9月
CBP-IN-1；化合物 CBP-IN-1CBP-IN-1 (2024/9/14)
簡介：cbp-in-1 (compound 12) acts as a potent cbp inhibitor exhibiting an ic50 of 1.5 nm and additionally suppresses cbp bret and brd4(1) with ic50 values of 690 nm and 3100 nm, respectively [1].
BET-IN-15；化合物 BET-IN-15BET-IN-15 (2024/9/14)
簡介：bet-in-15 (compound 1) is a potent, orally active inhibitor of bet, demonstrating inhibitory ic50 values of 0.64 nm for brd4-bd1 and 0.25 nm for brd4-bd2. it exhibits antiproliferative activity [1].
KRAS G12C inhibitor 60；化合物 KRAS G12C inhibitor 60KRAS G12C inhibitor 60 (2024/9/14)
簡介：kras g12c inhibitor 60 (compound 23), a selective inhibitor targeting the kras-g12c mutation, is utilized in the investigation of lung, colorectal, and pancreatic cancers [1].
DNA-PK-IN-10；化合物 DNA-PK-IN-10DNA-PK-IN-10 (2024/9/14)
簡介：dna-pk-in-10 is a dna-pk inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].
USP7-IN-12；化合物 USP7-IN-12USP7-IN-12 (2024/9/14)
簡介：usp7-in-12 (compound 1) is a potent, orally active inhibitor of usp7, exhibiting an ic50 of 3.67 nm and demonstrating antiproliferative activity [1].
RET-IN-24；化合物 RET-IN-24RET-IN-24 (2024/9/14)
簡介：ret-in-24 (compound 26) is a selective inhibitor of ret tyrosine kinase, demonstrating antitumor activity [1].
SOS1/KRAS-IN-1；化合物 SOS1/KRAS-IN-1SOS1/KRAS-IN-1 (2024/9/14)
簡介：sos1/kras-in-1 (compound 2) serves as an inhibitor of sos1/kras, with potential application in the study of diseases mediated by sos1/kras [1].
PROTAC PTPN2 degrader-2 TFA；化合物 PROTAC PTPN2 degrader-2 TFAPROTAC PTPN2 degrader-2 TFA (2024/9/14)
簡介：protac ptpn2 degrader-2 (example 187b) tfa is a potent degrader of protein tyrosine phosphatase non-receptor type 2 (ptpn2), with potential applications in cancer and metabolic disease research [1].
PROTAC PTPN2 degrader-2；化合物 PROTAC PTPN2 degrader-2PROTAC PTPN2 degrader-2 (2024/9/14)
簡介：protac ptpn2 degrader-2 (example 187b) is a potent agent capable of degrading ptpn2, which holds potential for research in cancer and metabolic diseases [1].
4-Acetamidobenzenesulfonyl azide；4-乙酰氨基苯磺酰疊氮4-Acetamidobenzenesulfonyl azide (2024/9/14)
簡介：4-acetamidobenzenesulfonyl azide is used in a variety of scientific research applications, including the synthesis of drugs, peptides and other biologically active molecules. it is also used as a catalyst in polymerization reactions and polymer synthesis.
Methyl 12-methyltridecanoate；化合物 Methyl 12-methyltridecanoateMethyl 12-methyltridecanoate (2024/9/14)
簡介：methyl 12-methyltridecanoate ((r)-betaxolol hydrochloride), a biosurfactant derived from brevibacterium casei ls14, enhances the biocompatibility of functionalized silver nanoparticles in vivo [1].
h15-LOX-2 inhibitor 1；化合物 h15-LOX-2 inhibitor 1h15-LOX-2 inhibitor 1 (2024/9/14)
簡介：compound 105 (h15-lox-2 inhibitor 1) is a potent inhibitor of human epithelial 15-lipoxygenase-2 (h15-lox-2), exhibiting an ic50 of 0.34 μm [1].
Pimicotinib；化合物PimicotinibABSK021|||ABSK-021；ABSK021|||ABSK-021 (2024/9/14)
簡介：pimicotinib (absk021) is a potent csf1r inhibitor with antitumor activity and can be used to study advanced solid tumors.
(R)-SKBG-1；化合物 (R)-SKBG-1(R)-SKBG-1 (2024/9/14)
簡介：(r)-skbg-1 is an inhibitor of the rna-binding protein nono, effectively downregulating androgen receptor expression by targeting both ar-fl mrna and ar-v7 mrna, with inhibition concentration (ic50) values of 3.1 μm and 5.5 μm, respectively [1].
5-HT2A receptor agonist-3；化合物 5-HT2A receptor agonist-35-HT2A receptor agonist-3 (2024/9/14)
簡介：5-ht2a receptor agonist-3 represents the highest selectivity for the human 5-ht2a receptor currently identified, exhibiting a k i of 2.5 nm. it also demonstrates a remarkable 124-fold selectivity over its structurally analogous 5-ht2c receptor [1].
Casein kinase 1δ-IN-5；化合物 Casein kinase 1δ-IN-5Casein kinase 1δ-IN-5 (2024/9/14)
簡介：casein kinase 1δ-in-5 is a potent and selective ck-1δ inhibitor, exhibiting an ic50 of 47 nm, and demonstrates neuroprotective and anti-inflammatory effects in vitro, with potential applications in neurodegenerative disease research.
