9月
Zanamivir-Cholesterol Conjugate；Zanamivir-Cholesterol ConjugateZanamivir-Cholesterol Conjugate (2024/9/8)
簡介：zanamivir-cholesterol conjugate is an extended-duration neuraminidase inhibitor highly effective against drug-resistant influenza strains.
CP-724714；化合物CP724714CP724714|||CP 724714；CP724714|||CP 724714 (2024/9/8)
簡介：cp-724714 (cp724714) is an effective and selective her2/erbb2 inhibitor (ic50: 10 nm), >640-fold selectivity against egfr, abl, insr, pdgfr, irg-1r, src, vegfr2, c-met etc.
H-Asn-Arg-OH；H-Asn-Arg-OHH-Asn-Arg-OH (2024/9/8)
簡介：h-asn-arg-oh is used for the solid-phase peptide synthesis.
2,3-Dibromoacrylic acid；2,3-二溴丙烯酸2,3-Dibromoacrylic acid (2024/9/8)
簡介：2,3-dibromoacrylic acid, an unsaturated carboxylic acid derivative, enriches the chemical profile of acrylic acid—the simplest form of such compounds—by integrating dibromo functionalities, serving as a versatile chemical intermediate.
PZ703b；PZ703bPZ703b (2024/9/8)
簡介：pz703b is a novel bcl-xl protac degrader with enhanced bcl-2 inhibition.
Diacetyl Agrochelin；Diacetyl AgrochelinDiacetyl Agrochelin (2024/9/8)
簡介：diacetyl agrochelin, an acetyl derivative of agrochelin, is a compound synthesized through the fermentation of marine agrobacterium sp. it possesses cytotoxic properties against tumor cell lines.
Agrochelin；AgrochelinAgrochelin (2024/9/8)
簡介：agrochelin, an alkaloid cytotoxic antibiotic, is synthesized via fermentation of a marine agrobacterium sp. this compound demonstrates cytotoxic activity against tumor cell lines.
Insulin β Chain Peptide (15-23)；Insulin β Chain Peptide (15-23)Insulin β Chain Peptide (15-23) (2024/9/8)
簡介：insulin β chain peptide (15-23), also referred to as ins, is an insulin-derived peptide that is specifically recognized by islet-associated t cells. the tetramer of insulin β chain peptide (15-23) effectively stained the ins-reactive ctl clone g9c8; however, neither this tetramer nor the negative control tetramer (tum) exhibited staining on the splenic cd8+ t cells obtained from nod or 8.3-tcrαβ transgenic nod mice.
SGC-CK2-1；SGC-CK2-1SGC-CK2-1；SGC-CK2-1 (2024/9/8)
簡介：sgc-ck2-1 is an atp-competitive chemical compound that acts as a highly potent and cell-active ck2 inhibitor. it demonstrates excellent selectivity towards both isoforms of human ck2, with ic50 values of 36 nm for ck2α and 16 nm for ck2α′ in the nanobret assay. given its properties, sgc-ck2-1 is a suitable tool for the investigation of neurodegenerative diseases.
Nur77 modulator 1；化合物Nur77 modulator 1Nur77 modulator 1；Nur77 modulator 1 (2024/9/8)
簡介：nur77 modulator 1 is a good nur77 binder (kd = 3.58 μm). nur77 modulator 1 up-regulates nur77 expression, mediates sub-cellular localization of nur77, induces nur77-dependent er stress and autophagy, and results in cell apoptosis. nur77 modulator 1 shows anti-hepatoma activity.
SGC2085 HCl；化合物SGC2085 HClSGC2085 HCl (2024/9/8)
簡介：sgc2085 is a potent and selective coactivator associated arginine methyltransferase 1 (carm1) inhibitor with an ic50 of 50 nm and more than undred-fold selectivity over other prmts. carm1 is an important positive modulator of wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo.
