9月
HDAC ligand-1；化合物 HDAC ligand-1HDAC ligand-1 (2024/9/14)
簡(jiǎn)介：hdac ligand-1 is a synthetic precursor utilized in the production of protac-based hdac degraders [1].
FITC-labeled ODN TTAGGG sodium；化合物 FITC-labeled ODN TTAGGG sodiumFITC-labeled ODN TTAGGG sodium (2024/9/14)
簡(jiǎn)介：fitc-labeled odn ttaggg (sodium) is an inhibitory oligonucleotide that functions as an antagonist of tlr9, aim2, and cgas. this compound facilitates the assessment of cpg odn cellular uptake and localization via confocal laser-scanning microscopy (excitation at 495 nm, emission at 520 nm) or flow cytometry.
Biotin-labeled ODN TTAGGG sodium；化合物 Biotin-labeled ODN TTAGGG sodiumBiotin-labeled ODN TTAGGG sodiu (2024/9/14)
簡(jiǎn)介：biotin-labeled odn ttaggg (sodium) is an inhibitory oligonucleotide (odn) that functions as an antagonist to tlr9, aim2, and cgas. it serves as a tool for assessing cellular uptake and localization of cpg odn using biotin detection systems and light microscopy.
FITC-labeled ODN 2395 sodium；化合物 FITC-labeled ODN 2395 sodiumFITC-labeled ODN 2395 sodium (2024/9/14)
簡(jiǎn)介：fitc-labeled odn 2395 (sodium), a class c oligodeoxynucleotide and tlr9 agonist, facilitates the assessment of cpg odn cellular uptake and localization through confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.
BAY-474；化合物BAY-474BAY-474 (2024/9/14)
簡(jiǎn)介：bay-474 is an inhibitor of tyrosine-protein kinase c-met. it acts as an epigenetics probe
Biotin-labeled ODN 2395 sodium；化合物 Biotin-labeled ODN 2395 sodiumBiotin-labeled ODN 2395 sodium (2024/9/14)
簡(jiǎn)介：biotin-labeled odn 2395 (sodium), a class c oligodeoxynucleotide and tlr9 agonist, serves to assess cellular uptake and localization of cpg odn through a biotin detection system coupled with light microscopy.
FITC-labeled ODN 2216 sodium；化合物 FITC-labeled ODN 2216 sodiumFITC-labeled ODN 2216 sodium (2024/9/14)
簡(jiǎn)介：fitc-labeled odn 2216 (sodium), a specific agonist for human toll-like receptor 9 (tlr9), facilitates the assessment of cpg odn cellular uptake and localization through confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.
Biotin-labeled ODN 2216 sodium；化合物 Biotin-labeled ODN 2216 sodiumBiotin-labeled ODN 2216 sodium (2024/9/14)
簡(jiǎn)介：biotin-labeled odn 2216 (sodium) serves as a specific agonist for human tlr9 (toll-like receptor 9), facilitating the assessment of cpg odn cellular uptake and localization through a biotin detection system coupled with light microscopy.
FITC-labeled ODN 2088 sodium；化合物 FITC-labeled ODN 2088 sodiumFITC-labeled ODN 2088 sodium (2024/9/14)
簡(jiǎn)介：fitc-labeled odn 2088 (sodium) serves as a potent inhibitor of tlr3, tlr7, and tlr9, and is utilized to assess cpg odn cellular uptake and localization utilizing confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.
Biotin-labeled ODN 2088 sodium；化合物 Biotin-labeled ODN 2088 sodiumBiotin-labeled ODN 2088 sodium (2024/9/14)
簡(jiǎn)介：biotin-labeled odn 2088 (sodium) acts as a potent inhibitor of tlr3, tlr7, and tlr9. it is utilized to assess cellular uptake and localization of cpg odn through a biotin detection system coupled with light microscopy.
FITC-labeled ODN 1668 sodium；化合物 FITC-labeled ODN 1668 sodiumFITC-labeled ODN 1668 sodium (2024/9/14)
簡(jiǎn)介：fitc-labeled odn 1668 (sodium), a class b cpg oligodeoxynucleotide (odn), functions as a tlr9 agonist. this compound is utilized to assess the cellular uptake and localization of cpg odns using techniques such as confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) and flow cytometry.
Biotin-labeled ODN 1668 sodium；化合物 Biotin-labeled ODN 1668 sodiumBiotin-labeled ODN 1668 sodium (2024/9/14)
簡(jiǎn)介：biotin-labeled odn 1668 (sodium), a class b cpg oligodeoxynucleotide (odn) and tlr9 agonist, facilitates the assessment of cellular uptake and localization of cpg odns via a biotin detection system and light microscopy.
FITC-labeled ODN 1585 sodium；化合物 FITC-labeled ODN 1585 sodiumFITC-labeled ODN 1585 sodium (2024/9/14)
簡(jiǎn)介：fitc-labeled odn 1585 (sodium) effectively induces ifn and tnfα production and serves to assess cpg odn cellular uptake and localization through confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.
Biotin-labeled ODN 1585 sodium；化合物 Biotin-labeled ODN 1585 sodiumBiotin-labeled ODN 1585 sodium (2024/9/14)
簡(jiǎn)介：biotin-labeled odn 1585 (sodium) serves as a potent inducer of ifn and tnfα production and facilitates the assessment of cpg odn cellular uptake and localization through detection with a biotin system and light microscopy analysis.
