9月
Decyl maltose neopentyl glycolDecyl maltose neopentyl glycolDMNG (2024/9/8)
簡介：decyl maltose neopentyl glycol (dmng) is a neopentyl glycol detergent known for its ability to maintain the integrity of the alkb oligomeric state. alkb, a nonheme di-iron alkane hydroxylase, is unaffected by dmng, making it a suitable choice for preserving the functionality of this enzyme.
Lauryl maltose neopentyl glycol；十二烷基麥芽糖乙戊二醇LMNG；LMNG (2024/9/8)
簡介：lauryl maltose neopentyl glycol (lmng) is a detergent that solubilizes and stabilizes membrane proteins. lauryl maltose neopentyl glycol extracts intact membrane proteins from membranes, thereby improving the stability of membrane proteins such as g protein-coupled receptors and respiratory system complexes. lauryl maltose neopentyl glycol neopentyl glycol has solubilizing effect.
Lyciumin B；Lyciumin BLyciumin B (2024/9/8)
簡介：lyciumin b is a cyclic peptide isolated from lysium chinense.
beta-Eudesmol；β-桉葉醇Beta-Selinenol；β-桉葉醇|||Beta-Selinenol|||beta-桉葉醇 (2024/9/8)
簡介：beta-eudesmol (beta-selinenol) is a noncompetitive antagonist of nicotinic acetylcholine receptors (nachrs). it is a sesquiterpene that has been found in a variety of plants, including cannabis, and has diverse biological activities.
Lyciumin A；Lyciumin ALyciumin A (2024/9/8)
簡介：lyciumin a, a cyclic octapeptide, possesses inhibitory properties against proteases, renin, and angiotensin-converting enzyme. it holds potential for hypertension research.
Cecropin P1, porcine acetate；化合物Cecropin P1, porcine acetateCecropin P1, porcine acetate (2024/9/8)
簡介：cecropin p1, porcine acetate is an antibacterial peptide found in hyalophora cecropia and pig intestine.
Cecropin P1, porcine；Cecropin P1, porcineCecropin P1, porcine (2024/9/8)
簡介：cecropin p1, porcine is an antibacterial peptide originally identified in moths (hyalophora cecropia) and later in pig intestine.
m-PEG9-Br；m-PEG9-Brm-PEG9-Br；m-PEG9-Br (2024/9/8)
簡介：m-peg9-br is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
GKT136901 hydrochloride；GKT136901 hydrochlorideGKT136901 hydrochloride；GKT136901 hydrochloride (2024/9/8)
簡介：gkt136901 hydrochloride is a powerful, selective, and orally active inhibitor of nadph oxidase (nox1/4). it exhibits k i values of 160 nm and 165 nm against nox1 and nox4, respectively. additionally, gkt136901 hydrochloride demonstrates selectivity and direct scavenging ability towards peroxynitrite. this compound finds utility in studying diabetic nephropathy, stroke, neurodegeneration, and possesses anti-inflammatory properties.
Acetyl-Hirudin (54-65) (sulfated)；Acetyl-Hirudin (54-65) (sulfated)Acetyl-Hirudin (54-65) (sulfated) (2024/9/8)
簡介：acetyl-hirudin (54-65) (sulfated) directly binds to thrombin-rhcii(l444r) and hinders the interaction between the n-terminal acidic domain of rhcii and anion-binding exosite i of thrombin, which stabilizes the complex.
Docetaxal；DocetaxalPNU-101383|||10-Acetyl docetaxel；PNU-101383|||10-Acetyl docetaxel (2024/9/8)
簡介：docetaxal, also known as 10-acetyl docetaxel, is an analog of docetaxel exhibiting potent anticancer properties. it acts as a microtubule disassembly inhibitor, effectively inhibiting mitosis.
Cefixime trihydrate；Cefixime trihydrateCL-284635trihydrate|||FR-17027 trihydrate|||FK-027trihydrate； (2024/9/8)
簡介：cefixime trihydrate (fr-17027 trihydrate) is a potent antibiotic belonging to the third generation of cephalosporins. its efficacy lies in the treatment of various bacterial infections.
AP 811；AP 811AP 811 (2024/9/8)
簡介：ap 811, a selective antagonist of the atrial natriuretic peptide clearance receptor (apn-cr, npr3) with a k i value of 0.48 nm, exhibits remarkable selectivity for npr3 over npr1 by more than 20,000-fold. moreover, ap 811 effectively eliminates anp-induced pump stimulation.
