9月
PACMA 31；化合物PACMA 31PACMA 31 (2024/9/8)
簡介：pacma 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (pdi) with an ic50 of 10 μm. pacma 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.
Peimisine hydrochloride；化合物 Peimisine hydrochloridePeimisine hydrochloride (2024/9/8)
簡介：peimisine hydrochloride non-competitively antagonizes tracheal smooth muscle m receptors and inhibits ach-induced smooth muscle contraction. it excites beta receptors and antagonizes calcium release, promotes nitric oxide release, relaxes airway smooth muscle, and has antiasthmatic effects.
PF-04753299；化合物PF-04753299PF-04753299 (2024/9/8)
簡介：pf-04753299 is a potent and selective inhibitor of udp-3-o-(r-3-hydroxymyristol)-n-acetylglucosamine deacetylase (lpxc), demonstrating bactericidal effects against gonococcal isolates. it exhibits inhibitory activity against e. coli, p. aeruginosa, and k. pneumoniae, with minimum inhibitory concentration (mic) 90 values of 2 μg/ml, 4 μg/ml, and 16 μg/ml, respectively. this compound is utilized in researching gram-negative bacterial infections [1].
p-Fluoro-L-phenylalanine；化合物p-Fluoro-L-phenylalaninep-Fluoro-L-phenylalanine (2024/9/8)
簡介：p-fluoro-l-phenylalanine is a substrate for tyrosine hydroxylase (th) that can be used to study the regulation of that enzyme. p-fluoro-l-phenylalanine binds to the l-leucine specific receptor of escherichia coli with an kd of 0.26 μm.
Phen Green SK diacetate；化合物 Phen Green SK diacetatePhen Green SK diacetate (2024/9/8)
簡介：phen green sk diacetate has a wide range of applications in life science related research.
PHOME；化合物 PHOMEPHOME (2024/9/8)
簡介：phome has a wide range of applications in life science related research.
Phosphatidylinositols, soya, sodium salts；化合物 Phosphatidylinositols, soya, sodium saltsPhosphatidyli (2024/9/8)
簡介：phosphatidylinositols, soya, sodium salts has a wide range of applications in life science related research.
PMK ethyl glycidate；化合物 PMK ethyl glycidatePMK ethyl glycidate (2024/9/8)
簡介：pmk ethyl glycidate has a wide range of applications in life science related research.
Pregnanediol 3-glucuronide；化合物 Pregnanediol 3-glucuronidePregnanediol 3-glucuronide (2024/9/8)
簡介：pregnanediol 3-glucuronide has a wide range of applications in life science related research.
PROTAC(H-PGDS)-7；化合物 PROTAC(H-PGDS)-7PROTAC(H-PGDS)-7 (2024/9/8)
簡介：protac(h-pgds)-7 is a selective and potent small molecule hematopoietic prostaglandin d synthase (h-pgds) protac degradation agent that exhibits degradation activity in ku812 cells with a dc50 of 17.3 pm. protac(h-pgds)-7 is a pharmacological compound that effectively inhibits prostaglandin d2 (pgd2) protac(h-pgds)-7 is a candidate compound for the treatment of dmd and other h-pgds-related diseases.
Rilmenidine；化合物 RilmenidineRilmenidine (2024/9/8)
簡介：rilmenidine has a wide range of applications in life science related research.
Riluzole hydrochloride；化合物 Riluzole hydrochlorideRiluzole hydrochloride (2024/9/8)
簡介：riluzole hydrochloride, a use-dependent na+ channel blocker with anticonvulsant properties, belongs to a category of drugs that also inhibit gaba uptake, exhibiting an inhibitory concentration 50 (ic50) of 43 μm.
Roridin L2；化合物 Roridin L2Roridin L2 (2024/9/8)
簡介：roridin l2 is a natural product for research related to life sciences. the catalog number is t41264 and the cas number is 85124-22-7.
SC144 hydrochloride；化合物 SC144 hydrochlorideSC144 hydrochloride (2024/9/8)
簡介：sc144 hydrochloride, a first-in-class, orally active, small-molecule gp130 (il6-beta) inhibitor, demonstrates potent inhibition of gp130 ligand-triggered signaling. by binding to gp130, it initiates gp130 phosphorylation (s782) and deglycosylation, impedes stat3 phosphorylation and nuclear translocation, and suppresses the expression of downstream target genes. furthermore, sc144 hydrochloride effectively induces apoptosis in human ovarian cancer cells [1].
CBL0137；化合物CBL0137Curaxin 137|||CBLC137；Curaxin 137|||CBLC137 (2024/9/8)
簡介：cbl0137 (curaxin 137), a metabolically stable curaxin, activates p53 (ec50: 0.37 μm) and inhibits nf-κb (ec50: 0.47 μm). it functionally inactivates the facilitates chromatin transcription complex (fact), driving the effects on p53 and nf-κb and promoting cancer cell death. cbl0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preclinicalal models of pancreatic cancer.
