9月
LY3027788LY3027788LY3027788 (2024/9/8)
簡介：ly3027788, a diester analog of ly3020371, an mglu2/3 receptor antagonist, is a highly potent and orally active prodrug of ly3020371. notably, ly3027788 exhibits significant antidepressant efficacy.
LY3020371；LY3020371LY3020371 (2024/9/8)
簡介：ly3020371 is a highly potent and selective antagonist targeting the glutamate (mglu) 2/3 receptor, showcasing excellent inhibition at ki values of 5.26 nm and 2.50 nm for hmglur2 and hmglur3, respectively. with its remarkable affinity and specificity, ly3020371 serves as a valuable tool in depression research.
LY3027788 hydrochloride；LY3027788 hydrochlorideLY3027788 hydrochloride (2024/9/8)
簡介：ly3027788 hydrochloride is a diester analog of ly3020371, a selective antagonist of the metabotropic glutamate 2 and 3 receptors (mglu2/3). it serves as a highly potent and orally bioavailable prodrug of ly3020371. notably, ly3027788 hydrochloride exhibits antidepressant efficacy.
Silychristin；水飛薊汀Silicristin；水飛薊亭|||水飛薊汀|||Silicristin (2024/9/8)
簡介：silychristin (silicristin) is a plant growth regulator. silychristin is an anti-hepatotoxic agent. silychristin is the inhibitor of horseradish peroxidases and lipoxygenase.
BMS-984923；BMS-984923BMS-984923 (2024/9/8)
簡介：bms-984923, a highly potent silent allosteric modulator (sam) of mglur5, demonstrates exceptional binding affinity (k i = 0.6 nm). additionally, this compound possesses favorable oral bioavailability and blood-brain barrier (bbb) penetration. bms-984923 effectively inhibits the interaction between prpc and mglur5, preventing pathological aβo signaling, while leaving physiological glutamate signaling unaffected.
MC-DM1；MC-DM1MC-DM1；MC-DM1 (2024/9/8)
簡介：mc-dm1 is a drug-linker conjugate composed of a potent microtubule-disrupting agent dm1 and a linker mc to make antibody drug conjugate (adc).
ER176；ER176ER176 (2024/9/8)
簡介：er176 is a novel pet radioligand utilized for the visualization of 18 kda translocator protein (tspo), a neuroinflammation biomarker, marking the advancement in imaging technology.
Nω-Propyl-L-arginine；Nω-Propyl-L-arginineN-omega-Propyl-L-arginine|||Nω-Propyl-L-arginine；N-omega-Pr (2024/9/8)
簡介：nω-propyl-l-arginine, a powerful and specific inhibitor of neuronal nitric oxide synthase (nnos), effectively inhibits nnos with a ki of 57 nm. it exhibits a remarkable 149-fold selectivity for nnos over endothelial nos (enos).
Histone H3 (21-44)；Histone H3 (21-44)Histone H3 (21-44)；Histone H3 (21-44) (2024/9/8)
簡介：histone h3 (21-44), derived from a sequence of 21-44 amino acids of histone h3, is commonly employed as a substrate, particularly for protein arginine methyltransferase assays, where methylation activity is being examined.
Histone H3 (1-25), amide；Histone H3 (1-25), amideHistone H3 (1-25), amide；Histone H3 (1-25), amide (2024/9/8)
簡介：histone h3 (1-25), amide is a n-terminal peptide fragment of histone h3 that serves as a substrate for histone methyltransferases (hmts). it can be utilized to identify the substrate for hmts. compared to histone h3 (15-39) and full-length histone h3, histone h3 (1-25), amide proves to be more efficient as a substrate for hmt g9a.
DOTA-tri(t-butyl ester)；DOTA-tri(t-butyl ester)DOTA-tri(t-butyl ester)|||DOTA tri(t butyl ester)|||D (2024/9/8)
簡介：dota-tri(t-butyl ester) is a versatile compound employed for the synthesis of third-generation (g3) nanoglobular magnetic resonance imaging (mri) contrast agents. these contrast agents find application in the fields of mr angiography and tumor angiogenesis imaging.
Mant-GTPγS；Mant-GTPγSMant-GTPγS (2024/9/8)
簡介：mant-gtpγs, an effective gtp analog, displays strong competitive inhibition of adenylyl cyclase (ac). additionally, it acts as a potent inhibitor of ydeh.
3,5-Dichlorocatechol；3,5-二氯鄰苯二酚3,5-Dichlorocatechol (2024/9/8)
簡介：3,5-dichlorocatechol serves as a substrate for the broad-spectrum chlorocatechol 1,2-dioxygenase found in pseudomonas chlororaphis rw71.
GSK2332255B；GSK2332255BGSK2332255B (2024/9/8)
簡介：gsk2332255b is a highly potent and selective trpc3 and trpc6 antagonist, exhibiting ic50 values of 5 nm and 4 nm for rat trpc3 and rat trpc6, respectively. furthermore, gsk2332255b demonstrates exceptional selectivity, surpassing a ≥100-fold difference when compared to other calcium-permeable channels.
簡介：raddeanin a (nsc-382873) has moderate inhibitory activity against histone deacetylases (hdacs). raddeanin a has high antiangiogenic potency, antitumor activity.
