9月
KRAS G12C inhibitor 58；化合物 KRAS G12C inhibitor 58KRAS G12C inhibitor 58 (2024/9/14)
簡(jiǎn)介：kras g12c inhibitor 58 is utilized in cancer research as an inhibitor of the kras g12c mutation [1].
Orexin receptor modulator-1；化合物 Orexin receptor modulator-1Orexin receptor modulator-1 (2024/9/14)
簡(jiǎn)介：orexin receptor modulator-1 is a compound utilized in the study of various conditions including substance addiction, panic disorder, anxiety, post-traumatic stress disorder (ptsd), pain, depression, seasonal affective disorder (sad), eating disorders, and hypertension [1].
Hedgehog IN-2；化合物 Hedgehog IN-2Hedgehog IN-2 (2024/9/14)
簡(jiǎn)介：hedgehog in-2 (compound 20) functions as an inhibitor of the hedgehog signaling pathway, exhibiting an ic50 of <0.003 μm in c3h10t1/2 cells [1].
TRPC3/6-IN-2；化合物 TRPC3/6-IN-2TRPC3/6-IN-2 (2024/9/14)
簡(jiǎn)介：trpc3/6-in-2 is a potent inhibitor of trpc3 and trpc6, exhibiting ic50 values of 16 nm for trpc3 and 29.8 nm for trpc6, respectively [1].
PCSK9-IN-17；化合物 PCSK9-IN-17PCSK9-IN-17 (2024/9/14)
簡(jiǎn)介：pcsk9-in-17 is a pcsk9 inhibitor utilized in the research of cholesterol metabolism.
PCSK9-IN-16；化合物 PCSK9-IN-16PCSK9-IN-16 (2024/9/14)
簡(jiǎn)介：pcsk9-in-16, holds potential for research into hypercholesterolemia and other cardiovascular diseases [1].
PCSK9-IN-15；化合物 PCSK9-IN-15PCSK9-IN-15 (2024/9/14)
簡(jiǎn)介：pcsk9-in-15 (compound 5) is a potent inhibitor of proprotein convertase subtilisin/kexin 9 (pcsk9, k d <200 nm) that plays a crucial role in cholesterol metabolism by regulating blood levels of low-density lipoprotein cholesterol (ldl-c). this compound is useful for researching cholesterol-lowering therapies and dyslipidemia [1].
JBI-589；化合物 JBI-589JBI-589 (2024/9/14)
簡(jiǎn)介：jbi-589 is an isoform-selective, non-covalent inhibitor of pad4 that diminishes cxcr2 expression and impedes neutrophil chemotaxis. additionally, it attenuates primary tumor growth and metastases, augmenting the efficacy of checkpoint inhibitors [1].
PBD-150；化合物PBD-150PBD-150 (2024/9/14)
簡(jiǎn)介：pbd-150 is an inhibitor of human glutaminyl cyclase (hqc) y115e-y117e variant( ki : 490 nm)
Tegeprotafib；化合物 TegeprotafibPTPN2/1-IN-1；PTPN2/1-IN-1 (2024/9/14)
簡(jiǎn)介：tegeprotafib (ptpn2/1-in-1) (compound 124) is an orally active inhibitor targeting both ptpn2 and ptpn1b, displaying potent ic50 values at 4.4 nm for ptpn2 and 1-10 nm for ptpn1b, respectively [1].
MEK-IN-6 hydrate；化合物 MEK-IN-6 hydrateMEK-IN-6 hydrate (2024/9/14)
簡(jiǎn)介：mek-in-6 hydrate (compound 69), a mek inhibitor, exhibits an ic50 value of 2 nm in a375 cells [1].
MEK-IN-6；化合物 MEK-IN-6MEK-IN-6 (2024/9/14)
簡(jiǎn)介：mek-in-6 (example 69), a potent mek inhibitor, effectively inhibits erk1/2 (thr202/tyr204) phosphorylation in a375 cells, with an ic50 of 2 nm, making it valuable for cancer research [1].
CDK4-IN-2；化合物 CDK4-IN-2CDK4-IN-2 (2024/9/14)
簡(jiǎn)介：cdk4-in-2 (a17) is a potent inhibitor of cdk4, exhibiting k i and ic 50 values of less than 10 nm and is utilized in cancer research [1].
AXL-IN-15；化合物 AXL-IN-15AXL-IN-15 (2024/9/14)
簡(jiǎn)介：axl-in-15 (cpd391) is a potent inhibitor of axl, exhibiting both a dissociation constant (k i) and a half-maximal inhibitory concentration (ic50) of less than 1 nanomolar (nm). it is applicable for cancer research [1].
RIP1 kinase inhibitor 7；化合物 RIP1 kinase inhibitor 7RIP1 kinase inhibitor 7 (2024/9/14)
簡(jiǎn)介：rip1 kinase inhibitor 7 (compound 41) serves as a potent inhibitory agent for receptor interacting protein 1 kinase (rip1) with an ic50 of under 100 nm. additionally, it demonstrates an ec50 ranging from 1 to 100 nm in cell necrosis assays [1].
RIP1 kinase inhibitor 6；化合物 RIP1 kinase inhibitor 6RIP1 kinase inhibitor 6 (2024/9/14)
簡(jiǎn)介：rip1 kinase inhibitor 6 is a potent and selective inhibitor of rip1 kinase, demonstrating inhibitory activity with an ic50 of less than 100 nm in a human r1p1 kinase assay[1].
