9月
CDK4/6-IN-17；化合物 CDK4/6-IN-17CDK4/6-IN-17 (2024/9/14)
簡介：cdk4/6-in-17 (compound 12) is an orally bioavailable inhibitor of cdk4/6, demonstrating potent activity with ic50 values between 10-100 nm in be(2) cells. it has shown efficacy in inhibiting tumor growth in the colo205 xenograft model [1].
PI3Kγ inhibitor 7；化合物 PI3Kγ inhibitor 7PI3Kγ inhibitor 7 (2024/9/14)
簡介：pi3kγ inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits pi3kγ with an ic50 of 3.42 nm and demonstrates antitumor activity [1]. it also exhibits varying inhibitory effects on other pi3k isoforms, with ic50 values of 4768 nm for pi3kα, 878.1 nm for pi3kβ, and 355.2 nm for pi3kδ.
JAK-IN-27；化合物 JAK-IN-27JAK-IN-27 (2024/9/14)
簡介：jak-in-27, also known as compound 1, is an orally active, potent inhibitor of the jaks family kinases, displaying inhibitory concentrations (ic50s) of 3.0 nm for tyk2, 7.7 nm for jak1, and 629.6 nm for jak3. moreover, jak-in-27 impedes ifn-α2b-induced phosphorylation of stat3 in jurkat cells with an ic50 of 23.7 nm [1].
Arbidol；化合物 T7911Arbidol (2024/9/14)
簡介：umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. umifenovir both suppresses virus propagation and modulates the expression of inflammatory cytokines and is used as an anti-influenza virus agent [3]. umifenovir could effectively inhibit the fusion of virus with host cells [1] [2]. umifenovir is an efficient inhibitor of sars-cov-2 in vitro [2].
Estrogen receptor modulator 8；化合物 Estrogen receptor modulator 8Estrogen receptor modulator 8 (2024/9/14)
簡介：estrogen receptor modulator 8 (compound 4) is an orally active inhibitor targeting estrogen receptor/err α with potent efficacy (ic50 = 0.437 nm in mcf-7 cells) and effectively hampers mcf-7 cell proliferation (ic50 = 0.1 nm) [1].
SHP2-IN-14；化合物 SHP2-IN-14SHP2-IN-14 (2024/9/14)
簡介：shp2-in-14 (compound 27) is a potent, orally active allosteric inhibitor of shp2, displaying strong anti-tumor activity with an ic50 of 7 nm. it inhibits tumor progression in nci-h358 tumor-bearing mice and demonstrates favorable pharmacokinetic properties and safety [1].
WRN inhibitor 1；化合物 WRN inhibitor 1WRN inhibitor 1 (2024/9/14)
簡介：wrn inhibitor 1 (example 7) is an inhibitor of the werner syndrome atp-dependent helicase enzyme (wrn), selectively targeting its helicase domain. this compound is potentially useful for cancer research [1].
SORT-PGRN interaction inhibitor 3；化合物 SORT-PGRN interaction inhibitor 3SORT-PGRN interaction inhibit (2024/9/14)
簡介：sort-pgrn interaction inhibitor 3 (compound 13), with an ic50 value of 0.17 μm, acts as an inhibitor of the sort-pgrn interaction, and is utilized in the study of neurodegenerative diseases [1].
BVFP；化合物 BVFPBVFP (2024/9/14)
簡介：bvfp exhibits affinity for the pgrn 588–593 peptide through binding with a dissociation constant (kd) of 20 μm and is capable of disrupting the interaction between pgrn and sort1. moreover, bvfp inhibits the sort1-mediated endocytosis of recombinant pgrn (rpgrn) [1].
β-Catenin modulator-5；化合物 β-Catenin modulator-5β-Catenin modulator-5 (2024/9/14)
簡介：β-catenin modulator-5 (compound iia-84), an oxazole and thiazole-based compound, serves as a potent and selective modulator of β-catenin [1].
β-Catenin modulator-4；化合物 β-Catenin modulator-4β-Catenin modulator-4 (2024/9/14)
簡介：β-catenin modulator-4 (compound iia-92), encompassing oxazole and thiazole moieties, acts as a potent and selective modulator of β-catenin [1].
β-Catenin modulator-3；化合物 β-Catenin modulator-3β-Catenin modulator-3 (2024/9/14)
簡介：β-catenin modulator-3 (compound iia-112), an oxazole and thiazole-based chemical entity, serves as a potent and selective modulator of β-catenin [1].
β-Catenin modulator-2；化合物 β-Catenin modulator-2β-Catenin modulator-2 (2024/9/14)
簡介：β-catenin modulator-2 (compound iia-130), which is an oxazole-thiazole derivative, serves as a potent and selective modulator of β-catenin [1].
β-Catenin modulator-1；化合物 β-Catenin modulator-1β-Catenin modulator-1 (2024/9/14)
簡介：β-catenin modulator-1 (iia-650) is a useful agent in cancer research for modulating β-catenin [1].
