9月
Bcl-xL antagonist 2；Bcl-xL拮抗劑2Bcl-xL antagonist 2 (2024/9/8)
簡(jiǎn)介：bcl-xl antagonist 2 is an effective and selective antagonist of bcl-xl with an ic50 of 91 nm and a ki of 65 nm. bcl-xl antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic leukemia and non-hodgkin’s lymphoma.
Prexasertib dimesylate；Prexasertib dimesylateLY2606368 dimesylate；LY2606368 dimesylate (2024/9/8)
簡(jiǎn)介：prexasertib dimesylate (ly2606368 dimesylate) is a highly selective atp-competitive second-generation inhibitor of checkpoint kinase 1 (chk1). with a k i of 0.9 nm and an ic 50 of <1 nm, prexasertib dimesylate effectively inhibits chk2 (ic 50 = 8 nm) and rsk1 (ic 50 = 9 nm). its mechanism of action involves inducing double-stranded dna breakage and replication catastrophe, ultimately leading to apoptosis. moreover, prexasertib dimesylate demonstrates potent anti-tumor activity.
Irigenin；野鳶尾黃素Irigenin (2024/9/8)
簡(jiǎn)介：irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the c-c loop of the extra domain a domain. it can sensitize trail-induced apoptosis by enhancing the expression of pro-apoptotic molecules in gastric cancer cells and has anti-cancer effects.
GSK1795091GSK1795091CRX-601 (2024/9/8)
簡(jiǎn)介：gsk1795091 (crx-601) is a synthetic tlr4 agonist and immunologic stimulator with demonstrated antitumor activity. it serves as a vaccine adjuvant, enhancing both mucosal and systemic immunity to influenza virus vaccines.
Mal-CO-PEG5-?NHS ester；Mal-CO-PEG5-NHS esterMal-CO-PEG5-NHS ester；Mal-CO-PEG5-NHS ester (2024/9/8)
簡(jiǎn)介：mal-co-peg5-nhs ester is a 5-unit peg-based, non-cleavable adc linker utilized in the fabrication of antibody-drug conjugates (adcs).
Biotin-TAT (47-57) acetate；化合物Biotin-TAT (47-57) acetateBiotin-TAT (47-57) acetate(1231898-25-1 free (2024/9/8)
簡(jiǎn)介：biotin-tat (47-57) acetate is a biotin-labeled tat polypeptide and a transactivator of transcription. biotin-tat (47-57) acetate is one of the most widely used peptides in protein transduction domains.
Biotin-TAT (47-57)；Biotin-TAT (47-57)Biotin-TAT (47-57) (2024/9/8)
簡(jiǎn)介：biotin-tat (47-57) is a biotin-tagged transactivator of transcription, commonly employed as a protein transduction domain (ptd) in various primary cells. its transduction capacity is contingent on atp and temperature, suggesting the participation of endocytosis.
Teprasiran；TeprasiranQPI-1002；QPI-1002 (2024/9/8)
簡(jiǎn)介：teprasiran (qpi-1002) is an rna-based compound that transiently suppresses p53-dependent apoptosis, a process involved in the development of acute kidney injury (aki).
Rimsulfuron；RimsulfuronDPX-E9636|||Rimsulfuron；DPX-E9636|||Rimsulfuron (2024/9/8)
簡(jiǎn)介：rimsulfuron (dpx-e9636) is a sulfonylurea herbicide specifically designed for postemergence application in maize crops. this compound effectively targets and manages grasses as well as certain types of broadleaf weeds.
TLR7 agonist 3；TLR7 agonist 3TLR7 agonist 3 (2024/9/8)
簡(jiǎn)介：tlr7 agonist 3 (compound 2), a potent activator of toll-like receptor 7 (tlr7), plays a critical role in initiating immune responses, positioning it as a promising target for immunomodulator development.
