9月
Sivopixant；化合物SivopixantS-600918|||Sivopixant；S-600918|||Sivopixant (2024/9/8)
簡(jiǎn)介：sivopixant (s-600918) (s-600918) is a potent and selective antagonist of p2x3 receptor (p2x3 ic 50 =4.2 nm; p2x2/3 ic 50 =1100 nm). sivopixant shows strong analgesic effect .
Evifacotrep；化合物EvifacotrepEvifacotrep (2024/9/8)
簡(jiǎn)介：evifacotrep is a short transient receptor potential channel 5 ( trpc5 ) antagonist (wo2020061162, compound 100). evifacotrep can be used for the research of neurological diseases.
TLR8 agonist 2 hydrochloride；TLR8 agonist 2 hydrochlorideTLR8 agonist 2 hydrochloride (2024/9/8)
簡(jiǎn)介：tlr8 agonist 2 hydrochloride is a highly potent and selective agonist for human tlr8, exhibiting an ec50 of 3 nm. however, its activity towards human tlr7 is considerably weaker, with an ec50 of 33.33 μm.
TLR8 agonist 2TLR8 agonist 2TLR8 agonist 2 (2024/9/8)
簡(jiǎn)介：tlr8 agonist 2 is a highly effective and specific compound that activates tlr8, possessing an ec 50 of 3 nm in human tlr8. notably, tlr8 agonist 2 demonstrates lower activity towards human tlr7, with an ec 50 of 33.33 μm.
UNC2399；UNC2399UNC2399；UNC2399 (2024/9/8)
簡(jiǎn)介：unc2399, a biotinylated version of unc1999, functions as a selective degrader of ezh2 and exhibits strong in vitro efficacy against ezh2, demonstrated by its ic 50 value of 17 nm.
TimtraxanibTimtraxanibAVI-3207 (2024/9/8)
簡(jiǎn)介：timtraxanib (avi-3207) is a potent and specific inhibitor of vegf-2, offering great potential for investigating senile macular degeneration.
Thalidomide-NH-PEG4-COOH；Thalidomide-NH-PEG4-COOHThalidomide-NH-PEG4-COOH；Thalidomide-NH-PEG4-COOH (2024/9/8)
簡(jiǎn)介：thalidomide-nh-peg4-cooh is a conjugate comprising an e3 ligase ligand-linker, utilized in the synthesis of dcbp-1. dcbp-1 itself functions as a powerful and selective heterobifunctional degrader targeting p300/cbp.
Thalidomide-NH-PEG2-COOH；Thalidomide-NH-PEG2-COOHThalidomide-NH-PEG2-COOH；Thalidomide-NH-PEG2-COOH (2024/9/8)
簡(jiǎn)介：thalidomide-nh-peg2-cooh is a conjugate, synthesized as an e3 ligase ligand-linker, that incorporates the cereblon ligand derived from thalidomide along with a linker commonly employed in protac technology.
GNF-8625 monopyridin-N-piperazine hydrochloride；化合物T40034GNF-8625 monopyridin-N-piperazine hydrochlo (2024/9/8)
簡(jiǎn)介：gnf-8625 monopyridin-n-piperazine hydrochloride is a protomyosin receptor kinase (trk) inhibitor.
CD73-IN-5；CD73-IN-5CD73-IN-5；CD73-IN-5 (2024/9/8)
簡(jiǎn)介：cd73-in-5 is a highly potent and selective small molecule inhibitor of cd73, demonstrating non-nucleotide characteristics. it exerts its inhibitory effects with a remarkable ic50 value of 19 nm.
Pomalidomide-PEG4-C2-NH2 hydrochloride；化合物Pomalidomide-PEG4-C2-NH2 hydrochlorideu00A0Pomalidomide-PE (2024/9/8)
簡(jiǎn)介：pomalidomide-peg4-c2-nh2 hydrochloride is a peg-based protac linker that can be used to synthesize protacs[1].
Thalidomide-O-C6-NH2 hydrochloride；薩力多胺-O-C6-氨基鹽酸鹽4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)i (2024/9/8)
簡(jiǎn)介：thalidomide-o-c6-nh2 hydrochloride (4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride) is a synthesized e3 ligase ligand-linker conjugate.
Thalidomide 4’-ether-alkylC2-amine hydrochloride化合物halidomide-linker 6halidomide-linker 6 (2024/9/8)
簡(jiǎn)介：thalidomide 4´-ether-alkylc2-amine hydrochloride (halidomide-linker 6) is a synthesized e3 ligase ligand-linker conjugate.
(S,R,S)-AHPC；化合物(S,R,S)-AHPC(S,R,S)-AHPC (2024/9/8)
簡(jiǎn)介：(s,r,s)-ahpc is a vhl ligand that used in the recruitment of the vhl protein.
(S,R,S)-AHPC-C6-NH2；化合物 T40027(S,R,S)-AHPC-C6-NH2 (2024/9/8)
簡(jiǎn)介：(s,r,s)-ahpc-c6-nh2 is a useful organic compound for research related to life sciences. the catalog number is t40027 and the cas number is 2306389-03-5.
