9月
ACAT-IN-6；ACAT-IN-6ACAT-IN-6 (2024/9/8)
簡介：acat-in-6, an acyl-coenzyme a: cholesterol acyltransferase (acat) inhibitor, displays potent inhibition of nf-κb mediated transcription.
ACAT-IN-10；ACAT-IN-10ACAT-IN-10 (2024/9/8)
簡介：acat-in-10 is an acyl-coenzyme a: cholesterol acyltransferase (acat) inhibitor. it inhibits nf-κb mediated transcription with a weak activity.
ACAT-IN-3；ACAT-IN-3ACAT-IN-3 (2024/9/8)
簡介：acat-in-3, a potent inhibitor of acyl-coenzyme a: cholesterol acyltransferase (acat), effectively suppresses nf-κb dependent transcription.
Human β-defensin-1；Human β-defensin-1Human β-defensin-1|||HβD-1；Human β-defensin-1|||HβD-1 (2024/9/8)
簡介：human β-defensin-1 (hβd-1) is a cysteine-rich cationic skin-antimicrobial peptide (sap) produced by epithelial surfaces, circulatory cells, and cells of the reproductive tract. it exhibits antimicrobial activity against a wide range of sperm bacteria.
Etoxazole；乙螨唑Etoxazole (2024/9/8)
簡介：etoxazole is an acaricide/insecticide that works via chitin biosynthesis inhibition for the control of mites. used as a standard for pesticide detection.
PPA；PPAPPA (2024/9/8)
簡介：ppa serves as an adc linker (us20060073528a1), facilitating the production of antibody-drug conjugates.
NH-3；化合物NH-3NH-3 (2024/9/8)
簡介：nh-3 is a potent orally active thyroid hormone receptor (thr) antagonist which exhibits reversible behavior, demonstrated by an ic 50 of 55 nm. derived from the selective thyromi-metic gc-1, nh-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.
Lenalidomide-4-aminomethyl hydrochloride；Lenalidomide-4-aminomethyl hydrochlorideLenalidomide-4-amin (2024/9/8)
簡介：lenalidomide-4-aminomethyl hydrochloride is a compound derived from lenalidomide, serving as a cereblon (crbn) ligand for the recruitment of crbn protein. by connecting lenalidomide-4-aminomethyl hydrochloride to the ligand via a linker, protac formation can be facilitated.
3-Methylthienyl-carbonyl-JNJ-7706621；3-Methylthienyl-carbonyl-JNJ-77066213-Methylthienyl-carbonyl-JN (2024/9/8)
簡介：3-methylthienyl-carbonyl-jnj-7706621 is a highly potent and selective inhibitor of cyclin-dependent kinase (cdk). it exhibits impressive ic50 values of 6.4 nm and 2 nm for cdk1/cyclin b and cdk2/cyclin a, respectively. additionally, 3-methylthienyl-carbonyl-jnj-7706621 demonstrates potent inhibition against gsk-3 (ic50 = 0.041 μm) and moderate potency towards cdk4, vegf-r2, and fgf-r2 (ic50 = 0.11 μm, 0.13 μm, and 0.22 μm, respectively). its applications in cancer research are noteworthy.
MES；2-嗎啉乙磺酸(MES)2-Morpholinoethanesulphonic acid|||4-Morpholineethanesulfonic acid；2-Morpholinoethan (2024/9/8)
簡介：mes (2-morpholinoethanesulphonic acid) (2-morpholinoethanesulphonic acid), a zwitterionic buffer, is effective in the ph range of 5.5-7.7. mes, as one of the good’s buffers, is broadly used to regulate ph value for plants culture medium, reagent solution, and physiological experiments.
NCGC00092410；化合物NCGC00092410ML008；ML008 (2024/9/8)
簡介：ncgc00092410 (ml008) is a glucocerebrosidase (gc) inhibitor with ic50 value of 31 nm. it can be used for the study of gaucher disease caused by mutation of glucocerebrase gene.
3-Furanmethanol；3-呋喃甲醇3-Furanmethanol (2024/9/8)
簡介：3-furanmethanol is a furan compound exhibiting diverse sensory properties. efficient and highly regioselective photocycloaddition reactions occur between 3-furanmethanol and 2-cyanonaphthalenes.
Sinbaglustat；化合物SinbaglustatACT-519276|||Sinbaglustat|||OGT2378；ACT-519276|||Sinbaglustat|||OGT2378 (2024/9/8)
簡介：sinbaglustat (ogt2378) (ogt2378) is a dual inhibitor of glucose ceramide synthetase (gcs) and non-lysosomal glucose ceramidase (gba2).sinbaglustat is an orally administered n-alkyl iminosugar that crosses the blood-brain barrier.sinbaglustat is used for the treatment of lysosomal storage disorders and for the study of central neurodegenerative disorders associated with lysosomal dysfunction. sinbaglustat is used for the treatment of lysosomal storage disorders and for the study of lysosomal dysf
α-Synuclein (61-75)；α-Synuclein (61-75)α-Synuclein (61-75) (2024/9/8)
簡介：α-synuclein (61-75) is a peptide fragment derived from the larger protein α-synuclein. α-synuclein is predominantly found in presynaptic nerve terminals and is considered to be a biomarker candidate for parkinson´s disease (pd).