DG-8；化合物 DG-8DG-8 (2024/9/14)
簡介：dg-8 serves as a potent inhibitor of stat3-dependent transcription, exhibiting an ic50 of 0.98 μm, and also functions as a fluorescent probe endowed with a dansyl moiety [1].
PROTAC EGFR degrader 8；化合物 PROTAC EGFR degrader 8PROTAC EGFR degrader 8 (2024/9/14)
簡介：protac egfr degrader 8 (t-184) is a protac that selectively degrades the epidermal growth factor receptor (egfr) with a dc50 of 15.56 nm in hcc827 cells. it effectively inhibits the growth of various cell lines, including h1975, pc-9, and hcc827, with ic50 values of 7.72 nm, 121.9 nm, and 14.21 nm, respectively. this compound is primarily used for cancer research, particularly in the context of non-small cell lung cancer (nsclc) [1].
TLR8 agonist 6；化合物 TLR8 agonist 6TLR8 agonist 6 (2024/9/14)
簡介：compound a, a potent tlr8 agonist, exhibits an ec50 of 0.052 μm and promotes the production of il-12p40 in human pbmcs with an ec50 of 0.031 μm. this compound is applicable for research in virus resistance, infection resistance, autoimmunity, and tumor studies [1].
KRAS G12C inhibitor 59；化合物 KRAS G12C inhibitor 59KRAS G12C inhibitor 59 (2024/9/14)
簡介：kras g12c inhibitor 59 is a compound with anticancer properties.
Magmas-IN-1；化合物 Magmas-IN-1Magmas-IN-1 (2024/9/14)
簡介：magmas-in-1 (compound 9), a small molecule magmas inhibitor (smmi), targets the mitochondria-associated granulocyte-macrophage colony-stimulating factor (gm-csf) signaling molecule and gm-csf inducible gene in myeloid cells. this compound effectively inhibits magmas, modulating mitochondrial function, and impedes yeast proliferation at a concentration of 4 μm [1].
PROTAC KRAS G12C degrader-3；化合物 PROTAC KRAS G12C degrader-3PROTAC KRAS G12C degrader-3 (2024/9/14)
簡介：protac kras g12c degrader-3 (comp 283) serves as a potent degrader of kras g12c, utilized in cancer research [1].
KRAS degrader-1；化合物 KRAS degrader-1KRAS degrader-1 (2024/9/14)
簡介：kras degrader-1 (compound 1) is a potent agent that selectively targets kras proteins for destruction via the autophagy-lysosomal degradation pathway [1].
MSU38225；化合物 MSU38225MSU38225 (2024/9/14)
簡介：msu38225, an nrf-2 inhibitor, elevates reactive oxygen species (ros) levels and suppresses the proliferation of human lung cancer cells. moreover, it augments the chemotherapy responsiveness of these cells in both in vitro and in vivo settings, making it a valuable agent in cancer research [1].
CK1-IN-2；化合物 CK1-IN-2CK1-IN-2 (2024/9/14)
簡介：ck1-in-2 (compound nr.4) is a potent inhibitor of ck1, exhibiting ic50 values of 123 nm for ck1a, 19.8 nm for ck1d, 26.8 nm for ck1e, and 74.3 nm for p38a [1].
PROTAC MEK1 Degrader-1；化合物 PROTAC MEK1 Degrader-1PROTAC MEK1 Degrader-1 (2024/9/14)
簡介：protac mek1 degrader-1, a targeted protein degradation agent, combines a mek1 inhibitor with a von hippel-lindau ligand to effectively inhibit erk1/2 phosphorylation. with a pic50 value of 7.0, it exhibits antiproliferative activity against a375 cells [1].
MS934；化合物 MS934MS934 (2024/9/14)
簡介：ms934, a novel vhl-recruiting mek 1/2 degrader, exhibits potent anti-proliferative effects on ht-29 cell growth, achieving a gi50 of 0.023 μm. it holds potential for researching various human cancers including melanoma, non-small cell lung cancer (nsclc), colorectal cancer, primary brain tumors, and hepatocellular carcinoma [1].
c-Met-IN-17；化合物 c-Met-IN-17c-Met-IN-17 (2024/9/14)
簡介：c-met-in-17 is a potent inhibitor of c-met kinase, demonstrating an ic50 of 0.031 μm, and is applicable in anticancer research. [1]
Mosnodenvir；化合物 MosnodenvirJNJ-1802；JNJ-1802 (2024/9/14)
簡介：mosnodenvir (jnj-1802), a pan-serotype dengue antiviral agent, exhibits picomolar to low nanomolar in vitro activity with a high barrier to resistance and is safe and well-tolerated in murine models [1] [2]. it functions by blocking the ns3-ns4b interaction within the viral replication complex.
αvβ6 integrin inhibitor 2；化合物 αvβ6 integrin inhibitor 2αvβ6 integrin inhibitor 2 (2024/9/14)
簡介：αvβ6 integrin inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (ic50) of 96.5 nm.
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