9月
ATM Inhibitor-9；化合物 ATM Inhibitor-9ATM Inhibitor-9 (2024/9/14)
簡介：atm inhibitor-9 (compd 7a) is a potent inhibitor of atm kinase, exhibiting an ic50 value of 5 nm, and is utilized in cancer research [1].
ATM Inhibitor-8；化合物 ATM Inhibitor-8ATM Inhibitor-8 (2024/9/14)
簡介：atm inhibitor-8 (compound 10r) is a potent, selective, and orally active inhibitor of atm, exhibiting anti-tumor activity [1], characterized by an ic50 value of 1.15 nm.
Semapimod；化合物 SemapimodCPSI-2364|||CNI-1493 free base；CPSI-2364|||CNI-1493 free base (2024/9/14)
簡介：semapimod is an inhibitor of proinflammatory cytokine production, capable of suppressing tnf-α, il-1β, and il-6. it hinders tlr4 signaling with an ic50 of approximately 0.3 μm, impedes p38 mapk, and reduces nitric oxide production in macrophages. this compound shows promise for treating various inflammatory and autoimmune disorders [1] [2] [3].
IACS-52825；化合物 IACS-52825IACS-52825 (2024/9/14)
簡介：iacs-52825 is a potent, selective dlk inhibitor, exhibiting a dissociation constant (kd) of 1.3 nm, and is valuable for researching chemotherapy-induced peripheral neuropathy (cipn) [1].
MK-8768；化合物 MK-8768MK-8768 (2024/9/14)
簡介：mk-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the mglur2 class, exhibiting an ic50 of 9.6 nm and characterized by excellent brain permeability.
Anticancer agent 140；化合物 Anticancer agent 140Anticancer agent 140 (2024/9/14)
簡介：compound 140 (compd 3) exhibits potential anticancer and antiparasitic activities [1].
hAChE-IN-4；化合物 hAChE-IN-4hAChE-IN-4 (2024/9/14)
簡介：compd 5d (hache-in-4) is a potent hache inhibitor that readily crosses the blood-brain barrier, exhibiting an ic50 of 0.25 μm, and is utilized in the study of alzheimer´s disease [1].
Linalyl Acetate；乙酸芳樟酯Linalyl Acetate (2024/9/14)
簡介：linalyl acetate is a natural product
hAChE-IN-3；化合物 hAChE-IN-3hAChE-IN-3 (2024/9/14)
簡介：hache-in-3 (compound 5c) serves as a potent inhibitor for ache, buche, mao-b, and bace-1, with respective ic50 values of 0.44, 0.08, 5.15, and 0.38 μm, demonstrating its ability to cross the blood-brain barrier. this compound also exhibits antioxidant properties and metal chelation capabilities. additionally, it targets peripheral anion sites, potentially modulating β-amyloid and ameliorating neurodegeneration linked to alzheimer´s disease, highlighting its research potential for this cond
Antifungal agent 61；化合物 Antifungal agent 61Antifungal agent 61 (2024/9/14)
簡介：antifungal agent 61 (compound 38) is an antifungal agent that inhibits v. mali, with an ec50 value of 0.50 mg/l. this compound impedes v. mali´s growth by inducing cell deformation and contraction, diminishing intracellular mitochondrial count, thickening the cell wall, and enhancing cell membrane permeability [1].
DZD1516；化合物 DZD1516DZD1516 (2024/9/14)
簡介：dzd1516, a potent and selective her2 inhibitor (ic50 = 0.56 nm), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in both central nervous system (cns) and subcutaneous xenograft mouse models [1].
JNK-IN-12；化合物 JNK-IN-12JNK-IN-12 (2024/9/14)
簡介：jnk-in-12 (compound p2) is a mitochondrial-targeted jnk inhibitor with an ic50 value of 66.3 nm, comprising a mitochondrial-specific cell-penetrating peptide linked to sp600125, a selective jnk inhibitor. it selectively impedes mitochondrial jnk phosphorylation without inhibiting nuclear jnk signaling and has been shown to ameliorate parkinson´s disease (pd) symptoms in both in vitro and in vivo studies [1].
