9月
TASP 0277308；TASP 0277308TASP 0277308 (2024/9/8)
簡(jiǎn)介：tasp 0277308 is a potent and selective sphingosine 1-phosphate 1 (s1p1) receptor antagonist (ic50 = 7.8 nm). tasp 0277308 inhibits s1p-induced chemotaxis (ic50 = 1.1-1.6 nm), huvec cell proliferation (ic50 = 3-3.6 nm) and suppresses angiogenesisin vivo. tasp 0277308 also blocks vegf-induced tube-formation of huvecsin vitroand reverses or impairs the development of arthritis or mechano-allodynia.
CYM5442 hydrochloride；CYM 5442 hydrochlorideCYM 5442 hydrochloride；CYM 5442 hydrochloride (2024/9/8)
簡(jiǎn)介：cym 5442 hydrochloride is a potent and selective s1p1agonistin vitro(ec50 = 1.35 nm). activates s1p1-mediated p42/p44 mapk phosphorylation in cho-k1 cells transfected with s1p1. induces acute lymphopenia in mice. brain penetrant.
pCPA methyl ester hydrochloride；4-氯-DL-苯基丙氨酸甲酯鹽酸鹽4-Chloro-DL-phenylalanine methyl ester hydrochlorid (2024/9/8)
簡(jiǎn)介：pcpa methyl ester hydrochloride (4-chloro-dl-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-ht synthesis. pcpa methyl ester hydrochloride is permeable across the blood-brain barrier and reduces 5-ht central availability.
Fullerene-C60Fullerene-C60Fullerene-C60 (2024/9/8)
簡(jiǎn)介：fullerene-c60, a carbon nanocompound, is considered a potential agent for photodynamic therapy owing to its distinctive physicochemical properties. it investigates the dynamics of intramolecular electron and energy transfer.
Eesperamicin A1；Eesperamicin A1Eesperamicin A1；Eesperamicin A1 (2024/9/8)
簡(jiǎn)介：esperamicin a1, an exceedingly potent antitumor antibiotic, is derived from actinomadura verrucosospora cultures. this compound plays a crucial role in antitumor research.
Diffractaic Acid；地弗地衣酸NSC 5901|||NSC 685595；NSC 5901|||地弗地衣酸|||NSC 685595 (2024/9/8)
簡(jiǎn)介：diffractaic acid (nsc 685595) can inhibit ltb4 biosynthesis in a-23187-stimulated bovine pmnl cells with activity value of 8 μm.
Prosaikogenin H；前柴胡皂苷H；柴胡次皂苷HProsaikogenin H (2024/9/8)
簡(jiǎn)介：prosaikogenin h, an intestinal metabolite derived from saikosaponin, exhibits weak hemolytic activity.
Prosaikogenin A；前柴胡皂苷A；柴胡次皂苷AProsaikogenin A (2024/9/8)
簡(jiǎn)介：prosaikogenin a, a triterpene saponin extracted from clinopodium chinense, exhibits notable platelet aggregation promotion activity, indicated by an ec 50 value of 12.2 μm.
Azedarachol；AzedaracholAzedarachol (2024/9/8)
簡(jiǎn)介：azedarachol possesses antifeedant activity.
Defensin HNP-1 human；Defensin HNP-1 humanDefensin HNP-1 human (2024/9/8)
簡(jiǎn)介：defensin hnp-1 human is a human neutrophil peptides (hnps), involved in endothelial cell dysfunction at the time of early atherosclerotic development.defensin hnp-1 human can regulate the growth of atherosclerosis.
Defensin HNP-2 human；Defensin HNP-2 humanDefensin HNP-2 human (2024/9/8)
簡(jiǎn)介：defensin hnp-2 is a naturally occurring antibiotic and monocyte chemotactic peptide synthesized by human neutrophils.
Ursonic acid methyl ester；3-羰基-熊果酸-28-甲酯Ursonic acid methyl ester (2024/9/8)
簡(jiǎn)介：ursonic acid methyl ester, an esterified derivative of ursolic acid, exhibits growth inhibitory activity against four tumor cell lines: hl-60, bgc, bel-7402, and hela, and the ed50 values for inhibition are >100 μg/ml.
DMT-dA(bz) PhosphoramiditeDMT-dA(bz) PhosphoramiditeDA-CE phosphoramidite|||DMT-dA(bz) Phosphoramidi (2024/9/8)
簡(jiǎn)介：dmt-da(bz) phosphoramidite is typically used in the synthesis of dna.
DMT-dT Phosphoramidite；DMT-dT PhosphoramiditeDMT-dT Phosphoramidite (2024/9/8)
簡(jiǎn)介：dmt-dt phosphoramidite is typically used in the synthesis of dna.
Bis-SS-C3-sulfo-NHS ester；Bis-SS-C3-sulfo-NHS esterBis-SS-C3-sulfo-NHS ester；Bis-SS-C3-sulfo-NHS est (2024/9/8)
簡(jiǎn)介：bis-ss-c3-sulfo-nhs ester is a cleavable adc linker employed for the synthesis of antibody-drug conjugates (adcs).
NBQX；二羥基喹酮FG9202|||NBQX disodium salt；二羥基喹酮|||FG9202|||NBQX disodium salt (2024/9/8)
簡(jiǎn)介：nbqx (fg9202) is a potent, selective and competitive ampa receptor antagonist. neuroprotective and anticonvulsant; active in vivo.
