WEHI-345 analog (2024/9/8)
簡介：desmethyl-wehi-345 analog, a protein kinase inhibitor, holds potential for colon cancer research.
Loureirin B龍血素 B龍血素B|||龍血素 B (2024/9/8)
簡介：loureirin b can downregulate the expression of fibrosis-related molecules by regulating mmps and timps levels, inhibit scar fibroblast proliferation and suppress tgf-β1-induced fibrosis, during which tgf-β1/smad2/3 pathway is likely involved.
ONO-8430506；化合物ONO-8430506ONO-8430506 (2024/9/8)
簡介：ono-8430506 is an orally available, potent autotaxin (atx)/enpp2 inhibitor (ic90: 100 nm) that inhibits atx activity in mouse plasma.
m-PEG9-azide；m-PEG9-azidem-PEG9-azide；m-PEG9-azide (2024/9/8)
簡介：m-peg9-azide is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Thiol-C10-amide-PEG8；Thiol-C10-amide-PEG8Thiol-C10-amide-PEG8；Thiol-C10-amide-PEG8 (2024/9/8)
簡介：thiol-c10-amide-peg8 is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Rafoxanide 13C6雷復(fù)尼特13C6雷復(fù)尼特13C6 (2024/9/8)
簡介：rafoxanide 13c6 is a labeled rafoxanide . rafoxanide is a salicylanilide used as an antiparasitic agent.
Trazpiroben；化合物 TrazpirobenTAK-906；TAK-906 (2024/9/8)
簡介：trazpiroben (tak-906) is a selective dopamine d2/d3 receptor antagonist used in the study of gastroparesis.
CR-1-31-B；CR-1-31-BCR-1-31-B (2024/9/8)
簡介：cr-1-31-b, a synthetic rocaglate, acts as a highly potent inhibitor of eif4a. by disrupting the interaction between eif4a and rna, it effectively obstructs the initiation phase of protein synthesis. specifically, cr-1-31-b interferes with the association between plasmodium falciparum eif4a (pfeif4a) and rna. additionally, cr-1-31-b induces apoptosis in neuroblastoma and gallbladder cancer cells [4].
EW-7195；化合物EW-7195EW-7195 (2024/9/8)
簡介：ew-7195 is a selective and potent inhibitor of alk5 (tgfβr1) with an ic50 value of 4.83 nm.ew-7195 has an affinity for alk5 that is more than 300-fold higher than that of p38α.ew-7195 has an inhibitory effect on tgf-β1-induced smad signaling, epithelial mesenchymal transition (emt), and breast cancer metastasis to the lungs.
Azido-PEG5-S-methyl ethanethioate；Azido-PEG5-S-methyl ethanethioateAzido-PEG5-S-methyl ethanethioate (2024/9/8)
簡介：azido-peg5-s-methyl ethanethioate is a polyethylene glycol (peg)-based linker utilized for the synthesis of proteolysis targeting chimeras (protacs).
ABBV-167；ABBV-167ABBV-167 (2024/9/8)
簡介：abbv-167 is a phosphate prodrug of the bcl-2 inhibitor venetoclax.
CLINODISIDE A；斷血流皂苷ACLINODISIDE A (2024/9/8)
簡介：clinodiside a in rats with one compartment open model into the body, rapid distribution, elimination rate.
Bis-propargyl-PEG10；Bis-propargyl-PEG10Bis-propargyl-PEG10；Bis-propargyl-PEG10 (2024/9/8)
簡介：bis-propargyl-peg10 is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Fmoc-D-Val-D-Cit-PAB；Fmoc-D-Val-D-Cit-PABFmoc-D-Val-D-Cit-PAB (2024/9/8)
簡介：fmoc-d-val-d-cit-pab is a cleavable linker for antibody-drug-conjugation (adc).
Fmoc-Val-D-Cit-PAB；Fmoc-Val-D-Cit-PABFmoc-Val-D-Cit-PAB (2024/9/8)
簡介：fmoc-val-d-cit-pab is a cleavable linker for antibody-drug-conjugation (adc).
Fmoc-D-Val-Cit-PAB；Fmoc-D-Val-Cit-PABFmoc-D-Val-Cit-PAB (2024/9/8)
簡介：fmoc-d-val-cit-pab is a cleavable linker for antibody-drug-conjugation (adc).
Bis-methacrylate-PEG5；Bis-methacrylate-PEG5Bis-methacrylate-PEG5；Bis-methacrylate-PEG5 (2024/9/8)
簡介：bis-methacrylate-peg5 is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
5-(Biotinamido)pentylazide；5-(Biotinamido)pentylazide5-(Biotinamido)pentylazide (2024/9/8)
簡介：5-biotinamidopentylazide is a protac linker compound derived from an alkyl chain. this compound finds utility in the synthesis of protacs.
Scrambled TRAP Fragment；Scrambled TRAP FragmentScrambled TRAP Fragment (2024/9/8)
簡介：scrambled trap fragment is a variant of the trap fragment compound, characterized by its random amino acid sequence. it is typically employed as a negative control due to its similarity in composition to the active fragment.
NSC639828；NSC639828NSC639828 (2024/9/8)
簡介：nsc639828 is an efficient inhibitor of dna polymerase α, exhibiting a remarkable ic50 value of 70 μm. additionally, nsc639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.
Phenylethanolamine A；Phenylethanolamine APhenylethanolamine A (2024/9/8)
簡介：phenylethanolamine a is a β-adrenergic agonist and a byproduct of the ractopamine synthesis process.
簡介：rivastigmine carbamate impurity (3-nitrophenyl ethyl(methyl)carbamate) is a byproduct found in rivastigmine, which is recognized as a powerful and orally active inhibitor of cholinesterase (che). specifically, rivastigmine effectively inhibits both butyrylcholinesterase (bche) and acetylcholinesterase (ache), with ic50 values of 0.037 μm and 4.15 μm, respectively.
Diosgenin glucoside延齡草苷延齡草苷|||地索苷|||Disogluside|||Trillin (2024/9/8)
簡介：diosgenin glucoside (trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis. significant inhibition of diosgenin glucoside synthesis and stimulation of solasodine glucosylation was found only with pc molecular species containing fatty acids with a chain length of 12-18 carbon atoms.
Mal-PEG2-Val-Cit-PABA-PNP；Mal-PEG2-Val-Cit-PABA-PNPMal-PEG2-Val-Cit-PABA-PNP；Mal-PEG2-Val-Cit-PABA-P (2024/9/8)
簡介：mal-peg2-val-cit-paba-pnp is a cleavable linker compound employed in the synthesis of antibody-drug conjugates (adcs).
ImifoplatinImifoplatinImifoplatin|||PT-112 (2024/9/8)
簡介：imifoplatin is a platinum-based agent belonging to the phosphaplatin family. imifoplatin exhibits antineoplastic activity.
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