Human PD-L1 inhibitor V TFA;化合物 Human PD-L1 inhibitor V TFAHuman PD-L1 inhibitor V TFA (2024/9/14)
簡介:human pd-l1 inhibitor v tfa, a peptide that binds to the human pd-1 protein, exhibits a dissociation constant (kd) of 3.32 μm and effectively inhibits the hpd-1/hpd-l1 interaction [1].
Human PD-L1 inhibitor V;化合物 Human PD-L1 inhibitor VHuman PD-L1 inhibitor V (2024/9/14)
簡介:human pd-l1 inhibitor v is a peptide that binds to the human pd-1 protein with an affinity characterized by a dissociation constant (kd) of 3.32 μm, effectively inhibiting the hpd-1/hpd-l1 interaction [1].
Bremelanotide Acetate;化合物bremelanotidebremelanotide|||PT-141 Acetate;bremelanotide|||PT-141 Acetate (2024/9/14)
簡介:bremelanotide acetate (pt-141 acetate) is an agonist of melanocortin receptor (mcr) .
[Pro9]-Substance P;化合物 [Pro9]-Substance P[Pro9]-Substance P (2024/9/14)
簡介:[pro9]-substance p is a highly effective, reversible, and selective agonist for nk-1 tachykinin receptors, demonstrating an ec50 value of 0.93 nm [1].
Neurogranin (48-76), mouse;化合物 Neurogranin (48-76), mouseNeurogranin (48-76), mouse (2024/9/14)
簡介:neurogranin (48-76), mouse, is a peptide comprising residues 48-76 of neurogranin, a post-synaptically exclusive calmodulin-binding protein that mediates nmdar-driven synaptic plasticity by regulating the calcium-calmodulin (ca2+-cam) pathway [1].
MMP-13 Substrate;化合物 MMP-13 SubstrateMMP-13 Substrate (2024/9/14)
簡介:mmp-13 substrate, a compound utilized in osteoarthritis (oa) research [1], functions as a substrate for mmp-13.
Histatin-8;化合物 Histatin-8Histatin-8 (2024/9/14)
簡介:histatin-8, a hemagglutination-inhibiting peptide within the central sequence of histatin-3, exhibits potent anti-fungal and antimicrobial activities against yeast strains. this makes it relevant for oral thrush research [1] [2].
{Boc}-Phe-Leu-Phe-Leu-Phe TFA;化合物 {Boc}-Phe-Leu-Phe-Leu-Phe TFA{Boc}-Phe-Leu-Phe-Leu-Phe TFA (2024/9/14)
簡介:{boc}-phe-leu-phe-leu-phe tfa is a selective antagonist of the formyl peptide receptor (fpr) family, effectively inhibiting actions mediated by fpr [1].
HIV Protease Substrate 1 TFA;化合物 HIV Protease Substrate 1 TFAHIV Protease Substrate 1 TFA (2024/9/14)
簡介:hiv protease substrate 1 tfa, a fluorogenic substrate for hiv protease, facilitates the investigation of the enzyme´s activity [1].
BH3 hydrochloride;化合物 BH3 hydrochlorideBH3 hydrochloride (2024/9/14)
簡介:bh3 hydrochloride, a peptide that crosses the blood-brain barrier, induces apoptosis either through direct activation of the pro-apoptotic proteins bax/bak or by inhibiting anti-apoptotic bcl-2 proteins (bcl-2, bcl-xl, bcl-w, mcl-1, and a-1) through their bh3 domain [1][2].
CCZ01048 TFA;化合物 CCZ01048 TFACCZ01048 TFA (2024/9/14)
簡介:ccz01048 tfa, an α-msh analogue, demonstrates a strong binding affinity for the melanocortin 1 receptor (mc1r), displaying a k i value of 0.31 nm. it exhibits rapid internalization into b16f10 melanoma cells and maintains high in vivo stability. ccz01048 tfa holds potential as an effective agent for pet imaging of malignant melanoma [1].
