9月
.@市場推送：西門子LDZ10501930可議價 (2024/9/14)
簡介：
Glucocerebrosidase；化合物 GlucocerebrosidaseGCase|||Glucosylceramidase；GCase|||Glucosylceramidase (2024/9/14)
簡介：glucocerebrosidase (glucosylceramidase; gba), a lysosomal enzyme, catalyzes the hydrolysis of the β-glucosidic linkage in glucocerebroside (gc) to yield glucose and ceramide [1].
.@市場推送：西門子A5E32855090功率單元可議價 (2024/9/14)
簡介：
Ecallantide；化合物 EcallantideDX-88；DX-88 (2024/9/14)
簡介：ecallantide (dx-88) is a recombinant inhibitor specifically targeting plasma kallikrein, which serves to impede the synthesis of bradykinin. it is utilized to prevent acute episodes of angioedema [1].
Albiglutide fragment TFA；化合物 Albiglutide fragment TFAGLP-1-Gly8 TFA|||GLP-1 (7-36) analog TFA；GLP-1- (2024/9/14)
簡介：albiglutide fragment (glp-1 (7-36) analog) tfa represents a biologically active segment of albiglutide, resistant to dpp-4 degradation due to its structure as a glp-1 analog. it functions as a long-acting agonist of the glp-1 receptor, derived from a fusion of a glp-1 dimer with the human albumin gene. clinically, this compound demonstrates a pronounced reduction in glycosylated hemoglobin (a1c) levels, rendering it a valuable therapeutic in type 2 diabetes (t2d) research [1] [2] [3] [4].
XE991；化合物 XE991XE991 (2024/9/14)
簡介：xe991 is a novel and selective kv7 (kcnq) channel blocker.xe 991 dihydrochloride inhibits kv7.1 (kcnq1), kv7.2 (kcnq2), kv7.2 + kv7.3 (kcnq3) channels, and m-current, and can be used for the study of neurological diseases.
DO1；分散橙1Disperse Orange 1；分散橙1|||Disperse Orange 1 (2024/9/14)
簡介：do1 (disperse orange 1) is an anti-amyloid agent which potently delays both seeded and non-seeded aβ42 polymerization at substoichiometric concentrations
CPT2；化合物 CPT2Carnitine palmitoyltransferase 2；Carnitine palmitoyltransferase 2 (2024/9/14)
簡介：carnitine palmitoyltransferase 2 (cpt2), an enzyme involved in fatty acid oxidation, serves as a prognostic biomarker for colorectal cancer (crc). overexpression of cpt2 activates phosphorylated p53, enhancing its expression, which in turn suppresses tumor growth and induces apoptosis. conversely, a deficiency in cpt2 leads to the prevalent hereditary disorder of long-chain fatty acid oxidation in skeletal muscle. additionally, the downregulation of cpt2 correlates strongly with the advancement
PI3Kδ-IN-15；化合物 PI3Kδ-IN-15PI3Kδ-IN-15 (2024/9/14)
簡介：pi3kδ-in-15 (compound 6b) is a potent and selective inhibitor of pi3kδ, exhibiting an ic50 of 0.5 nm for p110δ and demonstrating over 30-fold selectivity compared to pi3k isoforms γ, β, and α [1].
Moprolol；化合物 Moprolol(±)-Moprolol；(±)-Moprolol (2024/9/14)
簡介：moprolol ((±)-moprolol) is a beta-adrenergic receptor antagonist utilized in research pertaining to essential hypertension [1] [2] [3].
GlcNAcstatin；化合物 GlcNAcstatinGlcNAcstatin (2024/9/14)
簡介：glcnacstatin, a selective glucoimidazole-based inhibitor of bacterial o-glcnacase, exhibits a k_i value of 4.6 pm and demonstrates a specificity that is 100,000-fold greater than that for hexa/b [1].
Dihydro-5-azacytidine acetate；化合物 Dihydro-5-azacytidine acetateDHAC acetate|||NSC 264880 acetate；DHA (2024/9/14)
簡介：dihydro-5-azacytidine acetate (dhac), a nucleoside analog, becomes integrated into dna, thereby inhibiting dna methylation, and exhibits antitumor activity [1] [2].
Depramine；化合物 DepramineGP 31406；GP 31406 (2024/9/14)
簡介：depramine (gp 31406), a tricyclic antidepressant, exhibits pharmacological activity by inhibiting acetylcholinesterase, mg^2+-atpase, and na^+/k^+ atpase activity [1] [2].
[Leu13]-Motilin；化合物 [Leu13]-MotilinKW-5139；KW-5139 (2024/9/14)
簡介：[leu13]-motilin (kw-5139) is an analogue of the gastrointestinal hormone motilin that induces concentration-dependent contractions in rabbit gastrointestinal tissues, including the gastric antrum, duodenum, jejunum, ileum, and descending colon in vitro [1].
FX-06；化合物 FX-06Fibrin-derived peptide Bβ15-42；Fibrin-derived peptide Bβ15-42 (2024/9/14)
簡介：fx-06 (fibrin-derived peptide bβ15-42) is a peptide derived from the fibrin bbeta chain. it interacts with ve-cadherin to inhibit leukocyte transmigration and initiate ve-cadherin-mediated signaling pathways. this compound has applications in researching ischemia/reperfusion injury and dengue shock syndrome (dss) [1] [2] [4].
M62812 free base；化合物 M62812 free baseM62812 free base (2024/9/14)
簡介：m62812 (free base), a toll-like receptor 4 (tlr4) signal transduction inhibitor, suppresses activation of endothelial cells and leukocytes and prevents lethal septic shock in mice. it is utilized in sepsis research [1].
