9月
FEN1-IN-2；FEN1抑制劑2FEN1-IN-2 (2024/9/8)
簡介：fen1-in-2 is a selective and potent inhibitor of flap endonuclease 1 (fen1), inhibits fen1 and xpg, has potential anticancer activity, and can be used to study dna damage repair.
(S)-Sitagliptin phosphate；(S)-Sitagliptin phosphate(S)-Sitagliptin phosphate|||(S)-MK-0431 phosphate (2024/9/8)
簡介：(s)-sitagliptin phosphate, the less active s-enantiomer of sitagliptin phosphate, is a high-potency inhibitor of dpp4. it exhibits an ic50 of 19 nm in caco-2 cell extracts.
Mechercharmycin A；Mechercharmycin AMechercharmycin A (2024/9/8)
簡介：mechercharmycin a, a cytotoxic compound, was isolated from thermoactinomyces sp. ym3-251, a marine source. it demonstrates potent antitumor activity.
2-Aminoflubendazole；2-Aminoflubendazole2-Aminoflubendazole (2024/9/8)
簡介：2-aminoflubendazole, a metabolite of benzimidazoles (bz), belongs to a class of drugs effective against fungi, protozoa, and helminths.
DOTA-tris(tBu)ester NHS ester；DOTA-tris(tBu)ester NHS esterDOTA-tris(tBu)ester NHS ester (2024/9/8)
簡介：dota-tris(tbu)ester nhs ester, a derivative of dota, serves for the labeling of peptides and antibodies.
Beta-D-Glucopyranosyl nitromethane；Beta-D-Glucopyranosyl nitromethaneBeta-D-Glucopyranosyl nitrometh (2024/9/8)
簡介：beta-d-glucopyranosyl nitromethane is a glycosyl derivative of nitromethane, functioning as a salt of a highly basic anion exchanger in the oh cycle.
Peripheral Myelin Protein P2 (53-78), bovine；Peripheral Myelin Protein P2 (53-78), bovinePeripheral (2024/9/8)
簡介：bovine peripheral myelin protein p2 (53-78) is a derivative composed of amino acid residues 53 to 78 from the peripheral myelin p2 protein of bovine origin. it acts as a t cell epitope and is used to induce experimental autoimmune neuritis (ean) in lewis rats.
Tellimagrandin II；Tellimagrandin IIEugeniin；Eugeniin (2024/9/8)
簡介：tellimagrandin ii (eugeniin) is the initial intermediate in the 4 c 1 -glucose derived series of ellagitannins. additionally, it possesses the ability to inhibit antibiotic resistance exhibited by drug-resistant staphylococcus aureus.
Calcium lactate；乳酸鈣Lactic acid calcium|||Hemicalcium L-lactate|||Lactate calcium|||Conclyte calcium； (2024/9/8)
簡介：calcium lactate (conclyte calcium) is used by the beverage industry as a source of calcium to fortify fruit juice. calcium lactate facilitates the growth and phytic acid degradation of soybean sprouts.
Fluroxypyr-meptyl；氟草煙-1-甲基庚基酯Fluroxypyr-1-methylheptyl ester；氟草煙-1-甲基庚基酯|||Fluroxypyr-1-methylheptyl (2024/9/8)
簡介：fluroxypyr-meptyl (fluroxypyr-1-methylheptyl ester) is a herbicide in wheat fields.
TRV056TRV056TRV056 (2024/9/8)
簡介：trv056 is a gq-biased agonist of the angiotensin ii type 1 receptor (at1r), demonstrating efficacy in stimulating gq-mediated cellular signaling. it can serve as a foundation for the development of gq-biased at1r agonists.
AG126；化合物AG 126Tyrphostin AG126|||AG 126；Tyrphostin AG126|||AG 126 (2024/9/8)
簡介：ag126 (tyrphostin ag126) selectively inhibits the phosphorylation of erk1 (p44) and erk2 (p42) at 25-50 μm. it blocks the production of tnf-α in vitro2 and in vivo, attenuating signaling through nf-κb, the induced expression of cox-2 and inos, and the inflammatory response in diverse animal models. ag-126 weakly inhibits epidermal gfrk (ic50: 450 μm) and platelet-derived gfrk (ic50 > 100 μm).
L-Aspartic acid 13C；L-Aspartic acid 13CL-Aspartic acid 13C (2024/9/8)
簡介：l-aspartic acid 13c is a 13c labeled l-aspartic acid. l-aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.
Biotin-PEG1-NH2Biotin-PEG1-NH2Biotin-PEG1-NH2 (2024/9/8)
簡介：biotin-peg1-nh2 is a cleavable, 1-unit peg linker employed in the synthesis of antibody-drug conjugates (adcs).
3α-Hydroxy pravastatin sodium；3α-Hydroxy pravastatin sodium3α-Hydroxy pravastatin sodium (2024/9/8)
簡介：3α-hydroxy pravastatin sodium, the primary metabolite of pravastatin, is a potent competitive inhibitor of hmg-coa reductase.
