9月
BMS-1166-N-piperidine-COOH；BMS-1166-N-piperidine-COOHBMS-1166-N-piperidine-COOH (2024/9/8)
簡(jiǎn)介：bms-1166-n-piperidine-cooh is a chemical compound that functions as the bms-1166-based moiety. it binds to the e3 ligase ligand through a linker, leading to the formation of protac pd-1/pd-l1 degrader-1, which facilitates the degradation of pd-1/pd-l1. bms-1166 demonstrates potent inhibition of pd-1/pd-l1 interaction, with an ic 50 of 1.4 nm. by antagonizing the inhibitory effect of the pd-1/pd-l1 immune checkpoint on t cell activation, bms-1166 promotes t cell activation.
NCB-0846；化合物NCB0846NCB 0846；NCB 0846 (2024/9/8)
簡(jiǎn)介：ncb-0846 is an orally active tnik inhibitor (ic50: 21 nm).
APOL1-IN-1；APOL1抑制劑1APOL1-IN-1；APOL1-IN-1 (2024/9/8)
簡(jiǎn)介：apol1-in-1 is a potent inhibitor of apolipoprotein l1 (apol1) that can be used to study the pathogenesis of focal segmental glomerulosclerosis (fsgs) and nondiabetic kidney disease (ndkd), facilitating research into these diseases.
Inaxaplin；化合物InaxaplinVX-147；VX-147 (2024/9/8)
簡(jiǎn)介：inaxaplin is an apolipoprotein l1 ( apol1 ) function inhibitor. inaxaplin can be used for the research of kidney disease.
IL-17 modulator 4 sulfate；IL-17 modulator 4 sulfateIL-17 modulator 4 sulfate (2024/9/8)
簡(jiǎn)介：il-17 modulator 4 sulfate is a prodrug of il-17 modulator 1 . il-17 modulator 1 is an orally active, highly efficacious il-17 modulator.
IL-17 modulator 1；IL-17 modulator 1IL-17 modulator 1 (2024/9/8)
簡(jiǎn)介：il-17 modulator 1 is an orally active small molecule. it is highly efficacious in modulating il-17 and can effectively prevent, treat, or ameliorate various diseases such as psoriasis, ankylosing spondylitis, and psoriatic arthritis.
Pomalidomide-PEG3-C2-NH2 hydrochloride；Pomalidomide-PEG3-C2-NH2 hydrochloridePomalidomide-PEG3-C2-NH (2024/9/8)
簡(jiǎn)介：pomalidomide-peg3-c2-nh2 hydrochloride, also known as cereblon ligand-linker conjugate 5, is a chemically synthesized e3 ligase ligand-linker conjugate. this compound incorporates a cereblon ligand based on pomalidomide and a linker commonly employed in protac technology.
Thalidomide-NH-C8-NH2 hydrochloride；Thalidomide-NH-C8-NH2 hydrochlorideThalidomide-NH-C8-NH2 hydroch (2024/9/8)
簡(jiǎn)介：thalidomide-nh-c8-nh2 hydrochloride is a synthetic compound, which functions as an e3 ligase ligand-linker conjugate. it consists of a cereblon ligand derived from thalidomide, along with a linker commonly used in protac technology.
(±)-1,2-Diolein；甘油1,2-二油酸酯1,2-Dioleoyl-rac-glycerol；1,2-Dioleoyl-rac-glycerol|||甘油1,2-二油酸酯 (2024/9/8)
簡(jiǎn)介：(±)-1,2-diolein (1,2-dioleoyl-rac-glycerol) (1,2-dioleoyl-rac-glycerol) is a pkc activator. (±)-1,2-diolein could increases myotubes ca 2+ influx.
簡(jiǎn)介：juglone (regianin) is a natural naphthoquinone found in the black walnut (j. nigra) and other plants in the juglandaceae family. juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human pin1, yeast ess1/ptf1, and e. coli parvulin (ki = 55.9 nm). juglone also blocks transcription by rna polymerases i, ii, and iii (ic50s = 2-7 μm) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through pin1-independent
RET-IN-4；RET-IN-4RET-IN-4 (2024/9/8)
簡(jiǎn)介：ret-in-4 is a highly effective and specific ret inhibitor that can be administered orally. it demonstrates remarkable potency, with ic50 values of 1.29 nm, 1.97 nm, and 0.99 nm for inhibiting ret variants including ret (wt), ret (v804m), and ret (m918t), respectively. moreover, ret-in-4 exhibits superior selectivity towards kinases jak2 (ic50 of 4.4 nm) and flt3 (ic50 of 30.8 nm). additionally, ret-in-4 possesses pronounced anticancer properties.
IDO-IN-15；IDO-IN-15IDO-IN-15 (2024/9/8)
簡(jiǎn)介：ido-in-15 is an ido1 inhibitor ( ic 50 < 0.51 nm).
MNK/PIM-IN-1；MNK/PIM-IN-1MNK/PIM-IN-1 (2024/9/8)
簡(jiǎn)介：mnk/pim-in-1 is a novel dual inhibitor targeting both mnk and pim pathways, characterized by its favorable pharmacokinetic profile.
Chk1-IN-6Chk1-IN-6Chk1-IN-6 (2024/9/8)
簡(jiǎn)介：chk1-in-6 is a potent, selective, and orally bioavailable chk1 inhibitor candidate.
