9月
Verrucarin A；化合物 Verrucarin AVerrucarin A (2024/9/8)
簡介：verrucarin a (muconomycin a) is a type d macrocyclic mycotoxin. verrucarin a (va), a protein synthesis inhibitor, derived from the pathogen fungus myrothecium verrucaria, inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. verrucarin a effectively increased the phosphorylation of p38 mapk and diminished the phosphorylation of erk/akt. verrucarin a caused cell cycle deregulation through the induction of p21 and p53 [1] [2].
IKarisoside A；大花淫羊藿苷 AIcarisoside-|||Baohuoside II；Icarisoside-|||Baohuoside II (2024/9/8)
簡介：ikarisoside a(baohuoside ii) is a flavonol glycoside from the berberidaceae plant epimedium, with anti-inflammatory activity.
Verrucofortine；化合物 VerrucofortineVerrucofortine (2024/9/8)
簡介：verrucofortine has a wide range of applications in life science related research.
Viridicatumtoxin；化合物 ViridicatumtoxinViridicatumtoxin (2024/9/8)
簡介：viridicatumtoxin has a wide range of applications in life science related research.
W146 TFA；化合物 W146 TFAW146 TFA (2024/9/8)
簡介：w146 tfa is a selective sphingosine-1-phosphate receptor 1 ( s1pr1 ) antagonist with an ec 50 value of 398 nm.
Z-FY-CHO；化合物 Z-FY-CHOZ-FY-CHO (2024/9/8)
簡介：z-fy-cho (z-phe-tyr-cho) is a specific and potent cathepsin l (ctsl) inhibitor [1] [2].
γ-Linolenic acid ethyl ester；化合物 γ-Linolenic acid ethyl esterγ-Linolenic acid ethyl ester (2024/9/8)
簡介：γ-linolenic acid ethyl ester (ethyl γ-linolenate) is a leukotriene b 4 receptor 4 (ltb 4 ) antagonist which has a potential anti-inflammatory effect[1].
LY 379268 disodium salt；LY 379268 disodium saltLY 379268 disodium salt (2024/9/8)
簡介：ly 379268 disodium salt is a sodium salt of ly 379268, a highly selective group ii mglu receptor agonist.
Cis-22a；化合物Cis-22aCis-22a (2024/9/8)
簡介：cis-22a is a trpv6 inhibitor (ic50 = 0.32 μm), which exhibits selectivity against related trpv channels and calcium channels. cis-22a displays antiproliferative effects on t47d human breast cancer cells.
GSK 2833503A；GSK 2833503AGSK 2833503A (2024/9/8)
簡介：gsk 2833503a is a potent and selective trpc6 and trpc3 antagonist (ic50 = 3-16 nm and 21-100 nm, respectively). gsk 2833503a exhibits >63-fold selectivity over other ion channels, including other trp channels, cav1.2, herg and nav1.5. gsk 2833503a suppresses angiotensin ii or endothelin-1-induced cardiac hypertrophy signaling in hek293 cellsin vitroand in cardiomyocytes.
GP 1a；化合物GP 1aGP 1a (2024/9/8)
簡介：gp 1a is a potent agonist of cannabinoid receptor 2 (cb2) (ec50=7.1), as shown in camp, gtpγs and β-arrestin recruitment assays. gp 1a is approximately 30-fold more selective for cb2 receptors than cb1 receptors and increases p-erk1/2 expression in hl-60 cells in vitro. gp 1a is beneficial for skin wound healing. gp 1a inhibits inflammation and fibrogenesis while promoting epithelial re-formation.
CB 65；化合物CB 65CB 65 (2024/9/8)
簡介：cb 65 is a high affinity and selective cb2 receptor agonist with ki values of 3.3 and > 1000 nm for cb2 and cb1 receptors respectively.
LYN-1604；化合物LYN1604LYN1604；LYN1604 (2024/9/8)
簡介：lyn-1604 is a novel activator of ulk1, inducing cell death involved in atf3, rad21, and caspase3, accompanied by autophagy and apoptosis.
MD15；MD15MD15；MD15 (2024/9/8)
簡介：md15 is a negative control for md13.
CG 428-Neg；CG 428-NegCG 428-Neg (2024/9/8)
簡介：negative control for cg 428.
ARCC 4 negative control；ARCC 4 negative controlARCC 4 negative control (2024/9/8)
簡介：arcc 4 negative control is a negative control for arcc 4. binds androgen receptors (ar) without inducing degradation.
SIM1；SIM1SIM1 (2024/9/8)
簡介：sim1 is a potent and selective trivalent protac?degrader based on bet bromodomain inhibitors linked to a von hippel lindau (vhl) ligand via branched linkers. sim1 degrades all bet family proteins with a preference for brd2 (dc50values = 0.7 nm, 1.1 nm and 3.3 nm for brd4, brd2 and brd3, respectively). sim1 degrades brd2 more significantly and rapidly than brd3 and brd4, and degrades bet proteins with a higher potency than a bivalent degrader. sim1 also decreases protein levels for myc and hmox1
MD13；MD13MD13 (2024/9/8)
簡介：md13 is a macrophage migration inhibitor (mif) oriented protac (ki value: 71 nm). md13 can be used to study cancer.
