9月
Acenaphthylene；苊烯Acenaphthylene (2024/9/14)
簡(jiǎn)介：acenaphthylene is environmental polycyclic aromatic hydrocarbon (pah)pollutants
GBD-9；化合物 GBD-9GBD-9 (2024/9/14)
簡(jiǎn)介：gbd-9, a dual-mechanism degrader, effectively promotes the degradation of btk and gspt1 through recruitment of e3 ligase cereblon (crbn). as a protac molecule, gbd-9 induces btk degradation, while also acting as a molecular glue for gspt1 degradation, demonstrating potent inhibition of cancer cell growth [1].
Antitumor agent-100 hydrochloride；化合物 Antitumor agent-100 hydrochlorideAntitumor agent-100 hydrochlo (2024/9/14)
簡(jiǎn)介：antitumor agent-100 hydrochloride (compound a6), serving as both an apoptosis inducer and molecular glue, exhibits superior anti-tumor activity [1].
Monlunabant；化合物 Monlunabant(S)-MRI-1891；(S)-MRI-1891 (2024/9/14)
簡(jiǎn)介：monlunabant ((s)-mri-1891), a solid dispersion compound, functions as an inhibitor of the cannabinoid cb1 receptor [1].
DGKζ-IN-1；化合物 DGKζ-IN-1DGKζ-IN-1 (2024/9/14)
簡(jiǎn)介：dgkζ-in-1 (compound 9) is a dgkζ inhibitor with potential applications in cancer research, particularly for studying immunocyte activation and resistance to anti-pd-1/anti-pd-l1 antibody therapies [1].
FEN1-IN-7；化合物 FEN1-IN-7FEN1-IN-7 (2024/9/14)
簡(jiǎn)介：fen1-in-7 (compound 16), a selective flap endonuclease-1 (fen1) inhibitor with an ic50 of 18 nm, plays a role in dna damage repair in mammalian cells. additionally, it targets the related endonuclease, xeroderma pigmentosum g (xpg), with an ic50 of 3.04 μm. fen1-in-7 enhances the sensitivity of cancer cells to potent dna alkylating or methylating agents [1].
FEN1-IN-6；化合物 FEN1-IN-6FEN1-IN-6 (2024/9/14)
簡(jiǎn)介：fen1-in-6 (compound 9) is a potent flap endonuclease-1 (fen1, ic50 = 10 nm) inhibitor, crucial for dna damage repair in mammalian cells, and additionally targets the related endonuclease xeroderma pigmentosum g (xpg) with an ic50 of 23 nm [1].
UC-764864；化合物 UC-764864UC-764864 (2024/9/14)
簡(jiǎn)介：uc-764864, a ube2n inhibitor, impedes the enzymatic activity of ube2n and exhibits cytotoxic effects through the disruption of ube2n-dependent signaling in leukemic cells. it effectively hinders the ubiquitination of substrates related to innate immunity and inflammation in human aml cell lines [1].
Du011；化合物 Du011Du011 (2024/9/14)
簡(jiǎn)介：du011 is a biogenesis inhibitor of the e. coli polysaccharide capsule that specifically targets mpra, with potential applications in e. coli infection research [1].
KAT modulator-1；化合物 KAT modulator-1KAT modulator-1 (2024/9/14)
簡(jiǎn)介：kat modulator-1 (compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].
COX-2-IN-32；化合物 COX-2-IN-32COX-2-IN-32 (2024/9/14)
簡(jiǎn)介：cox-2-in-32 (compound 2f) is a dual inhibitor of inos and cox-2, known to downregulate nf-κb expression. demonstrating anti-inflammatory properties, it impedes no production in lps-induced raw264.7 macrophages with an ic50 value of 11.2 μm [1].
2-Bromobiphenyl；2-溴聯(lián)苯2-Bromobiphenyl (2024/9/14)
簡(jiǎn)介：2-bromobiphenyl is a persistent organic pollutant (pop) found primarily in soil and water. it is a known human carcinogen and has been linked to a variety of health effects including reproductive and developmental toxicity.
CRX000227；化合物 CRX000227CRX000227 (2024/9/14)
簡(jiǎn)介：crx000227 is a ppar modulator suitable for researching metabolic and cell proliferative disorders [1].
Antiviral agent 30；化合物 Antiviral agent 30Antiviral agent 30 (2024/9/14)
簡(jiǎn)介：antiviral agent 30 (example 118) is an active compound against hcv and rsv with an inhibitory concentration (ic 50) of greater than 25μm [1].
