9月
Ibuprofen alcohol；Ibuprofen alcoholIbuprofen alcohol (2024/9/8)
簡(jiǎn)介：ibuprofen alcohol, a nonsteroidal antiinflammatory drug (nsaid), exhibits very little activity for acid-sensing ion channels (asics).
Isomaltotetraose；異麥芽四糖Isomaltotetraose (2024/9/8)
簡(jiǎn)介：isomaltotetraose, a constituent of isomalto-oligosaccharide (imo) derived from dexkq, is known to stimulate the synthesis of dextranase.
BX517；化合物BX517PDK1 inhibitor 2|||BX 517|||BX-517；PDK1 inhibitor 2|||BX 517|||BX-517 (2024/9/8)
簡(jiǎn)介：bx517 (pdk1 inhibitor 2) is a potent and selective inhibitor of pdk1.
Transcriptional Intermediary Factor 2 (TIF2) (740-753)；Transcriptional Intermediary Factor 2 (TIF2) (2024/9/8)
簡(jiǎn)介：transcriptional intermediary factor 2 (tif2) (740-753) is a 14-amino acid peptide that serves as a coactivator of tif-2 protein. it specifically covers residues 740-753 of the tif-2 protein.
3-Keto petromyzonol；3-Keto petromyzonol3-Keto petromyzonol (2024/9/8)
簡(jiǎn)介：3-keto petromyzonol, a key constituent of sea lamprey male sex pheromones, governs the synthesis and release of gonadotropin releasing hormone (gnrh). this in turn regulates the hypothalamic-pituitary-gonadal (hpg) output in immature sea lamprey.
Cinerubin B；Cinerubin BCinerubin B (2024/9/8)
簡(jiǎn)介：cinerubin b is a glycosylated anthracycline antibiotic that exhibits anticancer activity. it is derived from streptomyces sp. spb74.
DMAPP；DMAPPDimethylallyl diphosphate；Dimethylallyl diphosphate (2024/9/8)
簡(jiǎn)介：dmapp, also known as dimethylallyl pyrophosphate, is an isoprenoid precursor found in all life forms. it serves as an isomer of isopentenyl pyrophosphate (ipp).
Bumadizone；布馬地宗Bumadizone (2024/9/8)
簡(jiǎn)介：bumadizone is a non-steroidal anti-inflammatory drug (nsaid) and can relieve pain.
N-Acetylpsychosine；N-AcetylpsychosineN-Acetylpsychosine|||C2 Galactosylceramide (d18:1/2:0)；N-Acetyl (2024/9/8)
簡(jiǎn)介：n-acetylpsychosine, also known as α-galactosylated c2-ceramide (d18:1/2:0), exhibits immunostimulatory properties. this compound, n-acetylpsychosine, holds potential as a valuable tool for studying the mechanisms of apoptosis and immune responses activated by dendritic cells (dcs).
Dihydrojasmonic acid；Dihydrojasmonic acidDihydrojasmonic acid (2024/9/8)
簡(jiǎn)介：dihydrojasmonic acid is a plant growth regulator.
Epetraborole hydrochloride；化合物Epetraborole hydrochlorideGSK2251052 hydrochloride；GSK2251052 hydrochl (2024/9/8)
簡(jiǎn)介：epetraborole hydrochloride (gsk2251052 hydrochloride) is a potent and selective leucyl-trna synthetase inhibitor.
3-ANOT；3-ANOT3-Amino-5-nitro-o-toluamide|||3-ANOT；3-Amino-5-nitro-o-toluamide|||3-ANOT (2024/9/8)
簡(jiǎn)介：3-anot is a metabolite derived from dinitolmide, a widely employed nitroamide coccidiostat in the poultry industry.
MS-PEG3-THP；MS-PEG3-THPMS-PEG3-THP；MS-PEG3-THP (2024/9/8)
簡(jiǎn)介：ms-peg3-thp is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T-705RMP；T-705RMPT-705RMP (2024/9/8)
簡(jiǎn)介：t-705rmp, the phosphorylated metabolite derived from t-705, demonstrates a limited inhibitory impact on the host cells´ imp dehydrogenase (impdh) activities, with an ic 50 value of 601 μm.
Cyclocreatine；CyclocreatineCyclocreatine (2024/9/8)
簡(jiǎn)介：cyclocreatine, a creatine analogue, exhibits potent bioenergetic protection by elevating atp levels. it demonstrates the ability to traverse cell membranes, including the blood-brain barrier, wherein it undergoes phosphorylation and dephosphorylation by creatine kinases.
THP-CH3-ethyl propionate；THP-CH3-ethyl propionateTHP-CH3-ethyl propionate；THP-CH3-ethyl propionate (2024/9/8)
簡(jiǎn)介：thp-ch3-ethyl propionate is a protac linker composed of alkyl and ether groups. it finds utility in protac synthesis.
