9月
SPR206 acetate；SPR206 acetateSPR206 acetate (2024/9/8)
簡介：spr206 acetate is a polymyxin analog that exhibits antibiotic activity against gram-negative pathogens, including multidrug-resistant (mdr) variants. by interacting with the outer membrane of the bacterium, spr206 acetate effectively combats bacterial infections. notably, spr206 acetate demonstrates significant efficacy with minimum inhibitory concentration (mic) values of 0.125 mg/l against pseudomonas aeruginosa pa14 and acinetobacter baumannii nctc13301.
DGK-IN-1；DGK-IN-1DGK-IN-1 (2024/9/8)
簡介：dgk-in-1, an extracted t cell activator, holds potential in leveraging tumor immunity.
(±)-ErSO(±)-ErSO(±)ErSO|||(±) ErSO (2024/9/8)
簡介：(±)-erso is the racemic form of erso. erso is a selective anticipatory activator of the unfolded protein response (a-upr).
ErSO；化合物ErSOErSO (2024/9/8)
簡介：erso is a selective activator of anticipatory unfolded protein response (upr) via erα receptor. erso can be used in studies about anti-cancer.
Itacitinib；伊他替尼INCB39110|||INCB039110；伊他替尼|||INCB39110|||INCB039110 (2024/9/8)
簡介：itacitinib (incb039110) is an orally bioavailable inhibitor of janus-associated kinase 1 (jak1) with potential antineoplastic activity.
(S)-ErSO；化合物(S)-ErSO(S)-ErSO (2024/9/8)
簡介：(s)-erso is an inactive dextrorotatory enantiomer of erso.
Dimethyl-F-OICR-9429-COOH；Dimethyl-F-OICR-9429-COOHDimethyl-F-OICR-9429-COOH (2024/9/8)
簡介：dimethyl-f-oicr-9429-cooh, a ligand for wd40 repeat domain protein 5 (wdr5). this compound is utilized as a key component in the synthesis of protacs.
6-Azathymine acid；6-Azathymine acid6-Azathymine acid (2024/9/8)
簡介：6-azathymine acid is a metabolite derived from pymetrozine, a potent insecticide known for its effectiveness against plant-sucking insects, specifically aphids and whiteflies. pymetrozine´s neuroactivity disrupts the feeding behavior of these pests, making it a valuable tool in protecting various crops, including vegetables, cotton, field crops, and fruits.
Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite；Propargyl-PEG3-1-o-(b-cyanoethyl-N, (2024/9/8)
簡介：propargyl-peg3-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a polyethylene glycol-based protac linker employed in protac synthesis.
Hydroxy-PEG3-MS；Hydroxy-PEG3-MSHydroxy-PEG3-MS；Hydroxy-PEG3-MS (2024/9/8)
簡介：hydroxy-peg3-ms is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
BM-1197；BM-1197BM-1197 (2024/9/8)
簡介：bm-1197, a highly potent and specific dual inhibitor of bcl-2 and bcl-xl, effectively targets these proteins with ic50 values of 3.5 nm and 5.2 nm for bcl-2 and bcl-xl, respectively. this compound demonstrates notable antitumor activity in both in vitro and in vivo settings.
Vaccarin；王不留行黃酮苷Vaccarin (2024/9/8)
簡介：vaccarin is a major flavonoid glycoside in vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation.
Loperamide phenyl；Loperamide phenylLoperamide phenyl (2024/9/8)
簡介：loperamide phenyl, an impurity detected in loperamide, is an opioid receptor agonist.
Cyclamic acid sodium；甜蜜素Cyclohexylsulfamicacidsodium|||Sodiumcyclamate；Cyclohexylsulfamicacidsodium| (2024/9/8)
簡介：cyclamic acid sodium (cyclohexylsulfamicacidsodium) is a carbonic anhydrase inhibitor and one of the most widely used artificial sweeteners in food and pharmaceuticals.cyclamic acid sodium shows moderate anticonvulsant activity in a maximal electroshock convulsive seizure model.cyclamic acid sodium is used in cancer research.
[Lys8, Lys9]-Neurotensin (8-13) acetate；化合物[Lys8, Lys9]-Neurotensin (8-13) acetate[Lys8, Lys9]-Neuro (2024/9/8)
簡介：[lys8, lys9]-neurotensin (8-13) acetate, a neurotensin analog, exerts its analgesic effects through activation of the g protein-coupled receptors nts1 and nts2, with ki values of 0.33 nm and 0.95 nm for hnts1 and hnts2 receptors, respectively[1].
