9月
Daphylloside；化合物 T4395Daphylloside (2024/9/8)
簡介：daphylloside, and asperuloside can be suggested as endoplasmic reticulum stress regulators.
Methyl Isoferulate；異阿魏酸甲酯Methyl Isoferulate (2024/9/8)
簡介：this product is isolated and purified from the leaves of phyllostachys heterocycla
MS049 2HCl (1502816-23-0(free base))；化合物MS049 2HClMS049 2HCl (1502816-23-0(free base)) (2024/9/8)
簡介：ms049 is a potent and selective inhibitor of prmt4 (ic50 = 34 nm) and prmt6 (ic50 = 43 nm). it is less active against additional type i prmts (ic50s = >130, >220, and 1.6 μm for prmt1, prmt3, and prmt8, respectively) and displays no inhibition against type ii or type iii prmts nor any additional methyltransferases or nonepigenetic targets tested.
Syk Inhibitor II dihydrochloride；化合物Syk Inhibitor II (hydrochloride)Syk Inhibitor II (hydrochloride) (2024/9/8)
簡介：spleen tyrosine kinase (syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of fcrγ chains and mediates downstream signaling related to platelet function and inflammation. syk inhibitor ii is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks syk (ic50 = 41 nm) in an atp-competitive manner. it is much less potent against pkcε, pkcβii, zap-70, btk, and itk (ic50s = 5.1, 11, 11.2, 15.5, an
ML221；化合物ML221ML221 (2024/9/8)
簡介：ml221 is a potent apelin /apj functional antagonist, inhibiting apelin-13-mediated activation of apj, with ic50s of 0.70 μm in the camp assay, and 1.75 μm in the β-arrestin assay, and ec80 of 10 nm in both assays.
SR-4370；化合物SR4370SR 4370；SR 4370 (2024/9/8)
簡介：sr-4370 is an hdac inhibitor. sr- 4370 exhibited ic50 values of 0.5 μm, 0.1 μm and 0.06 μm towards hdac1, hdac2 and hdac3, resp.
PHTPP；化合物PHTPPPHTPP (2024/9/8)
簡介：phtpp is a selective erβ antagonist.
evobrutinib；化合物evobrutinibMSC2364447C|||M2951；MSC2364447C|||M2951 (2024/9/8)
簡介：evobrutinib(m2951) , also known as m-2951 and msc-2364447c, is a highly selective inhibitor of the bruton´s tyrosine kinase (btk), which is important in the development and functioning of various immune cells including b -lymphocytes and macrophages. preclinical research suggests it may be therapeutically useful in certain autoimmune diseases.
PZM21；化合物PZM21PZM21 (2024/9/8)
簡介：pzm21 is an effective and selective μ opioid receptor agonist (ec50: 1.8 nm).
PF-4840154；化合物PF4840154PF-4840154 (2024/9/8)
簡介：pf-4840154 is a potent, selective agonist of the rat and human trpa1 channel and elicited trpa1-mediated nocifensive behaviour in mouse, with ec50 of 97 nm and 23 nm for rtrpa1 and htrpa1, respectively.
Halofenozide；氯蟲酰肼Halofenozide (2024/9/8)
簡介：halofenozide is an ecdysteroid agonist and used as a pesticide.
GSK-J4 Hydrochloride；化合物GSK-J4 HydrochlorideGSK J4 HCl|||GSK J4 HCl (1373423-53-0 free base)；GSK J4 (2024/9/8)
簡介：gsk-j4 hydrochloride (gsk j4 hcl) is a cell permeable, potent and selective histone demethylase(jmjd3 )inhibitor. is an ethyl ester derivative of the gsk-j1 with an ic50 value greater than 50 μm in vitro.
Proguanil hydrochloride；鹽酸氯胍Paludrine hydrochloride|||Chlorguanide hydrochloride|||Chloroquanil；Palu (2024/9/8)
簡介：proguanil hydrochloride (chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.upon hydrolysis, proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome p450 dependent reaction. cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking dna and protein synthesis
Lificiguat；利非西呱YC-1；利非西呱|||YC-1 (2024/9/8)
簡介：lificiguat (yc-1) is an nitric oxide (no)-independent activator of soluble guanylyl cyclase(sgc) and an inhibitor of hypoxia-inducible factor-1alpha (hif-1alpha).
Ac-CoA Synthase Inhibitor1；化合物Ac-CoA Synthase Inhibitor1ACSS2 inhibitor；ACSS2 inhibitor (2024/9/8)
簡介：ac-coa synthase inhibitor1 (acss2 inhibitor) is the most potent and specific inhibitor of acetate-dependent acetyl-coa synthetase 2 (acss2).