JAK2-IN-6；化合物JAK2-IN-6JAK2-IN-6；JAK2-IN-6 (2024/9/8)
簡(jiǎn)介：jak2-in-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of jak2 (ic50 at 22.86 μg/ml). jak2-in-6 inhibits the activity of jak2 enzymes by interfering with jak2-related signaling pathways, thereby producing therapeutic effects on the specific disease in which jak2 is dysregulated, and does not show activity on jak1 and jak3. jak2 is a protein involved in signaling pathways that regulate cell growth and division. abnormal activation of jak2 has been linked to a v
Propylparaben sodium羥苯丙酯鈉Propyl4-hydroxybenzoatesodium|||羥苯丙酯鈉|||Propylparahydroxybenzoatesodium (2024/9/8)
簡(jiǎn)介：propylparaben sodium (propyl parahydroxybenzoate) is a naturally occurring antimicrobial preservative found in plants and bacteria. widely utilized in cosmetics, pharmaceuticals, and foods, this compound impairs antral follicle growth and steroidogenic function by modifying the cell-cycle, apoptosis, and steroidogenesis pathways. additionally, propylparaben sodium reduces sperm count and motility in rats.
Azido-PEG6-MS；Azido-PEG6-MSAzido-PEG6-MS；Azido-PEG6-MS (2024/9/8)
簡(jiǎn)介：azido-peg6-ms is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Isobyakangelicol；IsobyakangelicolIsobyakangelicol|||Anhydrobyakangelicin；Isobyakangelicol|||Anhydrob (2024/9/8)
簡(jiǎn)介：isobyakangelicol, a coumarin compound present in angelica dahurica roots, exhibits inhibitory effects on the growth of hela and hepg2 cells, with ic50 values of 70.04 μm and 17.97 μm, respectively.
DprE1-IN-2；化合物DprE1-IN-2DprE1-IN-2 (2024/9/8)
簡(jiǎn)介：dpre1-in-2 is an effective dpre1 inhibitor.
SarizotanSarizotanEMD 128130 (2024/9/8)
簡(jiǎn)介：sarizotan (emd 128130) is an orally active compound that acts as an agonist for serotonin 5-ht 1a receptors and dopamine receptors. it has shown potent activity with ic 50 values of 6.5 nm for rat 5-ht 1a , 0.1 nm for human 5-ht 1a , 15.1 nm for rat d 2 , 17 nm for human d 2 , 6.8 nm for human d 3 , and 2.4 nm for human d 4.2 .
PEG-8 laurate；PEG-8 lauratePEG-8 laurate (2024/9/8)
簡(jiǎn)介：peg-8 laurate is a monofunctional surfactant and skin penetration enhancer. it disrupts the skin barrier and facilitates the formation of elastic vesicles when synthesized.
Caloxin 2A1 acetate；化合物Caloxin 2A1 acetateCaloxin 2A1 acetate (2024/9/8)
簡(jiǎn)介：caloxin 2a1 acetate is an inhibitor of extracellular plasma membrane ca2+-atpase (pmca) peptide. caloxin 2a1 acetate inhibits ca2+-dependent formation of the 140-kda acid-stable acylphosphate.
Caloxin 2A1；Caloxin 2A1Caloxin 2A1 (2024/9/8)
簡(jiǎn)介：caloxin 2a1 is an inhibitor peptide of the plasma membrane ca 2+-atpase (pmca) responsible for extracellular signaling. importantly, caloxin 2a1 has no impact on the basal mg 2+-atpase or na+-k+-atpase activities.
Chlorin e6 trimethyl ester二氫卟吩 e6 三甲酯二氫卟吩 e6 三甲酯 (2024/9/8)
簡(jiǎn)介：chlorin e6 trimethyl ester, a derivative of methyl pheophorbide-a, is an effective photosensitizer for photodynamic therapy (pdt).
6-Azido-hexylamine；6-Azido-hexylamine6-Azido-hexylamine (2024/9/8)
簡(jiǎn)介：6-azido-hexylamine is a cleavable linker employed for the synthesis of antibody-drug conjugates (adcs).
D-Cystine；D-胱氨酸D-Cystine (2024/9/8)
簡(jiǎn)介：d-cystine, the d-enantiomer of l-cystine, functions as an inhibitor of l-aspartate-β-semialdehyde dehydrogenase (asadh) derived from escherichia coli.
Mezerein；密執(zhí)毒素；歐瑞香脂；Mezerein (2024/9/8)
簡(jiǎn)介：mezerein is a chemical compound with antileukemic properties and acts as a pkc activator. it effectively inhibits the growth of yeast expressing pkc alpha (ic 50 = 1190 nm), pkc beta1 (ic 50 = 908 nm), and pkc delta (ic 50 = 141 nm). however, it does not inhibit the growth of yeast expressing pkc.
Anabaseine；假木賊堿Anabaseine (2024/9/8)
簡(jiǎn)介：anabaseine is a non-selective nicotinic agonist that stimulates all alpha-7 subtypes of achrs, with a preference for skeletal muscle and brain. additionally, it acts as a weak partial agonist at alpha-4 beta-2 nachrs.
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