9月
2,4-D isooctyl ester；2,4-D isooctyl ester2,4-D isooctyl ester (2024/9/8)
簡(jiǎn)介：2,4-d isooctyl ester is a chlorophenoxy compound herbicide characterized by its selective action and advantageous physical properties, such as a higher boiling point, low volatility, and low drift. it effectively manages broadleaf weeds across diverse environments, including agricultural fields, lawns, and forested areas.
Propargyl-PEG2-NHS ester；Propargyl-PEG2-NHS esterPropargyl-PEG2-NHS ester；Propargyl-PEG2-NHS ester (2024/9/8)
簡(jiǎn)介：propargyl-peg2-nhs ester is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Relebactam；瑞來(lái)巴坦MK-7655；瑞來(lái)巴坦|||MK-7655 (2024/9/8)
簡(jiǎn)介：relebactam (mk-7655) is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases.
Mal-PEG4-C2-NH2 TFA；Mal-PEG4-C2-NH2 TFAMal-PEG4-C2-NH2 TFA；Mal-PEG4-C2-NH2 TFA (2024/9/8)
簡(jiǎn)介：mal-peg4-c2-nh2 tfa is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
DHODH-IN-16；化合物DHODH-IN-16DHODH-IN-16 (2024/9/8)
簡(jiǎn)介：dhodh-in-16 is an effective inhibitor of dihydroorotate dehydrogenase (dhodh, ic50 = 0.396 nm for human).
BTNPO；BTNPOBTNPO (2024/9/8)
簡(jiǎn)介：btnpo is a unimolecular two-photon fluorescent probe.
Bexirestrant；BexirestrantBexirestrant (2024/9/8)
簡(jiǎn)介：bexirestrant is an orally active er-α degrader commonly employed in the research of antiestrogen and antineoplastic therapies.
OM99-2 TFA；OM99-2 TFAOM99-2 TFA；OM99-2 TFA (2024/9/8)
簡(jiǎn)介：om99-2 tfa is an eight-residue peptidomimetic compound, functioning as a tight-binding inhibitor of human brain memapsin 2. it exhibits a high affinity for the target with a ki value of 9.58 nm, making it a promising candidate in the development of bace1 inhibitors. due to its potential, om99-2 presents opportunities for further research in the field of alzheimer´s disease.
BPR1R024；BPR1R024BPR1R024；BPR1R024 (2024/9/8)
簡(jiǎn)介：bpr1r024 is an orally active and selective csf1r inhibitor ( ic 50 = 0.53 nm).
Acid-C3-SSPy；Acid-C3-SSPyAcid-C3-SSPy；Acid-C3-SSPy (2024/9/8)
簡(jiǎn)介：acid-c3-sspy is a cleavable dba-dm4 linker used in the synthesis of dba-dm4 , a drug-linker conjugate for adc.
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride；(Rac)-5-Hydroxymethyl Tolterodine hydrochloride(Rac) (2024/9/8)
簡(jiǎn)介：(rac)-5-hydroxymethyl tolterodine hydrochloride, also known as (rac)-desfesoterodine hydrochloride, is an active metabolite of tolterodine that functions as a machr antagonist. it exhibits significant affinity (k i values) for m1, m2, m3, m4, and m5 receptors, with values of 2.3 nm, 2 nm, 2.5 nm, 2.8 nm, and 2.9 nm, respectively. this compound is commonly employed in research related to overactive bladder conditions.
CDK2-IN-7CDK2-IN-7CDK2-IN-7 (2024/9/8)
簡(jiǎn)介：cdk2-in-7 is a cdk2 inhibitor for treating cancer ( ic 50 < 50 nm).
BMS-986020；化合物BMS986020AM152|||BMS986020；AM152|||BMS986020 (2024/9/8)
簡(jiǎn)介：bms-986020 (am152) is a selective antagonist of lpa1.
(4-NH2)-Exatecan；化合物 (4-NH2)-Exatecan(4-NH2)-Exatecan；(4-NH2)-Exatecan (2024/9/8)
簡(jiǎn)介：(4-nh2)-exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (adcs).
N-acetyldopamine；N-乙酰多巴胺NADA；NADA|||N-乙酰多巴胺 (2024/9/8)
簡(jiǎn)介：n-acetyldopamine (nada) is a catecholamine utilized by insects as a precursor for sclerotization, a process that strengthens their cuticle.
Hyp-Phe-Phe；Hyp-Phe-PheHyp-Phe-Phe (2024/9/8)
簡(jiǎn)介：hyp-phe-phe is a tripeptide known for its strong aromatic interactions between the phe rings, resulting in the formation of helical-like sheets and a cross helical architecture. notably, hyp-phe-phe exhibits excellent shear piezoelectricity properties, making it a valuable candidate for piezoelectric materials.
