9月
Glepaglutide；化合物 GlepaglutideGlepaglutide (2024/9/14)
簡介：glepaglutide (zp1848), a long-acting glucagon-like peptide-2 (glp-2) analogue, functions as a potent agonist of the glp-2 receptor (glp-2r), effectively reducing fecal output and enhancing intestinal absorption, while also alleviating inflammation in the small intestine. it holds potential for use in researching inflammatory bowel disease (ibd) and crohn´s disease [1] [2] [3].
GPLGIAGQ TFA；化合物 GPLGIAGQ TFAGPLGIAGQ TFA (2024/9/14)
簡介：gplgiagq tfa, an mmp2-cleavable polypeptide, serves as a stimulus-sensitive linker in liposomal and micellar nanocarriers for targeted mmp2-triggered tumor therapy. additionally, it is utilized in the synthesis of unique mmp2-targeted photosensitizers for photodynamic therapy (pdt) [1] [2] [3].
SAHM1 TFA；化合物 SAHM1 TFASAHM1 TFA (2024/9/14)
簡介：sahm1 tfa is a chemical compound that acts as a notch pathway inhibitor by stabilizing a hydrocarbon-stapled alpha helical peptide. it specifically targets the protein-protein interface, effectively preventing the assembly of the notch complex.
ELA-11(human) TFA；化合物 ELA-11(human) TFAELA-11(human) TFA (2024/9/14)
簡介：ela-11(human) tfa, a bioactive fragment of ela-32, acts as a high-affinity apelin receptor agonist (k i =14 nm). it effectively inhibits forskolin-induced camp production and promotes β-arrestin recruitment in vitro, highlighting its significant agonistic activity.
ELA-32(human) TFA；化合物 ELA-32(human) TFAELA-32(human) TFA (2024/9/14)
簡介：ela-32(human) tfa is a potent apelin receptor agonist with high affinity, demonstrating an ic50 of 0.27 nm and a kd of 0.51 nm. this compound does not bind to gpr15 or gpr25. it activates the pi3k/akt signaling pathway, facilitating self-renewal of human embryonic stem cells (hescs) through cell-cycle progression and protein synthesis. additionally, ela-32(human) tfa enhances the tgfβ pathway, predisposing hescs towards an endoderm lineage, and promotes angiogenesis in huvec cells.
NFF-3 TFA；化合物 NFF-3 TFANFF-3 TFA (2024/9/14)
簡介：nff-3 tfa, a selective matrix metalloproteinase (mmp) substrate, specifically interacts with mmp-3 and mmp-10 for hydrolysis. additionally, it undergoes cleavage by trypsin, hepatocyte growth factor activator, and factor xa. when labeled with the cydye pair, cy3/cy5q, nff-3 tfa generates fluorescence in cell assays, facilitating the detection of cell activity [1].
Avermectin B1a；阿維菌素 B1aAbamectin B1a|||Avamectin B1a；阿維菌素 B1a|||Abamectin B1a|||Avamectin B1a (2024/9/14)
簡介：avermectin b1a is a macrocyclic lactone disaccharide anthelmintic agent .
Demoxytocin；化合物 DemoxytocinDemoxytocin (2024/9/14)
簡介：demoxytocin, an analog of oxytocin and a heterodetic cyclic peptide, enhances cell membrane permeability to elevate calcium ion levels in smooth muscle cells, thereby augmenting contraction, including the smooth muscles of the uterus. this compound mirrors oxytocin´s function and is utilized in studies focusing on labor induction following premature rupture [1].