Lenalidomide-6-F；Lenalidomide-6-FLenalidomide-6-F (2024/9/8)
簡介：lenalidomide-6-f is a derivative of lenalidomide that serves as a cereblon (crbn) ligand facilitating the recruitment of crbn protein. with the addition of a linker, lenalidomide-6-f can be conjugated to the ligand for the protein, enabling the formation of protac.
IL-17 modulator 3；IL-17 modulator 3IL-17 modulator 3 (2024/9/8)
簡介：il-17 modulator 3 (us20200247785a1) is a chemical compound that acts as an il-17 modulator. it has potential applications in researching inflammation, cancer, and autoimmune diseases.
4,5-Dichloroguaiacol；4,5-二氯愈創(chuàng)木酚4,5-Dichloroguaiacol (2024/9/8)
簡介：4,5-dichloroguaiacol is the major component of chlorinated phenol.
Antifungal agent 20；Antifungal agent 20Antifungal agent 20 (2024/9/8)
簡介：antifungal agent 20 demonstrates significant antifungal efficacy against a range of fungal pathogens including colletotrichum gloeosprioides, rhizoctonia solani, phytophthora nicotianae var. nicotianae, diplodia pinea, colletotrichum acutatum, and fusarium oxysporum f. sp. niveum.
BMS-986251；BMS-986251BMS-986251 (2024/9/8)
簡介：bms-986251 is a potent and specific rorγt inverse agonist that exerts its action via oral administration. it shows an ec 50 of 12 nm for rorγt gal4. in human whole blood assay, bms-986251 effectively inhibits il-17 with an ec 50 of 24 nm. furthermore, bms-986251 exhibits strong therapeutic effects in mouse acanthosis and imiquimod-induced models, which are commonly used preclinical models for psoriasis.
L-Histidine benzyl ester bistosylate；L-組氨酸芐酯對甲苯磺酸酯L-Histidine benzyl ester bistosylate (2024/9/8)
簡介：l-histidine benzyl ester bistosylate may serve as an activator for hutp, an rna-binding protein.
SHP2-D26；SHP2-D26SHP2-D26；SHP2-D26 (2024/9/8)
簡介：shp2-d26 is a highly potent and effective shp2 degrader. its mechanism of action involves the induction of shp2 degradation through binding to vhl-1 and shp2 proteins. additionally, the degradation of shp2 induced by shp2-d26 is dependent on neddylation and proteasome activity.
FNC-TP；FNC-TPFNC-TP (2024/9/8)
簡介：fnc-tp, the intracellular active form of fnc, is a potent nucleoside reverse transcriptase inhibitor (nrti) with broad-spectrum antiviral activity against hiv, hbv, and hcv.
UNC926；化合物UNC 926UNC-926|||UNC 926 hydrochloride；UNC-926|||UNC 926 hydrochloride (2024/9/8)
簡介：unc926 (unc-926) inhibits l3mbtl1 (ic50: 3.9 μm). unc926 also exhibits a low micromolar affinity for l3mbtl3. unc926 inhibits binding of the 3xmbt domain to h4k20me1. it selectively and dose-dependently inhibits the l3mbtl13xmbt-h4k20me1 interaction. unc926 has not an effect on the binding of 53bp1 to h4k20me1.
TC-2559 difumarate；TC-2559 difumarateTC-2559 difumarate (2024/9/8)
簡介：tc-2559 idifumarate is a cns-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nachr) partial agonist with an ec 50 of 0.18 μm. it exhibits selectivity for α4β2 receptors over α2β4, α4β4, and α3β4 receptors, with ec 50 s ranging from 10 to 30 μm. tc-2559 difumarate also demonstrates antinociceptive effects.
Mal-PEG5-C2-NH2 hydrochloride；Mal-PEG5-C2-NH2 hydrochlorideMal-PEG5-C2-NH2 hydrochloride；Mal-PEG5-C2 (2024/9/8)
簡介：mal-peg5-c2-nh2 hydrochloride is a polyethylene glycol (peg)-based linker utilized for the synthesis of proteolysis targeting chimeras (protacs).