HIV-1 protease-IN-9；化合物 HIV-1 protease-IN-9HIV-1 protease-IN-9 (2024/9/14)
簡介：hiv-1 protease-in-9 (compound 5b), a potent hiv-1 protease inhibitor, exhibits strong antiviral efficacy with a dissociation constant (k_i) of 0.028 nm and a half-maximal inhibitory concentration (ic_50) of 66.8 nm [1].
NC-R17；化合物 NC-R17NC-R17 (2024/9/14)
簡介：nc-r17, an rsl3-based noncovalent gpx4 degrader implicated in ferroptosis, demonstrates anti-tumor activity and is utilized in the design of noncovalent gpx4-targeted proteolysis targeting chimeras (protacs) [1].
EGFR-IN-79；化合物 EGFR-IN-79EGFR-IN-79 (2024/9/14)
簡介：egfr-in-79 (compound 21), an egfr inhibitor, exhibits antitumor activity through ros-independent apoptosis and egfr/akt/mtor-mediated autophagy. it effectively induces cell death in proliferating and quiescent zones of ej28 spheroids and demonstrates a safety profile in zebrafish-based models [1].
PROTAC BTK Degrader-5；化合物 PROTAC BTK Degrader-5PROTAC BTK Degrader-5 (2024/9/14)
簡介：protac btk degraders-5 (compound 3e) is a selective bruton´s tyrosine kinase (btk) degrader with a dc50 of 7.0 nm in jeko-1 cells, demonstrating specificity by not affecting crbn neosubstrates. it also exhibits antiproliferative effects on various lymphoma cell lines, underscoring its potential application in chronic lymphoid malignancies research.
MmpL3-IN-2；化合物 MmpL3-IN-2MmpL3-IN-2 (2024/9/14)
簡介：mmpl3-in-2, an inhibitor targeting mmpl3, exhibits low cytotoxicity and moderate metabolic stability, making it suitable for tuberculosis research [1].
SRE-II；化合物 SRE-IISRE-II (2024/9/14)
簡介：sre-ii, an amide derivative, serves as an activatable photosensitizer tailored for photodynamic cancer research, exhibiting diminished fluorescence and photosensitizing properties. upon carboxylesterase-catalyzed amide bond cleavage, it transforms into its active form, sdu red. in light-exposed environments, sre-ii prompts dna damage and induces cell apoptosis, highlighting its potential as a theranostic agent for triple-negative breast cancer [1].
L-Aspartic Acid 4-Benzyl Ester；L-天冬氨酸-4-芐酯L-Aspartic Acid 4-Benzyl Ester (2024/9/14)
簡介：l-aspartic acid 4-benzyl ester is a chelating agent that forms stable complexes with metal ions. it has been used to study the effect of metal ions on enzyme activity and to investigate the role of metal ions in the regulation of gene expression.
Antiproliferative agent-27；化合物 Antiproliferative agent-27Antiproliferative agent-27 (2024/9/14)
簡介：antiproliferative agent-27 (compound 11) is a notable antiproliferative agent that markedly diminishes tumor cell colony formation and induces apoptosis, demonstrating potential for utilization in cancer research [1].
Antitubercular agent-38；化合物 Antitubercular agent-38Antitubercular agent-38 (2024/9/14)
簡介：antitubercular agent-38, a derivative of benzothiazinones (btzs), demonstrates potent antituberculosis activity while maintaining low cardiac toxicity and minimal cell cytotoxicity [1]. this orally active compound is a promising therapeutic in the treatment of tuberculosis.
SB-1295；化合物 SB-1295SB-1295 (2024/9/14)
簡介：sb-1295, an orally active cdk9/t1 inhibitor with an ic50 of 0.17 μm, exhibits antiproliferative effects on hct 116 and mia paca-2 cells. it promotes cell death in mia paca-2 by elevating intracellular ros levels, diminishing mitochondrial membrane potential, and triggering apoptosis. this compound holds potential for cancer research [1].
