9月
FitokSS-LU-ML16備件 (2024/9/14)
簡介：twkswf10b-01拉線開關(guān)
MAO-B-IN-18；化合物 MAO-B-IN-18MAO-B-IN-18 (2024/9/14)
簡介：mao-b-in-18 is a potent, selective inhibitor of mao b, demonstrating ic50 values of 52 nm for hmao b and 14 μm for hmao a. it exhibits cytoprotective effects against hydrogen peroxide-induced damage in neuroblastoma and astrocyte cultures [1].
TWKSWF10B-01拉線開關(guān) (2024/9/14)
簡介：twkswf10b-01拉線開關(guān)
N-(Hydroxymethyl)nicotinamide；N-羥甲基煙酰胺Nicoform|||N-hydroxymethylnicotinamide|||Bilamid|||Nikomethami (2024/9/14)
簡介：n-(hydroxymethyl)nicotinamide (bilamid) is an antimicrobial agent.
hAChE-IN-1；化合物 hAChE-IN-1hAChE-IN-1 (2024/9/14)
簡介：hache-in-1 (compound 24) is a potent inhibitor of human acetylcholinesterase (hache), exhibiting an inhibition concentration half-maximum (ic50) of 1.09 μm. additionally, it inhibits tau-oligomerization with an effective concentration half-maximum (ec50) of 2.71 μm as determined by a cellular tau fluorescence resonance energy transfer (fret) assay [1].
HPK1-IN-35；化合物 HPK1-IN-35HPK1-IN-35 (2024/9/14)
簡介：hpk1-in-35 is a potent, selective inhibitor of hpk1, demonstrating an ic50 value of 3.5 nm. this compound reduces p-slp76 expression and facilitates the secretion of il-2 [1].
IDO1-IN-21；化合物 IDO1-IN-21IDO1-IN-21 (2024/9/14)
簡介：ido1-in-21 (compound 10m), with an ic50 of 0.64 μm, acts as an ido1 inhibitor and has demonstrated efficacy in suppressing tumor growth in murine models [1].
Apoptosis inducer 11；化合物 Apoptosis inducer 11Apoptosis inducer 11 (2024/9/14)
簡介：apoptosis inducer 11 (compound 3u) promotes apoptosis via the mitochondrial pathway and elicits a g2/m block alongside a marked reduction in the s phase within non-hodgkin lymphoma cell lines [1].
Polymyxin B；多黏菌素BPolymyxin B (2024/9/14)
簡介：polymyxin b, an antibiotic, combats gram-negative infections through high-affinity binding to the bacterial wall´s lipopolysaccharides (lps), neutralizing endotoxin effects and inducing bacterial cell death by enhancing permeability. it is utilized in endotoxemia research [1] [3].
FFN246；化合物 FFN246FFN246 (2024/9/14)
簡介：ffn246, a fluorescent probe, concurrently targets the serotonin transporter (sert) and vesicular monoamine transporter 2 (vmat2), exhibiting excitation and emission spectra at 392/427 nm, respectively. it serves to label serotonergic neurons within mouse brain tissue via sert-dependent accumulation [1].
RET-IN-22；化合物 RET-IN-22RET-IN-22 (2024/9/14)
簡介：ret-in-22 (compound 17b) is a potent, selective, and orally active inhibitor of ret, exhibiting ic50 values of 20.9 nm for wild-type ret and 18.3 nm for ret-v804m. it demonstrates a highly selective inhibition profile across a broad spectrum of kinases, with notable specificity over egfr and vegfr2. additionally, ret-in-22 is implicated in exerting anticancer effects [1].
SJ1461；化合物 SJ1461SJ1461 (2024/9/14)
簡介：sj1461 is a potent, orally active inhibitor of the bet family, selectively targeting and inhibiting brd2 (bd1), brd2 (bd2), brd4 (bd1), and brd4 (bd2) with respective ic50 values of 1.6 nm, 0.1 nm, 6.5 nm, and 0.2 nm [1].
ITH12711；化合物 ITH12711ITH12711 (2024/9/14)
簡介：ith12711, a pp2a ligand, can traverse the blood-brain barrier (bbb) and exerts neuroprotection by restoring pp2a-phosphatase activity [1].
Antileishmanial agent-14；化合物 Antileishmanial agent-14Antileishmanial agent-14 (2024/9/14)
簡介：antileishmanial agent-14, a sulfuretin analog, exhibits potential activity against leishmania donovani promastigotes (ic 50 = 4.1 μm) and inhibits infection by l. donovani amastigotes (ic 50 = 11.1 μm) [1].
Farnesol法呢醇法呢醇|||里哪醇 (2024/9/14)
簡介：farnesol is a natural product, has the activity in inhibiting bacteria.
AChE/BuChE/MAO-B-IN-2；化合物 AChE/BuChE/MAO-B-IN-2AChE/BuChE/MAO-B-IN-2 (2024/9/14)
簡介：ache/buche/mao-b-in-2 (compound 4b) is a potent inhibitor of ache, buche, and hu mao-b, with respective ic50 values of 5.3 μm, 12.4 μm, and 1.9±0.08 μm, indicating good in vitro blood-brain barrier (bbb) permeability. it is effective in reducing excessive ache and buche levels associated with alzheimer´s disease (ad) and holds potential for use in anti-alzheimer´s research [1].
