9月
PF-06409577；化合物PF06409577PF 06409577；PF 06409577 (2024/9/8)
簡(jiǎn)介：pf-06409577 is an effective, orally active, and specific allosteric activator of ampk (ec50: 7 nm, for α1β1γ1).
CEP-40783；化合物CEP40783CEP 40783|||RXDX-106；CEP 40783|||RXDX-106 (2024/9/8)
簡(jiǎn)介：cep-40783 (rxdx-106) is an effective, specific and orally active axl/c-met inhibitor (ic50: 7/12 nm). it also inhibits mer and tyro3 (ic50: 29/19 nm).
JK-P3；化合物JK-P3JK-P3 (2024/9/8)
簡(jiǎn)介：jk-p3 is a pyrazole-based inhibitor of vegfr-2 (ic50: 7.8 μm). jk-p3 inhibits fgfr 1/3 kinase activity in vitro, but has no effect on fgfr signaling in cell-based assays. the compound blocks wound healing and tube formation in huvec without effecting endothelial cell proliferation.
SLV-2436；化合物SLV2436SEL-201|||SLV 2436|||SEL201-88；SEL-201|||SLV 2436|||SEL201-88 (2024/9/8)
簡(jiǎn)介：slv-2436 (sel201-88) is a novel effective and atp-competitive inhibitor of mnk1 and mnk2 (ic50: 10.8/5.4 nm).
LY 303511 hydrochloride；化合物L(fēng)Y303511 hydrochlorideLY303511 hydrochloride；LY303511 hydrochloride (2024/9/8)
簡(jiǎn)介：ly 303511 hydrochloride is a potent mtor inhibitor
Edonerpic maleate化合物Edonerpic maleateT-817MA|||T-817 maleate (2024/9/8)
簡(jiǎn)介：edonerpic maleate (t-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (aβ).
4-Hydroxytamoxifen；4-羥基他莫昔芬ICI 79280|||(Z)-4-hydroxy Tamoxifen|||trans-4-Hydroxytamoxifen；ICI 79280| (2024/9/8)
簡(jiǎn)介：4-hydroxytamoxifen (ici 79280) is the active metabolite of tamoxifen, an estrogen receptor modulator (serm) with selective and oral potency. 4-hydroxytamoxifen has antitumor activity and may be used in breast cancer research.
UNC2025 2HCl (1429881-91-3(free base))；化合物UNC2025 2HClUNC2025 2HCl (1429881-91-3(free base)) (2024/9/8)
簡(jiǎn)介：unc2025 is a potent and orally bioavailable mer/flt3 dual inhibitor with ic50 of 0.8/0.74 nm for mer/flt3.
GSK2879552 2HCl (1401966-69-5(free base))；化合物GSK2879552 2HClGSK2879552 2HCl (1401966-69-5(free base) (2024/9/8)
簡(jiǎn)介：gsk2879552 is an orally available, irreversible inhibitor of lysine specific demethylase 1 (lsd1), with potential antineoplastic activity.
LDC-4297 HCl (1453834-21-3(free base))；化合物L(fēng)DC-4297 HClLDC-4297 HCl (1453834-21-3(free base)) (2024/9/8)
簡(jiǎn)介：ldc4297 is a potent and selective cdk7 inhibitor with an ic50 of 0.13 nm.
Vinaginsenoside R3越南參皂苷 R3越南參皂苷 R3 (2024/9/8)
簡(jiǎn)介：vinaginsenoside r3 is a natural product of panax, araliaceae. the catalog number is t4416 and the cas number is 156012-92-9. vinaginsenoside r3 can be used as a reference standard.
Katacine；化合物KatacineKatacine (2024/9/8)
簡(jiǎn)介：katacine inhibits of oxygen consumption and suppresses the speed of electrons transfer from oxidation substrates via respiratory chain of mitochondria to molecular oxygen.katacine is a mixture of polymers of a-type proanthocyanidins at various stages of polymerisation , from polygonum coriarium of the polygonaceae family. katacine is an antihypoxic.
Eprenetapopt；化合物PRIMA-1MetAPR-246|||PRIMA-1Met；APR-246|||PRIMA-1Met (2024/9/8)
簡(jiǎn)介：eprenetapopt (prima-1met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. prima-1met also targets the selenoprotein thioredoxin reductase 1 (trxr1), a key regulator of cellular redox balance.
Poseltinib；化合物 T4413Poseltinib (2024/9/8)
簡(jiǎn)介：poseltinib is an orally active, selective, and irreversible bruton´s tyrosine kinase (btk) inhibitor, exhibiting a half-maximal inhibitory concentration (ic 50) of 1.95 nm. it demonstrates 0.3, 2.3, and 2.4-fold greater selectivity for btk over bmx, tec, and txk, respectively. this compound covalently binds to btk´s active site at the cysteine 481 residue, effectively inhibiting signaling pathways mediated by the b cell receptor (bcr), fc receptor (fcr), and toll-like receptor (tlr).
Roquinimex；羅喹美克Linomide|||LS2616|||FCF89|||ABR212616；Linomide|||羅喹美克|||LS2616|||FCF89|||ABR212616 (2024/9/8)
簡(jiǎn)介：roquinimex (fcf89) (linomide) is a quinoline derivative immunostimulant which increases nk cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of tnf alpha.
