9月
N-(3-Oxotetradecanoyl)-DL-homoserine lactone；N-(3-Oxotetradecanoyl)-DL-homoserine lactone3-Oxo-C14-A (2024/9/8)
簡(jiǎn)介：n-(3-oxotetradecanoyl)-dl-homoserine lactone, part of the n-acyl homoserine lactone (ahl) family derived from gram-negative bacteria, serves as a quorum sensing (qs) signaling molecule.
α-Farnesene；α-法呢烯α-Farnesene (2024/9/8)
簡(jiǎn)介：α-farnesene, a sesquiterpene, is a herbivore-induced plant volatile (hipv) that plays a significant role in insect resistance across various plant species.
TIE-2/VEGFR-2 kinase-IN-2；TIE-2/VEGFR-2 kinase-IN-2TIE-2/VEGFR-2 kinase-IN-2 (2024/9/8)
簡(jiǎn)介：tie-2/vegfr-2 kinase-in-2 is a powerful inhibitor of both vegfr2 and tie-2 kinases, displaying noteworthy pic 50 values of 8.61 and 8.56, respectively. this compound acts as an anti-angiogenic agent, making it highly relevant for cancer research.
17β-Estradiol sulfate sodium；17β-Estradiol sulfate 鈉鹽17β-Estradiol 3-sulfate sodium|||17β-Estradiol (2024/9/8)
簡(jiǎn)介：17β-estradiol sulfate sodium (17β-estradiol 3-sulfate sodium) is a neuroactive estrogen with vasoprotective properties that inhibits the growth of neisseria brasiliensis and disrupts aquatic ecosystems.
R-IMPP；化合物R-IMPPR-IMPP (2024/9/8)
簡(jiǎn)介：r-impp is an inhibitor of pcsk9 translation. r-impp stimulates uptake of ldl-c in hepatoma cells by increasing ldl-r levels, without altering levels of secreted transferrin.
Ganglioside GD3 disodium salt；Ganglioside GD3 disodium saltGanglioside GD3 disodium salt (2024/9/8)
簡(jiǎn)介：ganglioside gd3 disodium salt is a melanoma-associated antigen often targeted in immune therapy for melanomas.
β-Bisabolene；β-Bisaboleneβ-Bisabolene (2024/9/8)
簡(jiǎn)介：β-bisabolene, a sesquiterpene extracted from opoponax (commiphora guidotti), serves as an anticancer agent with potential applications in breast cancer research.
TAK1-IN-3；TAK1 抑制劑3TAK1-IN-3；TAK1-IN-3 (2024/9/8)
簡(jiǎn)介：tak1-in-3 is a novel atp-competitive tak1 inhibitor for the study of cancer.
(S)-Salsolidine；(S)-Salsolidine(S)-Salsolidine (2024/9/8)
簡(jiǎn)介：(s)-salsolidine, a chemical compound, functions as a weak inhibitor of monoamine oxidase (mao), exhibiting an inhibition constant (k i ) of 63 μm. r enantiomer demonstrating a greater efficacy than (s)-salsolidine, boasting a k i value of 26 μm compared to the s form.
ADPM06；ADPM06ADPM06 (2024/9/8)
簡(jiǎn)介：adpm06, an azadipyrromethene compound, is a new nonporphyrin photodynamic therapeutic (pdt) agent with potential as a lead candidate. it demonstrates significant ic50 values in the micro-molar range in human tumor cells, as well as inducing apoptosis.
Br-C3-methyl esterBr-C3-methyl esterBr-C3-methyl ester (2024/9/8)
簡(jiǎn)介：br-c3-methyl ester is an alkyl/ether-based protac linker utilized for the synthesis of protac pd-1/pd-l1 degrader-1.
Lesogaberan napadisylateLesogaberan napadisylateAZD-3355 napadisylate (2024/9/8)
簡(jiǎn)介：lesogaberan (azd-3355) napadisylate is a potent and selective agonist of gaba b receptors, with an ec 50 of 8.6 nm for human recombinant gaba b receptors. it demonstrates an affinity (ki) of 5.1 nm for rat gaba b receptors and 1.4 μm for gaba a receptors, as determined by its displacement of [3h]gaba binding in brain membranes. notably, lesogaberan napadisylate exerts a peripheral mode of action, inhibiting transient lower esophageal sphincter relaxation.
Benzyl-PEG8-alcohol；Benzyl-PEG8-alcoholBenzyl-PEG8-alcohol；Benzyl-PEG8-alcohol (2024/9/8)
簡(jiǎn)介：benzyl-peg8-alcohol is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
簡(jiǎn)介：lkktetq acetate is the active site in the protein thymosin β4 responsible for wound healing, actin binding and cell migration.
LKKTETQ；LKKTETQLKKTETQ (2024/9/8)
簡(jiǎn)介：lkktetq, a peptide segment within thymosin β 4, constitutes the protein´s active site responsible for actin binding, cell migration, and wound healing.