LTB4 antagonist 3；化合物 LTB4 antagonist 3LTB4 antagonist 3 (2024/9/14)
簡介：compound 24e, a leukotriene b4 (ltb4) antagonist, exhibits an inhibitory concentration 50 (ic50) of 477 nm and demonstrates anti-inflammatory activity [1].
LTB4 antagonist 2；化合物 LTB4 antagonist 2LTB4 antagonist 2 (2024/9/14)
簡介：ltb4 antagonist 2, a carboxamide-acid compound, serves as an antagonist to leukotriene b4 (ltb4), possessing potential anti-inflammatory properties. it exhibits high affinity for the ltb4 receptor, with an inhibitory concentration (ic50) of 439 nm [1].
ERα degrader 6；化合物 ERα degrader 6ERα degrader 6 (2024/9/14)
簡介：erα degrader 6 (compound 31q) is an erα degrader with a k i of 75 nm and also inhibits aro with an ic50 value of 37.7 nm. it effectively inhibits tumor growth in the mcf-7 tumor xenograft model and has applications in breast cancer research [1].
Neuraminidase-IN-13；化合物 Neuraminidase-IN-13Neuraminidase-IN-13 (2024/9/14)
簡介：neuraminidase-in-13 (compound 10), a neuraminidase inhibitor exhibiting antiviral activity, demonstrates significant inhibition of ndv infection in vero cells with minimal cytotoxicity by impeding the release of viral particles from infected cells [1].
Isopropyl dodec-11-enylfluorophosphonate；化合物 Isopropyl dodec-11-enylfluorophosphonateIDEFP；IDEFP (2024/9/14)
簡介：isopropyl dodec-11-enylfluorophosphonate (idefp) is an organophosphorus ester functioning as a central cannabinoid receptor (cb1) antagonist and exhibits equipotent inhibition of fatty acid amide hydrolase (faah), with both activities possessing an ic50 value of 2 nm [1].
Antibacterial agent 135；化合物 Antibacterial agent 135Antibacterial agent 135 (2024/9/14)
簡介：antibacterial agent 135 (example 7) effectively inhibits various bacteria, including p. aeruginosa, a. baumannii, e. coli, and k. pneumoniae, with a minimum inhibitory concentration (mic) greater than 64 μg/ml [1].
I-287；化合物 I-287I-287 (2024/9/14)
簡介：i-287 is a selective, orally active par2 inhibitor that functions as a negative allosteric modulator of gαq and gα12/13 activity and their downstream effectors. it has been shown to attenuate complete freund´s adjuvant-induced inflammation in mice, suggesting its utility in inflammation/immunology research [1].
Glucocerebrosidase-IN-1 hydrochloride；化合物 Glucocerebrosidase-IN-1 hydrochlorideGlucocerebrosidase-IN (2024/9/14)
簡介：glucocerebrosidase-in-1 (compound 11a) hydrochloride is a potent, selective gcase (glucocerebrosidase) inhibitor with ic50 and ki values of 29.3 μm and 18.5 μm, respectively. it is utilized in the research of gaucher disease (gd) and parkinson’s disease (pd) [1].
Xilmenolone；化合物 XilmenoloneXilmenolone (2024/9/14)
簡介：xilmenolone acts as a positive allosteric modulator of the gaba_a receptor [1].
Flutriafol；粉唑醇Flutriafol (2024/9/14)
簡介：flutriafol is a pesticide, demethylation inhibitor, and nmda receptor agonist
(1R,4S)-Yimitasvir diphosphate；化合物 (1R,4S)-Yimitasvir diphosphate(1R,4S)-DAG-181 diphosphate|||(1R,4 (2024/9/14)
簡介：yimitasvir diphosphate, also known as emitasvir, is an orally-administered inhibitor of the hepatitis c virus (hcv) nonstructural protein 5a (ns5a). it is utilized in the study of chronic hepatitis c virus infections [1].
FAPI-74；化合物 FAPI-74FAPI-74 (2024/9/14)
簡介：fapi-74 serves as a positron emission tomography (pet) tracer specifically targeting fibroblast activation protein (fap), utilized in the study of fap-positive tumors [1].
Egaptivon pegol；化合物 Egaptivon pegolARC 1779；ARC 1779 (2024/9/14)
簡介：egaptivon pegol (arc1779) is an aptamer that inhibits the interaction of von willebrand factor (vwf) with platelet gpib receptors, exhibiting anti-thrombotic efficacy.
FITC-labeled ODN 1826 sodium；化合物 FITC-labeled ODN 1826 sodiumFITC-labeled ODN 1826 sodium (2024/9/14)
簡介：fitc-labeled odn 1826 (sodium), a class b cpg odn (oligodeoxynucleotide) and tlr9 agonist, facilitates the assessment of cpg odn cellular uptake and localization through confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.
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