9月
β-Endorphin, equine TFA；化合物 β-Endorphin, equine TFAβ-Endorphin, equine TFA (2024/9/14)
簡介：β-endorphin, equine tfa, an endogenous opioid peptide, demonstrates high affinity binding to μ/δ opioid receptors and possesses analgesic properties [1] [2] [3] [4].
TNF-α (31-45), human TFA；化合物 TNF-α (31-45), human TFATNF-α (31-45), human TFA (2024/9/14)
簡介：tnf-α (31-45), human (tfa) is a peptide of tumor necrosis factor-α. tumour necrosis factor alpha (tnf alpha) is an inflammatory cytokine that induces necrosis or apoptosis [1] .
Urocortin III, mouse TFA；化合物 Urocortin III, mouse TFAUrocortin III, mouse TFA (2024/9/14)
簡介：urocortin iii, mouse tfa, a corticotropin-releasing factor (crf)-related peptide, preferentially activates crf-r2 [1], demonstrating its significant role in the behavioral stress response system as a component of urocortin iii (ucn3). additionally, it collaborates with crf-r2 in the medial amygdala to modulate complex social dynamics [2].
IKKγ NBD Inhibitory Peptide TFA；化合物 IKKγ NBD Inhibitory Peptide TFAIKKγ NBD Inhibitory Peptide TFA (2024/9/14)
簡介：ikkγ nbd inhibitory peptide tfa is a specific nf-κb inhibitor that functions by hindering the interaction between the ikkγ/nemo-binding domain (nbd) and ikkα and ikkβ. this action effectively prevents tnf-α-induced nf-kb activation. it has been demonstrated to significantly suppress inflammation and improve neurological deficits induced by cerebral ischemia [1] [2] [3].
Jagged-1 (188-204) (TFA)；化合物 Jagged-1 (188-204) (TFA)Jagged-1 (188-204) (TFA) (2024/9/14)
簡介：jagged-1 (188-204) tfa, a fragment of the jagged-1 (jag-1) protein, acts as a notch agonist. this compound is significantly present in both cultured and primary multiple myeloma (mm) cells, where jag-1 facilitates the maturation of monocyte-derived human dendritic cells [1] [2] [3].
Chemerin-9 (149-157) (TFA)；化合物 Chemerin-9 (149-157) (TFA)Chemerin-9 (149-157) (TFA) (2024/9/14)
簡介：chemerin-9 (149-157) tfa is a potent cmklr1 (chemokine-like receptor 1) agonist with anti-inflammatory properties. it activates phosphorylation of akt and erk and induces ros production, beneficially modulating immune responses, adipocyte differentiation, and glucose metabolism. additionally, it has been shown to alleviate aβ 1-42-induced memory impairment, highlighting its therapeutic potential [1] [2] [3] [4].
Myelin Basic Protein TFA；化合物 Myelin Basic Protein TFAMyelin Basic Protein TFA (2024/9/14)
簡介：myelin basic protein (mhp4-14) tfa, a synthetic peptide containing residues 4-14 of myelin basic protein, serves as a highly selective substrate for protein kinase c (pkc) with a k_m of 7 μm. it is not phosphorylated by cyclic amp-dependent protein kinase, casein kinases i and ii, ca^2+/calmodulin-dependent protein kinase ii, or phosphorylase kinase. this specificity makes myelin basic protein tfa an ideal candidate for protein kinase c assays in crude tissue extracts, ensuring minimal backgroun
AUNP-12 TFA；化合物 AUNP-12 TFAAUNP-12 TFA (2024/9/14)
簡介：aunp-12 tfa (np-12 tfa), a peptide antagonist of the pd-1 signaling pathway, exhibits equipotent antagonism toward pd-l1 and pd-l2, enhancing lymphocyte proliferation and effector functions. it promotes immune activation, shows significant antitumor activity, and holds potential for improved management of immune-related adverse events (iraes) [1].
Theaflavin；茶黃素Theaflavin (2024/9/14)
簡介：theaflavin is a polyphenolic flavonoid that has been found in black tea and has diverse biological activities, including antioxidant, anticancer, anti-inflammatory, and antiviral properties
Carbetocin acetate；卡貝縮宮素醋酸鹽Carbetocin acetate(37025-55-1 free base)；醋酸卡貝縮宮素|||Carbetocin acetate(370 (2024/9/14)
簡介：carbetocin acetate is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.