NS-102；NS-102NS-102 (2024/9/8)
簡介：ns-102 is a powerful and selective antagonist of the kainate receptor (gluk2), as well as a potent antagonist of the glur6/7 receptor.
DB2115 tertahydrochloride；DB2115 tertahydrochlorideDB2115 tertahydrochloride；DB2115 tertahydrochlori (2024/9/8)
簡介：db2115 (tertahydrochloride) is a powerful inhibitor of the myeloid master regulator pu.1. with significant potential in cancer research, particularly hematologic cancers like leukemia, as well as other conditions linked to pu.1 dysfunction, db2115 (tertahydrochloride) offers promising avenues of study.
Ilexoside O；冬青苷OIlexoside O (2024/9/8)
簡介：ilexoside o, a triterpene saponin derived from ilex pubescens roots, demonstrates modest inhibition of xanthine oxidase (xod) activity with an ic50 value of 53.05 μm.
LP-922056；化合物L(fēng)P-922056LP-922056 (2024/9/8)
簡介：lp-922056 is an inhibitor of notum pectinacetylesterase with ec50 values of 21 nm, 55 nm for human and mouse, respectively.
LeuRS-IN-1；LeuRS-IN-1LeuRS-IN-1 (2024/9/8)
簡介：leurs-in-1 is a highly potent and orally active inhibitor of the leucyl-trna synthetase enzyme derived from mycobacterium tuberculosis (m.tb leurs). it exhibits significant inhibitory activity against m.tb leurs with ic 50 and kd values of 0.06 μm and 0.075 μm, respectively. additionally, leurs-in-1 effectively inhibits human cytoplasmic leurs with an ic 50 value of 38.8 μm and suppresses protein synthesis in hepg2 cells with an ec 50 value of 19.6 μm.
E67-2E67-2E67-2 (2024/9/8)
簡介：e67-2, a derivative of e67, is a low-toxicity, selective inhibitor of the kiaa1718 jumonji domain. it has an ic 50 value of 3.4 μm. e67-2 specifically inhibits the jumonji demethylase for histone h3 lysine 9 (h3k9) and histone h3 lysine 4 (h3k4) demethylase.
LeuRS-IN-1 hydrochloride；LeuRS-IN-1 hydrochlorideLeuRS-IN-1 hydrochloride (2024/9/8)
簡介：leurs-in-1 hydrochloride is a potent and orally active inhibitor of m. tuberculosis leucyl-trna synthetase (m.tb leurs). it has ic 50 and kd values of 0.06 μm and 0.075 μm, respectively, for m.tb leurs. additionally, leurs-in-1 hydrochloride inhibits human cytoplasmic leurs with an ic 50 of 38.8 μm and hepg2 protein synthesis with an ec 50 of 19.6 μm.
I-PEG6-OH；I-PEG6-OHI-PEG6-OH；I-PEG6-OH (2024/9/8)
簡介：i-peg6-oh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Guanylate cyclase-IN-1；Guanylate cyclase-IN-1Guanylate cyclase-IN-1 (2024/9/8)
簡介：guanylate cyclase-in-1 (example 46) is a specific inhibitor of guanylate cyclase, employed in research related to cardiovascular diseases.
Esculentoside A；商陸皂苷甲Esculentoside A (2024/9/8)
簡介：esculentoside a can suppress inflammatory responses in lps-induced ali through inhibition of the nf-κb and mitogen-activated protein kinase signaling pathways. esculentoside a may be useful for the treatment of autoimmune disease through modulation on t cell-mediated adaptive immunity. esculentoside a may play significant roles in the treatment of bxsb mice through modulation of inflammatory cytokines, inhibition of renal cell proliferation and induction of apoptosis.
Quebecol；QuebecolQuebecol (2024/9/8)
簡介：quebecol is a nutraceutical agent against periodontitis.
Ocedurenone；OcedurenoneOcedurenone (2024/9/8)
簡介：ocedurenone, a corticosteroid receptor antagonist, is a compound utilized in the investigation of kidney disease (wo2018054357, compound i).
MRT-83 hydrochloride；MRT-83 hydrochlorideMRT-83 hydrochloride (2024/9/8)
簡介：mrt-83 (hydrochloride) is a potent antagonist of the smoothened (smo) receptor, effectively inhibiting the hedgehog (hh) signaling pathway and bodipy-cyclopamine binding to human smo. with its potential applications in the study of cancer disease, mrt-83 (hydrochloride) demonstrates promising prospects for research purposes.
Histone H3 (1-35) acetate；化合物Histone H3 (1-35) acetateHistone H3 (1-35) acetate (2024/9/8)
簡介：histone h3 (1-35) acetate is a 35-residue peptide of histone h3. histone h3 is an important protein that plays a role in the dynamic and long term regulation of genes.
Histone H3 (1-35)；Histone H3 (1-35)Histone H3 (1-35)；Histone H3 (1-35) (2024/9/8)
簡介：histone h3 (1-35) is a 35-residue peptide derived from histone h3, which is a key member of the five main histones participating in the formation of chromatin within eukaryotic cells.
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