9月
JAK-IN-29；化合物 JAK-IN-29JAK-IN-29 (2024/9/14)
簡介：jak-in-29 (compound 3) is a potent inhibitor of janus kinases (jak) [1].
RSV L-protein-IN-5；化合物 RSV L-protein-IN-5RSV L-protein-IN-5 (2024/9/14)
簡介：rsv l-protein-in-5 (compound e) serves as a potent inhibitor of the respiratory syncytial virus (rsv), with an ec50 value of 0.1 μm. it targets rsv polymerase with an ic50 of 0.66 μm and impedes rsv mrna synthesis through the inhibition of transcript guanylation. the compound demonstrates moderate cytotoxicity, with a cc50 of 10.7 μm in hep-2 cells, and effectively reduces viral titers in mouse models of rsv infection [1].
RSV L-protein-IN-4；化合物 RSV L-protein-IN-4RSV L-protein-IN-4 (2024/9/14)
簡介：rsv l-protein-in-4 (compound c) is a noncompetitive inhibitor of the rsv polymerase with an ic50 of 0.88 μm. it demonstrates potent antiviral activity against rsv strains, with an ec50 of 0.25 μm [1].
Kresoxim-Methyl；醚菌酯Kresoxim-Methyl (2024/9/14)
簡介：kresoxim-methyl is a strobilurin fungicide,inhibits conidial germination of v. inaequalis isolates from apple orchards .
RSV L-protein-IN-3；化合物 RSV L-protein-IN-3RSV L-protein-IN-3 (2024/9/14)
簡介：rsv l-protein-in-3 is an inhibitor of the wild-type rsv polymerase, exhibiting an ic50 of 10.4 μm and an ec50 of 2.1 μm (against rsv), and possesses lower cytotoxicity compared to the clinical agent ribavirin [1].
SARS-CoV-2-IN-41；化合物 SARS-CoV-2-IN-41SARS-CoV-2-IN-41 (2024/9/14)
簡介：sars-cov-2-in-41 (compound 2) is a potent inhibitor of sars-cov-2 3cl protease, exhibiting an ic50 of 0.022 μm and demonstrating antiviral efficacy [1].
RSV L-protein-IN-2；化合物 RSV L-protein-IN-2RSV L-protein-IN-2 (2024/9/14)
簡介：rsv l-protein-in-2 (compound a), a noncompetitive inhibitor of the rsv polymerase (ic50: 4.5 μm), exhibits antiviral activity against long rsv strains (ec50: 1.3 μm) [1].
Mcl-1 inhibitor 15；化合物 Mcl-1 inhibitor 15Mcl-1 inhibitor 15 (2024/9/14)
簡介：mcl-1 inhibitor 15 (compound (ra)-15), with a k i of 0.02 nm, is utilized in cancer research [1].
Mcl-1 inhibitor 14；化合物 Mcl-1 inhibitor 14Mcl-1 inhibitor 14 (2024/9/14)
簡介：compound (ra)-10, also known as mcl-1 inhibitor 14, is a potent inhibitor of myeloid cell leukemia-1 (mcl-1), exhibiting a k_i of 0.018 nm, and holds potential for use in anticancer research [1].
Tubulin/AKT1-IN-1；化合物 Tubulin/AKT1-IN-1Tubulin/AKT1-IN-1 (2024/9/14)
簡介：tubulin/akt1-in-1 (compound d1-1) serves as an inhibitor of both tubulin polymerization and akt pathway activation, effectively suppressing proliferation and metastasis of h1975 cells while modestly inducing apoptosis. this compound is utilized in the study of non-small-cell lung cancer (nsclc) [1].
AZD4747；化合物AZD4747AZD4747 (2024/9/14)
簡介：azd4747 is a selective and potent inhibitor of the mutant gtpase krasg12c that crosses the blood-brain barrier and has potential antitumor activity for the study of pancreatic and colorectal adenocarcinoma.
mTOR inhibitor-12；化合物 mTOR inhibitor-12mTOR inhibitor-12 (2024/9/14)
簡介：mtor inhibitor-12 (compound 11), a selective, brain-penetrant mtor inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to central nervous system (cns) diseases [1].
mTOR inhibitor-11；化合物 mTOR inhibitor-11mTOR inhibitor-11 (2024/9/14)
簡介：mtor inhibitor-11 (compound 9) is a brain-penetrant compound capable of inhibiting mtor with an ic50 of 21 nm for ps6. it also exhibits inhibitory activity against pchk1 and pde4d with ic50 values of 17.2 μm and 17.0 μm, respectively. this compound is utilized in cns disease research [1].
PIKfyve-IN-2；化合物 PIKfyve-IN-2PIKfyve-IN-2 (2024/9/14)
簡介：pikfyve-in-2 is a potent inhibitor of the pikfyve kinase, with potential applications in cancer and autoimmune disorder research [1].
β-Cyclocitral；β-環(huán)檸檬醛beta-Cyclocitral；beta-Cyclocitral|||β-環(huán)檸檬醛 (2024/9/14)
簡介：β-cyclocitral belongs to the class of organic compounds.
Ogremorphin；化合物 OgremorphinGPR68-IN-1|||OGM；GPR68-IN-1|||OGM (2024/9/14)
簡介：ogremorphin (gpr68-in-1) is a potent inhibitor of gpr68, exhibiting an ec50 of 170 nm.it is utilized in the study of autoimmune chronic inflammatory diseases [1].