CG 428；化合物CG 428CG 428 (2024/9/8)
簡介：cg 428 is a potent tropomyosin receptor kinase (trk) degrader (usmitetm) with a dc50 of 0.36 nm. cg 428 comprises an analog of the pan-trk inhibitor gnf-8625 joined by a linker to the cereblon e3 ligase ligand pomalidomide. cg 428 shows selectivity for trka over trkc and trkb with kds of 1nm, 4.2 nm, and 28 nm. cg 428 inhibits the growth of km12 colon cancer cells with an ic50 of 2.9 nm.
TAPI-1 trifluoroacetate (163847-77-6(free base))；化合物TAPI-1 trifluoroacetateTAPI-1 trifluoroacetate ( (2024/9/8)
簡介：tapi-1 is an adam17/tace inhibitor, which blocks shedding of cytokine receptors.
LC 2 Epimer；LC 2 EpimerLC 2 Epimer (2024/9/8)
簡介：negative control for lc 2.
(S)-BAY-293；異構體BAY-293BAY 294|||BAY 293 Negative Control；BAY 294|||BAY 293 Negative Control (2024/9/8)
簡介：(s)-bay-293 is a potent pan-kras inhibitor for the study of primary non-small lung and pancreatic cancers.
FTI 277；FTI 277FTI 277 (2024/9/8)
簡介：fti 277 is a prodrug form of fti 276 that inhibits farnesyltransferase (ftase) (ic50 = 0.5 nm). inhibits h-ras and k-ras processing in whole cells (ic50 values are 0.1 and 10μm respectively) and disrupts constitutive h-ras-specific activation of mapk. causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
CAM 833；CAM 833CAM 833 (2024/9/8)
簡介：cam 833 is an effective positivity inhibitor, which can inhibit the interaction between brca2 and rad51. the kd of chimrad51 protein is 366 nm. cam 833 inhibited the oligocoagulation of rad51 and promoted the process of apoptosis in g2/m cells.
PA Nic；PA NicPA Nic (2024/9/8)
簡介：pa nic is a coumarin-caged nicotine. releases nicotine when exposed to 390 ± 10 nm wavelength light (λmax = 404 nm). suitable for two-photon uncaging at <900 nm (maximum two-photon cross-section at 810 nm). extinction coefficient (ε) 17,400 m-1cm-1. evokes nicotinic currents in mouse brain slices under one and two-photon activation conditions.
Bicyclol；雙環(huán)醇SY801；SY801|||雙環(huán)醇 (2024/9/8)
簡介：bicyclol (sy801)(sy 801) is an anti-hepatitis drug. oral administration of bicyclol normalizes the elevated serum transaminases (alt, ast) by 50% in chronic viral hepatitis b and c, and also has a certain level of inhibiting hbv and hcv replication. in combination therapy of bicyclol with interferon alpha, lamivudine and adefovir dipivoxil in hbv or hcv, bicyclol may reduce ymdd mutant and side effects and increase the anti-viral efficacy.
DPNB-ABT 594；DPNB-ABT 594DPNB-ABT 594 (2024/9/8)
簡介：dpnb-abt 594 is a nitrobenzyl-caged abt 594, a selective α4β2 nachr agonist. one-photon uncaging evokes large inward currents and ca2+transients on cell bodies and dendrites of medial habenular neurons in mouse brain slices. two-photon uncaging induces fast nachr-mediated currents. photolyzed with high quantum yield of 0.20. effective photolysis occurs using one- or two-photon excitation; one-photon uncaging requires illumination at 410 nm for 1.5-3 ms; two-photon uncaging requires illumination
NB-caged Tyrosine hydrochlorideNB-caged Tyrosine hydrochlorideONBY|||NB-caged Tyrosine hydrochloride (2024/9/8)
簡介：nb-caged tyrosine hydrochloride is a l-tyrosine caged with photosensitiveortho-nitrobenzyl side chain. rapidly releases tyrosine when photolyzed (300-350 nm excitation). is readily incorporated intoe.coliproteins via inclusion in growth media.
Poly Vinyl Alcohol；聚乙烯醇Polyvinyl alcohol；Polyvinyl alcohol (2024/9/8)
簡介：poly vinyl alcohol (polyvinyl alcohol) is a water-soluble, biodegradable, wound-healing polymer used in a wide range of biomedical applications.poly vinyl alcohol is commonly used in the manufacture of medical excipients.
TAT-Gap19(I130A)；TAT-Gap19(I130A)TAT-Gap19(I130A)；TAT-Gap19(I130A) (2024/9/8)
簡介：tat-gap19(i130a) is a control peptide for tat-gap19, a cx43 hemichannel blocker. tat-gap19(i130a) consists of tat-gap19 with a i130a amino acid residue change at a key residue for gap19 activity. in c6 glioma cells expression cx43, tat-gap19(1130a) does not inhibit [ca2+]i-triggered atp release at 200 μm. tat-gap19(i130a) is cell permeable.
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