NS 1209；化合物NS 1209SPD 502；SPD 502 (2024/9/8)
簡(jiǎn)介：ns 1209 (spd 502) is a ampa receptor antagonist.
Amino-PEG7-t-butyl ester；Amino-PEG7-t-butyl esterAmino-PEG7-t-butyl ester；Amino-PEG7-t-butyl ester (2024/9/8)
簡(jiǎn)介：amino-peg7-t-butyl ester is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
TP0586352；TP0586352TP0586352 (2024/9/8)
簡(jiǎn)介：tp0586352 is a potent inhibitor of lpxc, exhibiting efficacy against carbapenem-resistant strains of klebsiella pneumoniae without inducing cardiovascular risks.
DSM502；DSM502DSM502 (2024/9/8)
簡(jiǎn)介：dsm502, a pyrrole-based dihydroorotate dehydrogenase (dhodh) inhibitor, demonstrates potent nanomolar activity against plasmodium dhodh and plasmodium parasites, while not inhibiting mammalian dhodhs.
Ophiopogonside A；川麥冬苷AOphiopogonside A (2024/9/8)
簡(jiǎn)介：ophiopogonside a is a naturally occurring compound derived from ophiopogon japonicas, with demonstrated anti-cancer activity.
Pomalidomide-amino-PEG5-NH2 hydrochloride；Pomalidomide-amino-PEG5-NH2 hydrochloridePomalidomide-amin (2024/9/8)
簡(jiǎn)介：pomalidomide-amino-peg5-nh2 hydrochloride is a chemical compound that has been synthesized as an e3 ligase ligand-linker conjugate. this compound combines a pomalidomide-based cereblon ligand with a linker commonly used in protac technology.
Pomalidomide-amino-PEG5-NH2；Pomalidomide-amino-PEG5-NH2Pomalidomide-amino-PEG5-NH2；Pomalidomide-amin (2024/9/8)
簡(jiǎn)介：pomalidomide-amino-peg5-nh2 is a synthesized conjugate combining the pomalidomide-based cereblon ligand and a linker utilized in protac technology. it acts as an e3 ligase ligand-linker conjugate.
GLUT inhibitor-1；GLUT抑制劑1GLUT inhibitor-1 (2024/9/8)
簡(jiǎn)介：glut inhibitor-1 is an orally active glut inhibitor with ic50 s of 242 nm and 179 nm for glut1 and glut3. glut inhibitor-1 can be used in studies about cancers and autoimmune diseases.
SEluc-2；SEluc-2SEluc-2 (2024/9/8)
簡(jiǎn)介：seluc-2, a bioluminescent probe derived from firefly luciferin, is designed for the sensitive and selective detection of thiols in living cells.
APC 366 TFA；APC 366 TFAAPC 366 TFA (2024/9/8)
簡(jiǎn)介：apc 366 (tfa) is a potent irreversible inhibitor of mast cell tryptase. it is particularly useful in studies related to allergic diseases.
(±)-Taxifolin(±)-二氫槲皮素(±)-Dihydroquercetin (2024/9/8)
簡(jiǎn)介：(±)-taxifolin ((±)-dihydroquercetin) is the racemate of taxifolin, a flavonoid commonly found in onion, silymarin, french maritime pine bark, and douglas fir bark, with anti-tyrosinase and anti-fibrotic activity.taxifolin is an inhibitor of collagenase, with an ic 50 value of 193.3 μm. taxifolin is a free radical scavenger with antioxidant capacity.
Metergoline；甲麥角林Methergoline|||Liserdol；甲麥角林|||Methergoline|||Liserdol (2024/9/8)
簡(jiǎn)介：metergoline (methergoline) is a dopamine agonist and serotonin antagonist. it has been used similarly to bromocriptine as a dopamine agonist and also for migraine disorder therapy.
Thalidomide-O-C5-NH2 hydrochloride；Thalidomide-O-C5-NH2 hydrochlorideThalidomide-O-C5-NH2 hydrochlor (2024/9/8)
簡(jiǎn)介：thalidomide-o-c5-nh2 hydrochloride is a synthetic compound consisting of a ligand-linker conjugate with e3 ligase activity. it combines a cereblon ligand based on thalidomide and a linker commonly utilized in protac technology.
(R)-Pomalidomide-pyrrolidine；(R)-Pomalidomide-pyrrolidine(R)-Pomalidomide-pyrrolidine (2024/9/8)
簡(jiǎn)介：(r)-pomalidomide-pyrrolidine, a crbn ligand, can be conjugated to a protein-targeting ligand via a linker, resulting in the formation of protacs.
ATR-IN-9；ATR-IN-9ATR-IN-9 (2024/9/8)
簡(jiǎn)介：atr-in-9 is a highly effective inhibitor of ataxia-telangiectasia and rad-3-related protein kinase (atr). with an ic50 value as low as 10 nm, atr-in-9 demonstrates exceptional potency.
Gersizangitide acetate；化合物Gersizangitide acetateGersizangitide acetate(2417491-82-6 Free base)；Gersi (2024/9/8)
簡(jiǎn)介：gersizangitide acetate is an inhibitor of angiogenesis.
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