9月
SDKPDMAEIEKFDKSK acetate；化合物SDKPDMAEIEKFDKSK acetateSDKPDMAEIEKFDKSK acetate(1339864-27-5 free base) (2024/9/8)
簡介：sdkpdmaeiekfdksk acetate is a thymosin β4 derivative. thymosin β4 inhibits pdgf-bb-induced fibrogenesis, proliferation and migration of hsc by blocking akt phosphorylation.
SDKPDMAEIEKFDKSK；SDKPDMAEIEKFDKSKSDKPDMAEIEKFDKSK (2024/9/8)
簡介：sdkpdmaeiekfdksk is a peptide derived from thymosin β4 (tβ4).
Nattokinase；NattokinaseNattokinase (2024/9/8)
簡介：nattokinase is a powerful fibrinolytic enzyme that effectively hydrolyzes fibrin and plasmin substrate, leading to the breakdown of blood clots. its efficacy renders it valuable for cardiovascular disease studies.
(2-Hydroxyethoxy)acetic acid；(2-羥基乙氧基)乙酸β-hydroxyethoxyacetic acid|||HEAA；β-hydroxyethoxyacetic acid (2024/9/8)
簡介：(2-hydroxyethoxy)acetic acid (β-hydroxyethoxyacetic acid) is the primary urinary metabolite of 1,4-dioxane. it serves as a dependable and sensitive short-term biomarker in urine.
Vazegepant；VazegepantZavegepant|||BHV-3500；Zavegepant|||BHV-3500 (2024/9/8)
簡介：vazegepant is an intranasal cgrp receptor antagonist utilized for conducting acute migraine research.
Ald-Ph-amido-PEG11-C2-NH2；Ald-Ph-amido-PEG11-C2-NH2Ald-Ph-amido-PEG11-C2-NH2；Ald-Ph-amido-PEG11-C2-N (2024/9/8)
簡介：ald-ph-amido-peg11-c2-nh2 is an 11-unit polyethylene glycol (peg) linker that is non-cleavable. it is specifically designed for use in the synthesis of antibody-drug conjugates (adcs).
PERK-IN-4；PERK抑制劑4PERK-IN-4 (2024/9/8)
簡介：perk-in-4 is a potent and selective perk inhibitor with an ic50 value of 0.3 nm.perk-in-4 can be used in the study of cancer and neurological disorders.
Ara-F-NAD+；Ara-F-NAD+Ara-F-NAD+ (2024/9/8)
簡介：ara-f-nad+, an arabino analogue of nad + , is a potent, slow-binding cd38 nadase inhibitor, with a k i of 169 nm.
griffonilide；格列風(fēng)內(nèi)酯griffonilide (2024/9/8)
簡介：griffonilide is an extract from the semiaquilegia adoxoides root, a traditional anticancer herb.
Melarsonyl dipotassium；美拉胂鉀Melarsonic acid dipotassium；美拉胂鉀|||Melarsonic acid dipotassium (2024/9/8)
簡介：melarsonyl dipotassium, also known as melarsonic acid dipotassium, is a potent anthelmintic agent with the ability to effectively inhibit parasites.
Biotin-PEG4-PFP ester；Biotin-PEG4-PFP esterBiotin-PEG4-PFP ester；Biotin-PEG4-PFP ester (2024/9/8)
簡介：biotin-peg4-pfp ester is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (adcs).
Azvudine hydrochloride；Azvudine hydrochlorideRO-0622 hydrochloride|||Azvudine hydrochloride|||FNChyd (2024/9/8)
簡介：azvudine hydrochloride (ro-0622) is a potent nucleoside reverse transcriptase inhibitor (nrti) that exhibits strong antiviral effects against hiv, hbv, and hcv. it demonstrates highly potent inhibition of hiv-1 (ec 50 ranging from 0.03 to 6.92 nm) and hiv-2 (ec 50 ranging from 0.018 to 0.025 nm). additionally, azvudine hydrochloride effectively inhibits nrti-resistant viral strains.
Chloroacetamido-C4-NHBoc；Chloroacetamido-C4-NHBocChloroacetamido-C4-NHBoc；Chloroacetamido-C4-NHBoc (2024/9/8)
簡介：chloroacetamido-c4-nhboc is an alkyl/ether-based linker commonly employed in the synthesis of proteolysis targeting chimeras (protacs).
Apalutamide-COOH；Apalutamide-COOHApalutamide-COOH (2024/9/8)
簡介：apalutamide-cooh is a metabolite derived from apalutamide, which acts as a highly potent and competitive antagonist of the androgen receptor (ar). it effectively binds to the ar with an ic50 value of 16 nm.
Modoflaner；化合物ModoflanerModoflaner (2024/9/8)
簡介：modoflaner is an antiparasitic (veterinary use).
β-Aminoarteether；化合物β-Aminoarteetherβ-Aminoarteether|||SM934 free base；β-Aminoarteether|||SM934 free (2024/9/8)
簡介：β-aminoarteether (sm934 free base), an orally active derivative of artemisinin, serves a pivotal role in the research of inflammation and autoimmune disorders, including those related to lupus diseases.