DAMGO TFA (78123-71-4(Free base))；化合物DAMGO TFADAMGO TFA (78123-71-4(Free base)) (2024/9/8)
簡(jiǎn)介：potent, selective agonist of mu-opioid receptor. antinociceptive. stimulates calcium-activated adenylyl cyclases related camp production. expresses chemokines and chemokine receptors through tgf-beta1. increases food intake of rats.
LM10；化合物L(fēng)M10LM10 (2024/9/8)
簡(jiǎn)介：selective tryptophan 2, 3-dioxygenase (tdo) inhibitor (ic50 values are 0.62 and 2 μm for human and mouse tdo, respectively). exhibits selectivity for tdo over ido, mao-a, mao-b, and a panel of receptors and transporters. reduces growth of tdo-expressing p815 mastocytoma tumors in mice. orally bioavailable.
Gilteritinib；吉列替尼ASP2215；吉列替尼|||ASP2215 (2024/9/8)
簡(jiǎn)介：gilteritinib (asp2215) is a flt3 inhibitor (ic50=0.29 nm) and an axl inhibitor (ic50=0.73 nm) with atp-competitive, selective, and oral activity. gilteritinib exhibits antitumor activity and can be used to treat flt3 mutation-positive aml.
Elafibranor；化合物ElafibranorGFT505；GFT505 (2024/9/8)
簡(jiǎn)介：elafibranor (gft505) is an agonist of the peroxisome proliferator-activated receptor-α (ppar-α) and peroxisome proliferator-activated receptor-δ (ppar-δ) with ec50 values of 45 and 175 nm, respectively.
SR17018；化合物SR17018SR17018 (2024/9/8)
簡(jiǎn)介：sr17018 is an mu-opioid-receptor (mor) agonist, binding with gtpγs, with an ec50 of 97 nm.
2,6-Dimethylbenzoquinone；2,6-二甲基苯醌m-Xyloquinone|||2,6-Dimethylquinone；m-Xyloquinone|||2,6-二甲基苯醌|||2, (2024/9/8)
簡(jiǎn)介：2,6-dimethylbenzoquinone (2,6-dimethylquinone) is a benzoquinone, a chemical compound found in rauvolfia vomitoria and in tibouchina pulchra.at physiological concentrations 2, 6-dimethoxy-p-benzoquinone is an antibacterial substance
Ceftibuten dihydrate；頭孢布烯二水合物Sch-39720 dihydrate；頭孢布烯二水合物|||Sch-39720 dihydrate (2024/9/8)
簡(jiǎn)介：ceftibuten dihydrate (sch-39720 dihydrate) is the dihydrate form of ceftibuten, and is a third-generation cephalosporin with antibacterial activity.
Methyl 2-(Boc-aMino)-2-(oxetan-3-yl)acetate化合物T44042 - {[(叔丁氧基)羰基]氨基} -2-(氧雜環(huán)丁烷-3-基)乙酸甲酯 (2024/9/8)
簡(jiǎn)介：methyl 2-(boc-amino)-2-(oxetan-3-yl)acetate can be used as a building block for the synthesis of various biologically active molecules such as peptides, proteins, and nucleic acids.
AX-024 hydrochloride；化合物AX-024 HClAX-024 HCl；AX-024 HCl (2024/9/8)
簡(jiǎn)介：ax-024 hydrochloride (ax-024 hcl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (il-6), tumor necrosis factor-α (tnfα), interferon-γ (ifn-γ), il-10 and il-17a.
(4-Chloro-thiazol-2-yl)acetic acid；(4-氯噻唑-2-基)乙酸(4-Chloro-thiazol-2-yl)acetic acid (2024/9/8)
簡(jiǎn)介：(4-chloro-thiazol-2-yl)acetic acid has been used in a variety of scientific research applications, including protein folding, enzyme inhibition and signal transduction.
DIM-C-pPhOH；化合物DIM-C-pPhOHCDIM8；CDIM8 (2024/9/8)
簡(jiǎn)介：dim-c-pphoh (cdim8) is a nur77 (nr4a1) antagonist,inhibits tgf-β induced cell migration of breast cancer cell lines,promotes ros/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines,mimics effects of nur77 rnai silencing.
ML239；化合物ML239CID-49843203；CID-49843203 (2024/9/8)
簡(jiǎn)介：ml239 (cid-49843203) is a potent and selective inhibitor of breast cancer stem cells, with an ic50 of 1.16 μm.
LX2343；化合物L(fēng)X2343LX2343 (2024/9/8)
簡(jiǎn)介：lx2343 is a bace1 enzyme inhibitor with an ic50 value of 11.43±0.36 μm. lx2343 acts as a non-atp competitive pi3k inhibitor with an ic50 of 15.99±3.23 μm. lx2343 stimulates autophagy in its promotion of aβ clearance.
DIM-C-pPhOCH3化合物DIM-C-pPhOCH3C-DIM5 (2024/9/8)
簡(jiǎn)介：dim-c-pphoch3 (c-dim5) is a nerve growth factor-induced bα (ngfi-bα, nur77) agonist
Officinalisinin I；新知母皂苷BIIOfficinalisinin I (2024/9/8)
簡(jiǎn)介：officinalisinin i can effectively reduce the blood glucose and protect nerve injuryin diabetic mice.
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