9月
Thiophene-2Thiophene-2Thiophene-2|||TP2 (2024/9/8)
簡介：thiophene-2 (tp2) is a targeted inhibitor of polyketide synthase 13 (pks13), specifically designed to disrupt mycolic acid biosynthesis. by doing so, it effectively induces rapid cell death in mycobacteria. thiophene-2 demonstrates notable anti-tuberculosis activity and exhibits a minimum inhibitory concentration (mic) value of 1 μm against mycobacterium tuberculosis.
KML29；化合物KML29KML29 (2024/9/8)
簡介：kml29 is highly selective and effective monoacylglycerol lipase (magl) inhibitor. it has effective inhibition of human/mouse/rat magl (ic50: 5.9/15/43 nm). it has not inhibitory for faah (ic50 > 50 μm). it also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-ag) in mice (ic50: 2.5 nm, 2-ag; >50 μm, aea).
Indicine N-oxide；Indicine N-oxide(+)-Indicine N-oxide|||Indicine N-oxide|||NSC132319；(+)-Indicine N- (2024/9/8)
簡介：indicine n-oxide (nsc 132319), a pyrrolizidine alkaloid, serves as an antitumor agent in pediatric cancer and solid tumors research.
C-Peptide 2, rat acetate；化合物C-Peptide 2, rat acetateC-Peptide 2, rat acetate (41594-08-5 Free base)； (2024/9/8)
簡介：c-peptide 2, rat acetate is a proinsulin component of inhibiting glucose-induced insulin secretion, consisting of acetate and a polypeptide composed of 31 amino acid residues [1] [2].
C-Peptide 2, rat；C-Peptide 2, ratC-Peptide 2, rat (2024/9/8)
簡介：c-peptide 2, rat, a 31-amino-acid peptide, serves as a constituent in proinsulin. it possesses the ability to hinder glucose-triggered insulin secretion.
GPR30 agonist-1GPR30 agonist-1GPR30 agonist-1 (2024/9/8)
簡介：gpr30 agonist-1 is a compound that acts as an agonist for g protein-coupled receptor 30 (gpr30), inducing vasorelaxation.
Nonylbenzene-PEG8-OH；Nonylbenzene-PEG8-OHNonylbenzene-PEG8-OH；Nonylbenzene-PEG8-OH (2024/9/8)
簡介：nonylbenzene-peg8-oh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Metamitron；苯嗪草酮Metamitron (2024/9/8)
簡介：metamitron is a photosynthetic electron transport chain inhibitor and can be used as a chemical thinner.
ESP 15228；化合物 ESP 152282,2,14,14-Tetramethyl-8-oxopentadecanedioic acid；2,2,14,14-Tetramethyl-8-oxop (2024/9/8)
簡介：2,2,14,14-tetramethyl-8-oxopentadecanedioic acid is a ketone compound, compound example ii-9. 2,2,14,14-tetramethyl-8-oxopentadecanedioic acid can be used for the research of cardiovascular diseases, dysproteinemias, dyslipidemias, and glucose metabolism disorders.
Echimidine N-oxide；Echimidine N-oxideEchimidine N-oxide (2024/9/8)
簡介：echimidine n-oxide, a pyrrolizidine alkaloid, exhibits significant inhibitory activity against acetylcholinesterase (ache) with an ic50 value of 0.347 mm.
TET 830 modified/T-helper epitope from tetanus toxoid；TET 830 modified/T-helper epitope from tetanus (2024/9/8)
簡介：tet 830 modified/t-helper epitope from tetanus toxoid is a t-cell stimulating peptide derived from tetanus toxoid. it acts as a helper peptide in vaccinations, eliciting t-cell responses.
Ac-RYYRWK-NH2 TFA；Ac-RYYRWK-NH2 TFAAc-RYYRWK-NH2 TFA；Ac-RYYRWK-NH2 TFA (2024/9/8)
簡介：ac-ryyrwk-nh2 is a highly effective and specific partial agonist for the nociceptin receptor (nop). it demonstrates a remarkable affinity for rat cortical membranes orl1, with [3h]ac-ryyrwk-nh2 exhibiting a kd value of 0.071 nm. however, it shows negligible affinity towards μ-, κ-, or δ-opioid receptors.
LDC4297；化合物L(fēng)DC4297LDC044297；LDC044297 (2024/9/8)
簡介：ldc4297 (ldc044297) is a potent and selective cdk7 inhibitor.
N-Octylmaleimide；N-OctylmaleimideN-Octylmaleimide (2024/9/8)
簡介：n-octylmaleimide is an alkylmaleimide, which can inhibit rat liver glucose 6-phosphatase.
