9月
RJW100；化合物RJW100RJW100 (2024/9/8)
簡介：rjw100 is a compound that acts as a potent agonist of liver receptor homolog 1 (lrh-1, nr5a2) and steroidogenic factor-1 (sf-1, nr5a1), exhibiting pec50 values of 6.6 and 7.5, respectively. additionally, rjw100 induces robust activation of the mir-200c (mirna-200c, microrna-200c) promoter.
Agnuside；穗花牡荊苷chasteberry oil；牡荊油|||穗花牡荊苷|||chasteberry oil (2024/9/8)
簡介：agnuside (chasteberry oil) inhibits cox-2 (ic50: 0.026 mg/ml) but exhibits less than 10% inhibition of cox-1 at this concentration. it also inhibits 46.3, 66.8, and 82.1% of p-glycoprotein (p-gp) atpase activity at concentrations of 5, 25, and 100 μm, respectively.
DODAP；DODAPDODAP (2024/9/8)
簡介：dodap, an ionizable cationic lipid, serves as a vital component in liposome formation. its applications encompass the capability to encapsulate sirna, immunostimulatory chemotherapeutic agents for in vitro and in vivo delivery, among others.
Benzyl-PEG3-acid；Benzyl-PEG3-acidBenzyl-PEG3-acid；Benzyl-PEG3-acid (2024/9/8)
簡介：benzyl-peg3-acid is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Benzyl-PEG3-methyl ester；Benzyl-PEG3-methyl esterBenzyl-PEG3-methyl ester；Benzyl-PEG3-methyl ester (2024/9/8)
簡介：benzyl-peg3-methyl ester is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Hikizimycin；HikizimycinAnthelmycin；Anthelmycin (2024/9/8)
簡介：hikizimycin is a potent anthelmintic and antibacterial natural product.
yGsy2p-IN-H23yGsy2p-IN-H23yGsy2p-IN-H23 (2024/9/8)
簡介：ygsy2p-in-h23 is a potent, first-in-class inhibitor specifically designed to target yeast glycogen synthase 2 (ygsy2p). it demonstrates an ic50 value of 875 μm for human glycogen synthase 1 (hgys1). this compound binds precisely within the uridine diphosphate glucose (udpg) binding pocket of ygsy2p. its utilization in research primarily focuses on studying glycogen storage diseases (gsds).
Sibiromycin；SibiromycinSibiromycin (2024/9/8)
簡介：sibiromycin, a glycosylated pyrrolobenzodiazepines (pbds) compound, is a naturally occurring and potent antitumor antibiotic. it exerts its activity by covalently binding to dna in the minor groove at the nh2 of guanine.
VTP-27999 Hydrochloride；VTP-27999 HydrochlorideVTP-27999 Hydrochloride (2024/9/8)
簡介：vtp-27999 hcl is an alkyl amine renin inhibitor; vtp-27999 is useful for hypertension and end-organ diseases.ic50 value:target: renin
m-PEG2-O-Ph-3-NH2m-PEG2-O-Ph-3-NH2m-PEG2-O-Ph-3-NH2 (2024/9/8)
簡介：m-peg2-o-ph-3-nh2 is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
t-Boc-N-amido-PEG6-Tos；t-Boc-N-amido-PEG6-Tost-Boc-N-amido-PEG6-Tos；t-Boc-N-amido-PEG6-Tos (2024/9/8)
簡介：t-boc-n-amido-peg6-tos is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Alpinetin；山姜素(-)-alpinetin；山姜素|||(-)-alpinetin (2024/9/8)
簡介：alpinetin ((-)-alpinetin) has antibacterial activity.alpinetin has anti-inflammatory activity.alpinetin can enhance the sensitivity of hepg2 hepatoma cells to the chemotherapeutic agent cddp. alpinetin has strong anti-hepatoma and pancreatic cancer cells effects, by inhibiting proliferation , regulating of the bcl-2 family and xiap expression, releasing of cytochrome c and activating caspases.
endo-BCN-PEG2-NH2；endo-BCN-PEG2-NH2endo-BCN-PEG2-NH2；endo-BCN-PEG2-NH2 (2024/9/8)
簡介：endo-bcn-peg2-nh2 is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
endo-BCN-O-PNB；endo-BCN-O-PNBendo-BCN-O-PNB (2024/9/8)
簡介：endo-bcn-o-pnb is a alkyl/ether-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Mal-Ph-CONH-PEG4-?NHS ester；Mal-Ph-CONH-PEG4-NHS esterMal-Ph-CONH-PEG4-NHS ester；Mal-Ph-CONH-PEG4-NH (2024/9/8)
簡介：mal-ph-conh-peg4-nhs ester, a non-cleavable four-unit polyethylene glycol (peg) adc linker, plays a crucial role in the synthesis of antibody-drug conjugates (adcs).