Bis-PEG6-t-butyl ester；Bis-PEG6-t-butyl esterBis-PEG6-t-butyl ester；Bis-PEG6-t-butyl ester (2024/9/8)
簡介：bis-peg6-t-butyl ester is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Dantrolene sodium hemiheptahydrate；丹曲林鈉五水合物Dantrolene sodium hydrate|||Dantrolene sodium salt|||Dant (2024/9/8)
簡介：dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. ryanodine receptors mediate the release of calcium from the sarcoplasmic reticulum, an essential step in muscle contraction. dantrolene sodium hemiheptahydrate (sodium dantrolene) is the sodium salt form of dantrolene, a hydantoin derivative, and direct-acting skeletal muscle relaxant.
Ibuprofen Impurity K；Ibuprofen Impurity KIbuprofen Impurity K (2024/9/8)
簡介：ibuprofen impurity k is a compound that serves as an impurity in ibuprofen. ibuprofen itself is an anti-inflammatory inhibitor specifically designed to target cox-1 and cox-2. it exhibits inhibitory activity with ic50 values of 13 μm and 370 μm for cox-1 and cox-2, respectively.
[Glu4]-Oxytocin；[Glu4]-Oxytocin[Glu4]-Oxytocin|||[Glu4] Oxytocin|||[Glu4]Oxytocin|||[Glu4]-Oxytocin| (2024/9/8)
簡介：[glu4]-oxytocin is a suitable derivative of oxytocin for conducting a thorough investigation, utilizing various methods, into the conformation of "oxytocin-like" molecules in aqueous solution.
[Leu3]-Oxytocin；[Leu3]-Oxytocin[Leu3]-Oxytocin；[Leu3]-Oxytocin (2024/9/8)
簡介：[leu3]-oxytocin, an oxytocin analogue, is a derivative of oxytocin wherein the leucine amino acid (leu) has been substituted at the 3rd position in the sequence.
THP-PEG10-THP；THP-PEG10-THPTHP-PEG10-THP；THP-PEG10-THP (2024/9/8)
簡介：thp-peg10-thp is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
MS-PEG10-THP；MS-PEG10-THPMS-PEG10-THP；MS-PEG10-THP (2024/9/8)
簡介：ms-peg10-thp is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
THP-PEG10-OH；THP-PEG10-OHTHP-PEG10-OH；THP-PEG10-OH (2024/9/8)
簡介：thp-peg10-oh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Ms-PEG6-THP；Ms-PEG6-THPMs-PEG6-THP；Ms-PEG6-THP (2024/9/8)
簡介：ms-peg6-thp is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
AST 487；化合物AST 487NVP-AST 487；NVP-AST 487 (2024/9/8)
簡介：ast 487 (nvp-ast 487) is a ret kinase inhibitor, inhibiting ret autophosphorylation and activation of downstream effectors. it also can inhibit flt-3.
(R)-(-)-1,2-Propanediol；(R)-(-)-1,2-丙二醇(R)-(-)-1,2-Propanediol (2024/9/8)
簡介：(r)-(-)-1,2-propanediol is the (r)-enantiomer of 1,2-propanediol, which is derived from glucose through the expression of nadh-linked glycerol dehydrogenase genes in escherichia coli.
Oxytocin free acid；Oxytocin free acid9-Deamidooxytocin；9-Deamidooxytocin (2024/9/8)
簡介：oxytocin free acid, also known as 9-deamidooxytocin, is an analog of oxytocin where the glycinamide residue at position 9 has been substituted with a glycine residue. oxytocin, a pleiotropic peptide hormone, has wide-ranging implications for general health, adaptation, development, reproduction, and social behavior.
Benzyl-PEG7-alcohol；Benzyl-PEG7-alcoholBenzyl-PEG7-alcohol；Benzyl-PEG7-alcohol (2024/9/8)
簡介：benzyl-peg7-alcohol is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Argentinogenin；ArgentinogeninArgentinogenin (2024/9/8)
簡介：argentinogenin is a natural compound with anti-cancer activity that could be found in traditional chinese drug chan su.
SW083688；SW083688SW083688 (2024/9/8)
簡介：sw083688 is a potent and highly selective inhibitor of thousand-and-one kinase 2 (taok2) with an ic 50 value of 1.3 μmol/l.
2′,3′-Di-O-acetylguanosine；2′,3′-Di-O-acetylguanosine2′,3′-Di-O-acetylguanosine (2024/9/8)
簡介：2′,3′-di-o-acetylguanosine is a nucleoside analog.
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