MRTX849 analog 24；MRTX849 analog 24MRTX849 analog 24；MRTX849 analog 24 (2024/9/8)
簡(jiǎn)介：mrtx849 analog 24 is an alkyne-containing click probe analogue of the mrtx849 inhibitor for kras g12c. it is specifically designed for studying the functionality of mrtx849.
FTX-6058 hydrochloride；FTX-6058 hydrochlorideFTX-6058 hydrochloride (2024/9/8)
簡(jiǎn)介：ftx-6058 hydrochloride is a potent and orally active inhibitor of embryonic ectoderm development (eed), with the ability to induce hbf protein expression in both cell and murine models. this compound is particularly valuable in the research of select hemoglobinopathies, such as sickle cell disease and β-thalassemia.
FTX-6058；FTX-6058FTX-6058 (2024/9/8)
簡(jiǎn)介：ftx-6058 is a potent orally active inhibitor targeting embryonic ectoderm development (eed). it effectively induces hbf protein expression in both cell and murine models. this compound holds significant potential for researching select hemoglobinopathies such as sickle cell disease and β-thalassemia.
BAMEA-O16B；BAMEA-O16BBAMEA-O16B；BAMEA-O16B (2024/9/8)
簡(jiǎn)介：bameao16b is a lipid nanoparticle that incorporates disulfide bonds for efficient delivery of cas9 mrna and sgrna into cells. in the intracellular environment, bameao16b responds to reduction by releasing rna, facilitating genome editing. this compound is valuable for gene editing research purposes.
AXC-715 hydrochloride；AXC-715 hydrochlorideAXC-715 hydrochloride (2024/9/8)
簡(jiǎn)介：axc-715 hydrochloride is a tlr7/tlr8 dual agonist, can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (pd-l1) linked to one or more adjuvants.
Thalidomide-5-propargyne-NH2 hydrochloride；Thalidomide-5-propargyne-NH2 hydrochlorideThalidomide-5-p (2024/9/8)
簡(jiǎn)介：thalidomide-5-propargyne-nh2 hydrochloride is a cereblon ligand derived from thalidomide that is utilized in the recruitment of crbn protein. it can be linked to the protein ligand through a linker to produce protacs, which are compounds used for protein degradation.
Trk-IN-6；Trk-IN-6Trk-IN-6 (2024/9/8)
簡(jiǎn)介：trk-in-6 shows excellent in vitro potency on a panel of trk mutants ( ic 50 = 0.2-0.7 nm).
HG-14-10-04；化合物HG-14-10-04HG-14-10-04 (2024/9/8)
簡(jiǎn)介：hg-14-10-04 is a potent and specific alk inhibitor.
Thalidomide-NH-PEG8-Ts；Thalidomide-NH-PEG8-TsThalidomide-NH-PEG8-Ts；Thalidomide-NH-PEG8-Ts (2024/9/8)
簡(jiǎn)介：thalidomide-nh-peg8-ts is a chemically synthesized conjugate consisting of a thalidomide-based cereblon ligand and an 8-unit peg linker. this conjugate serves as an e3 ligase ligand-linker in protac technology applications, including the degradation of ido1 by a protac degrader.
Pom-8PEG；Pom-8PEGPom-8PEG (2024/9/8)
簡(jiǎn)介：pom-8peg is an e3 ubiquitin ligase ligand-linker conjugate consisting of a cereblon (crbn) ligand and an 8-unit peg linker. this compound can be utilized for the synthesis of protac, including the ido1 protac degrader.
Sec61-IN-1；化合物Sec61-IN-1Sec61-IN-1；Sec61-IN-1 (2024/9/8)
簡(jiǎn)介：sec61-in-1 is a potent sec61 inhibitor.
CBP/p300 ligand 2；CBP/p300 ligand 2CBP/p300 ligand 2 (2024/9/8)
簡(jiǎn)介：cbp/p300 ligand 2 is a selective ligand that binds to the target protein for protac of dcbp-1, a potent and selective heterobifunctional degrader of p300/cbp.
PROTAC CBP/P300 Degrader-1；PROTAC CBP/P300 Degrader-1PROTAC CBP/P300 Degrader-1；PROTAC CBP/P300 Degr (2024/9/8)
簡(jiǎn)介：protac cbp/p300 degrader-1 is an effective compound that degrades cbp/p300 in a potent manner. it significantly reduces cell viability in various cancer cell lines.
Thalidomide-NH-CBP/p300 ligand 2；Thalidomide-NH-CBP/p300 ligand 2Thalidomide-NH-CBP/p300 ligand 2；Th (2024/9/8)
簡(jiǎn)介：thalidomide-nh-cbp/p300 ligand 2 (p-007) is a protac-based compound designed to degrade cbp and p300, acting as a functional antagonist (wo2020173440).
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