RIP1 kinase inhibitor 5；化合物 RIP1 kinase inhibitor 5RIP1 kinase inhibitor 5 (2024/9/14)
簡(jiǎn)介：rip1 kinase inhibitor 5 (example 1) serves as a potent regulator of tumor immunity by inhibiting rip1, functioning similarly to sir1-365 (compound 13) in suppressing necrosis and ferroptosis [2].
RIP1 kinase inhibitor 4；化合物 RIP1 kinase inhibitor 4RIP1 kinase inhibitor 4 (2024/9/14)
簡(jiǎn)介：rip1 kinase inhibitor 4 (compound 3) is an effective inhibitor of rip1k, exhibiting an ec50 of ≤ 1000 nm [1].
TRV-1387；化合物 TRV-1387TRV-1387 (2024/9/14)
簡(jiǎn)介：trv-1387, a benzofurazan derivative, inhibits the aggregation of tau and amyloid-β [1].
SR 19881；化合物SR 19881SR 19881 (2024/9/14)
簡(jiǎn)介：sr 19881 is a full agonist of errγ(ec50 value of 0.39 μm in a binding assay and an ec50 value of 4.7 μm in a cell-based assay).
GGGDTDTC-Mc-vc-PAB-MMAE；化合物 GGGDTDTC-Mc-vc-PAB-MMAEGGGDTDTC-Mc-vc-PAB-MMAE (2024/9/14)
簡(jiǎn)介：gggdtdtc-mc-vc-pab-mmae is a drug-linker conjugate for antibody-drug conjugates (adcs), incorporating the tubulin inhibitor monomethyl auristatin e (mmae) as the cytotoxic component [1].
Tau protein aggregation-IN-1；化合物 Tau protein aggregation-IN-1Tau protein aggregation-IN-1 (2024/9/14)
簡(jiǎn)介：tau protein aggregation-in-1 (compound 0c) serves as an inhibitor of tau protein aggregation, applicable in research related to protein folding disorders including alzheimer´s disease, dementia, parkinson´s disease, huntington´s disease, and prion-based spongiform encephalopathies [1].
CDK9-IN-23；化合物 CDK9-IN-23CDK9-IN-23 (2024/9/14)
簡(jiǎn)介：cdk9-in-23 (example 4) is a potent inhibitor of cdk9, exhibiting an ic50 value of less than 20 nm [1].
Mcl-1 inhibitor 13；化合物 Mcl-1 inhibitor 13Mcl-1 inhibitor 13 (2024/9/14)
簡(jiǎn)介：mcl-1 inhibitor 13 (example 9), with a ki of 8.2 nm, serves as an mcl-1 inhibitor suitable for cancer research [1].
PRMT5-IN-28；化合物 PRMT5-IN-28PRMT5-IN-28 (2024/9/14)
簡(jiǎn)介：prmt5-in-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (prmt5) enzyme, which is implicated in various cellular processes including gene transcription, mrna splicing, dna repair, protein cellular localization, cell fate determination, and signal transduction. dysregulated prmt5 activity contributes to oncogenesis by promoting cancer cell proliferation, apoptosis resistance, invasion, metastasis, and impacting immune evasion [1].
GXF-111；化合物 GXF-111GXF-111 (2024/9/14)
簡(jiǎn)介：gxf-111, a proteolysis targeting chimera (protac) molecule, efficiently induces the selective degradation of the brd3 and brd4-l proteins. it exhibits high binding affinities to both brd3 bd1 and brd3 bd2, with k i values of 11.97 nm and 2.35 nm, respectively. this compound is utilized in cancer research [1].
重慶開餐飲費(fèi)發(fā)票哪里有開重慶開餐飲費(fèi)發(fā)票 (2024/9/14)
簡(jiǎn)介：重慶開餐飲費(fèi)發(fā)票哪里有開重慶開餐飲費(fèi)發(fā)票【幵 票▇+wei亻言:dh98039▇楊建立】【此消息長(zhǎng)期有效】【正規(guī)保真】【辦事效率快】【當(dāng)天開當(dāng)天寄】【先開后付】
ATR-IN-22；化合物 ATR-IN-22ATR-IN-22 (2024/9/14)
簡(jiǎn)介：atr-in-22 (compound 34), an orally active atr inhibitor, exhibits potent anti-proliferative effects on miapaca-2 cells with an ic50 value of less than 1 μm and demonstrates anti-tumor activity in colon cancer [1].
Enpp-1-IN-17；化合物 Enpp-1-IN-17Enpp-1-IN-17 (2024/9/14)
簡(jiǎn)介：enpp-1-in-17 (example 274) is a potent inhibitor of enpp1, exhibiting inhibition constants (ki values) of 100 nm-1 μm for cgamp hydrolysis and >1 μm for atp hydrolysis, respectively, with a selectivity ratio of >6.4 favoring cgamp hydrolysis inhibition [1].
ATR-IN-21；化合物 ATR-IN-21ATR-IN-21 (2024/9/14)
簡(jiǎn)介：atr-in-21, also known as compound 60, is a potent inhibitor of atr, exhibiting an ic50 of less than 1000 nm [1].
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