9月
FAP-IN-1；化合物 FAP-IN-1FAP-IN-1 (2024/9/14)
簡(jiǎn)介：fap-in-1 is a fibroblast activation protein (fap) inhibitor, exhibiting an ic50 of 3.3 nm, and is utilized for cancer research [1].
HDAC-IN-58；化合物 HDAC-IN-58HDAC-IN-58 (2024/9/14)
簡(jiǎn)介：hdac-in-58, a selective hdac6 inhibitor, exhibits potent inhibitory activity with an ic50 of 2.06 nm, rendering it suitable for research into chronic neurodegenerative and psychiatric disorders [1].
β-catenin-IN-7；化合物 β-catenin-IN-7β-catenin-IN-7 (2024/9/14)
簡(jiǎn)介：β-catenin-in-7 (compound 9) is an inhibitor of β-catenin that disrupts its interaction with tcf-4, consequently impeding wnt-dependent gene expression, and exhibits anticancer activity [1].
Antitubercular agent-37；化合物 Antitubercular agent-37Antitubercular agent-37 (2024/9/14)
簡(jiǎn)介：antitubercular agent-37 exhibits antimycobacterial properties and functions as an antibacterial agent with an mic (minimum inhibitory concentration) value of 0.16 μg/ml, making it suitable for tuberculosis research [1].
Tubulin inhibitor 33；化合物 Tubulin inhibitor 33Tubulin inhibitor 33 (2024/9/14)
簡(jiǎn)介：tubulin inhibitor 33 is a dose-dependent inhibitor of tubulin polymerization, exhibiting an ic50 value of 9.05 μm. this compound demonstrates antitumor activity and induces apoptosis, making it useful for antitumor research [1].
AB21 oxalate；化合物 AB21 oxalateAB21 oxalate (2024/9/14)
簡(jiǎn)介：ab21 oxalate, a potent and selective s1r antagonist, exhibits binding affinities (kis) of 13 nm and 102 nm for s1r and s2r, respectively. it effectively reduces mechanical hypersensitivity [1].
AD186；化合物 AD186AD186 (2024/9/14)
簡(jiǎn)介：ad186, a potent and selective s1r agonist, exhibits dissociation constants (kis) of 2.7 nm for s1r and 27 nm for s2r. notably, ad186 completely reverses the antiallodynic effect of bd-1063 [1].
S-F24；化合物 S-F24S-F24 (2024/9/14)
簡(jiǎn)介：s-f24 is a broad-spectrum antifungal agent that demonstrates potent inhibition of cyp3a4, with an ic50 of 0.4 μm. it exhibits a favorable safety profile, characterized by high selectivity, minimal hemolytic effects, and a reduced propensity for resistance development. s-f24 is useful for fungal infection research [1].
AKT-IN-18；化合物 AKT-IN-18AKT-IN-18 (2024/9/14)
簡(jiǎn)介：akt-in-18, an akt inhibitor, demonstrates an ic50 value of 69.45 μm in a549 cells, effectively impeding akt activity. it promotes apoptosis and is suitable for use in non-small cell lung cancer research [1].
Antitumor agent-113；化合物 Antitumor agent-113Antitumor agent-113 (2024/9/14)
簡(jiǎn)介：antitumor agent-113 exhibits cytotoxicity in a549 cells, with an ic50 of 46.60 μm, and induces apoptosis, making it applicable for research in non-small cell lung cancer [1].
Antitumor agent-112；化合物 Antitumor agent-112Antitumor agent-112 (2024/9/14)
簡(jiǎn)介：antitumor agent-112 (compound 3a) is a potent antitumor agent that induces apoptosis and exhibits cytotoxic activity on a549 cells, with an ic50 value of 91.35 μm [1].
ZLY28；化合物 ZLY28ZLY28 (2024/9/14)
簡(jiǎn)介：zly28 is a novel, first-in-class compound with specific intestinal restriction and oral activity, serving as a dual modulator of fxr and fabp1. additionally, it is a pioneering anti-nash agent, utilized in the study of nonalcoholic steatohepatitis (nash) [1].
Ipidacrine；伊匹達(dá)克林NIK‐247；伊匹達(dá)克林|||NIK‐247 (2024/9/14)
簡(jiǎn)介：ipidacrine (nik‐247) (nik‐247) is an antidementia agent
Antitumor agent-97；化合物 Antitumor agent-97Antitumor agent-97 (2024/9/14)
簡(jiǎn)介：antitumor agent-97 (compound 42), an anticancer agent, effectively inhibits proliferation and autophagy in mgc 803 cells, induces apoptosis, and enhances ros accumulation, proving useful in cancer research [1].
Antifungal agent 50；化合物 Antifungal agent 50Antifungal agent 50 (2024/9/14)
簡(jiǎn)介：antifungal agent 50 exhibits minimum inhibitory concentrations (mics) ranging from less than 0.063 to 1 μg/ml [1].
MAO-B-IN-22；化合物 MAO-B-IN-22MAO-B-IN-22 (2024/9/14)
簡(jiǎn)介：mao-b-in-22 (compound 6h) represents a powerful mao-b inhibitor, boasting an ic50 value of 0.014 μm, and exhibits high antioxidant activity alongside effective metal-chelating properties. it also demonstrates adequate bbb permeability and notable neuroprotective effects [1].
CDK/HDAC-IN-3；化合物 CDK/HDAC-IN-3CDK/HDAC-IN-3 (2024/9/14)
簡(jiǎn)介：cdk/hdac-in-3 is an orally active dual inhibitor of hdacs and cdks, offering potent and selective inhibition of cdk9, cdk12, cdk13, hdac1, hdac2, and hdac3, with ic50 values of 98.32 nm, 98.85 nm, 100 nm, 62.12 nm, 93.28 nm, and 82.87 nm, respectively. this compound is applicable in the treatment of acute myeloid leukemia (aml) [1].
