9月
MC-VC-PAB-Cyclohexanediamine-Thailanstatin A；化合物 MC-VC-PAB-Cyclohexanediamine-Thailanstatin AMC-VC-P (2024/9/14)
簡(jiǎn)介：mc-vc-pab-cyclohexanediamine-thailanstatin a is a spliceostatin analog and a drug-linker conjugate for antibody-drug conjugates (adc), comprising the cytotoxic component thailanstatin a and the cleavable linker (mc-vc-pab). this compound is utilized in the synthesis of adcs [1].
BET bromodomain inhibitor 3；化合物 BET bromodomain inhibitor 3BET bromodomain inhibitor 3 (2024/9/14)
簡(jiǎn)介：bet bromodomain inhibitor 3 is a bet bromodomain inhibitor with an inhibitory ki value of >40 μm against brdt. it is utilized in research related to contraception, cancer, and heart disease [1].
HSP90-IN-22；化合物 HSP90-IN-22HSP90-IN-22 (2024/9/14)
簡(jiǎn)介：hsp90-in-22 (compound 35) is an hsp90 inhibitor exhibiting antiproliferative activity, with ic50 values of 3.65 μm in mcf7 breast cancer cells and 2.71 μm in skbr3 breast cancer cells.
HDAC8-IN-4；化合物 HDAC8-IN-4HDAC8-IN-4 (2024/9/14)
簡(jiǎn)介：hdac8-in-4 is a selective hdac8 inhibitor, exhibiting inhibitory activity with ic50 values of 0.15 μm for hdac8 and 12 μm for hdac3 [1].
ML 2-23；化合物 ML 2-23ML 2-23 (2024/9/14)
簡(jiǎn)介：ml 2-23 is a potent bcr-abl degrader operating as a protac, exhibiting selective proteasome-dependent degradation of bcr-abl within leukemia cells [1].
ROCK-IN-7；化合物 ROCK-IN-7ROCK-IN-7 (2024/9/14)
簡(jiǎn)介：rock-in-7 (compound 9) serves as a rock kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].
DL-Methionine Methylsulfonium ChlorideDL-蛋氨酸甲基氯化锍DL-蛋氨酸甲基氯化锍|||維生素U (2024/9/14)
簡(jiǎn)介：dl-methionine methylsulfonium chloride is a natural product, used in the treatment of peptic ulcers, colitis, and gastritis.
JAK1-IN-11；化合物 JAK1-IN-11JAK1-IN-11 (2024/9/14)
簡(jiǎn)介：jak1-in-11 (compound 11) serves as a potent inhibitor of janus kinases, exhibiting nanomolar inhibitory concentrations with ic50 values of 0.02 nm (jak1) and 0.44 nm (jak2), demonstrating high selectivity for jak1 over jak2 [1].
JAK1-IN-10；化合物 JAK1-IN-10JAK1-IN-10 (2024/9/14)
簡(jiǎn)介：jak1-in-10 (compound 9), a cyano-substituted cyclic hydrazine derivative, functions as a potent and selective inhibitor of jak1 [1].
ROCK-IN-6；化合物 ROCK-IN-6ROCK-IN-6 (2024/9/14)
簡(jiǎn)介：rock-in-6, a selective rock2 inhibitor, exhibits potent inhibition with an ic50 of 2.19 nm and holds promise for research into glaucoma and retinal diseases [1].
Lp-PLA2-IN-16；化合物 Lp-PLA2-IN-16Lp-PLA2-IN-16 (2024/9/14)
簡(jiǎn)介：lp-pla2-in-16 (example 1) is an inhibitor of lipoprotein-associated phospholipase a2 (lp-pla2) with potential applications in alzheimer´s disease research [1].
Lp-PLA2-IN-15；化合物 Lp-PLA2-IN-15Lp-PLA2-IN-15 (2024/9/14)
簡(jiǎn)介：lp-pla2-in-15 (example 2) is an inhibitor of lipoprotein-associated phospholipase a2 (lp-pla2) with potential application in alzheimer´s disease research [1].
Lp-PLA2-IN-14；化合物 Lp-PLA2-IN-14Lp-PLA2-IN-14 (2024/9/14)
簡(jiǎn)介：lp-pla2-in-14 (compound 19), an inhibitor of rhlp-pla2, exhibits a potent inhibitory effect with a pic50 value of 8.4. this compound is applicable in research pertaining to neurodegenerative disorders, including alzheimer disease (ad), glaucoma, age-related macular degeneration (amd), and cardiovascular diseases such as atherosclerosis [1].
Lp-PLA2-IN-13；化合物 Lp-PLA2-IN-13Lp-PLA2-IN-13 (2024/9/14)
簡(jiǎn)介：lp-pla2-in-13 (compound 15), a potent lp-pla2 inhibitor, holds potential for research in neurodegenerative-related diseases [1].
KRAS G12D modulator-1；化合物 KRAS G12D modulator-1KRAS G12D modulator-1 (2024/9/14)
簡(jiǎn)介：kras g12d modulator-1 (compound 6), a potent modulator of kras g12d, exhibits ic50 values ranging from 1-10 μm against nea-g12d, ppi-g12d, and p erk-ags, and is utilized in cancer research [1].