TRAP1-IN-2；化合物 TRAP1-IN-2TRAP1-IN-2 (2024/9/14)
簡介：trap1-in-2, also known as compound 36, is a selective degrader of the trap1 client protein that does not affect hsp90-cytosolic clients. it inhibits oxidative phosphorylation (oxphos) and shifts cellular metabolism toward glycolysis. additionally, trap1-in-2 compromises the stability of the trap1 tetramer and disrupts the mitochondrial membrane potential [1].
TRAP1-IN-1；化合物 TRAP1-IN-1TRAP1-IN-1 (2024/9/14)
簡介：trap1-in-1 (compound 35) is a potent, selective trap1 inhibitor affecting the mitochondrial variant of hsp90. it exhibits over 250-fold greater selectivity for trap1 compared to grp94, destabilizes trap1 tetramers, and promotes the degradation of trap1 client proteins. additionally, trap1-in-1 impedes mitochondrial complex i activity involved in oxidative phosphorylation oxphos, compromises the mitochondrial membrane potential, and augments glycolytic metabolism [1].
IR-251；化合物 IR-251IR-251 (2024/9/14)
簡介：ir-251 is a mitochondrion-targeting near-infrared (nir) fluorescent probe that selectively accumulates in tumor cell mitochondria through organic anion transporting polypeptides (oatps), leading to mitochondrial dysfunction. by impeding peroxisome proliferator-activated receptor gamma (pparγ), ir-251 promotes reactive oxygen species (ros) overproduction, consequently inhibiting the β-catenin signaling pathway as well as associated cell cycle and metastasis proteins. this mechanism contributes to
hCYP1B1-IN-1；化合物 hCYP1B1-IN-1hCYP1B1-IN-1 (2024/9/14)
簡介：hcyp1b1-in-1 (compound b18) is an inhibitor of hcyp1b1 with an ic50 value of 3.6 nm and also acts as an antagonist of the aryl hydrocarbon receptor. this compound demonstrates favorable metabolic stability and good cell permeability and has been shown to inhibit the migration of mcf-7 cells [1].
Antibacterial agent 144；化合物 Antibacterial agent 144Antibacterial agent 144 (2024/9/14)
簡介：antibacterial agent 144 (compound 8e) exhibits superior efficacy against multi-resistant staphylococcus aureus compared to chloromycin and amoxicillin. it acts by disrupting the bacterial cytoplasmic membrane and inhibiting biofilm formation. additionally, it binds to human serum albumin (hsa) with a dissociation constant (kd) of 13.2 μm, enhancing its bactericidal activity. this compound also forms a supramolecular complex with dna, thereby hindering dna replication [1].
Antimycobacterial agent-6；化合物 Antimycobacterial agent-6Antimycobacterial agent-6 (2024/9/14)
簡介：antimycobacterial agent-6 (compound 25) effectively inhibits mycobacterium tuberculosis, including wild-type and fluoroquinolone-resistant strains, by targeting the mtb dpre1-c387s mutant. it displays minimal inhibitory concentrations (mic90) of 0.9 μm for h37rv and moxr strains, and 0.5 μm for the dpre1-p116s strain [1].
Nav1.3 channel inhibitor 1；化合物 Nav1.3 channel inhibitor 1Nav1.3 channel inhibitor 1 (2024/9/14)
簡介：nav1.3 channel inhibitor 1 (compound 15b) is a state-dependent inhibitor of the voltage-gated sodium channel na v 1.3, with an ic50 value of 20 nm. it has the ability to cross the blood-brain barrier, making it applicable for research into nervous system disorders [1].
SARS-CoV-2 Mpro-IN-8；化合物 SARS-CoV-2 Mpro-IN-8SARS-CoV-2 Mpro-IN-8 (2024/9/14)
簡介：sars-cov-2 mpro-in-8 (compound 6b) is an antiviral agent effective against sars-cov-2 [1].
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