AChE-IN-29；化合物 AChE-IN-29AChE-IN-29 (2024/9/14)
簡(jiǎn)介：ache-in-29, a 3-oh pyrrolidine derivative, acts as a cholinesterase (che) inhibitor with potent activity against human acetylcholinesterase (hache), electric eel acetylcholinesterase (eeache), and equine butyrylcholinesterase (eqbche), exhibiting ic50 values of 0.25 μm, 0.23 μm, and 0.72 μm, respectively. it is utilized in alzheimer´s disease research [1].
Anticancer agent 110；化合物 Anticancer agent 110Anticancer agent 110 (2024/9/14)
簡(jiǎn)介：anticancer agent 110 exhibits potent in vitro anti-leukemia activity, demonstrating high cytotoxicity against k-562 lineage chronic myelogenous leukemia cells at nanomolar concentrations. it induces dna damage and subsequently triggers apoptosis [1].
Antibacterial agent 140 chloride；化合物 Antibacterial agent 140 chlorideAntibacterial agent 140 chlorid (2024/9/14)
簡(jiǎn)介：antibacterial agent 140 chloride, a first-of-its-kind ru-based aiegen photosensitizer, shows promise in detecting and treating gram-positive bacteria (g+). it effectively discriminates against and exterminates g+ by interacting with lipoteichoic acids (lta), displaying robust antibacterial activity under light irradiation [1].
CYP51/PD-L1-IN-4；化合物 CYP51/PD-L1-IN-4CYP51/PD-L1-IN-4 (2024/9/14)
簡(jiǎn)介：cyp51/pd-l1-in-4 (compound 14a-2) is a potent dual-target inhibitor of cyp51/pd-l1, displaying ic50 values of 0.17 and 0.021 μm, respectively. this compound demonstrates significant antifungal efficacy and combats drug-resistant fungal strains in vitro, making it a valuable agent for fungal infection research [1].
PPM-3；化合物 PPM-3PPM-3 (2024/9/14)
簡(jiǎn)介：ppm-3, a selective protac erk5 degrader, exhibits a potent inhibitory concentration (ic 50) of 62.4 nm. while not directly inhibiting tumor cell growth, ppm-3 affects tumor progression through influencing macrophage differentiation [1].
Antibacterial agent 157；化合物 Antibacterial agent 157Antibacterial agent 157 (2024/9/14)
簡(jiǎn)介：compound b12 (antibacterial agent 157) is a fungicidal agent that can impact protein synthesis in botrytis cinerea. it is utilized in research for controlling gray mold resistance [1].
SP-13786；化合物SP-13786UAMC-1110；UAMC-1110|||(S)-N-[2-(2-氰基-4,4-二氟-1-吡咯烷基)-2-氧代乙基]喹啉-4-甲酰胺 (2024/9/14)
簡(jiǎn)介：sp-13786 (uamc-1110) is an inhibitor of fibroblast activation protein (fap) (ic50 : 3.2 nm); also inhibits prolyl oligopeptidase (prep) ( ic50 : 1.8 μm).
Laccase-IN-1；化合物 Laccase-IN-1Laccase-IN-1 (2024/9/14)
簡(jiǎn)介：laccase-in-1 (compound 4b) is an orally active laccase inhibitor, demonstrating an ic50 of 11.3 μm. it exhibits both protective and curative effects against b. dothidea infections in apple fruits. the compound increases cell membrane permeability, disrupts mycelial surface morphology, alters cell ultrastructure, and decreases the ergosterol and exopolysaccharide levels in b. dothidea [1].
Lysyl hydroxylase 2-IN-2；化合物 Lysyl hydroxylase 2-IN-2Lysyl hydroxylase 2-IN-2 (2024/9/14)
簡(jiǎn)介：lysyl hydroxylase 2-in-2 (compound 13) is a potent inhibitor of lysyl hydroxylase 2 (lh2), exhibiting an ic50 of approximately 500 nm. it effectively inhibits cell migration in 344sq wt cells without affecting the migration of lh2 knockout cells [1].
Antibacterial agent 156；化合物 Antibacterial agent 156Antibacterial agent 156 (2024/9/14)
簡(jiǎn)介：antibacterial agent 156 (compound 57), a bactericidal that selectively targets c. difficile cell-wall synthesis, demonstrates potent activity with minimal inhibitory concentrations of 0.5 μg/ml for mimic50 (101 strains) and 1 μg/ml for mic90 (101 strains) [1].
SHP2-IN-22；化合物 SHP2-IN-22SHP2-IN-22 (2024/9/14)
簡(jiǎn)介：shp2-in-22, a potent shp2 allosteric inhibitor, exhibits an ic50 value of 17.7 nm and effectively suppresses proliferation, migration, and invasion in mia paca-2 pancreatic cancer cells. this compound is utilized in the study of kirsten rat sarcoma viral oncogene (kras) mutant cancer research [1].
NLRP3-IN-21；化合物 NLRP3-IN-21NLRP3-IN-21 (2024/9/14)
簡(jiǎn)介：nlrp3-in-21 (compound l38) is an inhibitor of the nlrp3 inflammasome that possesses anti-inflammatory properties. it suppresses the activation of the nlrp3 inflammasome and pyroptosis by inhibiting gasdermin d cleavage, asc oligomerization, and the assembly of the nlrp3 inflammasome [1].
Antifungal agent 78；化合物 Antifungal agent 78Antifungal agent 78 (2024/9/14)
簡(jiǎn)介：antifungal agent 78 (compound 25am) exhibits potent activity, with an ec50 of 13.46 μm against fusarium graminearum [1].
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