[Lys8, Lys9]-Neurotensin (8-13)；[Lys8, Lys9]-Neurotensin (8-13)JMV438|||[Lys8, Lys9]-Neurotensin (8- (2024/9/8)
簡介：[lys8, lys9]-neurotensin (8-13) (jmv438) is a neurotensin analog that elicits analgesic effects by activating the g protein-coupled receptors nts1 and nts2. the compound has k i values of 0.33 nm and 0.95 nm for hnts1 and hnts2 receptors, respectively.
Pasakbumin D；Pasakbumin D13β,21-Dihydroxyeurycomanone；13β,21-Dihydroxyeurycomanone (2024/9/8)
簡介：pasakbumin d is a quassinoid and can be used for the research of cancer.
Euphol acetate；Euphol acetateEuphol acetate (2024/9/8)
簡介：euphol acetate, a triterpene found in euphorbia broteri, has demonstrated inhibitory effects on the hepatic transport proteins known as organic anion-transporting polypeptide 1/3 (oatp1b1/3).
Patisiran sodium；Patisiran sodiumPatisiran sodium (2024/9/8)
簡介：patisiran sodium is a double-stranded small interfering rna (sirna) that selectively targets a specific sequence within the transthyretin (ttr) messenger rna (mrna). by doing so, it effectively blocks the hepatic synthesis of both mutant and wild-type ttr. patisiran sodium has significant applications in the field of hereditary ttr amyloidosis research.
TrimethobenzamideTrimethobenzamideRo 2-9578 free base|||Trimethobenzamide (2024/9/8)
簡介：trimethobenzamide (ro 2-9578 free base) is a d2 receptor antagonist and an antiemetic agent. primarily utilized to mitigate the occurrence of nausea and vomiting, trimethobenzamide effectively blocks the d2 receptor.
Fobrepodacin；FobrepodacinSPR720|||pVXc-486；SPR720|||pVXc-486 (2024/9/8)
簡介：fobrepodacin (spr720) is an orally active and potent phosphate prodrug of spr719 (vxc-486). fobrepodacin has potent bactericidal activities in vivo.
MMPI-1154；MMPI-1154MMPI-1154 (2024/9/8)
簡介：mmpi-1154 is a highly promising imidazole-carboxylic acid (ica) mmp-2 inhibitor (ic 50 = 6.6 μm) with excellent cardio-cytoprotective properties. it is specifically designed for the study of acute myocardial infarction. additionally, mmpi-1154 exhibits significant inhibitory effects on mmp-13, mmp-1, and mmp-9 activities with ic 50 values of 1.8 μm, 10 μm, and 13 μm, respectively.
Silydianin；水飛薊寧Silidianin；水飛薊寧|||Silidianin (2024/9/8)
簡介：silydianin (silidianin) exerts inhibition of ugt in human liver. silydianin exerts inhibition of oatp1b1, oatp1b3 (unknown origin) expressed in hek293 cells. silydianin exerts inhibition of oatp2b1 (unknown origin) expressed in mdck2 cells.
Mal-PFP ester；Mal-PFP esterMal-PFP ester (2024/9/8)
簡介：mal-pfp ester is a alkyl/ether-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
MBP MAPK Substrate acetate；化合物MBP MAPK Substrate acetateMBP MAPK Substrate acetate(138028-00-9 free (2024/9/8)
簡介：mbp mapk substrate acetate can be used as an exogenous substrate for mapk.
MBP MAPK Substrate；MBP MAPK SubstrateMBP MAPK Substrate (2024/9/8)
簡介：mbp mapk substrate is used as an exogenous substrate for mapk.
Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochloride；Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochlorideSuc-Ile-Glu (2024/9/8)
簡介：suc-ile-glu(γ-pip)-gly-arg-pna hydrochloride is a chromogenic substrate specifically designed for factor xa.
LLO (91-99) acetate；化合物LLO (91-99) acetateLLO (91-99) acetate(137856-41-8 free base)；LLO (91-99) ace (2024/9/8)
簡介：llo (91-99) acetate is an exotoxin and a class i mhc-restricted t-cell epitopes of listeriolysin. llo (91-99) acetate is essential for the induction of t-cell mediated immunity in vivo.
LLO (91-99)；LLO (91-99)LLO (91-99)|||Listeriolysin O (91-99)；LLO (91-99)|||Listeriolysin O (91-99) (2024/9/8)
簡介：llo (91-99), also known as listeriolysin o (91-99), is a class i mhc-restricted t-cell epitope derived from listeriolysin (llo), an exotoxin. it plays a vital role as an antigen in the induction of t-cell mediated immunity in vivo.
THI0019；THI0019THI0019；THI0019 (2024/9/8)
簡介：thi0019 is a highly potent agonist of the integrin α4β1 (vla-4) receptor, with an ec 50 range of 1-2 μm. it effectively promotes the adhesion of stem/progenitor cells. furthermore, thi0019 successfully modulates adhesion processes mediated by α4β7, α5β1, and αlβ2 integrins.
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