Biotin-labeled ODN 1018 sodium；化合物 Biotin-labeled ODN 1018 sodiumBiotin-labeled ODN 1018 sodium (2024/9/14)
簡(jiǎn)介：biotin-labeled odn 1018 (sodium), a tlr-9 agonist oligodeoxynucleotide, serves as a tool for assessing cellular uptake and localization of cpg odns through biotin detection systems and light microscopy.
VU0810464；化合物VU0810464VU0810464 (2024/9/14)
簡(jiǎn)介：vu0810464 is a non-ureag protein-gated inwardly-rectifying potassium channels (girk, kir3) activator.
BET-IN-16；化合物 BET-IN-16BET-IN-16 (2024/9/14)
簡(jiǎn)介：bet-in-16 (comp i), a bromodomain and extra-terminal (bet) inhibitor, demonstrates anticancer activity by impeding the growth of prostate cancer cells. it exhibits potent inhibitory effects with half-maximal inhibitory concentration (ic50) values of 0.043 μm for lncap cells and 0.034 μm for 22rv1 cells [1].
A-1293102；化合物 A-1293102A-1293102 (2024/9/14)
簡(jiǎn)介：a-1293102 is a potent, selective inhibitor of bcl-xl, effective in inducing apoptosis in tumor cells reliant on bcl-xl [1].
SA09-Cu；化合物 SA09-CuSA09-Cu (2024/9/14)
簡(jiǎn)介：sa09-cu is a potent, noncompetitive inhibitor of ndm-1, with an ic50 of 9.6 nm. it inactivates ndm-1 by oxidizing the enzyme´s zn(ii)-thiolate site and resists reduction by bacterial intracellular thiols. sa09-cu effectively restores meropenem efficacy against various clinical ndm-1-producing carbapenem-resistant enterobacteriaceae (cre) and hampers the progression of carbapenem resistance [1].
MDEG-541；化合物 MDEG-541MDEG-541 (2024/9/14)
簡(jiǎn)介：mdeg-541 is a potent myc-max degrader that exhibits antiproliferative activity by downregulating the expression of gspt1, myc, gspt2, and plk1 proteins [1].
Xanthine oxidase-IN-11；化合物 Xanthine oxidase-IN-11Xanthine oxidase-IN-11 (2024/9/14)
簡(jiǎn)介：xanthine oxidase-in-11, an analog of xo8, is an inhibitor of xanthine oxidase (xo) [1].
Xanthine oxidase-IN-10；Xanthine oxidase抑制劑10XO8 analog；XO8 analog (2024/9/14)
簡(jiǎn)介：xanthine oxidase-in-10 (xo8 analog) is a xanthine oxidase (xo) inhibitor for the study of gout.
STAT3 degrader-2；化合物 STAT3 degrader-2STAT3 degrader-2 (2024/9/14)
簡(jiǎn)介：stat3 degrader-2 is a protac-based compound that effectively reduces the total stat3 protein levels, and is utilized in the research of cancer and various diseases [1].
BK60106；化合物 BK60106BK60106 (2024/9/14)
簡(jiǎn)介：bk60106, a cd99 inhibitor, selectively targets and binds to the extracellular domain of cd99, effectively inducing apoptosis in ewing sarcoma (es) cells with minimal associated dna damage [1].
Xeniafaraunol A；化合物 Xeniafaraunol AXeniafaraunol A (2024/9/14)
簡(jiǎn)介：xeniafaraunol a (compound 31) is a potent inhibitor of the transient receptor potential melastatin 7 (trpm7) channel [1].
Pim-1 kinase inhibitor 5；化合物 Pim-1 kinase inhibitor 5Pim-1 kinase inhibitor 5 (2024/9/14)
簡(jiǎn)介：pim-1 kinase inhibitor 5 (compound 4c), with an ic50 of 0.61 μm, exhibits cytotoxicity against various cancer cell lines, including hepg2, mcf-7, pc3, and hct-116, with ic50 values ranging from 6.95 to 20.19 μm [1].
AUDA；化合物AUDAAUDA (2024/9/14)
簡(jiǎn)介：auda is an inhibitor of seh(ic50 values of 18 and 69 nm for the mouse and human enzymes, respectively)
HIV-1 inhibitor-56；化合物 HIV-1 inhibitor-56HIV-1 inhibitor-56 (2024/9/14)
簡(jiǎn)介：hiv-1 inhibitor-56 (compound 12126065) is a potent non-nucleoside reverse transcriptase inhibitor with significant antiviral activity against wild-type hiv-1, exhibiting an ec50 value of 0.24 nm in tzm cells. notably, this compound is capable of penetrating the blood-brain barrier [1].
Antitrypanosomal agent 13；化合物 Antitrypanosomal agent 13Antitrypanosomal agent 13 (2024/9/14)
簡(jiǎn)介：compound 4b (antitrypanosomal agent 13) is a potent antitrypanosomal with notable trypanocidal and cytotoxic activities, exhibiting gi50 values of 0.18 μm against t. brucei and 8.4 μm for hl-60 [1].
Antitrypanosomal agent 12；化合物 Antitrypanosomal agent 12Antitrypanosomal agent 12 (2024/9/14)
簡(jiǎn)介：antitrypanosomal agent 12, a c20-phenylthiourea, exhibits trypanocidal and cytotoxic activities, demonstrating antitrypanosomal activity with gi50 values of 0.22 μm. it induces faster cell swelling in bloodstream-form trypanosomes compared to salinomycin [1].
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