Oct4 inducer-2；化合物 Oct4 inducer-2Oct4 inducer-2 (2024/9/14)
簡介：oct4 inducer-2, an oct4 inducer, sustains hipsc formation by enhancing endogenous oct4 expression and has applications in anti-aging research [1].
SUCNR1-IN-1；化合物 SUCNR1-IN-1SUCNR1-IN-1 (2024/9/14)
簡介：sucnr1-in-1 (compound 20) serves as a potent sucnr1 inhibitor, exhibiting an ic50 of 88 nm against hsucnr1. it is utilized in the study of rheumatoid arthritis, liver fibrosis, and obesity [1].
MC-EVCit-PAB-MMAE；化合物 MC-EVCit-PAB-MMAEMC-EVCit-PAB-MMAE (2024/9/14)
簡介：mc-evcit-pab-mmae (linker-payload 11), a conjugate utilized in antibody-drug conjugates (adcs), comprises the mc-evcit-pab linker attached to the powerful tubulin polymerization inhibitor mmae [1].
PD-1/PD-L1-IN-34；化合物 PD-1/PD-L1-IN-34PD-1/PD-L1-IN-34 (2024/9/14)
簡介：pd-1/pd-l1-in-34 (compound (1s,2s)-a25) effectively inhibits the pd-1/pd-l1 interaction (ic 50 = 0.029 μm) and demonstrates selective binding affinity to pd-l1 (k d = 0.1554 μm), resulting in the activation of the immune microenvironment and suppression of tumor growth [1].
Anticancer agent 122；化合物 Anticancer agent 122Anticancer agent 122 (2024/9/14)
簡介：anticancer agent 122, a potent inhibitor of human lactate dehydrogenase a (h ldha), exhibits significant anticancer activities, rendering it suitable for use in cancer research [1].
Anticancer agent 121；化合物 Anticancer agent 121Anticancer agent 121 (2024/9/14)
簡介：anticancer agent 121, a human lactate dehydrogenase a (hldha) inhibitor, exhibits potent anticancer activities, suitable for use in anticancer research [1].
Anticancer agent 118；化合物 Anticancer agent 118Anticancer agent 118 (2024/9/14)
簡介：anticancer agent 118, an n?acylated ciprofloxacin derivative, exhibits antibacterial efficacy against gram-positive strains and antiproliferative effects on prostate pc3 cells, making it a potential candidate for antitumor research [1].
PTD10；化合物 PTD10PTD10 (2024/9/14)
簡介：ptd10, a highly potent protac btk degrader, exhibits a dc50 of 0.5 nm and a kd of 2.28 nm. it effectively degrades btk in ramos and jeko-1 cells with respective dc50 values of 0.5 nm and 0.6 nm. additionally, ptd10 inhibits cell growth and triggers apoptosis through the activation of both the caspase-dependent and mitochondrial pathways, making it suitable for research on b-cell dysregulation [1].
BBDDL2059；化合物 BBDDL2059BBDDL2059 (2024/9/14)
簡介：bbddl2059 is a selective covalent inhibitor targeting ezh2, exhibiting an ic50 of 1.5 nm against the ezh2-y641f mutant. it demonstrates potency in inhibiting lymphoma cell proliferation at nanomolar concentrations, proving its utility in anticancer research [1].
Geranylacetone；香葉基丙酮Geranylacetone (2024/9/14)
簡介：geranylacetone has trypanostatic activity and could protect animals against the t. congolense-induced anaemia through the inhibition of sialidase and/or the protection of the parasite-induced hepatosplenomegaly.
F-CRI1；化合物 F-CRI1F-CRI1 (2024/9/14)
簡介：f-cri1, a potent sting agonist with a dissociation constant (k d) of 40.62 nm, is an 18f-labeled radioactive probe employed for visualizing sting in the tumor microenvironment [1].
S-Gem；化合物 S-GemS-Gem (2024/9/14)
簡介：s-gem, a thioredoxin reductase (trxr)-dependent prodrug of gemcitabine, is selectively activated by trxr. studies indicate that s-gem exhibits lower cytotoxicity than gemcitabine [1].
4-Thiouridine 5′-triphosphate tetrasodium；化合物 4-Thiouridine 5′-triphosphate tetrasodium4-Thio-UTP te (2024/9/14)
簡介：4-thiouridine 5′-triphosphate (4-thio-utp) tetrasodium functions as a potent agonist at p2y 2 and p2y 4 receptors, with half-maximal effective concentrations (ec 50 s) of 35 nm for hp2y 2 and 350 nm for hp2y 4 . this compound is applicable in studies involving crosslinking experiments and labeling of the transcriptional complex [1] [2].
4-Thiouridine 5′-triphosphate tetralithium；化合物 4-Thiouridine 5′-triphosphate tetralithium4-Thio-UTP (2024/9/14)
簡介：4-thiouridine 5′-triphosphate tetralithium (4-thio-utp), a potent p2y2 and p2y4 receptor agonist, exhibits ec50 values of 35 nm for hp2y2 and 350 nm for hp2y4. it is utilized in crosslinking experiments and labeling of transcriptional complexes [1] [2].
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