9月
Tulathromycin A；托拉菌素 ACP 472295|||Draxxin|||Tulathromycin；CP 472295|||Draxxin|||Tulathromycin|||托拉菌素 (2024/9/8)
簡(jiǎn)介：tulathromycin a (cp 472295) is a macrolide antibiotic.
AZD4635；化合物AZD4635HTL1071；HTL1071 (2024/9/8)
簡(jiǎn)介：azd4635 (htl1071) is a new-type adenosine 2a receptor (a2ar) inhibitor(ki=1.7 nm).
Takinib；化合物TakinibEDHS-206；EDHS-206 (2024/9/8)
簡(jiǎn)介：takinib (edhs-206) is a specific and effective tak1 inhibitor(ic50= 9.5 nm).
BAY 61-3606；化合物BAY 61-3606Syk inhibitor IV；2-[[7-(3,4-二甲氧基苯基)咪唑并[1,2-C]嘧啶-5-基]氨基]-3-吡啶甲酰胺|||Syk inhi (2024/9/8)
簡(jiǎn)介：bay 61-3606 (syk inhibitor iv) is a potent, atp-competitive, reversible, and highly selective inhibitor of syk tyrosine kinase activity (ki= 7.5 nm), exhibiting no inhibitory effect against btk, fyn, itk, lyn, and src.
BPR1J-097 hydrochloride (1327167-19-0(free base))；化合物BPR1J-097 hydrochlorideBPR1J-097 hydrochloride (2024/9/8)
簡(jiǎn)介：bpr1j-097, a new-type small molecule flt-3 inhibitor(ic50=11±7 nm), is with great anti-tumor activities in vivo.
Capmatinib 2HCl；INCB28060鹽酸鹽INC-280 2HCl|||INCB28060 2HCl；INC-280 2HCl|||INCB28060鹽酸鹽|||INCB28060 2H (2024/9/8)
簡(jiǎn)介：capmatinib 2hcl (inc-280 2hcl) is a novel, atp-competitive inhibitor of c-met kinase with an ic50 with 0.13 nm.capmatinib 2hcl exhibits picomolar enzymatic potency and is highly specific for c-met with more than 10, 000-fold selectivity over a large panel of human kinases. this inhibitor potently blocks c-met phosphorylation and activation of its key downstream effectors in c-met-dependent tumor cell lines. as a result, capmatinib 2hcl potently inhibits c-met-dependent tumor cell proliferation a
GLPG0187；化合物GLPG0187GLPG0187 (2024/9/8)
簡(jiǎn)介：glpg0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (ic50: 1.3 nm).
TLR7 agonist 2；化合物TLR7-agonist-1TLR7-agonist-1|||TLR7-IN-1；TLR7-agonist-1|||TLR7-IN-1 (2024/9/8)
簡(jiǎn)介：tlr7 agonist 2 (tlr7-in-1) is a specific and effective toll-like receptor 7 (tlr7) agonist (lec=0.4 μm).
Belizatinib；化合物BelizatinibTSR-011；TSR-011 (2024/9/8)
簡(jiǎn)介：belizatinib (tsr-011) is an effective, oral and dual inhibitor of alk (ic50: 0.7 nm, wild-type recombinant alk) and trka, trkb, and trkc.
PTP1B-IN-2；化合物PTP1B-IN-2PTP1B-IN-2 (2024/9/8)
簡(jiǎn)介：ptp1b-in-2 is an effective protein tyrosine phosphatase 1b (ptp1b) inhibitor(ic50=50 nm).
TM5275 sodium；化合物TM5275 sodiumTM5275 sodium salt；TM5275 sodium salt (2024/9/8)
簡(jiǎn)介：tm5275 sodium (tm5275 sodium salt) is an inhibitor of plasminogen activator inhibitor 1 (pai-1).
TM5441；化合物TM5441TM5441 (2024/9/8)
簡(jiǎn)介：tm5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (pai-1).
Skp2 Inhibitor C1；化合物Skp2 Inhibitor C1SKPin C1；SKPin C1 (2024/9/8)
簡(jiǎn)介：skp2 inhibitor c1 (skpin c1)(skpin c1) is a specific small molecule inhibitor of skp2-mediated p27 degradation.
ML327；化合物ML327ML327 (2024/9/8)
簡(jiǎn)介：ml327 is a myc blocker. ml327 can also de-repress e-cadherin transcription and reverse epithelial-to-mesenchymal transition (emt).
GJ103 sodium salt；化合物GJ103 sodium saltGJ103 sodium salt (2024/9/8)
簡(jiǎn)介：gj103 sodium salt is an active analog of gj072, a read-through compound. it has been shown to reduce the surface tension of aqueous solutions, which makes it easier for molecules to move through the solution. it has also been shown to reduce the viscosity of aqueous solutions, which makes it easier for molecules to move through the solution. additionally, it has been shown to reduce the ph of aqueous solutions, which can have a variety of effects on the biochemical and physiological processes of
Bilastine；比拉斯汀Bilaxten；比拉斯汀|||Bilaxten (2024/9/8)
簡(jiǎn)介：bilastine (bilaxten) is a novel new-generation antihistamine that is highly selective for the h1 histamine receptor, has a rapid onset and prolonged duration of action.