CCZ01048;化合物 CCZ01048CCZ01048 (2024/9/14)
簡介:ccz01048, an analogue of α-melanocyte-stimulating hormone (α-msh), demonstrates a high binding affinity for the melanocortin 1 receptor (mc1r), with a ki of 0.31 nm. it rapidly internalizes into b16f10 melanoma cells and exhibits notable in vivo stability, making it a promising candidate for pet imaging of malignant melanoma [1].
Epinecidin-1 TFA;化合物 Epinecidin-1 TFAEpinecidin-1 TFA (2024/9/14)
簡介:epinecidin-1 tfa, a multifunctional antimicrobial peptide (amp) derived from the orange-spotted grouper (epinephelus coioides), exhibits a broad spectrum of bioactivities including antibacterial, antifungal, antiviral, anti-tumor, and immunomodulatory properties. it represents a promising alternative to conventional antibiotics [1].
Defensin HNP-1 human TFA;化合物 Defensin HNP-1 human TFADefensin HNP-1 human TFA (2024/9/14)
簡介:defensin hnp-1 human tfa, a human neutrophil peptide (hnp), plays a role in the early development of atherosclerosis by contributing to endothelial cell dysfunction. additionally, it has demonstrated broad-spectrum antimicrobial and anti-leishmanial effects [1] [2].
Tat-NR2Baa TFA;化合物 Tat-NR2Baa TFATat-NR2Baa TFA (2024/9/14)
簡介:tat-nr2baa tfa serves as the inactive control peptide for tat-nr2b9c, featuring a comparable sequence with a crucial distinction: a double-point mutation in its cooh-terminal tsxv motif. this alteration renders tat-nr2baa tfa unable to bind to psd-95, in contrast to tat-nr2b9c. the latter is a membrane-permeant peptide that impedes psd-95/nmdar interaction, specifically detaching nr2b- and/or nr2a-type nmdars from psd-95 [1].
Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA;化合物 Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFACyclo(Arg-Gly-Asp-D-Phe-Cys) TF (2024/9/14)
簡介:cyclo(arg-gly-asp-d-phe-cys) tfa (cyclo rgdfc) tfa, a cyclic rgd peptide, displays a high affinity for αvβ3 integrin, effectively disrupting cell-integrin interactions. it suppresses pluripotent marker expression in embryonic stem cells (escs) and reduces the tumorigenic capability of mescs in vivo, making it valuable in tumor research [1].
pm26TGF-β1 peptide TFA;化合物 pm26TGF-β1 peptide TFApm26TGF-β1 peptide TFA (2024/9/14)
簡介:pm26tgf-β1 tfa peptide is a synthetic peptide that emulates a segment of the human tgf-β1 molecule, demonstrating high affinity for the tgf-β1 receptor. it possesses potent anti-inflammatory capabilities while lacking the ability to attract neutrophils [1] [2].
pm26TGF-β1 peptide;化合物 pm26TGF-β1 peptidepm26TGF-β1 peptide (2024/9/14)
簡介:pm26tgf-β1 peptide, mimicking a portion of the human tgf-β1 molecule, demonstrates a high affinity for the tgf-β1 receptor. it exhibits potent anti-inflammatory properties without inducing neutrophils´ chemoattraction [1] [2].
Omiganan-FITC TFA;化合物 Omiganan-FITC TFAOmiganan-FITC TFA (2024/9/14)
簡介:omiganan-fitc tfa, a compound integrating the bactericidal and fungicidal cationic peptide omiganan with a fluorescein isothiocyanate (fitc), is under development as a topical gel aimed at preventing catheter-associated infections [1].
Omiganan-FITC;化合物 Omiganan-FITCOmiganan-FITC (2024/9/14)
簡介:omiganan-fitc is a complex of the cationic peptide omiganan, which possesses bactericidal and fungicidal properties and is under development as a topical gel for preventing catheter-associated infections, and fluorescein isothiocyanate (fitc), a fluorescein derivative used for amine labeling [1].
Beta-defensin 103 isoform X1, pig TFA;化合物 Beta-defensin 103 isoform X1, pig TFABeta-defensin 103 iso (2024/9/14)
簡介:beta-defensin 103 isoform x1, pig tfa, is an antimicrobial peptide present in various living organisms, playing a crucial role in the initial defense of their innate immune system against pathogens [1].