Tropifexor；化合物TropifexorLJN452；LJN452 (2024/9/8)
簡介：tropifexor (ljn452) is a novel and highly potent agonist of fxr with an ec50 of 0.2 nm.
MS049；化合物MS049MS-049|||arginine|||Histone Methyltransferase|||MS 049|||HEK293|||dimethylation|||MS 0 (2024/9/8)
簡介：ms 049 is a potent, selective, and cell-active dual inhibitor of prmt4 and prmt6 with ic 50 of 34 nm and 43 nm, respectively.
Pimodivir HCl；化合物 T4377LPimodivir hydrochloride hemihydrate|||Pimodivir hydrochloride；Pimodivir hydr (2024/9/8)
簡介：pimodivir is an inhibitor of influenza virus replication that blocks the pb2 cap-snatching activity of the influenza viral polymerase complex. the cell-based ec50 for vx-787 is 1.6 nm in a cytopathic effect (cpe) assay. vx-787 is active against a diverse panel of influenza a virus strains.
Pimodivir；化合物PimodivirVX-787；VX-787 (2024/9/8)
簡介：pimodivir (vx-787), an influenza a virus polymerases inhibitor via oral, interacts with the viral pb2 subunit.
Nampt-IN-1；化合物Nampt-IN-1LSN3154567；LSN3154567 (2024/9/8)
簡介：nampt-in-1 (lsn3154567) (lsn3154567) is a potent and selective nampt inhibitor. nampt-in-1 inhibits purified nampt with an ic50 of 3.1 nm.
Methiothepin maleate；甲替平Metitepine；Metitepine|||甲替平 (2024/9/8)
簡介：methiothepin maleate (metitepine) is a 5-ht1, 5-ht6, 5-ht7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
Edoxudine；乙去氧尿啶Aedurid|||EUDR|||Epoxudine；依度尿苷|||Aedurid|||EUDR|||Epoxudine|||乙去氧尿啶 (2024/9/8)
簡介：edoxudine (epoxudine), an antiviral drug, is an analogue of thymidine and shows effectiveness against the herpes simplex virus. edoxudine is used as a 5-fluorouracil (fu) modulator. edoxudine may be used to enhance the therapeutic index of 5-fu by reducing the catabolism, prolonging the plasma and intratumoral concentrations of 5-fu, and offering protection to normal organs by increasing the endogenous uridine levels. it can also enhance the antitumour action of 5-fu.
Brassinin；蕓苔寧BSN；BSN|||蕓苔寧 (2024/9/8)
簡介：brassinin (bsn) (bsn) is a phytoalexin isolated from b. campestris that exhibits anticancer, chemopreventative, antiproliferative, and antifungal activities.
CD4376-[3-(1-金剛烷基)-4-羥基苯基]-2-萘甲酸AHPN|||O-Desmethyl Adapalene|||6-[3-(1-金剛烷基)-4-羥基苯基]-2-萘甲酸|||Apoptos (2024/9/8)
簡介：cd437 (ahpn) is a specifc retinoic acid receptor γ (rarγ) agonist.
Resminostat hydrochloride；化合物Resminostat hydrochloride4SC-201 hydrochloride|||RAS2410 hydrochloride； (2024/9/8)
簡介：resminostat hydrochloride (ras2410 hydrochloride) is an effective inhibitor of hdac1/hdac3/hdac6 (ic50: 42.5/50.1/71.8 nm), respectively, and shows less potent activities against hdac8 (ic50: 877 nm).
SCH-23390 hydrochloride；化合物SCH 23390 hydrochlorideR-(+)-SCH23390 hydrochloride；R-(+)-SCH23390 hydroc (2024/9/8)
簡介：sch-23390 hydrochloride (r-(+)-sch23390 hydrochloride) is an effective dopamine receptor antagonist, and for the d1(ki=0.2 nm) and d5(ki=0.3 nm).
Miriplatin；米鉑SM-11355；米鉑|||SM-11355 (2024/9/8)
簡介：miriplatin (sm-11355) (sm-11355) is a platinum complex used in tace that has promise for the therapy of hepatocellular carcinoma (hcc).
Mycro 3；化合物Mycro-3Mycro-3；Mycro-3 (2024/9/8)
簡介：mycro 3 is potent and selective for c-myc in whole cell assays.
Quinovic acid；化合物 T4366Quinovic acid (2024/9/8)
簡介：quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by inducing apoptosis through modulation of nf-?ob.
FL-411；化合物FL411FL 411|||FL411|||BRD4-IN-1；FL 411|||FL411|||BRD4-IN-1 (2024/9/8)
簡介：fl-411 (brd4-in-1) is a potent and selective brd4 inhibitor with an ic50 of 0.43±0.09 μm for brd4.
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