9月
Biotin-labeled ODN 1826 sodium；化合物 Biotin-labeled ODN 1826 sodiumBiotin-labeled ODN 1826 sodium (2024/9/14)
簡介：biotin-labeled odn 1826 (sodium), a class b cpg oligodeoxynucleotide (odn), serves as a tlr9 agonist and facilitates assessment of cpg odn cellular uptake and localization through biotin detection systems and light microscopy.
FITC-labeled Agatolimod sodium；化合物 FITC-labeled Agatolimod sodiumFITC-labeled Agatolimod sodium (2024/9/14)
簡介：fitc-labeled agatolimod (sodium), a class b cpg odn (oligodeoxynucleotide) and tlr9 agonist, facilitates the assessment of cpg odn cellular uptake and localization via confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.
Biotin-labeled Agatolimod sodium；化合物 Biotin-labeled Agatolimod sodiumBiotin-labeled Agatolimod sodiu (2024/9/14)
簡介：biotin-labeled agatolimod (sodium), a class b cpg odn (oligodeoxynucleotide) and tlr9 agonist, facilitates the assessment of cellular uptake and localization of cpg odns through a biotin detection system with light microscopy.
TH-Z835；化合物 TH-Z835TH-Z835 (2024/9/14)
簡介：th-z835 is a selective inhibitor for the kras (g12d) mutation, demonstrating an inhibitory concentration (ic50) of 1.6 μm. it effectively hampers both mantgmppnp/gppnp and gppnp/mantgmppnp exchanges [1].
(S,R)-CFT8634；化合物 (S,R)-CFT8634(S,R)-CFT8634 (2024/9/14)
簡介：(s,r)-cft8634 is a selective and orally active brd9 protein degrader with potential for researching brd9-mediated disorders, such as abnormal cellular proliferation[1].
Difenoconazole；苯醚甲環(huán)唑Difenoconazole (2024/9/14)
簡介：difenoconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome p450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.
Crexavibart；化合物 CrexavibartBMS-986413|||C-144-LS；BMS-986413|||C-144-LS (2024/9/14)
簡介：crexavibart (bms-986413; c-144-ls), an igg1 λ2 antibody, specifically targets the receptor-binding domain of the sars-cov-2 spike (s) glycoprotein [1].
Pemvidutide TFA；化合物 Pemvidutide TFAPemvidutide TFA (2024/9/14)
簡介：pemvidutide (tfa), a glp-1r/gcgr dual agonist, effectively reduces body weight, liver fat, and serum lipid levels, and is utilized in research on non-alcoholic steatohepatitis (nash) and obesity [1].
Azilsartan mepixetil potassium；化合物 Azilsartan mepixetil potassiumQR-01019K；QR-01019K (2024/9/14)
簡介：azilsartan medoxomil potassium (qr-01019k), an angiotensin ii receptor antagonist, exhibits a potent and sustained antihypertensive effect, along with a more pronounced and enduring reduction in heart rate, and a high safety profile. it shows promise for investigation in the management of hypertension, chronic heart failure, and diabetic nephropathy[1].
ARG1-IN-1 hydrochloride；化合物 ARG1-IN-1 hydrochlorideARG1-IN-1 hydrochloride (2024/9/14)
簡介：arg1-in-1 hydrochloride is a potent inhibitor of human arginase 1, exhibiting an ic50 value of 29 nm [1].
Ferric nitrilotriacetate；化合物 Ferric nitrilotriacetateFerric nitrilotriacetate (2024/9/14)
簡介：ferric nitrilotriacetate (fe-nta), an iron complex of nitriloacetic acid, is widely used to provoke oxidative stress (os)-linked degenerative disorders. this compound has also been utilized in research to induce hyperglycemia, glycosuria, as well as renal and liver carcinogenesis [1].
MraY-IN-3 hydrochloride；化合物 MraY-IN-3 hydrochlorideMraY-IN-3 hydrochloride (2024/9/14)
簡介：mray-in-1 (compound 12a) is a potent inhibitor of mray, exhibiting an ic50 of 140 μm. this compound demonstrates antimicrobial activity, with mic50 values of 7 μg/ml against escherichia coli k12, 12 μg/ml for bacillus subtilis w23, and 46 μg/ml in the case of pseudomonas fluorescens pf-5. mray-in-1 is utilized in anti-bacterial research [1].
NS2B/NS3-IN-3 hydrochloride；化合物 NS2B/NS3-IN-3 hydrochlorideNS2B/NS3-IN-3 hydrochloride (2024/9/14)
簡介：ns2b/ns3-in-3 hydrochloride is a flavivirus ns2b-ns3 protease inhibitor [1].
p38α inhibitor 4；p38α 抑制劑4p38α inhibitor 4 (2024/9/14)
簡介：p38α inhibitor 4 is a selective mapk p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.
Glecirasib；化合物 GlecirasibJAB-21822|||KRAS G12C inhibitor 36；JAB-21822|||KRAS G12C inhibitor 36 (2024/9/14)
簡介：glecirasib (kras g12c inhibitor 36) is a potent inhibitor targeting the oncogenic kras g12c mutation, a key signaling molecule within the ras protein family that is crucial for cell growth and development. this compound shows promise for the investigation of cancers mediated by kras g12c mutations[1].
