9月
Cav 3.2 inhibitor 4；化合物 Cav 3.2 inhibitor 4Cav 3.2 inhibitor 4 (2024/9/14)
簡(jiǎn)介：cav 3.2 inhibitor 4 (compound 21) is a selective and potent inhibitor of the t-type calcium channel (ca v 3.2), demonstrating peripheral restriction with an ic50 value of 0.6 μm. it is utilized in atrial fibrillation research [1].
DRI-C25441；化合物 DRI-C25441DRI-C25441 (2024/9/14)
簡(jiǎn)介：dri-c25441 is a potent inhibitor of the cd40-cd40l interaction, exhibiting an ic50 value of 0.36 μm, and is capable of suppressing the immune response triggered by alloantigen [1].
DRI-C21041；化合物 DRI-C21041DRI-C21041 (2024/9/14)
簡(jiǎn)介：dri-c21041 is a potent inhibitor of the cd40/cd40l interaction, demonstrating an inhibitory concentration 50 (ic50) value of 0.31 μm. it effectively suppresses the immune response triggered by alloantigen [1].
DQn-1；化合物 DQn-1DQn-1 (2024/9/14)
簡(jiǎn)介：dqn-1, a potent antifolate, demonstrates efficacy against mycobacterium tuberculosis (mtb) with an mic 90 of 0.03 μm. it inhibits the dhfr enzyme, exhibiting ic 50 values of 8.7 nm for mtb dhfr and 7.6 nm for the human counterpart [1].
AMPA receptor modulator-5；化合物 AMPA receptor modulator-5AMPA receptor modulator-5 (2024/9/14)
簡(jiǎn)介：ampa receptor modulator-5 (example 217) serves as an ampa receptor modulator, utilized in neurological disease research [1].
Homouridine；化合物 HomouridineHomouridine (2024/9/14)
簡(jiǎn)介：homouridine, an analogue of uridine, functions as an intermediate in the synthesis of mmp-2 inhibitor (compound i, ic50 = 150 μm). moreover, the derivative of homouridine (compound i) inhibits the interaction of tnf-α with its receptor, tnf-αr1 [1].
6-Aminonicotinic acid；6-氨基煙酸6-Aminonicotinic acid (2024/9/14)
簡(jiǎn)介：6-aminonicotinic acid is a natural product.
1-Isopropyltryptophan；化合物 1-Isopropyltryptophan1-IsoPT；1-IsoPT (2024/9/14)
簡(jiǎn)介：1-isopropyltryptophan (1-isopt), an ido1 inhibitor, suppresses the expression of ido-1 and ido-2 mrna induced by ifn-γ stimulation [1].
BT100；化合物 BT100BT100 (2024/9/14)
簡(jiǎn)介：bt100, an aptamer, impedes the interaction of von willebrand factor (vwf) with platelet glycoprotein gpib, thus obstructing arterial thrombosis [1].
CT1113；化合物 CT1113CT1113 (2024/9/14)
簡(jiǎn)介：ct1113, a potent inhibitor of both usp28 and usp25, effectively reduces myc levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer cdx model [1].
STAT6-IN-3；化合物 STAT6-IN-3STAT6-IN-3 (2024/9/14)
簡(jiǎn)介：stat6-in-3 (compound 18a) serves as an inhibitor of stat6 with an ic50 value of 44 nm, specifically targeting the src homology 2 (sh2) domain. it is utilized in research studies focused on inflammatory disorders, including asthma [1].
STAT6-IN-2；化合物 STAT6-IN-2STAT6-IN-2 (2024/9/14)
簡(jiǎn)介：stat6-in-2 (comp r-84) serves as a stat6 inhibitor, effectively reducing the secretion of the chemokine eotaxin-3, which is known to induce eosinophil infiltration. this compound is useful in the study of immune diseases [1].
FKBP51F67V-selective antagonist Ligand2；化合物 FKBP51F67V-selective antagonist Ligand2FKBP51F67V-select (2024/9/14)
簡(jiǎn)介：fkbp51f67v-selective antagonist ligand2 (example 3-3), a potent ligand, selectively binds to the fkbp51 f67v variant, with no affinity for wild-type fkbp51 or fkbp52 [1]. it effectively reverses the anxiogenic phenotype resulting from fkbp51 f67v overexpression in the amygdala.
SOS1-IN-16；化合物 SOS1-IN-16SOS1-IN-16 (2024/9/14)
簡(jiǎn)介：sos1-in-16 (comp 54) serves as a selective sos1 inhibitor exhibiting an ic50 value of 7.2 nm and demonstrates inhibitory activity against cyp3a4 with an ic50 of 8.9μm when testosterone is employed as a substrate. this compound is utilized in cancer research [1].
PPARγ agonist 8；化合物 PPARγ agonist 8PPARγ agonist 8 (2024/9/14)
簡(jiǎn)介：pparγ agonist 8, a compound that acts on the peroxisome proliferator-activated receptor gamma (pparγ), has been shown to stimulate peroxisome proliferator response element (ppre)-luciferase activity with an effective concentration (ec50) of 0.2 μm [1].
K-80001；化合物 K-80001K-80001 (2024/9/14)
簡(jiǎn)介：k-80001 is a selective rxrα ligand and a cox-1/2 inhibitor, exhibiting ic50 values of 82.9μm for rxrα, 3.4μm for cox-1, and 1.2μm for cox-2, respectively [1].
GLX481369；化合物 GLX481369GLX481369 (2024/9/14)
簡(jiǎn)介：glx481369 is a redox-active substance that functions as an nox4 inhibitor, exhibiting antioxidant effects [1].
