9月
Roflumilast N-oxide；羅氟司特N-氧化物Roflumilast N-oxide (2024/9/8)
簡介：roflumilast n-oxide is an inhibitor of pde type 4.
3,5-Diiodo-L-thyronine；化合物 3,5-Diiodo-L-thyronineDiiodothyronine；3,5-二碘-L-甲狀腺素|||Diiodothyronine (2024/9/8)
簡介：3,5-diiodo-l-thyronine (diiodothyronine) is an iodinated thyronine hormone that regulates gene activity affecting processes such as homeostasis, lipid metabolism and insulin resistance.
Dapagliflozin ((2S)-1,2-propanediol, hydrate)；達格列凈 (2S)-1,2-丙二醇水合物BMS-512148 (2S)-1,2-propanediol, h (2024/9/8)
簡介：dapagliflozin ((2s)-1,2-propanediol, hydrate) (bms-512148 (2s)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (sglt2). it is in development for the treatment of type 2 diabetes mellitus (t2dm). it inhibits subtype 2 of the sodium-glucose transport proteins (sglt2), which is responsible for at least 90% of the glucose reabsorption in the kidney.
PK11000；化合物PK11000PK11000 (2024/9/8)
簡介：pk11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.
Pyridostatin Trihydrochloride；化合物Pyridostatin TrihydrochloridePyridostatin Trihydrochloride(free bas (2024/9/8)
簡介：pyridostatin trihydrochloride (rr-82 trihydrochloride) is a g-quadruplexe stabilizer, with a kd of 490 nm.
N4-Acetylcytidine；N4-乙酰胞苷N-Acetylcytidine；N4-乙酰胞苷|||N-Acetylcytidine (2024/9/8)
簡介：n4-acetylcytidine (n-acetylcytidine) is a modified nucleoside. n4-acetylcytidine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (trna); urinary nucleosides are biological markers for patients with colorectal cancer.
DL-3-Phenyllactic acid；DL-3-苯乳酸3-Phenyllactic acid|||2-Hydroxy-3-phenylpropanoic acid；DL-3-苯乳酸|||3-P (2024/9/8)
簡介：3-phenyllactic acid (phla) is a broad spectrum antimicrobial compound active against bacteria and fungi, dl-3-phenyllactic acid (3-phenyllactic acid) is a reagent involved in biological studies of nantioselectivity of lipase in transesterification and oxidation by glycolate oxidase and catalase.
Traumatic Acid愈傷酸Dodec-2-Enedioic Acid|||2E-Dodecenedioic Acid|||愈傷酸|||Trans-2-Dodecenedioic Acid (2024/9/8)
簡介：traumatic acid (dodec-2-enedioic acid) is a product of the hydroperoxide lyase pathway in plants. potential as a wound healing agent that stimulates cell division near a wound site to form a protective callus.
JD-5037；化合物JD5037JD 5037；JD 5037 (2024/9/8)
簡介：jd-5037 is a novel, peripherally restricted cb1r antagonist with an ic50 of 1.5 nm.
Estramustine phosphate；化合物 T4451LLS 299|||NSC 89199|||NSC-89199|||LS-299|||LS299；LS 299|||NSC 89199| (2024/9/8)
簡介：estramustine phosphate can be used to treat prostatic neoplasms; also has radiation protective properties.
Estramustine phosphate sodium雌莫司汀磷酸鈉Ro 21-8837/001|||Estramustine phosphate disodium|||雌莫司汀磷酸鈉 (2024/9/8)
簡介：estramustine phosphate sodium (ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the g2/m phase of the cell cycle.
LB100；化合物LB100LB-100|||LB 100；LB-100|||LB 100 (2024/9/8)
簡介：lb100 (lb-100) is a water soluble protein phosphatase 2a (pp2a) inhibitor.
NADP化合物 T4448NADP|||NADP (2024/9/8)
簡介：nadp, also known as nicotinamide adenine dinucleotide phosphate, is a vital redox cofactor essential for electron transfer in various metabolic processes. it plays a critical role in facilitating cellular energy production and maintaining redox balance within the cell.
Tolfenpyrad；唑蟲酰胺Tolfenpyrad (2024/9/8)
簡介：tolfenpyrad is an effective insecticide[1], used against pests that are resistant to existing insecticides such as organophosphates and carbamates.[2]
A-674563 HCl (552325-73-2(free base))；化合物A-674563 HClA-674563 HCl (552325-73-2(free base)) (2024/9/8)
簡介：a-674563 is an orally available, atp-competitive, and reversible inhibitor of akt (ki: 11 nm for akt1) [1]. it exhibits inhibitory activity against pka and cdk2 (ic50: 16/46 nm) but is 10- to >1, 800-fold selective for akt1 versus additional kinases in the cmgc, camk, and tk families [1].
AZ32；化合物AZ32AZ32 (2024/9/8)
簡介：az32 is an orally bioavailable and blood-brain barrier-penetrating atm inhibitor with an ic50 of <6.2 nm for atm enzyme, and an ic50 of 0.31 μm for atm in cell.
MK2-IN-1 hydrochloride；化合物MK2-IN-1 hydrochlorideMK2 Inhibitor|||MK 25；MK2 Inhibitor|||MK 25 (2024/9/8)
簡介：mk2-in-1 hydrochloride (mk 25) is a highly selective, non-atp competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (mapkapk2 or mk2, ic50: 0.11 μm) [1].
