9月
Methyl benzoin；安息香甲基醚Benzoin methyl ether；安息香甲基醚|||Benzoin methyl ether (2024/9/14)
簡介：methyl benzoin (benzoin methyl ether) is a biochemical.
Antitumor agent-101；化合物 Antitumor agent-101Antitumor agent-101 (2024/9/14)
簡介：antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases g9a/glp, demonstrating ic50 values of 8.5 nm for g9a and 5.5 nm for glp. it exhibits antitumor efficacy in the panc-1 xenograft model [1].
Anticancer agent 128；化合物 Anticancer agent 128Anticancer agent 128 (2024/9/14)
簡介：anticancer agent 128 (compound 1) is an iap inhibitor that covalently binds to the bir3 domains of xiap, ciap1, and ciap2, exhibiting ic50 values of 24.9 nm, 19.3 nm, and 10.3 nm, respectively [1].
Anticancer agent 127；化合物 Anticancer agent 127Anticancer agent 127 (2024/9/14)
簡介：anticancer agent 127 (142d6), an iap inhibitor, covalently binds to the bir3 domains of xiap, ciap1, and ciap2, with ic50 values of 12 nm, 14 nm, and 9 nm, respectively, demonstrating anticancer effects [1].
6-Iodoamiloride；化合物 6-Iodoamiloride6-Iodoamiloride (2024/9/14)
簡介：6-iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (asic1), exhibiting an ic50 value of 88 nm. it also effectively inhibits asic3-mediated currents in rat dorsal root ganglion neurons, with an ic50 of 230 nm [1].
SARS-CoV-2-IN-45；化合物 SARS-CoV-2-IN-45SARS-CoV-2-IN-45 (2024/9/14)
簡介：sars-cov-2-in-45 (compound 8p) serves as an inhibitor of sars-cov-2, effectively hindering viral replication in calu-3 cells with an ec50 value of 0.5 μm and exhibiting negligible cytotoxic effects [1].
SARS-CoV-2-IN-44；化合物 SARS-CoV-2-IN-44SARS-CoV-2-IN-44 (2024/9/14)
簡介：sars-cov-2-in-44, an inhibitor of sars-cov-2, effectively suppresses viral replication with an ec50 value of 0.6μm and exhibits negligible cytotoxicity in calu-3 cells, rendering it suitable for antiviral research [1].
SARS-CoV-2-IN-43；化合物 SARS-CoV-2-IN-43SARS-CoV-2-IN-43 (2024/9/14)
簡介：compound 8h, also known as sars-cov-2-in-43, is a powerful inhibitor effective in obstructing the replication of sars-cov-2, exhibiting significant antiviral activity [1].
Mcl-1 inhibitor 16；化合物 Mcl-1 inhibitor 16Mcl-1 inhibitor 16 (2024/9/14)
簡介：mcl-1 inhibitor 16 (compound 9), a platinum-based mitochondrial-targeting agent, inhibits mcl-1 and induces bax/bak-dependent apoptosis in cancer cells. this compound exhibits antitumor activity and may be utilized as a monotherapy or in combination with abt-199 [1].
PHD2-IN-1；化合物 PHD2-IN-1PHD2-IN-1 (2024/9/14)
簡介：phd2-in-1, a potent and orally active hif prolyl hydroxylase 2 (phd2) inhibitor, exhibits an ic50 of 22.53 nm and is applicable in anemia research [1].
DNA gyrase B-IN-2；化合物 DNA gyrase B-IN-2DNA gyrase B-IN-2 (2024/9/14)
簡介：dna gyrase b-in-2 (compound e), a 2-aminobenzothiazole derivative, serves as a potent inhibitor of dna gyrase b with substantial efficacy against eskape pathogens. the compound exhibits potent nanomolar-range inhibition (ic 50 < 10 nm) and a broad-spectrum antibacterial effect, with minimum inhibitory concentrations below 0.03 μg/ml for most gram-positive species and between 4–16 μg/ml for gram-negative species including e. coli, acinetobacter baumannii, pseudomonas aeruginosa, and klebsiella pn
8-Bromoguanosine；8-溴鳥苷8-Bromoguanosine (2024/9/14)
簡介：8-bromoguanosine is a brominated derivative of guanosine. it is activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects.
PCSK9-IN-19；化合物 PCSK9-IN-19PCSK9-IN-19 (2024/9/14)
簡介：pcsk9-in-19 (compound 1), a pcsk9 inhibitor, is utilized in researching the treatment of high ldl-cholesterol levels and the prevention of coronary artery disease [1].
SDH-IN-3；化合物 SDH-IN-3SDH-IN-3 (2024/9/14)
簡介：sdh-in-3 is a succinate dehydrogenase (sdh) inhibitor, demonstrating potent antifungal activity with an inhibition concentration (ic50) of 7.2 μg/ml and an effective concentration (ec50) of 1.9 μg/ml against nigrospora oryzae. this compound is valuable for anti-infection research [1].
α-Glucosidase-IN-27；化合物 α-Glucosidase-IN-27α-Glucosidase-IN-27 (2024/9/14)
簡介：α-glucosidase-in-27 (compound 8l), an α-glucosidase inhibitor with an ic50 value of 25.78 μm, demonstrates potential for research into type 2 diabetes (d2m) [1].
