9月
OSS_128167；化合物OSS_128167SIRT6-IN-1；SIRT6-IN-1 (2024/9/8)
簡介：oss_128167 (sirt6-in-1) is a specific sirt6 inhibitor, and for sirt6(ic50=89 μm), sirt1(ic50=1578 μm) and sirt2(ic50=751 μm).
Prexasertib dihydrochloride；化合物Prexasertib dihydrochlorideLY2606368 (dihydrochloride)|||Prexasertib (2024/9/8)
簡介：prexasertib dihydrochloride (ly2606368) is an atp-competitive chk1 inhibitor (ki: 0.9 nmol/l). in the cell-free assay, its ic50 values are 8 nm and 9 nm for chk2 and rsk, respectively.
AG 555；化合物AG 555Tyrphostin B46|||Tyrphostin AG 555；Tyrphostin B46|||Tyrphostin AG 555 (2024/9/8)
簡介：ag 555 (tyrphostin b46) is an egfr tyrosine kinase inhibitor.
COTI-2；化合物COTI2COTI 2|||COTI2；COTI 2|||COTI2 (2024/9/8)
簡介：coti-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity.
PQ401 hydrochloride (196868-63-0(free base))；化合物PQ401 hydrochloridePQ401 hydrochloride (196868-63-0( (2024/9/8)
簡介：pq401 inhibits autophosphorylation of igf-1r domain with ic50 of <1 μm.
PF-04457845；化合物PF04457845PF04457845|||PF 04457845；PF04457845|||PF 04457845 (2024/9/8)
簡介：pf-04457845 is a greatly and effctive faah inhibitor, and for hfaah(ic50=7.2±0.63 nm) and rfaah(ic50=7.4±0.62 nm).
2-Hydroxybutyric acid；2-羥基丁酸α-Hydroxybutyric acid；α-Hydroxybutyric acid (2024/9/8)
簡介：2-hydroxybutyric acid (α-hydroxybutyric acid) is a product of protein metabolism and a biomarker for type 2 diabetes and pre-eclampsia.
Indisulam化合物IndisulamE 7070 (2024/9/8)
簡介：indisulam (e 7070) is a carbonic anhydrase inibitor and antitumor cdk inhibitor. indisulam targets the g1 phase of the cell cycle by depleting cyclin e. inducing p53 and p21, and inhibiting cdk2, causing a blockade in the g1/s transition.
Flumatinib；化合物FlumatinibHHGV678；HHGV678 (2024/9/8)
簡介：flumatinib (hhgv678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.
Hispidol；化合物Hispidol(Z)-Hispidol；(Z)-Hispidol (2024/9/8)
簡介：hispidol ((z)-hispidol) ((z)-hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits tnf-α induced adhesion of monocytes to colon epithelial cells with an ic50 of 0.50 μm.
EOC317；化合物ACTB1003ACTB-1003|||ACTB1003|||ACTB 1003；ACTB-1003|||ACTB1003|||ACTB 1003 (2024/9/8)
簡介：eoc317 (actb-1003) is an oral kinase inhibitor (ic50: 6/2/4 nm, for fgfr1/vegfr2/tie-2).
PF 429242；化合物PF 429242PF 429242 (2024/9/8)
簡介：pf-429242 is a competitive inhibitor of sterol regulatory element-binding protein (srebp) site 1 protease (ic50 = 0.175 μm). it is selective for site 1 protease against a panel of serine proteases. pf-429242 inhibits rate of cholesterol synthesis in cho cells (ic50 = 0.53 μm).
ML365；化合物ML365ML365 (2024/9/8)
簡介：ml365 is a novel selective small molecule inhibitor of task1(kcnk3).
EPZ020411；化合物EPZ020411EPZ020411 2HCl；EPZ020411 2HCl (2024/9/8)
簡介：epz020411 is a specific and effective inhibitor of prmt6 (ic50=10 nm).
Tinoridine hydrochloride；鹽酸替諾立定Nonflamin|||Y-3642 hydrochloride；鹽酸替諾立定|||Nonflamin|||Y-3642 hydrochl (2024/9/8)
簡介：tinoridine hydrochloride (y-3642 hydrochloride) is a non-steroidal anti-inflammatory drug. tinoridine hydrochloride (5-100 μm), produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxide formation and renin release induced by 50 μm ascorbic acid in the renin granule fraction. on the other hand, indomethacin, hydrocortisone, and prednisolone, which had no ability to inhibit the lipid peroxidation in the renin granule fraction, did not influence the release of re
GPR120 Agonist 2；化合物GPR120 receptor agonistGPR120 receptor agonist；GPR120 receptor agonist (2024/9/8)
簡介：gpr120 agonist 2 is a potent and selective gpr120 receptor agonist.