UK-5099；化合物UK5099UK 5099|||PF-1005023|||UK5099；UK 5099|||PF-1005023|||UK5099 (2024/9/8)
簡介：uk-5099 (pf-1005023) is an inhibitor of the mitochondrial pyruvate transporter protein mpc. uk-5099 inhibits mpc by covalently and reversibly binding to the c54 of mpc2, which facilitates the transport of pyruvate across the inner mitochondrial membrane. uk-5099 has antitumor activity.
Saclofen；化合物SaclofenSaclofen (2024/9/8)
簡介：saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (gaba) that acts as a competitive antagonist of the gabab receptor (ic50: 7.8 μm).1 this compound can be used to determine the functional roles for the gabab receptor as a mediator of slow inhibitory postsynaptic potentials in the brain.
sn-Glycero-3-phosphocholine甘磷酸膽堿Choline Alfoscerate|||甘磷酸膽堿|||Glycerophosphocholine|||Glycerophospho (2024/9/8)
簡介：sn-glycero-3-phosphocholine (choline glycerophosphate) is a natural choline compound found in the brain and in milk. it is also a parasympathomimetic acetylcholine precursor which may have a potential for the treatment of alzheimer´s disease and dementia. sn-glycero-3-phosphocholine rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. it is a non-prescription drug in most countries due to its generally r
Porcn-IN-1；化合物Porcupine-IN-1Porcupine-IN-1；Porcupine-IN-1 (2024/9/8)
簡介：porcn-in-1 (porcupine-in-1) is an effective porcupine inhibitor (ic50: 0.5±0.2 nm).
RO1138452；化合物RO1138452CAY10441；CAY10441 (2024/9/8)
簡介：ro1138452 (cay10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pki: 8.3). it antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic amp accumulation in a dose-dependent manner. likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a ki of about 1.5 nm. at levels between 2-20 mg/kg in rats, cay10441 shows significant analgesic activity in standard antinociceptive assays [
E7820；化合物E7820ER68203-00；ER68203-00 (2024/9/8)
簡介：e7820 (er68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).
Tirapazamine；替拉扎明Tirazone|||Win59075|||SR4233|||SR259075；Tirazone|||Win59075|||SR4233|||替拉扎明|||SR259 (2024/9/8)
簡介：tirapazamine (win59075) is a potent cytotoxic agent under hypoxic conditions, can induce apoptosis by inducing breaks in single and double-stranded dna, as well as chromosomal breaks. the compound sensitizes cells to other ionizing radiation and other cytotoxic agents like cisplatin.
6-CFDA N-succinimidyl ester；化合物6-CFDA N-succinimidyl esterCarboxyfluorescein diacetate succinimidyl； (2024/9/8)
簡介：6-cfda n-succinimidyl ester (carboxyfluorescein diacetate succinimidyl) is capable of spontaneously and irreversibly binding to free amines. utilized in flow cytometry experiments for tracking cell division in both mammalian cells and bacteria. used in combination with several cell permeabilizers as an effective, nondestructive fluorescencent stain to quickly detect bacterial cells.
5-Carboxyfluorescein diacetate N-succinimidyl ester；化合物 T44325-Carboxyfluorescein diacetate N-succin (2024/9/8)
簡介：5-carboxyfluorescein diacetate n-succinimidyl ester has a wide range of applications in life science related research.
Olodanrigan；化合物EMA401PD-126055|||EMA401；PD-126055|||EMA401 (2024/9/8)
簡介：olodanrigan (ema401), a highly selective at2r antagonist, inhibition of augmented angii/at2r induced p38 and p42/p44 mapk activation, and hence inhibition of drg neuron hyperexcitability and sprouting of drg neurons. ema401 blocks p38, p42/p44 mitogen-activated protein kinase (mapk) activation, neurite outgrowth in adult rat drg neurons, and sensitization of adult rat and human drg neurons induced by angii. it inhibits capsaicin responses in cultured hdrg neurons.
Isosaponarin；異肥皂草苷Isosaponarin (2024/9/8)
簡介：isosaponarin increases collagen synthesis in human fibroblasts, causes by up-regulated tbetar-ii and p4h production.
Rauwolscine hydrochloride；蘿芙素鹽酸鹽Corynanthidine hydrochloride|||α-Yohimbine hydrochloride|||Isoyohimb (2024/9/8)
簡介：rauwolscine hydrochloride (isoyohimbine hydrochloride) , a natural alkaloid, is a specific and reversible α2-adrenergic receptor antagonist (ki: 12 nm) [1]. it is a stereoisomer of yohimbine, which potently antagonizes both α1- and α2-adrenergic receptors [1]. rauwolscine hydrochloride also acts as a receptor antagonist at the serotonin 5-ht2b receptor (ki: 14.3 nm) and as a weak partial agonist at 5-ht1a (ic50: 1.3 μm) [3]. the α2-adrenergic receptor has diverse physiological functions and anta
CCT241736；化合物CCT241736CCT241736 (2024/9/8)
簡介：cct241736 is an orally bioavailable dual flt3/aurora kinase inhibitor that also inhibits clinically relevant flt3-resistant mutants including flt3-itd and flt3, cct241736, an advanced analog of cct137690, is a preclinical development candidate for the treatment of human malignancies, and in particular aml in adults and children.
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