Beta-defensin 103 isoform X1, pig;化合物 Beta-defensin 103 isoform X1, pigBeta-defensin 103 isoform X1, (2024/9/14)
簡介:beta-defensin 103 isoform x1, pig, is an antimicrobial peptide prevalent in various organisms, playing a crucial role in the initial defense strategy of their innate immune system against pathogens [1].
Beta-defensin 1, pig TFA;化合物 Beta-defensin 1, pig TFABeta-defensin 1, pig TFA (2024/9/14)
簡介:beta-defensin 1, pig tfa, an antimicrobial peptide predominantly located in the tongue mucosa of pigs, exhibits activity against a diverse range of bacteria including escherichia coli, salmonella typhimurium, listeria monocytogenes, staphylococcus aureus, bordetella pertussis, and the fungus candida albicans [1] [2].
Beta-defensin 1, pig;化合物 Beta-defensin 1, pigBeta-defensin 1, pig (2024/9/14)
簡介:beta-defensin 1, pig, is an antimicrobial peptide predominantly located in the tongue mucosa of pigs. it exhibits activity against a variety of bacteria including escherichia coli, salmonella typhimurium, listeria monocytogenes, staphylococcus aureus, bordetella pertussis, and the fungus candida albicans [1] [2].
pBD-1 TFA;化合物 pBD-1 TFApBD-1 TFA (2024/9/14)
簡介:pbd-1 tfa, an endogenous antimicrobial peptide (amp) from porcine tissues, is constitutively expressed, particularly at pig mucosal epithelial sites. it exhibits antimicrobial activities, contributing to both mucosal and systemic host defenses in pigs [1].
Parathyroid hormone (1-34) (rat) acetate;化合物 Parathyroid hormone (1-34) (rat) acetateParathyroid hor (2024/9/14)
簡介:parathyroid hormone (1-34) (rat) (acetate) is a parathyroid hormone variant that enhances the structure of both cortical and cancellous bones. it is utilized in osteoporosis research [1] [2].
NLS-StAx-h TFA;化合物 NLS-StAx-h TFANLS-StAx-h TFA (2024/9/14)
簡介:nls-stax-h tfa is a selective and cell-permeable stapled peptide that inhibits wnt signaling, demonstrating an ic50 value of 1.4 μm and effectively suppressing β-catenin-transcription factor interactions. this compound exhibits anti-proliferative effects on cancer cells [1] [2].
SAH-SOS1A TFA;SAH-SOS1A TFASAH-SOS1A TFA (2024/9/14)
簡介:sah-sos1a tfa is a peptide-based sos1/kras protein interaction inhibitor. sah-sos1a tfa binds to wild-type and mutant kras (g12d, g12v, g12c, g12s, and q61h) with nanomolar affinity ( ec 50 =106-175 nm). sah-sos1a tfa directly and independently blocks nucleotide association. sah-sos1a tfa impairs kras-driven cancer cell viability and exerts its effects by on-mechanism blockade of the erk-mapk phosphosignaling cascade downstream of kras [1] .
Tat-beclin 1 TFA;化合物 Tat-beclin 1 TFATat-beclin 1 TFA (2024/9/14)
簡介:tat-beclin 1 tfa, a peptide originating from a segment of the autophagy protein beclin 1, effectively initiates autophagy and engages with the autophagy negative regulator, gapr-1 (glipr2). it notably reduces the buildup of polyglutamine expansion protein aggregates and curtails the in vitro replication of various pathogens, including hiv-1. moreover, tat-beclin 1 tfa has demonstrated a reduction in mortality rates in mice infected with either chikungunya (chikv) or west nile virus (wnv) [1].
Glepaglutide acetate;化合物 Glepaglutide acetateGlepaglutide acetate (2024/9/14)
簡介:glepaglutide (zp1848) acetate is a long-acting glucagon-like peptide-2 (glp-2) analogue and a potent glp-2 receptor (glp-2r) agonist. it significantly reduces fecal output and enhances intestinal absorption while also mitigating inflammation in the small intestine. glepaglutide acetate is relevant in researching inflammatory bowel disease (ibd) and crohn’s disease [1] [2] [3].