Casein kinase 1δ-IN-4；化合物 Casein kinase 1δ-IN-4Casein kinase 1δ-IN-4 (2024/9/14)
簡(jiǎn)介："casein kinase 1δ-in-4 (compound 567) is a potent inhibitor of casein kinase 1δ with potential application in alzheimer´s disease research [1]."
Protein kinase inhibitor 5 sulfate hydrate；化合物 Protein kinase inhibitor 5 sulfate hydrateProtein kin (2024/9/14)
簡(jiǎn)介：protein kinase inhibitor 5 sulfate hydrate, a potent trk-a inhibitor, exhibits an ic50 of 1.8 nm and impairs cell viability [1].
Protein kinase inhibitor 5；化合物 Protein kinase inhibitor 5Protein kinase inhibitor 5 (2024/9/14)
簡(jiǎn)介：protein kinase inhibitor 5 is a potent inhibitor of trk-a, demonstrating an ic50 of 1.8 nm, and effectively suppresses cell viability [1].
JGK-068S；化合物 JGK-068SJGK-068S (2024/9/14)
簡(jiǎn)介：compound i (jgk-068s) is a potent inhibitor of the epidermal growth factor receptor (egfr) [1].
PF-07284892；化合物 PF-07284892ARRY-558；ARRY-558 (2024/9/14)
簡(jiǎn)介：pf-07284892 (arry-558) is an orally active, potent inhibitor of shp2, demonstrating an ic50 of 21 nm, and is known to reduce the expression of perk [1] [2].
Insecticidal agent 2；化合物 Insecticidal agent 2Insecticidal agent 2 (2024/9/14)
簡(jiǎn)介：insecticidal agent 2 (example 2) is an effective pesticide that significantly inhibits pest growth [1].
ATR-IN-29；化合物 ATR-IN-29ATR-IN-29 (2024/9/14)
簡(jiǎn)介：atr-in-29, a potent, orally active inhibitor of atr kinase, exhibits an ic50 of 1 nm and demonstrates antiproliferative activity [1].
WM-586；化合物 WM-586WM-586 (2024/9/14)
簡(jiǎn)介：wm-586 is a covalent inhibitor of wdr5 that impedes the wdr5-myc binding. it selectively reduces the interaction between wdr5 and myc with an ic50 value of 101 nm, as determined by the htrf assay [1].
(?)-Myrtenal；(1R)-(-)-桃金娘烯醛(1R)-(?)-Myrtenal；(1R)-(-)-桃金娘烯醛|||桃金娘烯醛|||(1R)-(?)-Myrtenal (2024/9/14)
簡(jiǎn)介：(?)-myrtenal ameliorates hyperglycemia by enhancing glut2 through akt in the skeletal muscle and liver of diabetic rats.
Dodicin hydrochloride；化合物 Dodicin hydrochlorideDodicin hydrochloride (2024/9/14)
簡(jiǎn)介：dodicin hydrochloride, an effective disinfectant, demonstrates broad antimicrobial activity [1].
Dodicin；化合物 DodicinDodicin (2024/9/14)
簡(jiǎn)介：dodicin is a potent disinfectant exhibiting broad-spectrum antimicrobial activity [1].
Menin-MLL inhibitor 27；化合物 Menin-MLL inhibitor 27Menin-MLL inhibitor 27 (2024/9/14)
簡(jiǎn)介：menin-mll inhibitor 27 effectively inhibits the interaction between menin and mll, serving as a potential tool in cancer research, particularly for acute myeloid leukemia (aml) [1].
JAK-IN-28；化合物 JAK-IN-28JAK-IN-28 (2024/9/14)
簡(jiǎn)介：jak-in-28 (compound 111) is a janus kinase (jak) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].
P2X3 antagonist 38；化合物 P2X3 antagonist 38P2X3 antagonist 38 (2024/9/14)
簡(jiǎn)介：compound 38, also known as compound 4, is a potent, orally active p2x3 antagonist that demonstrates inhibitory activity with ic50 values of 0.132 μm, 0.165 μm, and 0.421 μm against human (hp2x3), rat (rp2x3), and guinea pig (gpp2x3) p2x3 receptors, respectively [1].
URAT1 inhibitor 5；化合物 URAT1 inhibitor 5URAT1 inhibitor 5 (2024/9/14)
簡(jiǎn)介：urat1 inhibitor 5 (compound 16) serves as a powerful inhibitor of urat1 and is utilized in hyperuricemia research [1].
BTK-IN-25；化合物 BTK-IN-25BTK-IN-25 (2024/9/14)
簡(jiǎn)介：btk-in-25 (compound 71) is a potent btk inhibitor, demonstrating an ic50 of 0.77 nm against btk(c481s) and achieving an ic50 of 1 nm in dohh2 cells [1].
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