chlorpromazine hydrochloride is the prototypical phenothiazine antipsychotic drug. like the other drugs in this class chlorpromazine´s antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. chlorpr
(r,s)-anatabine is a minor tobacco alkaloid found in the solanaceae family of plants,and can be used as a specific marker for the detection of tobacco use.
ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. ribocil strongly inhibits gfp expression, achieving a 50% effective concentration (ec50: 0.3 μm).
(s,s,s)-ahpc hydrochloride is a vhl amino building block, is a ligand used as a negative control for (s,r,s)-ahpc. it is the vh032-based vhl ligand used in the recruitment of the vhl protein.
shield-1 is a specific, high-affinity and cell-permeant ligand of fk506-binding protein-12 (fkbp), and reverses the instability by binding to mutated fkbp (mtfkbp), allowing conditional expression of mtfkbp-fused proteins. shield-1 can stabilize the entir
panthenol (pantothenol) is the alcohol analog of pantothenic acid (vitamin b5) and is thus a provitamin of b5. in organisms, it is quickly oxidized to pantothenate.
hymecromone is a coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. it is also used in analytical chemistry techniques for the determination of nitric acid.
sodium butyrate is the sodium salt of butyrate with potential antineoplastic activity. butyrate, a short chain fatty acid, competitively binds to the zinc sites of class i and ii histone deacetylases (hdacs).
ibuprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (nsaid) with anti-inflammatory, analgesic, and antipyretic effects. ibuprofen inhibits the activity of cyclo-oxygenase i and ii, resulting in a decreased formation of precursor
uc-514321 directly targets stat3/5 and represses tet1 expression. uc-514321 has the potential to treat acute myeloid leukemia (aml) both in vitro and in vivo, with low toxicity.
unc6852 contains an eed ligand (ic50 = 247 nm) and a von hippel-lindau ligand and is a selective polycomb repressive complex 2 (prc2) degrader based on protac.
zl0580 induces hiv suppression by inhibiting tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the hiv promoter.
(s)-3-hydroxybutyric acid is a normal human metabolite that has been found elevated in geriatric patients remitting from depression. 3-hydroxybutyric acid is synthesized in the liver from acetyl-coa in humans, and can be used as an energy source by the br
tadalafil is a carboline-based compound with vasodilatory activity. tadalafil selectively inhibits the cyclic guanosine monophosphate (cgmp)-specific type 5 phosphodiesterase- (pde-5)-mediated degradation of cgmp, which is found in the smooth muscle of th
demeclocycline hydrochloride is a tetracycline analog having a 7-chloro and a 6-methyl. because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
11-beta-hydroxyandrostenedione is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. measuring plasma 11-beta-hydroxyan
2,2,5,7,8-pentamethyl-6-chromanol is the anti-oxidant moiety of vitamin e (α-tocopherol), which has potent androgen receptor (ar) signaling modulation and anti-cancer activity against prostate cancer cell lines.
ay 9944 is a specific cholesterol biosynthesis inhibitor. ay 9944 inhibits the 7-dehydro cholesterol δ7-reductase (dhcr7) enzyme (ic50=13 nm). at high doses, ay 9944 inhibits also in cultured embryos sterol δ7-δ8 isomerase, which causes the accumulation o
az pfkfb3 26 is an effective and selective pfkfb3 inhibitor with an ic50 of 23 nm. the ic50s for pfkfb1 and pfkfb2 are 2.06 and 0.384 μm, respectively.
az10606120 dihydrochloride has anti-depressant effects and reduces tumour growth[1]. az10606120 dihydrochloride is a selective, high affinity antagonist for p2x7 receptor (p2x7r) at human and rat with an ic50 of ~10 nm and it is little or no effect at oth
az1495 is an oral active inhibitor of interleukin-1 receptor associated kinase 4 (irak4), with ic50 values of 5 nm and 23 nm for irak4 and irak1, respectively. which shows activity in treatment of mutant myd88l265p diffuse large b-cell lymphoma (dlbcl).
azd-0284 is an inverse agonist of the nuclear receptor rorγ. in development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].