Erianin；毛蘭素Erianin (2024/9/8)
簡介：erianin is a nature product extracted from dendrobium chrysotoxum, has notable antitumour activity , can cause extensive tumour necrosis, growth delay. erianin has antiangiogenic action by inhibiting endothelial metabolism in a jnk/sapk-dependent manner and inducing endothelial cytoskeletal disorganisation. erianin shows potent inhibitory activity on the proliferation of hl-60 cells, the inhibition might be relative to the apoptosis induced by erianin and the altered expression of bcl-2 and bax
4-Trifluoromethylsalicylic acid-13C6；4-Trifluoromethylsalicylic acid-13C64-Trifluoromethylsalicylic (2024/9/8)
簡介：4-trifluoromethylsalicylic acid-13c6 is 13c-labeled 4-trifluoromethylsalicylic acid, mainly used as a quantitative tracer in drug development. 4-trifluoromethylsalicylic acid is also a platelet aggregation inhibitor.
Roy-Bz；Roy-BzRoy-Bz (2024/9/8)
簡介：roy-bz is a potent and selective activator of protein kinase c delta (pkcδ). it effectively inhibits proliferation in colon cancer cells by initiating a mitochondrial apoptotic pathway that relies on pkcδ and involves the activation of caspase-3.
Monophosphoryl lipid A；Monophosphoryl lipid AGlucopyranosyl lipid A；Glucopyranosyl lipid A (2024/9/8)
簡介：monophosphoryl lipid a (mpla), also known as glucopyranosyl lipid a, is an agonist of toll-like receptor 4. derived from the cell wall of nonpathogenic salmonella, mpla is a valuable compound for research on immunization and vaccine development.
Kdo2-Lipid A ammonium；Kdo2-Lipid A銨鹽Kdo2-Lipid A ammonium (2024/9/8)
簡介：kdo2-lipid a ammonium (kla) is a selective and potent tlr4 agonist, a lipopolysaccharide.kdo2-lipid a ammonium induces the release of tnf and pge2.
Histamine H4 receptor antagonist-1；Histamine H4 receptor antagonist-1Histamine H4 receptor antagonis (2024/9/8)
簡介：histamine h4 receptor antagonist-1 is a potent antagonist of the histamine h4 receptor.
(Rac)-Pyrotinib(Rac)-Pyrotinib(Rac)-Pyrotinib|||(Rac)-SHR-1258 (2024/9/8)
簡介：(rac)-pyrotinib ((rac)-shr-1258) is the racemate of pyrotinib. pyrotinib is a potent and selective egfr/her2 dual inhibitor.
Ald-Ph-amido-PEG11-NH-Boc；Ald-Ph-amido-PEG11-NH-BocAld-Ph-amido-PEG11-NH-Boc；Ald-Ph-amido-PEG11-NH-B (2024/9/8)
簡介：ald-ph-amido-peg11-nh-boc is a non-cleavable 11-unit polyethylene glycol (peg) linker employed in the synthesis of antibody-drug conjugates (adcs).
Ludaterone；LudateroneLudaterone (2024/9/8)
簡介：ludaterone is an antiandrogen agent, with potent antiandrogenic activity.
簡介：chikusetsusaponin iva (calenduloside f) is a novel ampk activator, can induce insulin secretion from βtc3 cells via gpr4 mediated calcium and pkc pathways, may be developed into a new potential for therapeutic agent used in t2dm patients.
Folate-PEG3-alkyne；Folate-PEG3-alkyneFolate-PEG3-alkyne；Folate-PEG3-alkyne (2024/9/8)
簡介：folate-peg3-alkyne is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Azido-PEG2-propargyl；Azido-PEG2-propargylAzido-PEG2-propargyl；Azido-PEG2-propargyl (2024/9/8)
簡介：azido-peg2-propargyl is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Biotin-PEG3-SH；Biotin-PEG3-SHBiotin-PEG3-SH；Biotin-PEG3-SH (2024/9/8)
簡介：biotin-peg3-sh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
GSK143；GSK143GSK143 (2024/9/8)
簡介：gsk143 is a potent orally active and highly selective inhibitor of spleen tyrosine kinase (syk) with a pic 50 of 7.5. furthermore, gsk143 effectively inhibits phosphorylated erk (perk) with a pic 50 value of 7.1. in addition, gsk143 exhibits promising anti-inflammatory properties by reducing inflammation and impeding the recruitment of immune cells in the intestinal muscularis of mice.
Tanimilast；化合物TanimilastCHF-6001；CHF-6001 (2024/9/8)
簡介：tanimilast (chf-6001) is a novel, potent and selective phosphodiesterase 4 inhibitor with an ic 50 value of 0.026 ± 0.006 nm.tanimilast has potent anti-inflammatory activity and is indicated for topical use in the lungs.tanimilast was used in the study of obstructive lung disease.
Fosifidancitinib；化合物FosifidancitinibFosifidancitinib (2024/9/8)
簡介：fosifidancitinib is a potent inhibitor of jak 1 and jak 3.
IfidancitinibIfidancitinibATI-502|||ATI-50002 (2024/9/8)
簡介：ifidancitinib, a potent and selective inhibitor of jak kinases 1/3, is utilized in the research of allergies, asthma, and autoimmune diseases.
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