[pTyr5] EGFR (988-993) (TFA)；化合物 [pTyr5] EGFR (988-993) (TFA)[pTyr5] EGFR (988-993) (TFA) (2024/9/14)
簡介：[ptyr5] egfr (988-993) tfa, originating from the tyr992 autophosphorylation site of the epidermal growth factor receptor (egfr 988-993), frequently forms a complex with catalytically inactive protein-tyrosine phosphate 1b (ptp1b) [1].
Lactoferrin (17-41) (acetate)；化合物 Lactoferrin (17-41) (acetate)Lactoferrin (17-41) (acetate) (2024/9/14)
簡介：lactoferrin 17-41 (lactoferricin b) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms , including gram-positive and gramnegative bacteria, viruses, protozoa, and fungi. lactoferrin 17-41 acetate has antitumor activities [1] [2] .
CTTHWGFTLC, CYCLIC TFA；化合物 CTTHWGFTLC, CYCLIC TFACTTHWGFTLC, CYCLIC TFA (2024/9/14)
簡介：ctthwgftlc, also known as cyclic tfa, is a cyclic peptide that acts as an inhibitor of matrix metalloproteinases (mmp-2 and mmp-9), with an ic50 value of approximately 8 μm for mmp-9 [1].
M2e, human TFA；化合物 M2e, human TFAM2e, human TFA (2024/9/14)
簡介：m2e, the human transmembrane domain of m2 protein (tfa), encompasses the 23 extracellular residues of m2, the third integral membrane protein of influenza a, and exhibits remarkable conservation across all strains of human influenza a. this conservation positions m2e, human tfa as a promising and adaptable vaccine candidate capable of providing protection against all strains of human influenza a [1].
HPV16 E7 (86-93) (TFA)；化合物 HPV16 E7 (86-93) (TFA)HPV16 E7 (86-93) (TFA) (2024/9/14)
簡介：hpv16 e7 (86-93) tfa, a peptide derived from hpv16 e7, is restricted by human leukocyte antigen (hla)-a2.1 and exhibits immunogenic properties in cervical carcinomas [1] [2].
IGF-I (24-41) (TFA)；化合物 IGF-I (24-41) (TFA)IGF-I (24-41) (TFA) (2024/9/14)
簡介：insulin-like growth factor i (24-41) tfa, a fragment comprising amino acids 24 to 41 of the full igf-i tfa molecule, is a variant of igf-i tfa, which itself is a 70 amino acid polypeptide hormone. this hormone serves as a trophic factor beneficial for both neurons and glial cells, playing a significant role in mediating the effects of growth hormone (gh) on systemic growth. additionally, igf-i tfa exhibits anabolic, antioxidant, anti-inflammatory, and cytoprotective properties. the specific frag
Carbonic anhydrase；化合物 Carbonic anhydraseCarbonic anhydrase (2024/9/14)
簡介：carbonic anhydrase is ubiquitous zinc-containing metalloenzyme present in prokaryotes and eukaryotes. carbonic anhydrase can catalyze reversible conversion of carbon dioxide to bicarbonate and protons. carbonic anhydrase can be used for the research of cancer , glaucoma, obesity and epilepsy [1] [2] .
IGF-I (30-41) (TFA)；化合物 IGF-I (30-41) (TFA)IGF-I (30-41) (TFA) (2024/9/14)
簡介：igf-i (30-41) (tfa) is a fragment consisting of amino acids 30 to 41 from insulin-like growth factor i (igf-i), a compound responsible in part for systemic gh (growth hormone) activities. it exhibits an array of properties including anabolic, antioxidant, anti-inflammatory, and cytoprotective actions [1].
Adrenomedullin (16-31), human TFA；化合物 Adrenomedullin (16-31), human TFAAdrenomedullin (16-31), human (2024/9/14)
簡介：adrenomedullin (16-31), human tfa, a fragment comprising amino acid residues 16-31 of human adrenomedullin (hadm), demonstrates significant affinity for the cgrp1 receptor. this compound exhibits pressor activity in the rat´s systemic vascular bed but lacks this effect in cats [1].