SJ6986；化合物SJ6986SJ6986 (2024/9/8)
簡介：sj6986 is a potent, selective and orally active gspt1/2 degrader. sj6986 degrades gspt1 with a dc 50 of 2.1 nm (d max 99%) [1].
SP-96；化合物SP-96SP-96 (2024/9/8)
簡介：sp-96 is a highly effective and selective inhibitor of aurora b with an ic50 of 0.316 nm. sp-96 shows selective growth inhibition in nci60 screening, including mda-md-468 (gi50=107 nm). sp-96 can be used in triple negative breast cancer studies.
Specific PXR antagonist 70；化合物SPA70Specific PXR antagonist 70 (2024/9/8)
簡介：specific pxr antagonist 70 is a selective pregnane x receptor (pxr) antagonist with an ic50 of 540 nm and ki of 390 nm for human pcr and enhances the chemosensitivity of cancer cells.
Sterculic acid；化合物 Sterculic acidSterculic acid (2024/9/8)
簡介：sterculic acid, a stearoyl-coa desaturase-1 (scd1) inhibitor, effectively suppresses delta-9 desaturase (δ9d) activity in a dose-dependent manner, exhibiting an inhibition concentration (ic50) value of 0.9 μm [1].
Taprostene；化合物 TaprosteneTaprostene (2024/9/8)
簡介：taprostene (cg-4203), a synthetic and chemically stable analogue of prostacyclin (pgi2), effectively protects the endothelium and myocardium following acute myocardial ischemia and reperfusion in cats. it enhances cytoprotective actions and minimizes undesired hemodynamic effects [1].
Teneligliptin hydrobromide hydrate；化合物 Teneligliptin hydrobromide hydrateTeneligliptin hydrobromide (2024/9/8)
簡介：teneligliptin hydrobromide hydrate is a potent, competitive, and long-lasting dpp-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant dpp-4 in vitro, with ic 50 s of approximately 1 nm [1].
HSF1A；化合物HSF1AHSF1A (2024/9/8)
簡介：hsf1a is a cell-permeable activator of hsf1 that protects mammalian cells against stress-induced apoptosis.
Tenofovir alafenamide fumarate；替諾福韋艾拉酚胺富馬酸鹽GS-7340 fumarate；GS-7340 fumarate (2024/9/8)
簡介：tenofovir alafenamide fumarate (gs-7340 fumarate) is an orally available tenofovir precursor compound tenofovir alafenamide fumarate has anti-hiv activity and can be used to prevent hiv infection.
Thiocolchicine；硫代秋水仙堿Thiocolchicine (2024/9/8)
簡介：thiocolchicine is an effective inhibitor of tubulin polymerization with an ic50 of 2.5 μm and a ki of 0.7 μm. thiocolchicine induces cell apoptosis. thiocolchicine can be used as an adc cytotoxin in adc technology.
Thioperamide maleate；硫丙咪胺馬來酸MR-12842 maleate；MR-12842 maleate|||硫丙咪胺馬來酸 (2024/9/8)
簡介：thioperamide maleate (mr-12842 maleate) is an effective and selective antagonist of h3 receptor (ki = 4.3 nm) for inhibition of [3h]histamine synthesis (ki = 31 nm).
Thromboxane B2；化合物 Thromboxane B2Thromboxane B2 (2024/9/8)
簡介：thromboxane b2 is a prostaglandin derivative that is released during anaphylaxis. thromboxane b2 induces platelet aggregation and arterial contraction.
Trimethylamine N-oxide；三甲胺N-氧化物Trimethylamine N-oxide (2024/9/8)
簡介：trimethylamine n-oxide (tmao) is a colorless amine oxide produced from choline, betaine, and carnitine via intestinal microbial metabolism that accumulates in tissues of marine animals and prevents the protein-damaging effects of urea.trimethylamine n-oxide induces inflammation through activation of ros/nlrp3 inflammasomes, which can induce fibroblast differentiation and cardiac fibrosis.
Triticonazole；滅菌唑Triticonazole (2024/9/8)
簡介：triticonazole is a triazole pesticide and fungicide. triticonazole shows endocrine disrupting activities.
Tumulosic acid；化合物 Tumulosic acidTumulosic acid (2024/9/8)
簡介：tumulosic acid is a natural product for research related to life sciences. the catalog number is t41243 and the cas number is 508-24-7.
Uric acid sodium尿酸鈉尿酸鈉 (2024/9/8)
簡介：uric acid sodium, scavengers of oxygen radicals, is a potent and common antioxidant that helps maintain stable blood pressure and resist oxidative stress. uric acid sodium, which removes reactive oxygen species (ros) such as singlet oxygen and peroxynitrite, has an inhibitory effect on lipid peroxidation and is associated with the pathogenesis of gout joint disease and the formation of calcium oxalate stones.
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