9月
CLOZAPINE N-OXIDE氯氮平N-氧化物氯氮平N-氧化|||氯氮平N-氧化物 (2024/9/8)
簡介：clozapine n-oxide is the major metabolite of clozapine and is blood-brain barrier permeable. clozapine n-oxide is an agonist of dreadds and activates the dreadd receptors hm3dq and hm4di. clozapine n-oxide is also a dopamine antagonist and selective muscarinic m4 receptor agonist.
Bictegravir；化合物BictegravirGS-9883；GS-9883 (2024/9/8)
簡介：bictegravir (gs-9883) is a potent inhibitor of hiv-1 integrase (ic50: 7.5 nm).
pocapavir；化合物pocapavirSCH-48973|||V-073；SCH-48973|||V-073 (2024/9/8)
簡介：pocapavir (sch-48973) is an investigational enterovirus (ev) capsid inhibitor.
LMPTP INHIBITOR 1 hydrochloride；化合物LMPTP INHIBITOR 1 hydrochlorideLMPTP INHIBITOR 1 hydrochloride (1 (2024/9/8)
簡介：lmptp inhibitor 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase ( lmptp ), with an ic 50 of 0.8 μm for lmptp-a.
PF-01247324；化合物PF01247324PF-01247324 (2024/9/8)
簡介：pf-01247324 is a selective and orally bioavailable nav1.8 channel blocker (ic50: 196 nm).
簡介：akt-in-1 (azd-26) is an allosteric akt inhibitor (ic50: 1.04 μm).
GSK-25；化合物GSK25GSK25；GSK25 (2024/9/8)
簡介：gsk-25 maintains good selectivity against a panel of 31 kinases, as well as rsk1 and p70s6k (rsk1 ic50 of 398 nm, p70s6k ic50 of 1000nm), and a dramatically improved p450 profile (>2.2 um at all isozymes tested).
TNP；IP3K抑制劑IP3K Inhibitor；IP3K Inhibitor (2024/9/8)
簡介：tnp (ip3k inhibitor) is a cell-permeable inhibitor of ip6k1 and ip3k, with ic 50 values of 0.55 μm and 10.2 μm for ip6k1 and ip3k, respectively. tnp binds to the atp-binding sites of both enzymes [1].
iCRT 14；化合物iCRT 14iCRT 14 (2024/9/8)
簡介：icrt 14 is a novel potent inhibitor of β-catenin-responsive transcription (crt)(ic50= 40.3 nm in assays of wnt pathway activity).
Lazertinib；化合物LazertinibLazertinib (YH25448)|||GNS-1480|||YH25448；Lazertinib (YH25448)|||GNS-1480||| (2024/9/8)
簡介：lazertinib (gns-1480) is an effective, highly mutant-selective and irreversible egfr-tki with ic50 values of 1.7 nm, 2 nm, 5 nm, 20.6 nm and 76 nm for del19/t790m, l858r/t790m, del19, l85r and wild type egfr respectively.
1,7-Dihydroxy-2,3-methylenedioxyxanthone；1,7-二羥基-2,3-亞甲二氧基呫噸酮1,7-Dihydroxy-2,3-methylenedioxyxanthon (2024/9/8)
簡介：1,7-dihydroxy-2,3-methylenedioxyxanthone has antiulcerogenic, anti-oxidation, and antihyperalgesic activities, it can inhibit the carrageenan-induced hyperalgesia.
CC-671；化合物CC-671CC-671 (2024/9/8)
簡介：cc-671 is a dual ttk protein kinase (ic50: 0.005 μm) /clk2 (ic50: 0.006 μm) inhibitor.
Tucidinostat；西達本胺HBI-8000|||Chidamide|||CS 055；HBI-8000|||Chidamide|||西達本胺|||CS 055 (2024/9/8)
簡介：tucidinostat (chidamide) is an hdac inhibitor with inhibitory activity against hdac1, hdac2, hdac3, and hdac10 (ic50=95/160/67/78 nm). tucidinostat has antitumor activity and can be used for the treatment of t-cell leukemia-lymphoma.
Vardenafil dihydrochloride；二鹽酸伐地那非Levitra|||Vardenafil Hydrochloride；Levitra|||Vardenafil Hydrochlor (2024/9/8)
簡介：vardenafil dihydrochloride (levitra) is a new type pde inhibitor with ic50 of 0.7 and 180 nm for pde5 and pde1, respectively.
Isomaculosidine；化合物 T4479Isomaculosidine (2024/9/8)
簡介：isomaculosidine can significantly inhibit nitric oxide (no) production in lipopolysaccharide (lps)-stimulated bv2 cells.