Pomalidomide 4’-alkylC3-acid；化合物 Pomalidomide 4’-alkylC3-acid4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dio (2024/9/8)
簡(jiǎn)介：butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1h-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid) is a cereblon ligand with alkyl linker and terminal acid for onward chemistry.
Pomalidomide-PEG1-CO2H；化合物T40024Pomalidomide-PEG1-C2-COOH；Pomalidomide-PEG1-C2-COOH (2024/9/8)
簡(jiǎn)介：pomalidomide-peg1-co2h is a synthetic e3 ligase ligand-linker conjugate containing a pomalidomide-based cereblon ligand and a 2-unit peg linker.
Pomalidomide-PEG3-CO2H；化合物Pomalidomide-PEG3-CO2HThalidomide-NH-PEG3-propionic acid；Thalidomide-NH-PE (2024/9/8)
簡(jiǎn)介：pomalidomide-peg3-co2h (thalidomide-nh-peg3-propionic acid) is a synthesized e3 ligase ligand-linker conjugate. pomalidomide-peg3-co2h incorporates the thalidomide based cereblon ligand and 3-unit peg linker used in protac technology.
Pomalidomide-C2-acid；化合物Pomalidomide-C2-acidPomalidomide-C2-acid (2024/9/8)
簡(jiǎn)介：pomalidomide-c2-acid is a protac building block.
Thalidomide-5-NH2-CH2-COOH；化合物T40019Thalidomide-5-NH2-CH2-COOH (2024/9/8)
簡(jiǎn)介：thalidomide-5-nh2-ch2-cooh (compound 114) is a selective inhibitor of the protomyosin receptor kinase. it is a ligand for e3 ligase and has potential for studying one or more diseases.
SY2-062；化合物 SY2-0624-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione；4-Bromo-2-(2,6-dioxopipe (2024/9/8)
簡(jiǎn)介：4-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione has potential as an anticancer, prodrug for the treatment of parkinson´s disease, and as an anti-inflammatory agent.
5-Aminothalidomide；化合物 5-Aminothalidomide5-Aminothalidomide (2024/9/8)
簡(jiǎn)介：5-aminothalidomide is a e3 ligase ligand used in protac technology.
Thalidomide-NH-CH2-COOH；化合物T40016inhibit|||Ligands for E3 Ligase|||E3 ligase-recruiting Moiety|||Inh (2024/9/8)
簡(jiǎn)介：thalidomide-nh-ch2-cooh ((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) is a synthesized e3 ligase ligand-linker conjugate containing a thalidomide-based cereblon ligand and a linker.
Pomalidomide-PEG2-NH2 hydrochloride；化合物Pomalidomide-PEG2-NH2 hydrochloridePomalidomide-PEG2-NH2 hydr (2024/9/8)
簡(jiǎn)介：pomalidomide-peg2-nh2 hydrochloride is a synthesized e3 ligase ligand-linker conjugate that incorporates the pomalidomide based crbn ligand and linker used in protac technology.
Pomalidomide-C4-OH；化合物Pomalidomide-C4-OHPomalidomide-C4-OH (2024/9/8)
簡(jiǎn)介：pomalidomide-c4-oh is a synthesized e3 ligase ligand-linker conjugate that incorporates the pomalidomide based crbn ligand and linker used in protac technology.
Thalidomide-O-CH2CONH-CH2COOH；化合物Thalidomide-O-CH2CONH-CH2COOHThalidomide-O-CH2CONH-CH2COOH (2024/9/8)
簡(jiǎn)介：thalidomide-o-ch2conh-ch2cooh is a synthesized e3 ligase ligand-linker conjugate that incorporates the thalidomide based crbn ligand and linker used in protac technology.
Thalidomide-CH2CONH-C2-COOH；化合物Thalidomide-CH2CONH-C2-COOHThalidomide-CH2CONH-C2-COOH (2024/9/8)
簡(jiǎn)介：thalidomide-ch2conh-c2-cooh is a synthesized e3 ligase ligand-linker conjugate that incorporates the thalidomide based crbn ligand and linker used in protac technology.
Thalidomide-CH2CONH-C3-COOH；化合物Thalidomide-CH2CONH-C3-COOHThalidomide-CH2CONH-C3-COOH (2024/9/8)
簡(jiǎn)介：thalidomide-ch2conh-c3-cooh is a synthesized e3 ligase ligand-linker conjugate that incorporates the thalidomide based crbn ligand and linker used in protac technology.
Euxanthone；優(yōu)咕噸酮1,7-Dihydroxyxanthone；1,7-Dihydroxyxanthone (2024/9/8)
簡(jiǎn)介：euxanthone (1,7-dihydroxyxanthone), an xanthone derivative extracted from the roots of polygala tenuifolia willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates aβ1-42-induced oxidative stress and apoptosis by inducing autophagy.sb-674042 is used for the treatment of depression.sb-674042 is used for the treatment of depression.sb-674043 is used for the treatment of depression.sb-674044 is used for the treatment of depression.sb-674045 is used for the treatment of dep
Pomalidomide-C4-COOH；化合物Pomalidomide-C4-COOHPomalidomide-C4-COOH (2024/9/8)
簡(jiǎn)介：pomalidomide-c4-cooh is a synthesized e3 ligase ligand-linker conjugate that incorporates the pomalidomide based crbn ligand and linker used in protac technology.
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