9月
1R,3R-RSL3；1R,3R-RSL31R,3R-RSL3；1R,3R-RSL3 (2024/9/8)
簡介：1r,3r-rsl3 is a negative control for1s, 3r-rsl3.
TP 472N；TP 472NTP 472N (2024/9/8)
簡介：tp 472n is a negative control fortp 472. inactive against other bromodomains (>20μm against brd9).
cis-VZ 185；cis-VZ 185cis-VZ 185 (2024/9/8)
簡介：cis-vz 185 is a negative control for vz 185.
cis MZ 1；cis MZ 1cis MZ 1 (2024/9/8)
簡介：cis mz 1 is a negative control for mz1. exhibits no significant vhl binding affinity.
N-MethylsarcosineN,N-二甲基甘氨酸N,N-Dimethylglycine|||N,N-Dimethylaminoacetic acid|||Dimethylglycine|||N, (2024/9/8)
簡介：n-methylsarcosine (dimethylglycine) is used as an athletic performance enhancer and immunostimulant. it is also used in the treatment of autism, epilepsy and mitochondrial disease. it is also employed as a biomarker of protein degradation in chronic obstructive lung disease (copd) patients. further, it is used as a substrate to identify, differentiate and characterize amino acid methyltransferase. it plays an important role in the development of glycine-based ionic liquids and emulsifiers.
cis-SIM1；cis-SIM1cis-SIM1；cis-SIM1 (2024/9/8)
簡介：cis-sim1 is the negative control for sim1.
BRD PHOTAC-I-3；BRD PHOTAC-I-3BRD PHOTAC-I-3 (2024/9/8)
簡介：brd photac-i-3 is a photoswitchable bet bromodomain degrader (photac, photochemically targeting chimera). brd photac-i-3 comprises a ligand for an e3 ligase, a photoswitch, and the bet bromodomain targeting ligand (+)-jq1. exhibits cytotoxicity and degrades brd4, brd3 and to a lesser extent brd2 in lymphoblast cells upon irradiation with 390 nm light, but not in the dark.
Phalloidin-Janelia Fluor?646；Phalloidin-Janelia Fluor?646Phalloidin-Janelia Fluor?646|||Phalloidin-J (2024/9/8)
簡介：phalloidin-janelia fluor?646 is a red fluorescent f-actin probe. phalloidin-janelia fluor?646 is composed of the f-actin probe, phalloidin, conjugated to janelia fluor?646. it is suitable for use in confocal and super-resolution microscopy techniques such as dstorm. excitation/emission maximum λ = 646/664 nm.
Phalloidin-FITC；Phalloidin-FITCPhalloidin-FITC (2024/9/8)
簡介：phalloidin-fitc is a green fluorescent cytoskeleton stain. binds and labels f-actin. for most fluorescent imaging applications, cells should be fixed and permeablilized. excitation/emission maxima λ ~496/516 nm.
FFN 206 dihydrochloride；FFN 206二鹽酸鹽FFN 206 dihydrochloride (2024/9/8)
簡介：ffn 206 dihydrochloride is a fluorescent vmat2 substrate that can be used to detect vmat2 subcellular sites in cell culture and shows no detectable inhibition of dat.
FFN 102 mesylate；FFN 102甲磺酸鹽FFN 102 mesylate (2024/9/8)
簡介：ffn 102 mesylate is a ph responsive fluorescent false neurotransmitter (ffn), a selective dopamine transporter (dat) and vmat2 substrate. exhibits no significant binding to a panel of 38 cns receptors, including dopamine and serotonin receptors. inhibits dopamine uptake. excitation maxima are 340 nm at ph 5 and 370 nm at ph 7.5. emission maximum is 435 nm at both ph 5 and 7.5.ffn 102 mesylate is a ph-responsive fluorescent pseudoneurotransmitter (ffn) that acts as a substrate for selective dopam
FFN 270；FFN 270FFN 270 (2024/9/8)
簡介：ffn 270 is a fluorescent false neurotransmitter (ffn). fluorescent substrate for net and vmat2. labels noradrenergic neurons and their synaptic vesicles, and enables imaging of synaptic vesicle content release from specific axonal sitesin vivo. selectively labels na neurons over other monoamine and cns targets. exhibits two resolved absorption/excitation maxima depending on solvent ph (excitation maxima: 320 nm or 365 nm, emission maxima: 475 nm).
CNV Dopamine；CNV DopamineCNV Dopamine (2024/9/8)
簡介：cnv dopamine is a carboxynitroveratryl (cnv)-caged dopamine; releases dopamine upon ultraviolet light stimulation (365 nm). induces dopaminergic currents upon photolysis in brain slices expressing wild-type or gfp-labeled d2receptors. displays no decrease in current (rundown) with uv light flash duration of up to 100 ms. pharmacologically inactive prior to photolysis.
AY 77；化合物AY77Unk-Cha-Chg-NH2；Unk-Cha-Chg-NH2 (2024/9/8)
簡介：ay 77 (unk-cha-chg-nh2) is a potent and selective par2 agonist. ay 77 showed selectivity for ca2+ and erk1/2 signaling (ec50 value of ca2+ release was 40 nm and ec50 value of erk1/2 phosphorylation was 2 μm). ay 77 can promote migration of human breast cancer cells in vitro.
Octreotide Acetate；醋酸奧曲肽SMS 201995|||Longastatin|||Sandostatin|||SMS 201-995 (acetate)；醋酸奧曲肽|||SMS 2 (2024/9/8)
簡介：octreotide acetate (sandostatin) is a potent, long-acting synthetic somatostatin octapeptide analog that inhibits secretion of growth hormone.