HAMNO；化合物HAMNONSC111847；NSC111847 (2024/9/8)
簡介：hamno (nsc-111847) is a protein interaction inhibitor of replication protein a (rpa).
Prexasertib mesylate；化合物 T4310L2LY-2606368|||LY2606368|||LY 2606368；LY-2606368|||LY2606368|||LY 2606 (2024/9/8)
簡介：prexasertib is a potent and selective chk1/chk2 inhibitor. prexasertib increases the effectiveness of conventional therapy in b-/t- cell progenitor acute lymphoblastic leukemia. ly2606368 causes replication catastrophe and antitumor effects through chk1-dependent mechanisms. treatment of cells with ly2606368 results in the rapid appearance of tunel and ph2ax-positive double-stranded dna breaks in the s-phase cell population.
Prexasertib lactate hydrate；化合物 T4310LPrexasertib monolactate monohydrate|||LY-2606368|||LY 2606368| (2024/9/8)
簡介：prexasertib is an effective and selective chk1/chk2 inhibitor. prexasertib causes replication catastrophe and antitumor effects through chk1-dependent mechanisms.
Prexasertib；化合物PrexasertibLY2606368；5-[[5-[2-(3-氨基丙氧基)-6-甲氧基苯基]-1H-吡唑-3-基]氨基]-2-吡嗪甲腈|||LY2606368 (2024/9/8)
簡介：prexasertib (ly2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.
CIL56；化合物CIL56CA3；CA3 (2024/9/8)
簡介：cil56 (ca3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ros). it also induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in ht-1080 cells in vitro.ht-1080 cells lacking acetyl-coa carboxylase 1 (acc1), the rate-limiting enzyme in fatty acid synthesis, exhibit 5-fold resistance to cil56 treatment, indicating acc1 activity sensitizes cells to cil56-induced cell death.
F1063-0967；化合物F1063-0967F1063-0967 (2024/9/8)
簡介：f1063-0967 is a dual-specificity phosphatase 26 (dusp26) inhibitor with an ic50 of 11.62 μm.
PF-06840003；化合物PF06840003EOS200271|||PF 06840003；EOS200271|||PF 06840003 (2024/9/8)
簡介：pf-06840003 (eos200271) is a specific and oral active ido-1 inhibitor.
CCG-203971；化合物CCG203971CCG203971；CCG203971 (2024/9/8)
簡介：ccg-203971 is an inhibitor of sre activation in the prostate cancer cell line pc-3 (ic50: 6.4 μm), with 87% inhibition of sre activation achieved at 100 μm. this compound also inhibits pc-3 cell migration (ic50: 4.2 μm), as determined by a scratch wound assay. ccg-203971(ccg203971) causes no cytotoxicity when evaluated by the wst-1 assay. it is well tolerated in normal mice up to doses of 100 mg/kg given intraperitoneally over five days.
Azoramide；N-[2-[2-(4-氯苯基)-4-噻唑基]乙基]丁酰胺Azoramide (2024/9/8)
簡介：azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.
4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxylic acid；4-甲基-2-(4-三氟甲基苯基)噻唑-5-羧酸4-methyl-2- (2024/9/8)
簡介：4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxylic acid is used as a pharmaceutical intermediate.
iCRT3；化合物iCRT3iCRT3 (2024/9/8)
簡介：icrt3 is a wnt and β-catenin-responsive transcription inhibitor.
AD80；化合物AD80AD80 (2024/9/8)
簡介：ad80, a multikinase inhibitor, inhibits ret, raf, srcand s6k, with greatly reduced mtor activity.
AZD2098；化合物AZD2098AZD2098 (2024/9/8)
簡介：azd2098 is a potent cc-chemokine receptor 4 (ccr4) inhibitor used for asthma research.
AS-2444697；化合物AS-2444697AS-2444697 (2024/9/8)
簡介：as-2444697 is an inhibitor of irak-4 (c50 = 21 nm). as-2444697 exhibits renoprotective effects through anti-inflammatory action. as-2444697 potently inhibits human and rat irak-4 activity.
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