7OQL；化合物 7OQL7OQL (2024/9/14)
簡介：compound 54 (7oql) is a selective mettl3 inhibitor with an ic50 value of 0.054 μm, showing promise for cancer research applications [1].
JAK-IN-30；化合物 JAK-IN-30JAK-IN-30 (2024/9/14)
簡介：jak-in-30 (compound 31) is a water-soluble inhibitor of janus kinases (jaks), demonstrating inhibitory potency with half-maximal inhibitory concentration (ic50) values of 2 nm for jak2, 15 nm for jak1, 18 nm for jak3, and 2 nm for tyk2. the compound has been identified as having research potential for the treatment of dry eye disease (ded) [1].
RdRP-IN-7；化合物 RdRP-IN-7RdRP-IN-7 (2024/9/14)
簡介：rdrp-in-7, a rna-dependent rna polymerase (rdrp) inhibitor, demonstrates efficacy against sars-cov-2 infection with an inhibitory concentration (ic50) of 8.2 μm and (ic90) of 14.1 μm, alongside a cytotoxic concentration (cc90) of 79.1 μm, rendering it suitable for antiviral research [1].
RdRP-IN-6；化合物 RdRP-IN-6RdRP-IN-6 (2024/9/14)
簡介：rdrp-in-6 (compound 27) is an inhibitor of rna-dependent rna polymerase (rdrp), exhibiting an ic90 value of 14.1 μm. it has potential applications in antiviral and anticancer research [1].
MARK4 inhibitor 2；化合物 MARK4 inhibitor 2MARK4 inhibitor 2 (2024/9/14)
簡介：mark4 inhibitor 2 is a potent inhibitor of microtubule affinity-regulating kinase 4 (mark4), exhibiting a k? of 6.3×10? and an ic?? of 0.82 μm. it effectively inhibits the growth of human cells, thereby offering potential for use in cancer research [1].
DSO-5a；化合物 DSO-5aDSO-5a (2024/9/14)
簡介：dso-5a, a potent and selective orally active bb3 agonist, is a dmako-00 derivative that enhances ppar-γ activity via bb3 and stimulates erk1/2 phosphorylation. it is utilized in diabetes-related research [1].
JET-209；化合物 JET-209JET-209 (2024/9/14)
簡介：jet-209 is a potent proteolysis-targeting chimera (protac) that effectively degrades cbp/p300, exhibiting half-maximal degradation concentration (dc50) values of 0.05 nm for cbp and 0.2 nm for p300. the compound comprises lenalidomide (the cereblon ligand), a connecting linker, and gne-207 (the bromodomain inhibitor). jet-209 is utilized in cancer research [1].
2-Amino-3-hydroxypyridine；[2-氨基-3-羥基吡啶]2-Amino-3-hydroxypyridine (2024/9/14)
簡介：2-amino-3-hydroxypyridine as a chromogenic reagent for the spectrophotometric determination of osmium.
ETAP；化合物 ETAPETAP (2024/9/14)
簡介：etap, a dual inhibitor of both monoamine oxidase a (mao-a) and monoamine oxidase b (mao-b), exhibits antidepressant-like effects and is utilized in the research of major depressive disorder [1].
SARS-CoV-2-IN-50；化合物 SARS-CoV-2-IN-50SARS-CoV-2-IN-50 (2024/9/14)
簡介：sars-cov-2-in-50 (compound x77c) is a potent inhibitor of the sars-cov-2 main protease (m^pro), exhibiting high affinity for the enzyme´s catalytic site [1].
SARS-CoV-2-IN-49；化合物 SARS-CoV-2-IN-49SARS-CoV-2-IN-49 (2024/9/14)
簡介：sars-cov-2-in-49 acts as an irreversible covalent inhibitor targeting the main protease of sars-cov-2 [1].
AMPK activator 11；化合物 AMPK activator 11AMPK activator 11 (2024/9/14)
簡介：ampk activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (crcs), acting through the selective activation of amp-activated protein kinase (ampk) and enhancement of oxidative phosphorylation (oxphos) (mitochondrial metabolism). this compound demonstrates particular efficacy in inhibiting rko xenograft growth, rendering it useful for anti-tumor and metabolic disease research [1].
α-Amylase/α-Glucosidase-IN-3；化合物 α-Amylase/α-Glucosidase-IN-3α-Amylase/α-Glucosidase-IN-3 (2024/9/14)
簡介：α-amylase/α-glucosidase-in-3 (compound 17) serves as a dual inhibitor targeting both α-amylase and α-glucosidase, exhibiting ic50 values of 0.70 μm and 1.10 μm, respectively. it is applicable for type-ii diabetes mellitus research [1].
Ara-SH；化合物 Ara-SHAra-SH (2024/9/14)
簡介：ara-sh, a derivative of cytarabine with a mercaptopropionic acid substitution, serves as the initiator for the self-assembly of a smart, co-loaded cytarabine and venetoclax nanoparticle (av-np), demonstrating notable synergistic antileukemia effects both in vitro and in vivo [1].
BMPR2-IN-1；化合物 BMPR2-IN-1BMPR2-IN-1 (2024/9/14)
簡介：bmpr2-in-1 (compound 8a), is a potent inhibitor of bmpr2, exhibiting an ic50 value of 506 nm and a kd of 83.5 nm. it is utilized in the study of various diseases including pulmonary arterial hypertension, alzheimer´s disease, and cancer [1].
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