(Z)-PUGNAc；化合物(Z)-PUGNAc(Z)-PUGNAc (2024/9/8)
簡介：(z)-pugnac is a potent o-glcnacase inhibitor that is more active than (e)-pugnac, removes o-glcnac from proteins (peptide o-glcnac-β-n-acetylaminoglucosidase), and can be used to increase the levels of o-glcnac on nuclear and cytoplasmic proteins in vivo.
ALD-PEG4-OPFP；ALD-PEG4-OPFPALD-PEG4-OPFP；ALD-PEG4-OPFP (2024/9/8)
簡介：ald-peg4-opfp is a cleavable adc linker consisting of four units of peg. it is specifically formulated for use in the synthesis of antibody-drug conjugates (adcs).
SR-31747 free base；SR-31747 free baseSR-31747 free base (2024/9/8)
簡介：sr-31747 free base is an immunosuppressive and anti-inflammatory sigma ligand that efficiently inhibits cell proliferation through the inhibition of sterol isomerase activity.
Nodakenin；紫花前胡苷(+)-Marmesinin；紫花前胡苷|||(+)-Marmesinin (2024/9/8)
簡介：nodakenin ((+)-marmesinin) is a compound with anti-allergic and anti-inflammatory activities.
Influenza HA (110-119) acetate；化合物Influenza HA (110-119) acetateInfluenza HA (110-119) acetate (2024/9/8)
簡介：influenza ha (110-119) acetate is the 110-119 fragment of influenza virus hemagglutinin that can stimulate treg cells proliferation[1][2].
Influenza HA (110-119)；Influenza HA (110-119)Influenza HA (110-119) (2024/9/8)
簡介：influenza ha (110-119) refers to a specific fragment (110-119) derived from the hemagglutinin protein of the influenza virus. this fragment has the ability to induce the proliferation of treg cells.
Cytarabine triphosphate；Cytarabine triphosphateCytarabine triphosphate|||Ara-CTP；Cytarabine triphosp (2024/9/8)
簡介：cytarabine triphosphate (ara-ctp), a competitive inhibitor of dna synthesis and an active metabolite of cytarabine, exhibits predictive potential for leukemic blasts´ chemosensitivity to cytarabine through intracellular levels.
Cyclohexane-PEG1-Br；Cyclohexane-PEG1-BrCyclohexane-PEG1-Br；Cyclohexane-PEG1-Br (2024/9/8)
簡介：cyclohexane-peg1-br is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
SAR247799；SAR247799SAR247799|||S1P1 agonist 3；SAR247799|||S1P1 agonist 3 (2024/9/8)
簡介：sar247799 (s1p1 agonist 3) is an orally-active, selective g-protein-biased agonist for the sphingosine-1 phosphate receptor-1 (s1p1). it demonstrates ec50 values ranging from 12.6 to 493 nm in s1p1-overexpressing cells and huvecs. sar247799 holds promise as a valuable tool for investigating endothelial protection, particularly in the context of type-2 diabetes and metabolic syndrome[4].
MSDC-0602K；化合物MSDC-0602KMSDC-0602K|||Azemiglitazone potassium；MSDC-0602K|||Azemiglitazone potassium (2024/9/8)
簡介：msdc-0602k (azemiglitazone potassium) (azemiglitazone potassium) is a pparγ-sparing thiazolidinedione (ps-tzd) compound that binds to pparγ with an ic50 of 18.25 μm. it also modulates the mitochondrial pyruvate carrier (mpc). this compound, msdc-0602k, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. msdc-0602k acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both
Boc-NH-PPG2；Boc-NH-PPG2Boc-NH-PPG2；Boc-NH-PPG2 (2024/9/8)
簡介：boc-nh-ppg2 is a alkyl/ether-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH；Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OHFmoc-Asn(Ac3AcNH-beta-Glc)-OH|||F (2024/9/8)
簡介：fmoc-l-asn(beta-d-glcnac(ac)3)-oh, also known as fmoc-asn(ac3acnh-beta-glc)-oh, is a chemical compound used in the synthesis of silicon-fluoride acceptor (sifa) derivatized octreotate derivatives. sifa-octreotate analogues, which serve as tumor imaging agents, are valuable tools for positron emission tomography (pet) research.
YF-2 hydrochloride；YF-2 hydrochlorideYF-2 hydrochloride (2024/9/8)
簡介：yf-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. it specifically acetylates h3 in the hippocampus, with ec50 values of 2.75 μm, 29.04 μm, and 49.31 μm for cbp, pcaf, and gcn5, respectively. notably, it does not affect hdac activity. moreover, yf-2 hydrochloride demonstrates promising anti-cancer and anti-alzheimer´s disease properties.
JH295；JH295JH295 (2024/9/8)
簡介：jh295 is a highly potent and selective inhibitor of nima-related kinase 2 (nek2), exhibiting irreversible inhibition activity with an ic 50 value of 770 nm. this compound effectively inhibits cellular nek2 using the alkylation of cys22. importantly, jh295 does not exhibit any inhibitory effects toward cdk1, aurora b, or plk1, which are kinases involved in mitotic processes. furthermore, jh295 has no impact on bipolar spindle assembly or the spindle assembly checkpoint mechanism.
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