TRV120056 acetate；化合物TRV120056 acetateTRV120056 acetate (40678-47-5 Free base)；TRV120056 acetate (40 (2024/9/8)
簡介：trv120056 acetate is a gq-biased agonist with 10-fold greater molecular efficiency on at1r-gq fusion proteins than at1r-βarr2 fusion proteins.
TRV120056；TRV120056TRV120056 (2024/9/8)
簡介：trv120056 is a gq-biased agonist that demonstrates a molecular efficacy ten times greater at the at1r-gq fusion protein than at the at1r-βarr2 fusion protein.
BTO-1；BTO-1BTO-1 (2024/9/8)
簡介：bto-1 is a compound known as a polo-like kinase (plk) inhibitor, commonly employed for its effectiveness in regulating processes involving phosphorylation and dephosphorylation.
Pendimethalin；二甲戊靈Pendimethalin (2024/9/8)
簡介：pendimethalin is a herbicide with selective that controls annual grasses and certain annual broadleaf weeds.
N-Desmethyl imatinib mesylate；N-Desmethyl imatinib mesylateImatinibmetaboliteN-Desmethylimatinibmesy (2024/9/8)
簡介：norimatinib mesylate, also known as n-desmethyl imatinib mesylate, is a metabolite derived from imatinib, which acts as a potent multi-target inhibitor of v-abl, c-kit, and pdgfr.
Thalidomide-5-methyl；化合物Thalidomide-5-methylThalidomide-5-methyl (2024/9/8)
簡介：thalidomide-5-methyl is the thalidomide-based cereblon (crbn) ligand. thalidomide-5-methyl is used in the recruitment of crbn protein.
2-Hydroxymethyl-5-hydroxypyridine；6-(羥甲基)吡啶-3-醇2-Hydroxymethyl-5-hydroxypyridine (2024/9/8)
簡介：2-hydroxymethyl-5-hydroxypyridine is found in the the matured, ripened and dried seeds of s. lychnophora.
Erucifoline；ErucifolineErucifoline (2024/9/8)
簡介：erucifoline, a pyrrolizidine alkaloid, is present in the aerial components of senecio aquaticus.
GSK2981278；化合物GSK2981278ROR gama modulator 1；ROR gama modulator 1 (2024/9/8)
簡介：gsk2981278 (ror gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ror gamma).
Dentonin acetate；化合物Dentonin acetateDentonin acetate (400090-20-2 Free base)；Dentonin acetate (40009 (2024/9/8)
簡介：dentonin acetate enhances osteogenesis and facilitates immature adherent cell survival. dentonin acetate, a synthetic fragment derived from mepe, can be used in phosphate homeostasis and bone metabolism studies.
Dentonin；DentoninAC-100；AC-100 (2024/9/8)
簡介：dentonin (ac-100) is a synthetic fragment derived from mepe that enhances osteogenesis by promoting osteoprogenitor adhesion and facilitating the survival of immature adherent cells. it does not have a significant effect on mature osteoblasts. dentonin is useful for research on phosphate homeostasis and bone metabolism.
3,4-Dichlorocatechol；3,4-二氯兒茶酚3,4-Dichlorocatechol (2024/9/8)
簡介：3,4-dichlorocatechol serves as a substrate for the broad-spectrum chlorocatechol 1,2-dioxygenase enzyme found in pseudomonas chlororaphis rw71.
Elastase from porcine pancreas；化合物Elastase from porcine pancreasEC 3.2.1.35；彈性蛋白酶|||EC 3.2.1.35 (2024/9/8)
簡介：porcine pancreatic elastase is a serine protease composed of a single polypeptide chain with 240 amino acid residues. it has the ability to hydrolyze polypeptides and proteins, and can induce emphysema in hamsters.
Bis-isopropyl-PEG1；Bis-isopropyl-PEG1Bis-isopropyl-PEG1；Bis-isopropyl-PEG1 (2024/9/8)
簡介：bis-isopropyl-peg1 is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
3,6-Dichlorocatechol；3,6-二氯鄰苯二酚3,6-Dichlorocatechol (2024/9/8)
簡介：3,6-dichlorocatechol serves as a substrate for the broad-spectrum chlorocatechol 1,2-dioxygenase found in pseudomonas chlororaphis rw71.
Benzyl-PEG9-Ots；Benzyl-PEG9-OtsBenzyl-PEG9-Ots；Benzyl-PEG9-Ots (2024/9/8)
簡介：benzyl-peg9-ots is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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