TAK-683 acetate；化合物 TAK-683 acetateTAK-683 acetate (2024/9/14)
簡介：tak-683 acetate is a nonapeptide metastin analog and a potent full agonist of the kiss1 receptor (kiss1r), exhibiting ic 50 =170 pm and enhanced metabolic stability. this compound shows agonistic activities towards kiss1r, with ec 50 values of 0.96 nm and 1.6 nm for human and rat kiss1r, respectively. tak-683 acetate effectively depletes gnrh in the hypothalamus and reduces plasma levels of fsh, lh, and testosterone in vivo, showcasing its potential for hormone-dependent prostate cancer research
TAK-683 TFA；化合物 TAK-683 TFATAK-683 TFA (2024/9/14)
簡介：tak-683 tfa, a potent full kiss1 receptor (kiss1r) agonist with a half-maximal inhibitory concentration (ic50) of 170 pm, exhibits enhanced metabolic stability. as a nonapeptide metastin analog, it demonstrates agonistic activities towards kiss1r, with effective concentration (ec50) values of 0.96 nm for humans and 1.6 nm for rats. in vivo, tak-683 tfa reduces gonadotropin-releasing hormone (gnrh) levels in the hypothalamus and decreases plasma follicle-stimulating hormone (fsh), luteinizing hor
BigLEN(rat) TFA；化合物 BigLEN(rat) TFABigLEN(rat) TFA (2024/9/14)
簡介：biglen(rat) is a potent gpr171 agonist with an ec 50 of 1.6 nm [1] .
Colistin A sulfate hydrate；化合物 Colistin A sulfate hydrateColistin A sulfate hydrate (2024/9/14)
簡介：colistin a sulfate hydrate, a key constituent of the polymyxin antibiotic colistin, effectively combats infections from challenging gram-negative bacteria [1].
Elabela(19-32) TFA；化合物 Elabela(19-32) TFAElabela(19-32) TFA (2024/9/14)
簡介：elabela(19-32) tfa, an effective fragment of elabela (ela), selectively engages with the apelin receptor (apj). this compound initiates g αi1 and β-arrestin-2 signaling, demonstrating ec50 values of 8.6 nm and 166 nm, respectively. it facilitates receptor internalization, lowers arterial pressure, and has a positive inotropic impact on cardiac function [1].
S961 acetate；化合物 S961 acetateS961 acetate (2024/9/14)
簡介：s961 acetate is a selective and high-affinity antagonist of the insulin receptor (ir), demonstrating ic50 values of 0.048 nm for hir-a, 0.027 nm for hir-b, and 630 nm for the human insulin-like growth factor i receptor (higf-ir) in spa assays [1].
S961 TFA；化合物 S961 TFAS961 TFA (2024/9/14)
簡介：s961 tfa is a highly selective and high-affinity antagonist of the insulin receptor (ir), demonstrating ic50 values of 0.048 nm for hir-a, 0.027 nm for hir-b, and 630 nm for the human insulin-like growth factor i receptor (higf-ir) in spa assays [1].
Angiopeptin TFA；化合物 Angiopeptin TFAAngiopeptin TFA (2024/9/14)
簡介：angiopeptin tfa, a cyclic octapeptide analogue of somatostatin, acts as a partial agonist at sst 2/sst 5 receptors, exhibiting ic50 values of 0.26?nm and 6.92?nm, respectively. this compound effectively inhibits the release of growth hormone and the production of insulin-like growth factor-1 (igf-1). additionally, it either inhibits adenylate cyclase activity or promotes extracellular acidification. notably, angiopeptin tfa shows promise for use in coronary atherosclerosis research [1] [2].
GIP (1-30) amide,human acetate；化合物 GIP (1-30) amide,human acetateGIP (1-30) amide,human acetate (2024/9/14)
簡介：gip (1-30) amide, human acetate is a fragment of glucose-dependent insulinotropic polypeptide (gip), an incretin hormone that plays a crucial role in stimulating insulin secretion and mitigating postprandial glycemic excursions. this compound has been shown to enhance insulin secretion in a dose-dependent manner across concentrations of 10^-9 to 10^-6 m [1].
Dusquetide TFA；化合物 Dusquetide TFADusquetide TFA (2024/9/14)
簡介：dusquetide (sgx942) tfa, a first-in-class innate defense regulator (idr), modulates the innate immune response to pathogen-associated molecular patterns (pamps) and damage-associated molecular patterns (damps) by interacting with p62. this compound is effective in both diminishing inflammation and enhancing the elimination of bacterial infections [1].
Valrubicin；戊柔比星Valstar|||AD-32；Valstar|||AD-32|||戊柔比星 (2024/9/14)
簡介：valrubicin (ad-32) (ad 32) inhibits tpa- and pdbu-induced pkc activation (ic50s: 0.85 and 1.25 μm) and has antitumor and anti-inflammatory activity.