AY 254；AY 254AY 254 (2024/9/8)
簡介：ay 254 is a potent par2 biased agonist. selectively activates erk1/2 signaling (ec50= 2 nm for erk1/2 phosphorylation versus 80 nm for ca2+release). reduces cytoki ne-induced caspase 3/8 activation, promotes scratch-wound healing, and induces il-8 secretion, in human colorectal cancer (ht29) cellsin vitro.
BIBP 3226 trifluoroacetate；BIBP 3226 trifluoroacetateBIBP 3226 trifluoroacetate (2024/9/8)
簡介：bibp 3226 trifluoroacetate is a mixed non-peptide neuropeptide y y1(npy y1) and neuropeptide ff (npff) receptor antagonist (kivalues are 1.1, 79, 108, > 1000, > 1000 and >1000 for rnpy y1, hnpff2, rnpff, rnpy y2, rnpy y4and rnpy y5respectively). produces an anxiogenic-like effect in rats following i.c.v. administration.
(S)-ZINC-3573；(S)-ZINC 3573(S)-ZINC-3573 (2024/9/8)
簡介：(s)-zinc 3573 is a negative control for (r)-zinc 3573. (s)-zinc 3573 displays no activity at mrgprx2 at concentrations below 100 μm.
Clocinnamox mesylateClocinnamox mesylateC-CAM|||NIH 10443 (2024/9/8)
簡介：clocinnamox mesylate is a systemically active, irreversibleμ-opioid receptor antagonist (apparent kivalues are 0.7, 1.9 and 5.7 nm for mouseμ,δandκreceptors respectively).
Helianorphin-19；Helianorphin-19Helianorphin-19 (2024/9/8)
簡介：helianorphin-19 is a high affinity, potent and selective κ-opioid receptor (kor) agonist (ki = 25 nm; ec50= 45 nm). helianorphin-19 exhibits approximately 200-fold selectivity for kor over μ and δ-opioid receptors.in vivohelianorphin-19 shows potent peripheral analgesic efficacy in a mouse model of visceral pain without affecting motor coordination/sedation.
Ifenprodil hemitartrate；Ifenprodil hemitartrateIfenprodil hemitartrate (2024/9/8)
簡介：ifenprodil hemitartrate is a nmda receptor antagonist, acting at the polyamine site. also anα-adrenergic vasodilator.σ2ligand displaying about 3-fold selectivity overσ1sites.
iP300v；iP300viP300v (2024/9/8)
簡介：ip300v is a negative control for ip300w
JQAD1；化合物JQAD1JQAD1 (2024/9/8)
簡介：jqad1 is a potent and selective histone acetyltransferase ep300 degrader (protac?; dc50≤ 31.6 nm); comprises an ep300 inhibitor, a485, joined by a linker to a cereblon e3 ligase ligand. jqad1 brings about degradation of ep300 in neuroblastoma cell lines in a proteasome-dependent manner. jqad1 suppresses both h3k27ac and ep300 expression levels and induces apoptosis. jqad1 suppresses tumors growth in nsg mice xenografted with kelly cells. crc and mycn genes are downregulated in tumors treated wit
SB 271046 hydrochloride；化合物SB 271046 hydrochlorideSB 271046A；SB 271046A (2024/9/8)
簡介：sb 271046 hydrochloride (sb 271046a) is selective, orally active 5-ht6 antagonist (pki values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-ht6, 5-ht1a, 5-ht1d and d3, and 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and 200-fold selective over 55 other receptors, enzymes and ion channels. it increases extracellular aspartate and glutamate in the frontal cortex and exhibits anticonvulsant act
Zuclopenthixol dihydrochloride；化合物 T4117L2Zuclopenthixol dihydrochloride (2024/9/8)
簡介：zuclopenthixol dihydrochloride is an d1 and d2 dopamine receptors antagonist.
CL 82198 hydrochloride；CL 82198 hydrochlorideCL 82198 hydrochloride (2024/9/8)
簡介：cl 82198 hydrochloride is a selective inhibitor of mmp-13 (89% inhibition at 10μg/ml) that displays no activity at mmp-1, mmp-9 or tace. inhibitsin vitroinvasion by the human pituitary adenoma cell line hp75. rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish.
SSM 3 trifluoroacetate；SSM 3 trifluoroacetateSSM 3 trifluoroacetate (2024/9/8)
簡介：ssm 3 trifluoroacetate is a potent furin inhibitor (ec50= 54 nm). blocks furin-dependent cell surface processing of anthrax protective antigen-83in vitro.
Galidesivir dihydrochloride；Galidesivir dihydrochlorideBCX 4430；BCX 4430 (2024/9/8)
簡介：galidesivir is a viral rna-dependent rna polymerase (rdrp) inhibitor and broad spectrum antiviral nucleotide.in vitro, galidesivir displays antiviral activity against a range of rna viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (ec50values range from 3 μm to >100 μm). galidesivir protects against ebola and marburg viral infection in animal models.
PARPYnD；PARPYnDPARPYnD (2024/9/8)
簡介：parpynd is a potent photoaffinity probe for poly(adp-ribose) polymerase (parp) (ic50 values for parp2, parp1 and parp6 are 6, 38 and 230 nm, respectively). parpynd labels parp1 and parp2 in the cell when an n3 functionalized fluorescent probe is attached and can inhibit isolated parp6.
OB 24 hydrochloride；OB 24 hydrochlorideOB 24 hydrochloride (2024/9/8)
簡介：ob 24 hydrochloride is a potent and selective heme oxygenase 1 (ho-1) inhibitor (ic50 values are 1.9 and >100 μm for ho-1 and ho-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (pca). inhibits cell proliferationin vitroand pca tumor growth and lymph node/lung metastasesin vivo. synergizes with taxol.
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