9月
O-Acetyl-L-serine hydrochloride；O-乙酰-L-絲氨酸鹽酸鹽O-Acetyl-L-serine hydrochloride (2024/9/8)
簡介：o-acetylserine (oass) is an acylated amino acid derivative. it is an intermediate in the biosynthesis of the common amino acid cysteine in bacteria and plants. its presence in humans arises from either microbial metabolism in the gut or through consumption of foods containing oass.
β-Nicotinamide mononucleotide；煙酰胺單核苷酸NMN|||β-NM；NMN|||β-NM|||β煙酰胺單核苷酸|||煙酰胺單核苷酸 (2024/9/8)
簡介：β-nicotinamide mononucleotide (β-nm) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for nad biosynthesis. instead of the deamidation to nicotinic acid, nicotinamide is directly converted to β-nicotinamide mononucleotide by nicotinamide phosphoribosyltransferase (nampt, ec 2.4.2.12). the enzyme nicotinamide mononucleotide adenylyltransferase (nmnat, ec 2.7.7.1), which i
6-Hydroxypyridin-2(1H)-one hydrochloride；2,6-二羥基吡啶鹽酸鹽2,6-Dihydroxypyridine hydrochloride；2,6-二羥基吡啶鹽酸 (2024/9/8)
簡介：6-hydroxypyridin-2(1h)-one hydrochloride (2,6-dihydroxypyridine hydrochloride) is used as a reagent to synthesize uridine phosphorylase inhibitors that increase uridine (urd) (u829910) levels. uridine is a promising biochemical modulator to reduce 5-fluorouracil (5-fu) toxicity without impairing its antitumor activity.
簡介：1,4-d-gulonolactone (d-gulonic acid γ-lactone) (also known as reduced ascorbic acid, raa) is the substrate of the enzyme l-gulono-1,4-lactone oxidoreductase (ec 1.1.3.8), which catalyzes the last step of the biosynthesis of l-ascorbic acid (vitamin c) in plants and animals. the enzyme l-gulono-1,4-lactone oxidase is missing in scurvy-prone, vitamin c-deficient animals, such as humans. 1,4-d-gulonolactone is present in human blood and has been used as one of the markers to compare changes in exer
25-Hydroxycholesterol25-羥基膽固醇25-羥基膽固醇|||25-羥基膽甾醇 (2024/9/8)
簡介：25-hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (srebps). it inhibits hmg-coa reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis after an acute dietary cholesterol challenge. 25-hydroxycholesterol is a potent (ec50≈65 nm) and selective suppressor of iga production by b cells.
Pyrrole-2-carboxylic acid；吡咯-2-羧酸2-Pyrrolecarboxylic acid|||Minaline；吡咯-2-羧酸|||2-Pyrrolecarboxylic a (2024/9/8)
簡介：pyrrole-2-carboxylic acid (minaline) was first identified as a degradation product of sialic acids, then as a derivative of the oxidation of the d-hydroxyproline isomers by mammalian d-amino acid oxidase. the latter relationship results from the lability of the direct oxidation product, a´-pyrroline-4-hydroxy-2-carboxylic acid, which loses water spontaneously to form the pyrrole. a similar reaction is catalyzed by the more specific allohydroxy-d-proline oxidase of pseudomonas. in whole ani
Phosphorylcholine chloride calcium salt tetrahydrate；膽堿磷酸氯化鈣四水Phosphocholine chloride calcium salt t (2024/9/8)
簡介：phosphorylcholine chloride calcium salt tetrahydrate (phosphocholine chloride calcium salt tet) is a small haptenic molecule, is found in a wide variety of organisms. human hepatic tumors undergo an elevation in the concentration of phosphorylcholine as the principal metabolic change is observed (pmid: 11076016 ). phosphorylcholine chloride calcium salt tetrahydrate is the precursor metabolite of choline in the glycine, serine and threonine metabolism pathways (kegg, map00260) and in intermediat
H-D-cis-Hyp-OH；順式-4-羥基-D-脯氨酸D-allo-Hydroxyproline|||cis-4-Hydroxy-D-proline；順式-4-羥基-D-脯氨酸|||D-allo-H (2024/9/8)
簡介：h-d-cis-hyp-oh (d-allo-hydroxyproline) belongs to the class of organic compounds known as proline and derivatives. proline and derivatives are compounds containing proline or a derivative thereof resulting from a reaction of proline at the amino group or the carboxyl group, or from the replacement of any hydrogen of glycine by a heteroatom.