U-89843A；化合物 U-89843AU-89843A (2024/9/14)
簡介：u-89843a is an allosteric modulator of the gaba_a receptor, known to enhance gaba-induced cl^- currents [1].
Naphthol AS-E；色酚 AS-EnAS-E；色酚 AS-E|||nAS-E (2024/9/14)
簡介：naphthol as-e (nas-e) is an the kix-kid interaction and creb-mediated gene transcription inhibitor.
PDE7-IN-3；化合物 PDE7-IN-3PDE7-IN-3 (2024/9/14)
簡介：pde7-in-3 (example 2) serves as an inhibitor of phosphodiesterase pde7 and exhibits potential analgesic properties. it is applicable in the research of various pain types including inflammatory, neuropathic, visceral, and nociceptive pain [1].
GNE-7883；化合物 GNE-7883GNE-7883 (2024/9/14)
簡介：gne-7883, a pan-tead inhibitor, exhibits anti-cell proliferation effects and mitigates resistance to kras g12c inhibitors through the inhibition of yap/taz activation in various preclinical models, potentially aiding in the research of yap/taz-dependent cancers [1].
HOIPIN-1；化合物JTP0819958JTP0819958；JTP0819958 (2024/9/14)
簡介：hoipin-1 (jtp0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (lubac) (ic50 >2.8 μm).hoipin-1 inhibits lubac-mediated nf-kb activation.
Antidepressantu00A0agentu00A05；抗抑郁劑5Antidepressantu00A0agentu00A05 (2024/9/14)
簡介：antidepressant?agent?5 is a 7-substituted tetrahydroisoquinoline derivative with antidepressant activity.antidepressant?agent?5 acts similarly to magnoflorine in the study of depression and can be used for the prevention and treatment of depressive disorders.
BRD4u00A0Inhibitor-27；BRD4抑制劑27BRD4u00A0Inhibitor-27 (2024/9/14)
簡介：brd4?inhibitor-27 is a potent brd4 inhibitor that inhibits brd4 bd1 and brd4 bd2 with ic50s of 9.6 and 11.3 μm, respectively.brd4?inhibitor-27 has anticancer activity and can be used for breast cancer research.
Tyrosinase-IN-12；Tyrosinase抑制劑12Tyrosinase-IN-12 (2024/9/14)
簡介：tyrosinase-in-12(non-competitive tyrosinase inhibitor) is a potent non-competitive tyrosinase inhibitor with an ic50 of 49.33 ± 2.64 μm and a ki of 31.25 ± 0.25 μm. tyrosinase-in-12 has significant antioxidant and free radical scavenging activity (ic50:25.39 ± 0.77 μm), reducing reactive oxygen species (ros) production. tyrosinase inhibitor (tyrosinase-in-12) has significant antioxidant and free radical scavenging activity and reduces the production of reactive oxygen species (ros) (ic50:25.39 ±
PB118；化合物 PB118PB118|||PB 118|||PB-118|||PB118；PB118|||PB 118|||PB-118|||PB118 (2024/9/14)
簡介：pb118 has the capacity to effectively clear aβ deposits by augmenting phagocytosis, enhance the tubulin/microtubule network through increased acetyl α-tubulin levels, modulate various inflammation-associated cytokines and chemokines, and notably diminish phospho-tau (p-tau) levels linked to alzheimer´s disease (ad). the ic50 of pb118 for hdac6 is 5.6 nm.
Glycolithocholic acid 3-sulfate disodium；化合物 Glycolithocholic acid 3-sulfate disodiumGlycolithochola (2024/9/14)
簡介：glycolithocholic acid 3-sulfate (disodium) demonstrates inhibitory effects on in vitro hiv-1 replication and has potential applications in hiv infection and gallbladder disease research [1] [2].
Sodium pyrophosphate；焦磷酸二鈉Sodium acid Pyrophosphate|||Disodium Pyrophosphate|||SAPP|||SAPP|||Disodiu (2024/9/14)
簡介：sodium pyrophosphate (disodium pyrophosphate), an inorganic food additive, exhibits potential hematotoxic and immunotoxic effects [1].
Ethylene glycol dimethacrylate；乙二醇二(甲基丙烯酸)酯Ethylene glycol dimethacrylate (2024/9/14)
簡介：ethylene glycol dimethacrylate, a methacrylate monomer, demonstrates cytotoxic and genotoxic impacts on human gingival fibroblasts (hgfs), elevating intracellular reactive oxygen species (ros) levels, inducing dna damage, enhancing apoptosis, and triggering cell cycle arrest in the g1/g0 phase [1].
3-Hydroxyxanthone；3-羥基占噸-9-酮3-Hydroxy-xanthen-9-one；3-Hydroxy-xanthen-9-one (2024/9/14)
簡介：3-hydroxyxanthone (3-hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on nadph-catalyzed lipid peroxidation in human umbilical vein endothelial cells (huvecs) and suppresses tnf-alpha-induced icam-1 expression [1].
2-Phenyl-2-(2-pyridyl)acetonitrile；化合物 2-Phenyl-2-(2-pyridyl)acetonitrileα-Phenyl-2-pyridineacetonit (2024/9/14)
簡介：2-phenyl-2-(2-pyridyl)acetonitrile represents the principal metabolite of the antigastric agent sc 15396, produced by the supernatant fraction of rat liver homogenate; sc 15396 functions to inhibit gastric secretion [1].
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