2-Amino-2-dichlorobenzophenone；2-氨基-2＇,5-二氯二苯酮2-Amino-2-dichlorobenzophenone (2024/9/14)
簡(jiǎn)介：2-amino-2-dichlorobenzophenone is an aromatic natural compound that has been used to study the effects of various compounds on cell metabolism, protein synthesis and enzyme activity. it has also been used in the synthesis of drugs, such as antitumor drugs and anti-inflammatory agents.
GLX481304；化合物 GLX481304GLX481304 (2024/9/14)
簡(jiǎn)介：glx481304 is a selective nox-2 and nox-4 inhibitor, exhibiting ic50 values of 1.25 μm. it inhibits ros production in isolated mouse cardiomyocytes and enhances their contractility. this compound is useful in research focused on ischemic cardiac injury [1].
WRN inhibitor 2；化合物 WRN inhibitor 2WRN inhibitor 2 (2024/9/14)
簡(jiǎn)介：wrn inhibitor 2 (example 118), a potent inhibitor of the wrn (werner syndrome atp-dependent helicase enzyme), exhibits a pic50 value of 7.0 or greater [1].
URAT1&XO inhibitor 2；化合物 URAT1&XO inhibitor 2URAT1&XO inhibitor 2 (2024/9/14)
簡(jiǎn)介：compound bdeo (urat1&xo inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (xo) and urat1, demonstrating an ic50 value of 3.3 μm for xo inhibition. it effectively impedes uric acid uptake in hek293 cells with urat1 expression, evidenced by a ki of 0.145 μm. in hyperuricemic mice models, the compound has been shown to reduce serum urate levels and uric acid excretion, indicating potential utility for hyperuricemia research [1].
URAT1 inhibitor 6；化合物 URAT1 inhibitor 6URAT1 inhibitor 6 (2024/9/14)
簡(jiǎn)介：urat1 inhibitor 6 (compound 1h), with an ic50 of 35 nm for hurat1, demonstrates 200-fold and 8-fold greater potency compared to lesinurad and benzbromarone, respectively. this compound is utilized in the study of inflammation [1].
URAT1&XO inhibitor 1；化合物 URAT1&XO inhibitor 1URAT1&XO inhibitor 1 (2024/9/14)
簡(jiǎn)介：urat1&xo inhibitor 1 (compound 29) serves as a dual inhibitor with ic50 values of approximately 10 μm for urat1 and 1.01 μm for xanthine oxidase. it induces a hypouricemic effect in the potassium oxonate-induced hyperuricemic rat model and is utilized in research pertaining to hyperuricemia [1].
PF-06478939 TFA；化合物 PF-06478939 TFAPF-06478939 TFA (2024/9/14)
簡(jiǎn)介：pf-06478939 tfa is a peptide that acts as a non-brain-penetrating agonist at the oxytocin (ot) and vasopressin receptors, exhibiting ec50 values of 0.01 nm and 0.078 nm, respectively [1].
PF-06478939；化合物 PF-06478939PF-06478939 (2024/9/14)
簡(jiǎn)介：pf-06478939 is a peptide that functions as an agonist at the oxytocin (ot) receptor and vasopressin receptor without crossing the blood-brain barrier. it exhibits ec50 values of 0.01 nm at the ot receptor and 0.078 nm at the vasopressin receptor [1].
PF-06655075；化合物 PF-06655075PF-06655075 (2024/9/14)
簡(jiǎn)介：pf-06655075 is a novel, non-brain-penetrant oxytocin receptor agonist that demonstrates enhanced selectivity for the oxytocin receptor and substantially improved pharmacokinetic stability. this compound serves as a tool to further investigate the function of peripheral oxytocin in behavioral responses [1].
Bcl-2-IN-11；化合物 Bcl-2-IN-11Bcl-2-IN-11 (2024/9/14)
簡(jiǎn)介：bcl-2-in-11 (compound 6) is a potent and selective inhibitor of bcl-2 activity, exhibiting an ic50 of 0.9 nm, and demonstrates minimal inhibition against bcl-xl (ic50 > 1000 nm). this compound is utilized in researching various cancers linked to the overexpression of bcl-2 family proteins, primarily malignant hematologic conditions such as acute lymphoid leukemia. importantly, bcl-2-in-11 minimizes the risk of toxic side effects, including thrombocytopenia [1], by sparing bcl-xl.
Immuno modulator-1；化合物 Immuno modulator-1Immuno modulator-1 (2024/9/14)
簡(jiǎn)介：immuno modulator-1 (compound 22) effectively suppresses the secretion of tnfα and il-2 in human peripheral blood mononuclear cells (hpbmc) with ic50 values of 4.7 nm and 26 nm, respectively. additionally, this compound exhibits a 20% inhibitory effect on the herg potassium channel at a concentration of 3 μm [1].
4’-Hydroxychalcone；4′-羥基查耳酮2-Benzal-4-Hydroxyacetophenone；4-羥基查耳酮|||4′-羥基查耳酮|||2-Benzal-4-Hydroxyace (2024/9/14)
簡(jiǎn)介：4´-hydroxychalcone (2-benzal-4-hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity
CDK7-IN-22；化合物 CDK7-IN-22CDK7-IN-22 (2024/9/14)
簡(jiǎn)介：cdk7-in-22 (compound 101) is a selective cdk7 inhibitor that exhibits antitumor activity, demonstrating specificity for cdk7 [1].
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