2,4-Dihydroxypyrimidine-5-carboxylic acid脲嘧啶-5-羧酸脲嘧啶-5-羧酸|||Isoorotic acid|||Uracil-5-carboxylic aci (2024/9/8)
簡介：2,4-dihydroxypyrimidine-5-carboxylic acid (isoorotic acid) has been obtained from 5-formyluracil by the action of enzyme, thymine 7-hydroxylase. 2,4-dihydroxypyrimidine-5-carboxylic acid has been used to synthesize n1-alkylated uracil derivatives.
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride；鹽酸 D-甘露糖胺D-Mannosamine hydrochloride (2024/9/8)
簡介：(2s,3r,4s,5r)-2-amino-3,4,5,6-tetrahydroxyhexanal hydrochloride (d-mannosamine hydrochloride) is a pharmaceutical compound used in the development of mannosylated liposomes for bioadhesive oral drug delivery via m cells of peyer´s patches.
D-N-AcetylgalactosamineN-乙酰-D-半乳糖胺D-GalNAc|||N-Acetyl-D-galactosamine|||N-乙酰-D-半乳糖胺 (2024/9/8)
簡介：d-n-acetylgalactosamine (n-acetyl-d-galactosamine) is an important constituent of brain heteropolysaccharides (glycoproteins).
3-Hydroxyanthranilic acid；3-羥基-2-氨基苯甲酸3-HYDROXY-2-AMINOBENZOIC ACID；3-HYDROXY-2-AMINOBENZOIC ACID||| (2024/9/8)
簡介：3-hydroxyanthranilic acid (3-hydroxy-2-aminobenzoic acid), also known as 2-amino-3-hydroxy-benzoate or 3-ohaa, belongs to the class of organic compounds known as hydroxybenzoic acid derivatives. 3-hydroxyanthranilic acid has been found in human epidermis and bladder tissues, and has also been detected in multiple biofluids, such as urine and blood. within the cell, 3-hydroxyanthranilic acid is primarily located in the cytoplasm. 3-hydroxyanthranilic acid exists in all eukaryotes, ranging from ye
Aminoadipic acid；DL-2-氨基己二酸DL-2-Aminoadipic acid；DL-2-Aminoadipic acid|||DL-2-氨基己二酸 (2024/9/8)
簡介：aminoadipic acid (dl-2-aminoadipic acid) (2-aminoadipate) is a metabolite in the principal biochemical pathway of lysine. it is an intermediate in the metabolism (i.e. breakdown or degradation) of lysine and saccharopine. it antagonizes neuroexcitatory activity modulated by the glutamate receptor n-methyl-d-aspartate (nmda). aminoadipic acid has also been shown to inhibit the production of kynurenic acid, a broad spectrum excitatory amino acid receptor antagonist, in brain tissue slices.
L-Anserine nitrate；L-鵝肌肽硝酸鹽L-Anserine nitrate salt；L-鵝肌肽硝酸鹽|||L-Anserine nitrate salt (2024/9/8)
簡介：l-anserine nitrate (l-anserine nitrate salt) is a dipeptide found in most animal tissues. in model systems it is a potent antioxidant and scavener of hydroxyl radicals. the compound inhibits nonenzymatic protein glycation induced by aldose and ketose reducing sugars. it is much less potent than l-carnosine as an inhibitor of protein crosslinking.
(3-Carboxypropyl)trimethylammonium chloride；(3-羧丙基)三甲基氯化銨γ-Butyrobetaine hydrochloride|||(3-Carboxyp (2024/9/8)
簡介：(3-carboxypropyl)trimethylammonium chloride ((3-carboxypropyl)trimethylammonium chlor) is a synthetic carnitine related compound used as a transporter substrate in the cloning and sequencing of human carnitine transporter 2 (ct2).
Diclofop-methyl；禾草靈Diclofop-methyl (2024/9/8)
簡介：diclofop-methyl is used as the active ingredient in many herbicides that are used to control weed growth in plants such as wheat and wild oats.
1,3,5-Trihydroxy-4-prenylxanthone；化合物 T47001,3,5-Trihydroxy-4-prenylxanthone (2024/9/8)
簡介：1,3,5-trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (pde5), with an ic50 value of 3.0 μm; it shows in vitro inhibitory activity against acetylcholinesterase (ache) and butyrylcholinesterase (bche), with ic50 values of 56.3plusmn;0.4 and 46.0plusmn;0.3 m, respectively. 1,3,5-trihydroxy-4-prenylxanthone inhibits lps-induced nf-κb and ap-1 activations by interfering with the posttranslational modification (phosphorylation and/or ubiquitinylation) of irak-1
8-Fluoro-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one化合物T46988-氟-1,3,4,5-四氫-2-[4-[(甲基氨基)甲基]苯基] (2024/9/8)
簡介：8-fluoro-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one serves as a pharmaceutical intermediate.