Antileishmanial agent-1；Antileishmanial agent-1Antileishmanial agent-1 (2024/9/8)
簡介：antileishmanial agent-1 demonstrates activity against both l. amazonensis promastigotes (ic 50 = 15.52 μm) and intracellular amastigotes (ic 50 = 4.10 μm).
IL-17A inhibitor 2；IL-17A inhibitor 2IL-17A inhibitor 2 (2024/9/8)
簡介：il-17a inhibitor 2 is an il-17a inhibitor for treating psoriasis, rheumatoid arthritis, and multiple sclerosis.
GAD65 (206-220)；GAD65 (206-220)GAD65 (206-220)；GAD65 (206-220) (2024/9/8)
簡介：gad65 (206-220) is a synthetic peptide derived from glutamic acid decarboxylase (gad) 65, specifically corresponding to residues 180-188. it is known that gad65 interacts with i-ag7 mhc class ii molecules and is a significant pancreatic antigen that self-reactive t cells target in type i diabetes mellitus.
RSV-IN-2；RSV-IN-2RSV-IN-2 (2024/9/8)
簡介：rsv-in-2 is a powerful compound that acts as a dual inhibitor of both wild-type and mutant respiratory syncytial virus (rsv) fusion proteins. it efficiently inhibits the activity of these proteins, with an ec50 value of 0.27 nm for the wild-type and 0.70 nm for the d486n-mutant protein.
Benzyl 2-hydroxy-6-methoxybenzoate；Benzyl 2-hydroxy-6-methoxybenzoateBenzyl 2-hydroxy-6-methoxybenzo (2024/9/8)
簡介：benzyl 2-hydroxy-6-methoxybenzoate exhibits potent antifungal activity, demonstrating an ic 50 of 25–26 μg/ml against fungal strains.
PROTAC PD-1/PD-L1 degrader-1；PROTAC PD-1/PD-L1 degrader-1PROTAC PD-1/PD-L1 degrader-1；PROTAC PD-1/PD (2024/9/8)
簡介：protac pd-1/pd-l1 degrader-1, a cereblon e3 ligand-based compound, is a pd-1/pd-l1 protac that effectively inhibits the interaction between pd-1 and pd-l1 with an ic50 value of 39.2 nm. it successfully restores the suppressed immune response in a co-culture model consisting of hep3b/os-8/hpd-l1 cells and cd3 t cells. additionally, this compound moderately decreases pd-l1 protein levels through a lysosome-dependent mechanism.
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride；化合物T40111LBMS-1166-N-piperidine-CO-N-piperazin (2024/9/8)
簡介：bms-1166-n-piperidine-co-n-piperazine dihydrochloride is a resorcinol di-ph ether scaffold-based programmed cell death-1 (pd-1)/programmed cell death ligand 1 (pd-l1) inhibitor that inhibits the pd-1/pd-l1 interaction with an ic50 of 39.2 nm.bms-1166-n-piperidine-co-n-piperazine dihydrochloride contains the target protein pd-1/pd-l1 ligand and protac linker.bms-1166-n-piperidine-co-n-piperazine dihydrochloride can be used to synthesize protac linker. bms-1166-n-piperidine-co-n-piperazine dihydro
BMS-1166-N-piperidine-CO-N-piperazine；BMS-1166-N-piperidine-CO-N-piperazineBMS-1166-N-piperidine-CO- (2024/9/8)
簡介：bms-1166-n-piperidine-co-n-piperazine is a chemical compound that contains a pd-1/pd-l1 immune checkpoint ligand and a protac linker. it can be utilized in the synthesis of protac pd-1/pd-l1 degrader-1, which effectively inhibits the pd-1/pd-l1 interaction, demonstrating an ic50 value of 39.2 nm.
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