N-CBZ-Phe-Arg-AMC TFA；化合物 N-CBZ-Phe-Arg-AMC TFAN-CBZ-Phe-Arg-AMC TFA (2024/9/14)
簡介：n-cbz-phe-arg-amc (z-fr-amc) tfa serves as a substrate for cathepsin, facilitating the evaluation of lysosomal cathepsin enzyme activity [1] [2].
Carbetocin卡貝縮宮素卡貝縮宮素|||醋酸卡貝縮宮素 (2024/9/14)
簡介：carbetocin is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.
Thermolysin；化合物 ThermolysinThermolysin (2024/9/14)
簡介：thermolysin, a thermostable neutral metalloproteinase enzyme secreted by the gram-positive bacterium bacillus thermoproteolyticus, catalyzes the hydrolysis of peptide bonds containing hydrophobic residues [1].
Protein Kinase C (19-31) (TFA)；化合物 Protein Kinase C (19-31) (TFA)Protein Kinase C (19-31) (TFA) (2024/9/14)
簡介：protein kinase c (19-31) tfa is a peptide inhibitor derived from the pseudo-substrate regulatory domain of pkca (residues 19-31), featuring a serine substitution for alanine at position 25. it serves as a substrate peptide for evaluating protein kinase c (pkc) activity. pkc tfa plays a crucial role in modulating protein functions by phosphorylating the hydroxyl groups of serine and threonine amino acids on target proteins [1] [2].
RGD peptide (GRGDNP) (TFA)；化合物 RGD peptide (GRGDNP) (TFA)RGD peptide (GRGDNP) (TFA) (2024/9/14)
簡介：rgd peptide (grgdnp) tfa functions as an inhibitor of integrin-ligand interactions, competitively blocking α5β1´s interaction with the extracellular matrix (ecm). it induces apoptosis by triggering conformational changes that facilitate pro-caspase-3 activation and autoprocessing. furthermore, rgd peptide (grgdnp) tfa is critical in regulating cell adhesion, migration, growth, and differentiation [1] [2] [3].
Tirzepatide TFA；化合物 Tirzepatide TFATirzepatide TFA(2023788-19-2 free base)|||LY3298176 TFA；Tirzepati (2024/9/14)
簡介：tirzepatide tfa (ly3298176 tfa), a dual glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) receptor agonist, is under development for type 2 diabetes treatment [1].
Super-TDU (1-31) (TFA)；化合物 Super-TDU (1-31) (TFA)Super-TDU (1-31) (TFA) (2024/9/14)
簡介：super-tdu (1-31) tfa, a peptide fragment of super-tdu, acts as an inhibitor of the yap-tead complex. demonstrating potent anti-tumor activity, it effectively suppresses tumor growth in a gastric cancer mouse model [1] [2].
Super-TDU (1-31)；化合物 Super-TDU (1-31)Super-TDU (1-31) (2024/9/14)
簡介：super-tdu (1-31), a peptide fragment of super-tdu, acts as an inhibitor of the yap-tead complex. demonstrating potent anti-tumor activity, it effectively suppresses tumor growth in a gastric cancer mouse model [1] [2].
Super-TDU TFA；化合物 Super-TDU TFASuper-TDU TFA (2024/9/14)
簡介：super-tdu tfa, a specialized yap antagonist, specifically inhibits the interaction between yap and teads. this compound demonstrates tumor growth suppression in a gastric cancer mouse model [1].
MSG606 TFA；化合物 MSG606 TFAMSG606 TFA (2024/9/14)
簡介：msg606 tfa, a potent antagonist of the human mc1 receptor (ic50 = 17 nm), functions as a partial agonist at the human mc3 and mc5 receptors (ec50 values of 59 and 1300 nm, respectively). it demonstrates binding affinity for a375 melanoma cells in vitro and selectively reverses induced hyperalgesia in female mice without affecting male mice.
Spexin TFA；化合物 Spexin TFASpexin TFA (2024/9/14)
簡介：spexin tfa, a potent agonist for galanin receptor 2/3 (gal2/gal3) with ec50 values of 45.7 and 112.2 nm respectively, shows no significant activity towards galanin receptor 1. as an endogenous peptide promoting satiety, it reduces long chain fatty acid uptake by adipocytes and lowers food consumption in diet-induced obese mice and rats. additionally, it moderates lh secretion in goldfish and demonstrates anxiolytic effects in vivo.
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