Nrf2 activator-3；Nrf2 激活劑3Nrf2 activator-3 (2024/9/14)
簡介：nrf2 activator-3 is a potent nrf2 activator with potential anti-inflammatory, antioxidant and anti-tumor activity, which can be used to study neurological and immune-related diseases.
Danofloxacin達氟沙星達氟沙星|||達諾沙星|||Danofloxacino|||Danofloxacin free base|||Danofloxacine (2024/9/14)
簡介：danofloxacin (danofloxacin free base) is a fluoroquinolone antibiotic used in veterinary medicine.
MAO-B-IN-4；化合物 MAO-B-IN-4MAO-B-IN-4 (2024/9/14)
簡介：mao-b-in-4 (compound 26) is a reversible monoamine oxidase b (mao-b) inhibitor with potent in vitro activity, characterized by an ic50 value of 9 nm. this orally active compound exhibits favorable metabolic stability, a satisfactory safety profile, and effective brain permeability. demonstrating antidepressant effects in rodent models, mao-b-in-4 is suitable for research into alzheimer´s disease [1].
MAO-B-IN-3；化合物 MAO-B-IN-3MAO-B-IN-3 (2024/9/14)
簡介：mao-b-in-3 is a reversible, selective inhibitor of monoamine oxidase b (mao-b) with an ic50 of 96 nm and demonstrates affinity for the 5-ht6 receptor with a ki of 696 nm, making it suitable for alzheimer´s disease research [1].
PROTAC BRD4 Degrader-16；化合物 PROTAC BRD4 Degrader-16PROTAC BRD4 Degrader-16 (2024/9/14)
簡介：protac brd4 degrader-16 is a potent degrader of brd4, exhibiting ic50 values of 34.58 nm for brd4 (bd1) and 40.23 nm for brd4 (bd2). it significantly reduces cyclin b1 expression, thereby impeding g2/m phase progression, and induces apoptosis in mv-4-11 cells [1].
Estrogen receptor antagonist 8；Estrogen receptor 拮抗劑 8Estrogen receptor antagonist 8 (2024/9/14)
簡介：estrogen receptor antagonist 8 acts as an estrogen receptor (er) antagonist with anti-uterine activity and potential anti-tumorigenic activity and can be used to study ovarian dysfunction.
ZL-2201；化合物 ZL-2201ZL-2201 (2024/9/14)
簡介：zl-2201 is a potent inhibitor of dna-pk, demonstrating an ic50 value of 1 nm.
A-77636；化合物 A-77636A-77636 (2024/9/14)
簡介：a-77636 is a potent, selective, and long-acting oral dopamine d1 receptor agonist with an effective concentration (ec50) of 1.1 nm and a corresponding pec50 value of 8.13. it demonstrates the highest affinity for the dopamine d1 receptor with a dissociation constant (ki) of 39.8 nm and a pki of 7.40 ± 0.09. notably, a-77636 exhibits antiparkinsonian activity [1].
ER-27319；化合物 ER-27319ER-27319 (2024/9/14)
簡介：er-27319, an acridone derivative, serves as a potent and selective inhibitor of spleen tyrosine kinase (syk), effectively impeding both the tyrosine phosphorylation and enzymatic activity of syk. with an inhibitory concentration (ic50) of 10 μm, this compound suppresses the release of allergic mediators from human and rat mast cells triggered by antigens, making it useful for allergy research [1] [2].
Z-LLF-CHO；化合物 Z-LLF-CHOZ-Leu-Leu-Phe-CHO；Z-Leu-Leu-Phe-CHO (2024/9/14)
簡介：z-llf-cho (z-leu-leu-phe-cho) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a ki value of 460 nm. additionally, this compound serves as an inhibitor of nf-κb nuclear translocation, as documented in references [1] [2].
Chlorpropham；氯苯胺靈Chlorpropham (2024/9/14)
簡介：chlorpropham acts as a plant growth regulator and herbicide.
Oxidized ATP trisodium salt；化合物 Oxidized ATP trisodium saltoATP trisodium salt；oATP trisodium salt (2024/9/14)
簡介：oxidized atp trisodium salt (oatp) is a broad-spectrum inhibitor of p2 receptors, irreversibly antagonizing p2x7r activation and inhibiting c-reactive protein (crp)-induced nlrp3 inflammasome activation. it is utilized in atherosclerosis research [1] [2].
Clezutoclax；化合物 ClezutoclaxClezutoclax (2024/9/14)
簡介：clezutoclax, a potent bcl-xl inhibitor, serves as an effective payload for the synthesis of antibody-drug conjugates (adcs) [1].
.@市場推送：西門子羅賓康LDZ31000082.660C可議價 (2024/9/14)
簡介：
ddTTP trisodium；化合物 ddTTP trisodiumddTTP trisodium (2024/9/14)
簡介：dideoxythymidine triphosphate trisodium (ddttp), a 2´,3´-dideoxyribonucleoside 5´-triphosphate (ddntp), functions as a chain-elongation inhibitor of dna polymerase in dna sequencing applications [1].
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