HPK1 antagonist-1；化合物 HPK1 antagonist-1HPK1 antagonist-1 (2024/9/14)
簡(jiǎn)介：hpk1 antagonist-1 (i-792) is an inhibitor targeting hpk1, with potential applications in cancer and immune disease research [1].
Pentixafor；化合物 PentixaforPentixafor (2024/9/14)
簡(jiǎn)介：pentixafor is a peptide that selectively targets the cxcr4 receptor and can be labeled with gallium-68 (68ga) for visualization using positron emission tomography (pet) imaging [1].
7-Methoxyflavone；7-甲氧基黃酮7-Methoxyflavone (2024/9/14)
簡(jiǎn)介：7-methoxyflavone isolated from zornia brasiliensis with antinociceptive effects.
TLR7/8 agonist 9；化合物 TLR7/8 agonist 9TLR7/8 agonist 9 (2024/9/14)
簡(jiǎn)介：tlr7/8 agonist 9 (compound 25a), exhibiting ec50 values of 40 nm and 23 nm for htlr7 and htlr8 respectively, demonstrates anti-tumor properties and enhances the efficacy of pd-1/pd-l1 blockade treatments. this compound is utilized in cancer immunotherapy research [1].
TLR7/8 agonist 8；化合物 TLR7/8 agonist 8TLR7/8 agonist 8 (2024/9/14)
簡(jiǎn)介：tlr7/8 agonist 8 (compound 24m) is a potent dual agonist for toll-like receptors 7 and 8 (tlr7/8), exhibiting half-maximal effective concentrations (ec50s) of 27 nm for human tlr7 (htlr7) and 12 nm for human tlr8 (htlr8). this compound has been shown to enhance the efficacy of pd-1/pd-l1 inhibitors in antitumor activity [1].
PROTAC BTK Degrader-3；化合物 PROTAC BTK Degrader-3PROTAC BTK Degrader-3 (2024/9/14)
簡(jiǎn)介：protac btk degrader-3 is a potent degrader of bruton´s tyrosine kinase (btk), exhibiting a dc50 (median degradation concentration) of 10.9 nm in mino cells. this compound shows promise for research into b-cell malignancies, such as chronic lymphoid malignancies [1].
THRβ receptor agonist-1；化合物 THRβ receptor agonist-1THRβ receptor agonist-1 (2024/9/14)
簡(jiǎn)介：thrβ receptor agonist-1 is an agonist for the thrβ receptor [1].
WWL0245；化合物 WWL0245WWL0245 (2024/9/14)
簡(jiǎn)介：wwl0245 is a potent and selective brd4-targeting protac that exhibits sub-nanomolar degradation efficiency (dc50 1 μm). it demonstrates pronounced selective cytotoxicity in beti-sensitive cancer cell lines, particularly in ar-positive prostate cancer lines, making it a promising candidate for research in ar-positive prostate cancer and a valuable tool for the investigation of brd4´s biological function [1].
Estrogen receptor modulator 7；化合物 Estrogen receptor modulator 7Estrogen receptor modulator 7 (2024/9/14)
簡(jiǎn)介：estrogen receptor modulator 7 is a potent modulator of estrogen receptors, utilized in cancer research [1].
IRE1α kinase-IN-9；化合物 IRE1α kinase-IN-9IRE1α kinase-IN-9 (2024/9/14)
簡(jiǎn)介：ire1α kinase-in-9 (compound 2) is a potent inhibitor of ire-1α, demonstrating an average ic50 value of less than 0.1 μm. it is suitable for research into diseases linked to the unfolded protein response or regulated ire1-dependent decay (ridd) [1].
IRE1α kinase-IN-8；化合物 IRE1α kinase-IN-8IRE1α kinase-IN-8 (2024/9/14)
簡(jiǎn)介：ire1α kinase-in-8, a benzoheterocyclecarboxaldehyde derivative, serves as a potent inhibitor of ire-1α. this compound is utilized in research pertaining to diseases linked to the unfolded protein response and regulated ire1-dependent decay (ridd) [1].
VMAT2-IN-2 tosylate；化合物 VMAT2-IN-2 tosylateVMAT2-IN-2 tosylate (2024/9/14)
簡(jiǎn)介：vmat2-in-2 tosylate is a potent inhibitor of vmat2 and is applicable in the research of tardive dyskinesia [1].
MOR agonist-1；化合物 MOR agonist-1MOR agonist-1 (2024/9/14)
簡(jiǎn)介：mor agonist-1 is a μ-opioid receptor (mor) agonist noted for its potent analgesic properties and is utilized in research concerning pain and associated disorders [1].
CXCR4-IN-1；化合物 CXCR4-IN-1CXCR4-IN-1 (2024/9/14)
簡(jiǎn)介：cxcr4-in-1 (example c5), with an ic50 of 20 nm, is a potent inhibitor of cxcr4, applicable for the research of various conditions such as cancer, hiv, diabetic retinopathy, and inflammation [1].
ATR-IN-24；化合物 ATR-IN-24ATR-IN-24 (2024/9/14)
簡(jiǎn)介：atr-in-24 (compound 1) is an atr inhibitor with demonstrated anticancer activity [1].
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