ABBV-744；化合物ABBV-744ABBV744；ABBV744 (2024/9/8)
簡介：abbv-744 is a bdii-selective bet bromodomain inhibitor that inhibits brd2/3/4. it is used in the research on inflammatory diseases, cancer, and aids.
BMS202 hydrochloride (1675203-84-5(free base))；化合物BMS202 hydrochloridePD-1/PD-L1 inhibitor 2 hydroch (2024/9/8)
簡介：bms202 hydrochloride (1675203-84-5(free base)) (pd-1/pd-l1 inhibitor 2 hydrochloride) is a small-molecule pd-1/pd-l1 interaction inhibitor (ic50: 18 nm). biophysical studies demonstrate that bms202 binds directly to pd-l1. binding of bms202 promotes pd-l1 dimerisation and blocks the pd-l1/ pd1 interaction.
CP671305；化合物CP671305CP671305 (2024/9/8)
簡介：cp671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-d.
AG-1557 hydrochloride (189290-58-2(free base))；化合物AG-1557 hydrochlorideAG-1557 hydrochloride (189290 (2024/9/8)
簡介：ag-1557 is an inhibitor of the epidermal growth factor receptor (egfr) tyrosine kinase (pic50: 8.194).
2-Aminoethyl diphenylborinate；二苯基酸2-Aminoethoxydiphenyl borate|||2-APB；2-Aminoethoxydiphenyl borate| (2024/9/8)
簡介：2-aminoethyl diphenylborinate (2-apb) is a chemical that acts to inhibit both ip3 receptors and trp channels (although it activates trpv1, trpv2, & trpv3 at higher concentrations).
Protein kinase inhibitors 1 hydrochlorid；化合物T4692Protein kinase inhibitors 1 hydrochlorid (1365986-4 (2024/9/8)
簡介：protein kinase inhibitors 1 hydrochlorid (protein kinase inhibitors 1 hydrochlorid (1365986-44-2(free base))) is a novel inhibitor of hipk2 with an ic50 of 74 nm and kd of 9.5 nm.
Asimadoline hydrochloride；阿西馬朵林鹽酸鹽EMD-61753 hydrochloride；EMD-61753 hydrochloride|||阿西馬朵林鹽酸鹽 (2024/9/8)
簡介：asimadoline hydrochloride (emd-61753 hydrochloride) is a κ-opioid receptor agonist potentially for the treatment of pruritus. asimadoline hydrochloride has also been shown to be used in the treatment of irritable bowel syndrome.
Betrixaban hydrochloride(330942-05-7(free base))；鹽酸貝曲西班PRT054021 hydrochloride；PRT054021 hydrochlori (2024/9/8)
簡介：betrixaban hydrochloride(330942-05-7(free base)) (prt054021 hydrochloride) is a potent, selective, and orally efficacious factor xa (fxa) inhibitor (ic50: 1.5 nm).
Palosuran hydrochloride 540769-28-6(free base）；化合物Palosuran hydrochlorideACT-058362 hydrochloride；AC (2024/9/8)
簡介：palosuran hydrochloride 540769-28-6(free base)(act-058362 hydrochloride) is a new potent and specific antagonist of the human ut receptor with an ic50 of 3.6±0.2 nm.
Pipequaline hydrochloride；鹽酸哌夸林PK-8165 hydrochloride；PK-8165 hydrochloride|||鹽酸哌夸林 (2024/9/8)
簡介：pipequaline hydrochloride (pk-8165 hydrochloride) is an anticonflict & anticonvulsant quinoline derivative. it is an anxiolytic drug that was never marketed. it possesses a novel chemical structure that is not closely related to other drugs of this type. the drug has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and very little sedative, amnestic or anticonvulsant effects, and so is classified as a nonbenzodiazepine anxiolytic.
Ro5-3335；化合物Ro 5-3335CBFβ-Runx1 inhibitor II|||Ro 5-3335；CBFβ-Runx1 inhibitor II|||Ro 5-3335 (2024/9/8)
簡介：ro5-3335 (cbfβ-runx1 inhibitor ii) is core binding factor (cbf) inhibitor; preferentially kills human leukemia cell lines with cbf fusion proteins (ic50 = 1.1 μm). ro5-3335 represses runx1/cbfβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by runx1 and cbfβ. ro5-3335 also reduces the leukemia burden in a mouse model. attenuates runx1-dependent hematopoiesis in zebrafish embryos. it also is a tat antagonist and inhibits hiv-1 replication in vitro.
Simeprevir；西咪匹韋TMC435|||TMC-435350|||Olysio；TMC435|||西咪匹韋|||TMC-435350|||Olysio (2024/9/8)
簡介：simeprevir (tmc435) is a potent hcv ns3/4a protease inhibitor, and inhibits hcv replication with ec50 of 8 nm.
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