Tigecycline hydrate；Tigecycline hydrateGAR-936 hydrate；GAR-936 hydrate (2024/9/8)
簡(jiǎn)介：tigecycline hydrate (gar-936 hydrate) is a broad spectrum glycylcycline antibiotic. tigecycline hydrate is bacteriostatic, that inhibits protein synthesis by binding to the 30s ribosomal subunit of bacteria and thereby blocking entry of aminoacyl-trna into the a site of the ribosome during prokaryotic translation. tigecycline hydrate is active against resistant strains of gram-positive and gram-negative bacteria .
Linaprazan glurate；化合物L(fēng)inaprazan glurateLinaprazan glurate (2024/9/8)
簡(jiǎn)介：linaprazan glurate inhibits exogenously or endogenously stimulated gastric acid secretion. linaprazan glurate can be used in studies about gastrointestinal inflammatory diseases and peptic ulcer diseases.
Seco-DUBA；Seco-DUBASeco-DUBA (2024/9/8)
簡(jiǎn)介：seco-duba, a duocarmycin (duba) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. this compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (adcs).
Pirepemat；PirepematIRL752；IRL752 (2024/9/8)
簡(jiǎn)介：pirepemat (irl752) is a cortical-preferring catecholamine agent that enhances cognition. it is utilized in the investigation of parkinson´s disease.
Isobavachalcone；補(bǔ)骨脂乙素Corylifolinin|||Isobacachalcone；Corylifolinin|||Isobacachalcone|||補(bǔ)骨脂乙素 (2024/9/8)
簡(jiǎn)介：isobavachalcone (corylifolinin) is a chalcone constituent of angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in brain diseases associated with inflammation.
Mycalolide B；Mycalolide BMycalolide B (2024/9/8)
簡(jiǎn)介：mycalolide-b is a marine sponge-derived compound that functions as a selective inhibitor of actomyosin atpase. it effectively hinders atp-induced contraction and mg2+-atpase activity in the absence of ca2+.
Brilacidin tetrahydrochloride；Brilacidin tetrahydrochloridePMX 30063 tetrahydrochloride；PMX 30063 te (2024/9/8)
簡(jiǎn)介：brilacidin tetrahydrochloride (pmx 30063 tetrahydrochloride) is a defensin mimetic antibiotic compound, exhibiting potent anti-infective antimicrobial activity against a range of bacteria. it demonstrates mic90 values of 1 μg/ml and 8 μg/ml against the gram-positive bacteria streptococcus pneumoniae and streptococcus viridans, respectively. additionally, it has a mic90 value of 8 μg/ml for the gram-negative bacteria haemophilus influenzae and a mic90 value of 4 μg/ml for pseudomonas aeruginosa.
Etoposide phosphate disodiumEtoposide phosphate disodiumBMY-40481 disodium|||Etoposide phosphate dis (2024/9/8)
簡(jiǎn)介：etoposide phosphate disodium (bmy-40481 disodium), a phosphate ester prodrug of etoposide, functions as a potent chemotherapeutic agent by selectively inhibiting topoisomerase ii, hindering the re-ligation of dna strands. it is regarded as the active equivalent of etoposide, effectively inducing cell cycle arrest, apoptosis, and autophagy in cancer cells.
Sinapine hydroxide；Sinapine hydroxideSinapine hydroxide (2024/9/8)
簡(jiǎn)介：sinapine hydroxide, an alkaloid derived from the seeds of cruciferous plants, demonstrates a variety of beneficial properties including anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic, and radio-protective effects. additionally, it acts as an inhibitor of acetylcholinesterase (ache), making it valuable for researching neurodegenerative conditions such as alzheimer’s disease, ataxia, myasthenia gravis, and parkinson’s disease[4].
NCT-504；化合物NCT-504NCT-504 (2024/9/8)
簡(jiǎn)介：nct-504, a selective allosteric inhibitor of pip4kγ, exhibits an ic50 value of 15.8 μm. it holds promise for the investigation of huntington´s disease.