Bis-SS-C3-NHS ester；Bis-SS-C3-NHS esterBis-SS-C3-NHS ester；Bis-SS-C3-NHS ester (2024/9/8)
簡(jiǎn)介：bis-ss-c3-nhs ester is a cleavable linker compound employed in adc synthesis. it finds application in the construction of antibody-drug conjugates (adcs).
Bromochloroacetaldehyde；溴化氯乙醛Bromochloroacetaldehyde (2024/9/8)
簡(jiǎn)介：bromochloroacetaldehyde is a dihalogenated acetaldehyde compound that is commonly found as a byproduct in drinking water. it exhibits genotoxic properties.
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol；3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol3β,6α (2024/9/8)
簡(jiǎn)介：3β,6α,12β-dammar-e-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a sirt1 activator, effectively enhancing sirt1 activity. additionally, it demonstrates notable anti-tumor properties.
Kizuta saponin K11；Kizuta saponin K11Kizuta saponin K11 (2024/9/8)
簡(jiǎn)介：kizuta saponin k11 is a saponin derived from kalopanax pictum var. maximowiczii leaves, which is a widely used korean medicinal plant.
1,3-Dihydroxyacetone；1,3-二羥基丙酮1,3-Dihydroxyacetone (2024/9/8)
簡(jiǎn)介：1,3-dihydroxyacetone is the main active ingredient in sunscreen tanning skin care preparations, an important precursor for the synthesis of a variety of fine chemicals, and a food additive that can be produced on an industrial scale by microbial fermentation on gluconobacter oxydans. 1,3-dihydroxyacetone has the ability to increase camp levels. 1,3-dihydroxyacetone has the ability to increase camp levels.
Elubrixin tosylate；Elubrixin tosylateSB-656933 tosylate|||Elubrixin tosylate；SB-656933 tosylate|||El (2024/9/8)
簡(jiǎn)介：elubrixin tosylate (sb-656933 tosylate) is a high-potency, selective, competitive, and reversible cxcr2 antagonist, as well as an antagonist of the il-8 receptor. it effectively inhibits upregulation of neutrophil cd11b (with an ic50 of 260.7 nm) and shape change (with an ic50 of 310.5 nm). this compound holds promise for the study of inflammatory diseases, including inflammatory bowel disease and airway inflammation.
Fmoc-Asn(Trt)-Thr(psi(Me,Me)pro)-OH；Fmoc-Asn(Trt)-Thr(psi(Me,Me)pro)-OHFmoc-Asn(Trt)-Thr(psi(Me,Me)p (2024/9/8)
簡(jiǎn)介：fmoc-asn(trt)-thr(psi(me,me)pro)-oh is a dipeptide.
Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH；Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OHFmoc-Glu(OtBu)-Thr(psi(Me,M (2024/9/8)
簡(jiǎn)介：fmoc-glu(otbu)-thr(psi(me,me)pro)-oh is a dipeptide.
Fmoc-Lys(Boc)-Ser(psi(Me,Me)pro)-OH；Fmoc-Lys(Boc)-Ser(psi(Me,Me)pro)-OHFmoc-Lys(Boc)-Ser(psi(Me,Me)p (2024/9/8)
簡(jiǎn)介：fmoc-lys(boc)-ser(psi(me,me)pro)-oh is a dipeptide.
FV-100；化合物FV-100Valnivudine HCl；Valnivudine HCl (2024/9/8)
簡(jiǎn)介：fv-100 (valnivudine hcl) is a potent, selective and orally active anti-vaxx-zoster agent.fv-100 is the api for cf-1743.fv-100 exhibits very low toxicity in vivo.fv-100 is a potent, selective and orally active anti-vaxx-zoster agent.fv-100 is the api for cf-1743.fv-100 exhibits very low toxicity in vivo.
N-Boc-C1-PEG5-C3-NH2；N-Boc-C1-PEG5-C3-NH2N-Boc-C1-PEG5-C3-NH2；N-Boc-C1-PEG5-C3-NH2 (2024/9/8)
簡(jiǎn)介：n-boc-c1-peg5-c3-nh2 is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
LIN28 inhibitor LI71 enantiomer；LIN28 inhibitor LI71 enantiomerLIN28 inhibitor LI71 enantiomer (2024/9/8)
簡(jiǎn)介：lin28 inhibitor li71 enantiomer, the enantiomer of lin28 inhibitor li71，exhibits reduced activity compared to its parent compound. lin28 inhibitor li71 is a highly potent and cell-permeable inhibitor of lin28, effectively blocking lin28-mediated oligouridylation with an ic50 of 7 um.
Fmoc-Asp(OtBu)-Ser(psi(Me,Me)pro)-OH；Fmoc-Asp(OtBu)-Ser(psi(Me,Me)pro)-OHFmoc-Asp(OtBu)-Ser(psi(Me,M (2024/9/8)
簡(jiǎn)介：fmoc-asp(otbu)-ser(psi(me,me)pro)-oh is a dipeptide.
EFdA-TP；EFdA-TPEFdA-TP (2024/9/8)
簡(jiǎn)介：efda-tp, a highly potent nucleoside reverse transcriptase (rt) inhibitor, exerts its inhibitory effect on rt-catalyzed dna synthesis through both immediate and delayed chain termination mechanisms, commonly referred to as ict and dct, respectively. additionally, efda-tp demonstrates its efficacy in inhibiting hiv-1 rt through multiple pathways.
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