4-Methoxybenzaldehyde；4-甲氧基苯甲醛Anisaldehyde|||p-Anisaldehyde|||Anisic aldehyde|||4-Anisaldehyde|||P-M (2024/9/14)
簡介：4-methoxybenzaldehyde (p-anisaldehyde) is a naturally occurring fragrant phenolic compound , it has significant antifungal activity against candida, including azole-resistant strains.
RET-IN-23；化合物 RET-IN-23RET-IN-23 (2024/9/14)
簡介：ret-in-23 (compound 17) is a potent, orally active inhibitor of ret, displaying ic50 values of 1.32 nm for ret-wt, 2.50 nm for ret-ccdc6, 6.54 nm for ret-v804l, 1.03 nm for ret-v804m, and 1.47 nm for ret-m918t. the compound demonstrates significant anti-tumor activity [1].
PROTAC SOS1 degrader-4；化合物 PROTAC SOS1 degrader-4PROTAC SOS1 degrader-4 (2024/9/14)
簡介：protac sos1 degrader-4 (compound 10) is a potent degrader of sos1 and exhibits antiproliferative activity [1].
PROTAC IRAK4 degrader-8；化合物 PROTAC IRAK4 degrader-8PROTAC IRAK4 degrader-8 (2024/9/14)
簡介：protac irak4 degrader-8 (compound 2) is a protac designed to target irak4 with an ic50 of 15.5 nm [1].
IPG7236；化合物 IPG7236IPG7236 (2024/9/14)
簡介：ipg7236, a selective ccr8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancer research [1].
SB-649701；化合物 SB-649701SB-649701 (2024/9/14)
簡介：sb-649701 is a potent antagonist of the human ccr8 receptor, exhibiting a pic50 value of 7.7, and is utilized in asthma research [1].
Bromodomain inhibitor-12 (edisylate)；化合物 Bromodomain inhibitor-12 (edisylate)Bromodomain inhibitor-1 (2024/9/14)
簡介：bromodomain inhibitor-12 edisylate (example 303) serves as a bromodomain inhibitor applicable to autoimmune and inflammatory disease research [1].
Bromodomain inhibitor-12；化合物 Bromodomain inhibitor-12Bromodomain inhibitor-12 (2024/9/14)
簡介：bromodomain inhibitor-12 (example 303) is a research compound utilized in the study of autoimmune and inflammatory diseases [1].
TH-Z827；化合物 TH-Z827TH-Z827 (2024/9/14)
簡介：th-z827 is a mutant-selective inhibitor targeting kras(g12d) with an ic50 of 2.4 μm, demonstrating specificity by not binding to kras(wt) or kras(g12c). additionally, it disrupts the kras(g12d)-craf interaction with an ic50 of 42 μm [1].
Bivamelagon hydrochloride；化合物 Bivamelagon hydrochlorideMC-4R Agonist 2 hydrochloride；MC-4R Agonist 2 (2024/9/14)
簡介：mc-4r agonist 2 hydrochloride (example 1) serves as an mc4r agonist, with applications in researching obesity, diabetes, inflammation, and erectile dysfunction. [1]
Bivamelagon；化合物 BivamelagonMC-4R Agonist 2；MC-4R Agonist 2 (2024/9/14)
簡介：mc-4r agonist 2 (example 1), a melanocortin 4 receptor (mc4r) agonist, is employed in the research of conditions such as obesity, diabetes, inflammation, and erectile dysfunction [1].
α-Terpineneα-松油烯松油烯|||α-松油烯 (2024/9/14)
簡介：α-terpinene is a terpenoid,has acaricidal, antiprotozoal, and antioxidant properties
THR-β modulator-1；化合物 THR-β modulator-1THR-β modulator-1 (2024/9/14)
簡介：thr-β modulator-1 (compound 1a) is a potent modulator of the thyroid hormone receptor β, utilized in the study of thyroid hormone receptor-associated disorders [1].
Chlamydia pneumoniae-IN-1；化合物 Chlamydia pneumoniae-IN-1Chlamydia pneumoniae-IN-1 (2024/9/14)
簡介：chlamydia pneumoniae-in-1 (compound 55), a benzimidazole derivative, exhibits potent antibacterial activity, inhibiting 99% of c. pneumoniae growth at a concentration of 10 μm and maintaining 95% viability of the host cells at the same concentration. it effectively inhibits the cv-6 strain of c. pneumoniae with a minimum inhibitory concentration (mic) of 12.6 μm, demonstrating its antichlamydial efficacy [1].
Antifungal agent 59；化合物 Antifungal agent 59Antifungal agent 59 (2024/9/14)
簡介：antifungal agent 59 exhibits potent activity, reflected by mic values ranging from 0.01 to 1 μg/ml, and inhibits the formation of fungal biofilms, while maintaining safety [1].
MC4171；化合物 MC4171MC4171 (2024/9/14)
簡介：mc4171 (compound 34), a selective kat8 inhibitor (ic50=8.1 μm), demonstrates moderate antiproliferative activity at micromolar concentrations in various cancer cell lines, such as nsclc and aml. this property highlights its potential utility in cancer research [1].
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