Hoechst 33258 trihydrochloride；化合物Hoechst 33258Hoechst 33258|||Pibenzimol|||Bisbenzimide|||H 33258 t (2024/9/8)
簡(jiǎn)介：hoechst 33258 trihydrochloride (bisbenzimide) is a benzimidazole anti-filarial agent. it is fluorescent when it binds to certain nucleotides in dna, thus providing a tool for the study of dna replication. it also interferes with mitosis.
Hygric acid；古液酸N-Methyl-L-proline；N-Methyl-L-proline|||古液酸；古柯葉液堿酸 (2024/9/8)
簡(jiǎn)介：hygric acid (n-methyl-l-proline) (n-methyl-l-proline) is a proline analogue found in the citrus juices and the bergamot juice.
Fmoc-MMAE；Fmoc-MMAEFmoc-MMAE (2024/9/8)
簡(jiǎn)介：fmoc-mmae, a protective group-conjugated variant of monomethyl auristatin e (mmae), serves as a powerful inhibitor of tubulin. it finds application in the synthesis of antibody-drug conjugates (adc).
2,6,6-Trimethylbicyclo[3.1.1]heptan-3-ol；2,6,6-Trimethylbicyclo[3.1.1]heptan-3-ol2,6,6-Trimethylbicy (2024/9/8)
簡(jiǎn)介：2,6,6-trimethylbicyclo[3.1.1]heptan-3-ol is isolated from chrysanthemum indicum l..
5MPN；5MPN5MPN (2024/9/8)
簡(jiǎn)介：5mpn is a novel compound that functions as a highly potent and selective inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (pfkfb4). this compound demonstrates oral activity and serves as a first-in-class inhibitor. through competitive inhibition of the f6p binding site, 5mpn effectively hinders the functionality of pfkfb4, with a ki value of 8.6 μm. importantly, it exhibits no inhibitory effects on pfk-1 or pfkfb3. by specifically targeting the sugar metabolism of tumors, 5mpn
Neoabietic acid；新松脂酸Neoabietic acid (2024/9/8)
簡(jiǎn)介：neoabietic acid is an abietic-type acid isolated from the oleoresin and rosin of pinus palustris . neoabietic acid is highly susceptible to mineral acid. neoabietic acid has antibacterial activity in vitro.
Sandaracopimaric acid；山達(dá)海松酸Sandaracopimaric acid (2024/9/8)
簡(jiǎn)介：sandaracopimaric acid is an anti-inflammatory diterpenoid compound that effectively reduces the contraction of phenylephrine-induced pulmonary arteries. with an ec50 of 43.93 μm, it exhibits noteworthy anti-inflammatory properties.
ThrRS-IN-2；ThrRS-IN-2ThrRS-IN-2 (2024/9/8)
簡(jiǎn)介：thrrs-in-2 is an inhibitor of threonyl-trna synthetase (thrrs), exhibiting an inhibition concentration (ic50) value of 56.5 ± 3.5 μm.
Benzyl selenocyanate芐硒腈Benzyl selenocyanate (2024/9/8)
簡(jiǎn)介：benzyl selenocyanate is a chemopreventive agent that effectively inhibits chemically induced tumors at both initiation and postinitiation stages in animal models. it acts as a potent inhibitor of dna (cytosine-5)-methyltransferase (mtase), with an ic50 of 8.4 μm.
Tribromonitromethane；TribromonitromethaneTribromonitromethane (2024/9/8)
簡(jiǎn)介：tribromonitromethane is a member of the class of halonitromethanes, a newly identified group of disinfection by-products (dbps) found in drinking water.
Triclosan-methyl；三氯生甲基Triclosan-methyl (2024/9/8)
簡(jiǎn)介：triclosan-methyl is a derivative of triclosan, which functions as a bactericide in various personal care products including toothpaste, shampoos, and soaps. additionally, triclosan serves as a stabilizing agent in numerous detergents and cosmetics.
Simvastatin Acyl-β-D-glucuronide；Simvastatin Acyl-β-D-glucuronideSimvastatin Acyl-β-D-glucuronide (2024/9/8)
簡(jiǎn)介：simvastatin acyl-β-d-glucuronide, a metabolite formed from simvastatin, acts as a competitive inhibitor of hmg-coa reductase, showcasing a potent ki of 0.2 nm.
簡(jiǎn)介：lyp-1 acetate is a tumor homing peptide specifically binding to p32 receptors overexpressed in various tumor-associated cells.
LyP-1；LyP-1LyP-1 (2024/9/8)
簡(jiǎn)介：lyp-1 is a cyclic peptide comprised of 9 amino acids, designed to target and bind selectively to p32 receptors that are overexpressed in a range of tumor-associated cells.
ACAT-IN-4；ACAT-IN-4ACAT-IN-4 (2024/9/8)
簡(jiǎn)介：acat-in-4 (example 208) is a chemical compound that functions as an inhibitor of acyl-coenzyme a: cholesterol acyltransferase (acat). additionally, acat-in-4 effectively inhibits the transcription process mediated by nf-κb.
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