MOTS-c(human) acetate；化合物 MOTS-c(human) acetateMOTS-c(human) acetate (2024/9/14)
簡介：mots-c(human) acetate, a mitochondrial-derived peptide, induces the accumulation of amp analog aicar, enhances ampk activation, and upregulates its downstream target, glut4. this compound promotes glucose uptake and enhances insulin sensitivity, playing a significant role in managing obesity, diabetes, and supporting exercise and longevity outcomes [1].
Ac-Nle-Pro-Nle-Asp-AMC；化合物 Ac-Nle-Pro-Nle-Asp-AMCAc-Nle-Pro-Nle-Asp-AMC (2024/9/14)
簡介：ac-nle-pro-nle-asp-amc is a specific substrate for the 26s proteasome and is utilized in analyzing the proteasome´s caspase-like activity [1] [2] [3].
A-71915 TFA；化合物 A-71915 TFAA-71915 TFA (2024/9/14)
簡介：a-71915 (tfa) is a selective atrial natriuretic peptide-receptor (anp receptor) inhibitor that promotes apoptosis and reduces insulin secretion in rinm5f pancreatic β-cells [1].
CysHHC10 TFA；化合物 CysHHC10 TFACysHHC10 TFA (2024/9/14)
簡介：cyshhc10 tfa, a synthetic antimicrobial peptide (amp), demonstrates potent effectiveness against a broad spectrum of bacteria, including both gram-positive and gram-negative strains. specifically, minimum inhibitory concentration (mic) values for cyshhc10 tfa are determined to be 10.1 mm against e. coli, 20.2 mm against p. aeruginosa, 2.5 mm against s. aureus, and 1.3 mm against s. epidermidis, highlighting its potential as a versatile antimicrobial agent [1].
Cortistatin-14 TFA；化合物 Cortistatin-14 TFACortistatin-14 TFA (2024/9/14)
簡介：cortistatin-14 (tfa), a neuropeptide resembling somatostatin-14 in structure, operates through interaction with somatostatin receptors (sst1-sst5). this compound exhibits anticonvulsive and neuroprotective effects alongside significant anti-inflammatory properties [1] [2] [3] [4].
Humanin；化合物 HumaninHumanin (2024/9/14)
簡介：humanin, a 24-amino acid anti-apoptotic peptide and bax inhibitor, prevents bax translocation from the cytosol to mitochondria and obstructs its activation. this mitochondria-associated peptide has neuroprotective properties against alzheimer´s disease (ad)-related neurotoxicity and enhances insulin sensitivity in animals, linking it to aging processes [1] [2]. an analogue named hng, with serine at position 14 substituted for glycine, has been developed [2].
Calcitonin Gene Related Peptide (CGRP) II, rat TFA；化合物 Calcitonin Gene Related Peptide (CGRP) II, ra (2024/9/14)
簡介：calcitonin gene-related peptide (cgrp) ii, rat tfa, functions as a potent and enduring vasodilator by activating cgrp receptors. this compound is utilized in cardiovascular disease research [1].
[pThr3]-CDK5 Substrate TFA；化合物 [pThr3]-CDK5 Substrate TFA[pThr3]-CDK5 Substrate TFA (2024/9/14)
簡介：[pthr3]-cdk5 substrate tfa, a potent phospho-thr3cdk5 substrate, originates from the histone h1 peptide sequence that binds to cdk5´s active site. this substrate undergoes phosphorylation by cdk5, demonstrating a k_m value of 6 μm [1].
Bim BH3, Peptide IV TFA；化合物 Bim BH3, Peptide IV TFABim BH3, Peptide IV TFA (2024/9/14)
簡介：bim bh3, peptide iv tfa, is a 26-residue peptide derived from the bh3-only protein bim, a member of the pro-apoptotic bcl-2 protein family [1] [2].
Pinaverium bromide；匹維溴銨Pinaverium bromide (2024/9/14)
簡介：pinaverium bromide is an calcium channel blocker with antispasmodic and effectively relieves pain, diarrhea and intestinal discomfort.
Amylin (IAPP), feline TFA；化合物 Amylin (IAPP), feline TFAAmylin (IAPP), feline TFA (2024/9/14)
簡介：amylin (iapp), feline tfa, a 37-amino acid polypeptide derived from felines, stands as a principal secretion product of the pancreatic islets´ β-cells. this regulatory peptide notably inhibits the secretion of insulin and glucagon [1].
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