CID 16020046；化合物CID 16020046C390-0219；C390-0219 (2024/9/8)
簡介：cid 16020046 (c390-0219) is a selective gpr55 antagonist, inhibiting gpr55 constitutive activity with ic50 of 0.15 μm in yeast.
Domatinostat tosylate；化合物4SC-202 tosylate4SC-202 tosylate|||4SC-202；4SC-202 tosylate|||4SC-202 (2024/9/8)
簡介：domatinostat tosylate (4sc-202) is a selective inhibitor of class i hdac for hdac1/2/3 (ic50: 1.20/1.12/0.57 μm). it also displays inhibitory activity against lysine-specific demethylase 1 (lsd1).
AS1517499；化合物AS1517499AS1517499 (2024/9/8)
簡介：as1517499 is a potent stat6 inhibitor with ic50 of 21 nm
JNJ-632；化合物JNJ-632JNJ-632 (2024/9/8)
簡介：jnj-632 is a hepatitis b virus (hbv) capsid assembly modulator.
Asunaprevir；阿那匹韋BMS-650032；BMS-650032|||阿那匹韋 (2024/9/8)
簡介：asunaprevir (bms-650032) is an effective hepatitis c virus (hcv) ns3 protease inhibitor.
Ibiglustat；化合物IbiglustatVenglustat|||SAR402671|||GZ402671；Venglustat|||SAR402671|||GZ402671 (2024/9/8)
簡介：ibiglustat (gz402671) is a potent and selective glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. ibiglustat blocks the formation of glucosylceramide (gl-1), a key intermediate in the synthesis of gl-3. ibiglustat is potentially useful for treating fabry disease. fabry disease is a rare lysosomal storage disorder, which results in abnormal tissue deposits of a particular fatty substance called globotriaosylceramide (gl-3 or gb3) throughout the body.
NMS-P118；化合物NMS-P118NMS-P118 (2024/9/8)
簡介：nms-p118 is a potent, selective and orally available inhibitor of parp-1 for cancer therapy.
E7449；化合物E7449Stenoparib|||UNII-9X5A2QIA7C；Stenoparib|||UNII-9X5A2QIA7C (2024/9/8)
簡介：e7449 (unii-9x5a2qia7c) is a potent parp1 and parp2 inhibitor and also inhibits tnks1 and tnks2, with ic50s of 2.0, 1.0, ～50 and ～50 nm for parp1, parp2, tnks1 and tnks2, respectively, using 32p-nad+ as substrate.
Pyridostatin TFA；化合物Pyridostatin TFAPyridostatin TFA (2024/9/8)
簡介：pyridostatin trifluoroacetate salt is a g-quadruplexe stabilizer with kd of 490 nm in a cell-free assay, which targets a series of proto-oncogenes including c-kit, k-ras and bcl-2.
Nemorubicin；奈莫柔比星Methoxymorpholinyldoxorubicin|||PNU-152243A|||PNU 152243；Methoxymorpholinyldoxorubi (2024/9/8)
簡介：nemorubicin (pnu 152243) is a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. the drug is active on tumors resistant to alkylating agents, topoisomerase ii inhibitors and platinum derivatives.
WAY 316606；化合物WAY 316606WAY 316606 (2024/9/8)
簡介：way 316606 is an inhibitor of the secreted protein sfrp-1, an endogenous antagonist of the secreted glycoprotein wnt.
UAMC00039 dihydrochloride；化合物UAMC 00039 dihydrochlorideUAMC 00039 dihydrochloride；UAMC 00039 dihydro (2024/9/8)
簡介：uamc00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase ii inhibitor with an ic50 of 0.48 nm.
Pitofenone hydrochloride；吡托非農鹽酸鹽Baralgin Ketone Hydrochloride|||Pitophenone hydrochloride；Baralgin K (2024/9/8)
簡介：pitofenone hydrochloride (pitophenone hydrochloride), a spasmolytic compound, inhibits the acetylcholinesterase (ache) activity from bovine erythrocytes and from electric eel with kis of 36 and 45 μm, respectively.
Irosustat；化合物Irosustat667-Coumate|||BN83495|||STX64；667-Coumate|||BN83495|||STX64 (2024/9/8)
簡介：irosustat (667-coumate) is a potent steroid sulfatase inhibitor, with an ic50 of 8 nm, and exhibits anti-breast cancer activity.
Rucaparib；瑞卡帕布AG-14447|||PF-01367338|||AG014699；AG-14447|||PF-01367338|||瑞卡帕布|||AG014699 (2024/9/8)
簡介：rucaparib (pf-01367338) is an inhibitor of parp with ki of 1.4 nm for parp1 in a cell-free assay, and also shows binding affinity to eight other parp.
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