AZD3759 hydrochloride；化合物AZD3759 hydrochlorideAZD3759 hydrochloride (2024/9/8)
簡(jiǎn)介：azd3759 (hydrochloride) is an effective, orally active and central nervous system-penetrant egfr inhibitor. at km atp concentrations, the ic50s are 0.2/0.3/0.2 nm for egfr (l858r)/egfr (wt)/egfr (exon 19del).
T.cruzi Inhibitor (1350920-22-7(free base))；T.cruzi InhibitorT.cruzi Inhibitor (1350920-22-7(free ba (2024/9/8)
簡(jiǎn)介：t.cruzi inhibitor is a trypanosoma cruzi inhibitor.
I-CBP112 hydrochloride；化合物I-CBP112 hydrochlorideI-CBP112 hydrochloride (2024/9/8)
簡(jiǎn)介：i-cbp112 is a selective inhibitor of the bromodomain-containing transcription factors. i-cbp112 (1 mm) has little activity against other bromodomains. i-cbp112 targets the cbp/p300 bromodomains. i-cbp112 significantly reduced the leukemia-initiating potential of mll-af9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. interestingly, i-cbp112 increased the cytotoxic activity of bet bromodomain inhibitor jq1 as well as doxorubicin.
Varenicline；化合物 T4246LVarenicline (2024/9/8)
簡(jiǎn)介：varenicline (cp 526555), a cytisine-based nicotinic ligand, is a potent partial agonist for the α4β2 nicotinic acetylcholine receptor (nachr) with an ec50 value of 2.3 μm and acts as a full agonist for α7 and α3β4 nachrs, with respective ec50 values of 18 μm and 55 μm [1]. notably, its effectiveness and potential in smoking cessation treatments are underscored by its pharmacological profile [2].
Varenicline dihydrochloride；Varenicline 鹽酸鹽Varenicline dihydrochloride (2024/9/8)
簡(jiǎn)介：varenicline dihydrochloride is a selective α4β2 nicotinic acetylcholine receptor partial agonist.
IWP-4；化合物IWP 4Inhibitor of Wnt Production-4；Inhibitor of Wnt Production-4 (2024/9/8)
簡(jiǎn)介：iwp-4 (inhibitor of wnt production-4) is a potent wnt inhibitor.
Methylophiopogonone A；甲基麥冬高黃酮AMethylophiopogonone A (2024/9/8)
簡(jiǎn)介：methylophiopogonone a, an isoflavone isolated from the roots of ophiopogon japonicus, exhibits anti-inflammatory properties.
Catechin 3-rhamnoside；化合物 T4242Catechin 3-rhamnoside (2024/9/8)
簡(jiǎn)介：catechin 3-rhamnoside has antioxidant activity.
Rubiadin；茜草素1,3-Dihydroxy-2-Methylanthracene-9,10-Dione；1,3-Dihydroxy-2-Methylanthracene-9,10-Dione| (2024/9/8)
簡(jiǎn)介：rubiadin (1,3-dihydroxy-2-methylanthracene-9,10-dione) possesses potent antioxidant property, it can prevent lipid peroxidation induced by feso4 and t-butylhydroperoxide (t-bhp) in a dose dependent manner.
1,3-dimethyl-2-oxobenzimidazole-5-carbaldehyde；化合物T42391,3-DIMETHYL-2-OXO-2,3-DIHYDRO-1H-BENZIMIDAZO (2024/9/8)
簡(jiǎn)介：1,3-dimethyl-2-oxobenzimidazole-5-carbaldehyde serves as an intermediate.
Glycocyamine；乙酸胍2-Guanidinoacetic acid|||Guanidoacetic acid；乙酸胍|||2-Guanidinoacetic acid|||Guanidoac (2024/9/8)
簡(jiǎn)介：glycocyamine (2-guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird. glycocyamine is an important marker for renal failure, kidney transplantation, and the renal metabolic activity. the compound is a metabolite of guanidine.
Rubiadin-1-methyl ether；3-羥基-1-甲氧基-2-甲基蒽醌Rubiadin 1-methyl ether；Rubiadin 1-methyl ether|||3-羥基-1-甲氧 (2024/9/8)
簡(jiǎn)介：rubiadin-1-methyl ether (rubiadin 1-methyl ether) is a natural product.it inhibits osteoclastic bone resorption via inhibition on the phosphorylation of nf-κb p65 and the degradation of iκbα as well as decrease in the nuclear translocation of p65.
AR-M 1000390 hydrochloride化合物AR-M 1000390 hydrochlorideARM390 Hydrochloride|||ARM-390 HCl (2024/9/8)
簡(jiǎn)介：ar-m 1000390 hydrochloride (arm-390 hcl) , also known as arm-390, is a low-internalizing nonpeptidic δ-selective opioid receptor agonist; derivative of snc 80. does not trigger acute desensitization of the analgesic response; reduces cfa-induced hyperalgesia. brain penetrant following systemic administration.
Roblitinib；化合物RoblitinibFGF-401；FGF-401 (2024/9/8)
簡(jiǎn)介：roblitinib (fgf-401) is an inhibitor of human fibroblast growth factor receptor 4 (fgfr4), with potential antineoplastic activity. upon administration, roblitinib binds to and inhibits the activity of fgfr4, which leads to an inhibition of tumor cell proliferation in fgfr4-overexpressing cells. roblitinib is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cell proliferation, differentiation, angiogenesis, and survival.
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