penicillic acid inhibits fas ligand-induced apoptosis by blocking self-processing of caspase-8.penicillic acid is a polyketide mycotoxin produced by several species of aspergillus and penicillium. penicillic acid exhibits cytotoxicity in rat alveolar macr
phytohemagglutinin is a lectin, isolated from the red kidney bean , induces apoptosis via increasing proapoptotic protein bax and activating caspases-3. anti-tumor activity
chlorpromazine hydrochloride is the prototypical phenothiazine antipsychotic drug. like the other drugs in this class chlorpromazine´s antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. chlorpr
(r,s)-anatabine is a minor tobacco alkaloid found in the solanaceae family of plants,and can be used as a specific marker for the detection of tobacco use.
ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. ribocil strongly inhibits gfp expression, achieving a 50% effective concentration (ec50: 0.3 μm).
(s,s,s)-ahpc hydrochloride is a vhl amino building block, is a ligand used as a negative control for (s,r,s)-ahpc. it is the vh032-based vhl ligand used in the recruitment of the vhl protein.
shield-1 is a specific, high-affinity and cell-permeant ligand of fk506-binding protein-12 (fkbp), and reverses the instability by binding to mutated fkbp (mtfkbp), allowing conditional expression of mtfkbp-fused proteins. shield-1 can stabilize the entir
panthenol (pantothenol) is the alcohol analog of pantothenic acid (vitamin b5) and is thus a provitamin of b5. in organisms, it is quickly oxidized to pantothenate.
hymecromone is a coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. it is also used in analytical chemistry techniques for the determination of nitric acid.
sodium butyrate is the sodium salt of butyrate with potential antineoplastic activity. butyrate, a short chain fatty acid, competitively binds to the zinc sites of class i and ii histone deacetylases (hdacs).
ibuprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (nsaid) with anti-inflammatory, analgesic, and antipyretic effects. ibuprofen inhibits the activity of cyclo-oxygenase i and ii, resulting in a decreased formation of precursor
uc-514321 directly targets stat3/5 and represses tet1 expression. uc-514321 has the potential to treat acute myeloid leukemia (aml) both in vitro and in vivo, with low toxicity.
unc6852 contains an eed ligand (ic50 = 247 nm) and a von hippel-lindau ligand and is a selective polycomb repressive complex 2 (prc2) degrader based on protac.
zl0580 induces hiv suppression by inhibiting tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the hiv promoter.
(s)-3-hydroxybutyric acid is a normal human metabolite that has been found elevated in geriatric patients remitting from depression. 3-hydroxybutyric acid is synthesized in the liver from acetyl-coa in humans, and can be used as an energy source by the br
tadalafil is a carboline-based compound with vasodilatory activity. tadalafil selectively inhibits the cyclic guanosine monophosphate (cgmp)-specific type 5 phosphodiesterase- (pde-5)-mediated degradation of cgmp, which is found in the smooth muscle of th
demeclocycline hydrochloride is a tetracycline analog having a 7-chloro and a 6-methyl. because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
11-beta-hydroxyandrostenedione is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. measuring plasma 11-beta-hydroxyan
2,2,5,7,8-pentamethyl-6-chromanol is the anti-oxidant moiety of vitamin e (α-tocopherol), which has potent androgen receptor (ar) signaling modulation and anti-cancer activity against prostate cancer cell lines.