C12-200；化合物C12-200C12-200；C12-200 (2024/9/8)
簡(jiǎn)介：c12-200 is a benchmark ionizable cationic lipidoid along with helper lipids and can be used in the delivery of mrna.
Vitronectin (367-378)；Vitronectin (367-378)Vitronectin (367-378) (2024/9/8)
簡(jiǎn)介：vitronectin (367-378) is a peptide derived from residues 367-378 of the multifunctional glycoprotein known as vitronectin. vitronectin plays a pivotal role in cell growth, angiogenesis, and metastasis within various human tumors.
(E/Z)-Eltrombopag 13C4；(E/Z)-Eltrombopag 13C4(E/Z)-Eltrombopag 13C4|||(E/Z)-SB-497115 13C4；(E/Z)-Elt (2024/9/8)
簡(jiǎn)介：(e/z)-eltrombopag 13c4 ((e/z)-sb-497115 13c4) is a mixture complex of e-eltrombopag and z-eltrombopag, with 13c labeled. z-eltrombopag is a thrombopoietin (tpo) receptor agonist developed for certain conditions that lead to thrombocytopenia.
GYKI-47261 dihydrochloride；GYKI-47261 dihydrochlorideGYKI-47261 dihydrochloride (2024/9/8)
簡(jiǎn)介：gyki-47261 dihydrochloride is a selective ampa receptor antagonist, administered orally, and exhibits competitive activity with an ic 50 of 2.5 μm. it displays a wide range of anticonvulsive effects and demonstrates neuroprotective properties. additionally, gyki-47261 dihydrochloride is a potent inducer of cyp2e1.
N-ε-propargyloxycarbonyl-L-lysineN-ε-propargyloxycarbonyl-L-lysineN-ε-propargyloxycarbonyl-L-lysine| (2024/9/8)
簡(jiǎn)介：n-ε-propargyloxycarbonyl-l-lysine (h-l-lys(poc)-oh) is an unnatural amino acid (uaa) derived from lysine. it is commonly employed for bio-conjugation purposes, specifically for attaching fluorescent probes in a variety of organisms ranging from e. coli to mammalian cells, including animals.
Isoliquiritin apioside；芹糖異甘草苷Isoliquiritin apioside (2024/9/8)
簡(jiǎn)介：isoliquiritin apioside, isolated from glycyrrhizae radix rhizome, significantly decreases pma-induced increases in mmp9 activities and suppresses pma-induced activation of mapk and nf-κb. isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells. isoliquiritin apioside has marked potential to combat oxidative stress-induced genotoxicity.
HPK1-IN-8；HPK1-IN-8HPK1-IN-8；HPK1-IN-8 (2024/9/8)
簡(jiǎn)介：hpk1-in-8 is an allosteric inhibitor that selectively targets the inactive conformation of full-length hpk1.
CBK289001；CBK289001CBK289001 (2024/9/8)
簡(jiǎn)介：cbk289001 is a tartrate-resistant acid phosphatase (trap/acp5) inhibitor. cbk289001 inhibits trap 5b mv , trap 5b ox and trap 5a ox with ic 50 s of 125 μm, 4.21 μm and 14.2 μm, respectively.
SPDP-sulfo；SPDP-sulfoSPDP-sulfo (2024/9/8)
簡(jiǎn)介：spdp-sulfo is a cleavable linker vital in adc synthesis. spdp-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. the cleavable nature ensures controlled drug release, optimizing adc effectiveness.
9,10-Dihydroxystearic acid；9,10-二羥硬脂酸；9,10-二羥基十八酸9,10-Dihydroxystearic acid (2024/9/8)
簡(jiǎn)介：9,10-dihydroxystearic acid, an oxidation derivative of oleic acid, exhibits beneficial effects on glucose tolerance and insulin sensitivity in kkay mice.
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