CP-346086 dihydrate；CP-346086 dihydrateCP-346086 dihydrate (2024/9/8)
簡介：cp-346086 dihydrate is a potent and orally active inhibitor of microsomal triglyceride transfer protein (mtp), exhibiting an ic50 value of 2.0 nm for both human and rodent mtp. this compound effectively lowers plasma cholesterol and triglyceride levels in vivo.
OVA-E1 peptide TFA；化合物OVA-E1 peptide TFAOVA-E1 peptide TFA；OVA-E1 peptide TFA (2024/9/8)
簡介：ova-e1 peptide tfa activates the p38 and jnk cascades similarly in mutant and wild-type thymocytes.
Novokinin TFA；Novokinin TFANovokinin TFA (2024/9/8)
簡介：novokinin tfa is a peptide agonist of the angiotensin at2 receptor.
Benzyl-PEG6-MS；Benzyl-PEG6-MSBenzyl-PEG6-MS；Benzyl-PEG6-MS (2024/9/8)
簡介：benzyl-peg6-ms is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Fmoc-Gly-Thr(psi(Me,Me)pro)-OH；化合物Fmoc-Gly-Thr(psi(Me,Me)pro)-OHFmoc-Gly-Thr(psi(Me,Me)pro)-OH (2024/9/8)
簡介：fmoc-gly-thr(psi(me,me)pro)-oh is a polypeptide composed of two amino acids.
NH2-PEG3-C6-Cl；NH2-PEG3-C6-ClNH2-PEG3-C6-Cl；NH2-PEG3-C6-Cl (2024/9/8)
簡介：nh2-peg3-c6-cl is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
AT-9010；AT-9010AT-9010 (2024/9/8)
簡介：at-9010, a triphosphate derivative of at-527, exhibits strong inhibitory activity against niran, a crucial viral replication function. this compound effectively suppresses the replication of sars-cov-2.
Macelignan；安五脂素Anwuligan|||(+)-Anwulignan；安五脂素|||Anwuligan|||(+)-Anwulignan (2024/9/8)
簡介：macelignan (anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against streptococcus mutans and other streptococcus species.
mGluR5 modulator 1；mGluR5 modulator 1mGluR5 modulator 1 (2024/9/8)
簡介：mglur5 modulator 1 is a compound that acts as a positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mglur5). its primary application lies in the field of schizophrenia and cognitive impairment research.
3-(β-D-Glucopyranosyloxy)-1,6-dihydroxy-2-methyl-9,10-anthracenedione；3-(β-D-Glucopyranosyloxy)-1,6- (2024/9/8)
簡介：3-(β-d-glucopyranosyloxy)-1,6-dihydroxy-2-methyl-9,10-anthracenedione, also known as an anthraquinone, has been specifically extracted from rubia cordifolia.
2-Naphthalenecarboxylic acid, 4-(D-glucopyranosyloxy)-1-hydroxy-3-(3-hydroxy-3-methylbutyl)-, methyl (2024/9/8)
簡介：2-naphthalenecarboxylic acid, 4-(d-glucopyranosyloxy)-1-hydroxy-3-(3-hydroxy-3-methylbutyl)-, methyl ester (compound 3) is a naturally occurring substance found in the dried roots of rubia cordifolia.
Nusinersen；NusinersenNusinersen (2024/9/8)
簡介：nusinersen, an antisense oligonucleotide drug, modifies the pre-messenger rna (pre-mrna) splicing of the smn2 gene, thereby enhancing the production of the full-length survival motor neuron (smn) protein.
Trifludimoxazin；化合物TrifludimoxazinTrifludimoxazin (2024/9/8)
簡介：trifludimoxazin is an inhibitor of protoporphyrinogen oxidase and can be used as a herbicide.
Cotosudil；化合物 CotosudilCotosudil (2024/9/8)
簡介：cotosudil is a rock kinase inhibitor with antihypertensive activity and is used to treat or prevent diseases or conditions caused by cataracts, cardiovascular or neurodegenerative diseases or nerve damage.
HG-7-85-01；HG-7-85-01HG-7-85-01 (2024/9/8)
簡介：hg-7-85-01 is a type ii atp competitive inhibitor targeting wild-type and gatekeeper mutations forms of bcr-abl, pdgfrα, kit, and src kinases. it effectively inhibits t315i mutant bcr-abl kinase, as well as kdr and ret kinases with ic50 values of 3 nm, 20 nm, and 30 nm, respectively. in contrast, hg-7-85-01 exhibits weak or no inhibition towards other kinases (ic50 >2 μm). furthermore, this compound inhibits cell proliferation through the induction of apoptosis and by impeding cell-cycle progres
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