9月
Apraglutide TFA；化合物 Apraglutide TFAApraglutide TFA (2024/9/14)
簡介：apraglutide tfa (fe 203799 tfa), a synthetic 33-amino-acid peptide functioning as a long-acting glp-2 analogue, promotes adaptation and linear growth of the intestine in neonatal piglet models of short bowel syndrome following complete ileum resection [1].
Aurantimycin A；化合物 Aurantimycin AAurantimycin A (2024/9/14)
簡介：aurantimycin a (adipogen), a depsipeptide antibiotic, exhibits potent efficacy against gram-positive bacteria and serves as a substrate for the lieab transporter [1] [2].
Fucoxanthin；藻褐素all-trans-Fucoxanthin；all-trans-Fucoxanthin (2024/9/14)
簡介：fucoxanthin (all-trans-fucoxanthin) is a carotenoid that occurs naturally in certain algae. it is found as an accessory pigment in the chloroplasts of brown algae and most other heterokonts, giving them a brown or olive-green color.it shows anti-obesity, anti-oxidant, anti-diabetic, anticancer and anti-inflammatory activities.
Balixafortide TFA；化合物 Balixafortide TFABalixafortide TFA (2024/9/14)
簡介：balixafortide tfa (pol6326 tfa) is a potent, selective cxcr4 antagonist that exhibits excellent tolerance levels and demonstrates an ic50 of less than 10 nm. it displays over 1000-fold selectivity for cxcr4 over a large panel of other receptors, including cxcr7. this compound effectively inhibits β-arrestin recruitment and calcium flux with ic50 values under 10 nm. additionally, balixafortide tfa serves as a powerful agent for mobilizing hematopoietic stem and progenitor cells (hspc) and has doc
cyclo(RLsKDK) TFA；化合物 cyclo(RLsKDK) TFAcyclo(RLsKDK) TFA (2024/9/14)
簡介：cyclo(rlskdk) (tfa) (bk-1361 (tfa)) is a specific inhibitor of the metalloproteinase adam8, demonstrating an ic50 value of 182 nm. it has shown potential for application in the treatment of inflammatory diseases and cancer [1].
Acetyl-PHF6 amide TFA；化合物 Acetyl-PHF6 amide TFAAcetyl-PHF6 amide TFA (2024/9/14)
簡介：acetyl-phf6 amide tfa (acphf6 tfa) is a tau derived hexapeptide.
Murepavadin TFA；化合物 Murepavadin TFAMurepavadin TFA (2024/9/14)
簡介：murepavadin (pol7080) (tfa), a 14-amino-acid cyclic peptide, serves as a highly potent, specific antibiotic with remarkable antimicrobial activity against p. aeruginosa, demonstrated by mic 50 and mic 90 values of 0.12 mg/l. it uniquely targets the lipopolysaccharide transport protein d, showing potential for research on bacterial resistance [1] [2].
SOR-C13 TFA；化合物 SOR-C13 TFASOR-C13 TFA (2024/9/14)
簡介：sor-c13 tfa, a truncated carboxy-terminal peptide, serves as a potent trpv6 antagonist, demonstrating high affinity with an ic 50 value of 14 nm. trpv6, a non-voltage-gated calcium channel linked to malignancy and poor prognosis in breast cancer, is effectively targeted by sor-c13 tfa, indicating its anticancer activity [1].
SPR741 TFA；化合物 SPR741 TFASPR741 TFA (2024/9/14)
簡介：spr741 tfa (nab741 tfa), a cationic peptide derived from polymyxin b, acts as a potentiator molecule that enhances the permeability of gram-negative bacteria´s outer membrane, thereby facilitating the treatment of severe gram-negative bacterial infections. this compound effectively inhibits multidrug-resistant gram-negative bacteria and, when combined with antibiotics, broadens their spectrum of activity [1] [2].
Pepsin A；化合物 Pepsin APepsin A (2024/9/14)
簡介：pepsin a, a primary gastric protease in both pigs and humans, functions similarly to minor gastric proteolytic enzymes. it plays a crucial role in the proteolysis of food proteins within the vertebrate stomach [1] [2].
Buforin II；化合物 Buforin IIBuforin II (2024/9/14)
簡介：buforin ii, a powerful antimicrobial peptide originating from buforin i (a protein extracted from the asian toad bufo bufo gargarizans´s stomach), exhibits broad-spectrum antimicrobial properties against both gram-positive and gram-negative bacteria [1].
Ganirelix；化合物 GanirelixGanirelix (2024/9/14)
簡介：ganirelix is a selective and competitive antagonist of gonadotropin-releasing hormone (gnrh), effectively preventing endogenous gnrh from triggering the release of luteinizing hormone (lh) and follicle-stimulating hormone [1].
Cyclo(Arg-Gly-Asp-D-Phe-Val)；化合物 Cyclo(Arg-Gly-Asp-D-Phe-Val)Cyclo(Arg-Gly-Asp-D-Phe-Val) (2024/9/14)
簡介：cyclo(arg-gly-asp-d-phe-val) is an integrin αvβ3 inhibitor with antitumor properties, utilized in the research of acute myeloid leukemia [1].
Sunifiram；桑尼菲拉姆DM-235；桑尼菲拉姆|||DM-235|||桑尼非拉姆 (2024/9/14)
簡介：sunifiram (dm-235) is a potent nootropic agent.