S-(+)-Arundic Acid；S-(+)-Arundic Acid(S)ONO-2506|||(S)-2-Propyloctanoicacid|||S-(+)-Arundic Acid；(S) (2024/9/8)
簡介：s-(+)-arundic acid ((s)ono-2506) is the s-enantiomer of arundic acid, which acts as an astrocyte-modulating agent and shows promise in stroke and alzheimer´s disease research.
9-Carboxymethoxymethylguanine；9-Carboxymethoxymethylguanine9-Carboxymethoxymethylguanine (2024/9/8)
簡介：9-carboxymethoxymethylguanine is the primary metabolite derived from aciclovir, a guanosine analogue with potent antiviral properties. aciclovir, also known as acyclovir, acts as an orally active antiviral agent.
Cognac oil；Cognac oilCognac oil (2024/9/8)
簡介：cognac oil, predominantly derived from wine lees, exhibits distinctive fatty acid compositions, characterized by high proportions of palmitic acid (59.26%), linoleic acid (11.92%), myristic acid (8.97%), and oleic acid (8.3%) among other fatty acids. notably, the application of cognac oil enhances the permeability of rhodamine 6g (r6g) across various membranes, resulting in a generalized increase in permeation.
Temuterkib；化合物L(fēng)Y3214996LY3214996；LY3214996 (2024/9/8)
簡介：temuterkib (ly3214996) is a potent and selective, orally available inhibitor of the extracellular signal-regulated kinase (erk) 1 and 2, with potential antineoplastic activity.
Diafenthiuron；丁醚脲Diafenthiuron (2024/9/8)
簡介：diafenthiuron is a widely utilized thiourea-based pesticide that effectively hinders mitochondrial activity in insect pests.
KLD-12；KLD-12KLD-12 (2024/9/8)
簡介：kld-12, a 12-residue self-assembling peptide, displays properties that promote chondrogenic differentiation of bone marrow stromal cells (bmscs). moreover, kld-12 hydrogel can effectively fill full-thickness osteochondral defects in their original location, leading to improved cartilage repair.
Theophyllol；乙酸鈉茶堿Theophyllol (2024/9/8)
簡介：theophyllol (theophylline sodium acetate) can alter calcium levels in subcellular fractions of rat brain cortex.
2-Nitrosopyridine；2-Nitrosopyridine2-Nitrosopyridine (2024/9/8)
簡介：2-nitrosopyridine is a versatile nitroso compound employed in the synthesis of antibiotics. it serves as a valuable derivatization reagent for click and diels-alder reactions, displaying exceptional dienophile characteristics.
Levopimaric acid；左旋海松酸Levopimaric acid (2024/9/8)
簡介：levopimaric acid is a plant-derived diterpene resin acid that exhibits multiple beneficial properties. it promotes cancer cell apoptosis, while also possessing anticancer, antioxidant, antibacterial, and cardiovascular activities.
ACG548B；ACG548BACG548B (2024/9/8)
簡介：acg548b (compound 24) is a highly effective inhibitor of acetyl- and butyrylcholinesterase (ache and bche) with ic50 values of 1.78 and 0.496 μm, respectively. it exhibits a greater affinity for ache and demonstrates selectivity over bche and chok (choline kinase).
ACG416B；ACG416BACG416B (2024/9/8)
簡介：acg416b (compound 18) exhibits formidable inhibitory effects on choline kinase (chok), with an ic 50 measurement of 0.4 μm. notably, acg416b demonstrates superior inhibitory activities against ht-29 human colon cancer cells, resulting in pronounced antiproliferative effects.
Aderbasib；AderbasibINCB007839|||INCB7839；INCB007839|||INCB7839 (2024/9/8)
簡介：aderbasib (incb007839) is a highly potent and orally active hydroxamate-based inhibitor of adam10 and adam17, with low nanomolar affinity. this compound demonstrates strong antineoplastic activity and holds potential for cancer research in various areas, such as diffuse large b-cell non-hodgkin lymphoma, her2-positive breast cancer, gliomas, and more.
PF-06282999；化合物PF06282999PF-06282999 (2024/9/8)
簡介：pf-06282999 is a potent and selective myeloperoxidase inhibitor which is potentially useful for the treatment of cardiovascular diseases.
2-Chloroacetamide；氯乙酰胺2-Chloroacetamide (2024/9/8)
簡介：2-chloroacetamide is a versatile chemical compound with several applications. acting as a preservative and herbicide, it effectively controls vegetation in upland areas as well as paddy fields. additionally, it serves as a biocide in diverse sectors including agriculture, glues, paints, and coatings. notably, 2-chloroacetamide demonstrates inhibitory properties toward very-long-chain fatty acid elongase, further highlighting its multifaceted nature.
DMHCA；DMHCADMHCA (2024/9/8)
簡介：dmhca, a potent, selective lxr agonist, specifically activates the lxr pathway´s cholesterol efflux arm, avoiding triglyceride synthesis stimulation. this compound exhibits anti-inflammatory properties and is utilized in researching cholesterol homeostasis and diabetes.
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