Malantide TFA；化合物 Malantide TFAMalantide TFA (2024/9/14)
簡介：malantide tfa, a synthetic dodecapeptide, originates from the phosphorylation site targeted by camp-dependent protein kinase (pka) on the β-subunit of phosphorylase kinase. exhibiting a high specificity for pka with a michaelis constant (km) of 15 μm, this compound demonstrates more than 90% inhibition of substrate phosphorylation in the presence of protein inhibitor (pki) across various rat tissue extracts [1]. moreover, malantide tfa acts as an effective substrate for protein kinase c (pkc) wi
Dynorphin A (1-10) (TFA)；化合物 Dynorphin A (1-10) (TFA)Dynorphin A (1-10) (TFA) (2024/9/14)
簡介：dynorphin a (1-10) (tfa), an endogenous opioid neuropeptide, interacts with κ-opioid receptor´s extracellular loop 2 and inhibits nmda-activated currents with an ic 50 of 42.0 μm.
Mini Gastrin I, human TFA；化合物 Mini Gastrin I, human TFAMini Gastrin I, human TFA (2024/9/14)
簡介：mini gastrin i, human (tfa) is a truncated form of the human gastrin peptide, encompassing amino acids 5-17 of the original sequence.
G3-C12 TFA；化合物 G3-C12 TFAG3-C12 TFA (2024/9/14)
簡介：g3-c12 (tfa), a galectin-3 binding peptide, demonstrates anticancer activity with a dissociation constant (k d) of 88 nm.
ACTH (1-14) (TFA)；化合物 ACTH (1-14) (TFA)ACTH (1-14) (TFA) (2024/9/14)
簡介：acth (1-14) (tfa) is a regulatory fragment of adrenocorticotropin, specifically involved in the control of cortisol and androgen synthesis [1].
AMARA peptide TFA；化合物 AMARA peptide TFAAMARA peptide TFA (2024/9/14)
簡介：amara peptide (tfa) serves as a substrate for both salt-inducible kinase (sik) and adenosine monophosphate-activated protein kinase (ampk).
TAT (48-57) (TFA)；化合物 TAT (48-57) (TFA)TAT (48-57) (TFA) (2024/9/14)
簡介：tat (48-57) (tfa) is a peptide capable of penetrating cells, sourced from residues 48-57 of the hiv-1 tat (transactivator of transcription) protein.
LCMV gp33-41 TFA；化合物 LCMV gp33-41 TFALCMV gp33-41 TFA (2024/9/14)
簡介：lcmv gp33-41 (tfa), an 11-amino-acid carboxyl-extended peptide, comprises a lymphocytic choriomeningitis virus sequence that is presented by mhc class i h-2db molecules to cytotoxic t lymphocytes [1].
PUMA BH3 TFA；化合物 PUMA BH3 TFAPUMA BH3 TFA (2024/9/14)
簡介：puma bh3 (tfa), a peptide from the bh3 domain of the p53 upregulated modulator of apoptosis (puma), directly activates bak with a dissociation constant (kd) of 26 nm [1].
Calcium N5-methyltetrahydrofolate；N5-甲基四氫葉酸鈣NSC173328；5-甲基四氫葉酸鈣|||N5-甲基四氫葉酸鈣|||NSC173328 (2024/9/14)
簡介：calcium n5-methyltetrahydrofolate (nsc-173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers
ACTH (11-24) (acetate)；化合物 ACTH (11-24) (acetate)ACTH (11-24) (acetate) (2024/9/14)
簡介：acth (11-24) (acetate), a fragment of adrenocorticotropic hormone (acth), functions as a receptor antagonist and promotes cortisol release. this compound is utilized in researching the central nervous system [1].
β-CGRP, human TFA；化合物 β-CGRP, human TFAβ-CGRP, human TFA (2024/9/14)
簡介：human β-cgrp tfa (β-cgrp, human tfa) is a calcitonin peptide that functions through interaction with the calcitonin-receptor-like receptor (crlr) and receptor-activity-modifying protein (ramp) complex, demonstrating ic50 values of 1 nm and 300 nm for crlr/ramp1 and crlr/ramp2, respectively, in cellular assays [1].
ACTH (1-17) (TFA)；化合物 ACTH (1-17) (TFA)ACTH (1-17) (TFA) (2024/9/14)
簡介：acth (1-17) tfa, an analogue of adrenocorticotropin, serves as a highly effective agonist for the human melanocortin 1 (mc1) receptor, exhibiting a dissociation constant (k i) of 0.21 nm.
Urotensin I TFA；化合物 Urotensin I TFAUrotensin I TFA (2024/9/14)
簡介：urotensin i (catostomus urotensin i) tfa is a crf-like neuropeptide that functions as an agonist for crf receptors, demonstrating efficacy through pec50 values of 11.46 for human crf1, 9.36 for human crf2, and 9.85 for rat crf2α receptors in cho cells. it also exhibits binding affinities (ki) of 0.4 nm for hcrf1, 1.8 nm for rcrf2α, and 5.7 nm for mcrf2β receptors, respectively [1] [2].
Angiotensin III, human, mouse TFA；化合物 Angiotensin III, human, mouse TFAAngiotensin III, human, mouse (2024/9/14)
簡介：angiotensin iii, human, mouse (tfa) is an angiotensin.
Cecropin A TFA；化合物 Cecropin A TFACecropin A TFA (2024/9/14)
簡介：cecropin a tfa, a linear 37-residue antimicrobial polypeptide derived from hyalaphora cecropia pupae, exhibits anti-bacterial, anti-inflammatory [1], and anti-cancer activities [2].
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