9月
EP4 receptor antagonist 3EP4 receptor antagonist 3EP4 receptor antagonist 3 (2024/9/8)
簡(jiǎn)介：ep4 receptor antagonist 3 is a highly potent and specific inhibitor of the ep4 receptor. it is intended for research purposes in studying ep4 receptor-mediated diseases such as acute and chronic pain, osteoarthritis, rheumatoid arthritis, and cancer.
MK-5204；MK-5204MK-5204 (2024/9/8)
簡(jiǎn)介：mk-5204 is an orally active β-1,3-glucan synthesis inhibitor.
1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone；1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4( (2024/9/8)
簡(jiǎn)介：methyl-2-[(6z,9z)-6,9-pentadecadienyl]-4(1h)-quinolone9, a quinolone alkaloid derived from evodia rutaecarpa, is a potent antagonist of the angiotensin ii receptor, displaying an ic50 value of 48.2 μm.
Regaloside F；Regaloside FRegaloside F (2024/9/8)
簡(jiǎn)介：regaloside f is a phenolic glycerol glucoside that can be found in lily bulbs.
Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA)；Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA)Biotinyl-NH-PEG3- (2024/9/8)
簡(jiǎn)介：biotinyl-nh-peg3-c3-amido-c3-cooh (dipea) is a polyethylene glycol (peg)-based proteolysis targeting chimera (protac) linker, utilized for synthesizing protacs.
Biotin-PEG1-azide；Biotin-PEG1-azideBiotin-PEG1-azide；Biotin-PEG1-azide (2024/9/8)
簡(jiǎn)介：biotin-peg1-azide is a cleavable 1-unit polyethylene glycol (peg) linker employed in the synthesis of antibody-drug conjugates (adcs).
Neopanaxadiol；擬原人參二醇Neopanaxadiol (2024/9/8)
簡(jiǎn)介：neopanaxadiol, an aglycone derived from protopanaxadiol type ginsenosides, exhibits promising potential for alzheimer´s disease research.
Amphotericin B trihydrate；兩性霉素B三水合物Amphotericin B trihydrate (2024/9/8)
簡(jiǎn)介：amphotericin b trihydrate, a polyene antibiotic, is derived from streptomyces nodosus fermenter cultures. it exhibits antileishmanial properties.
Chrysophanol triglucoside；大黃酚-1-O-Β-三葡萄糖苷Chrysophanol triglucoside (2024/9/8)
簡(jiǎn)介：chrysophanol triglucoside, an anthraquinone derivative obtained from cassia obtusifolia, demonstrates inhibitory activity against protein tyrosine phosphatases 1b (ptp1b) and α-glucosidase, with half-maximal inhibitory concentration (ic50) values of 80.17 μm and 197.06 μm, respectively. this compound exhibits potential for diabetes research.
Grepafloxacin；Grepafloxacindl-Grepafloxacin|||OPC-17116；dl-Grepafloxacin|||OPC-17116 (2024/9/8)
簡(jiǎn)介：grepafloxacin (opc-17116) is a fluoroquinolone antibiotic that is administered orally. it possesses strong efficacy against community-acquired respiratory pathogens, notably streptococcus pneumonia. grepafloxacin exhibits excellent tissue penetration and demonstrates a promising pharmacodynamic profile.
Tetrachlorocatechol；四氯鄰苯二酚Tetrachlorocatechol (2024/9/8)
簡(jiǎn)介：tetrachlorocatechol (tcc) is a chlorinated catechol compound that serves as a metabolite of pentachlorophenol. it is prominently generated during the chlorobleaching process in pulp production and is commonly detected in effluents from kraft pulp mills [1] [2]. tcc stands out as one of the most highly toxic chlorinated catechols.
ALK-IN-12；ALK-IN-12ALK-IN-12 (2024/9/8)
簡(jiǎn)介：alk-in-12 is a highly potent and orally active inhibitor of anaplastic lymphoma kinase (alk), demonstrating an exceptional ic50 value of 0.18 nm. additionally, alk-in-12 displays inhibitory activity against insulin-like growth factor 1 receptor (igf1r) and insulin receptor (insr), with ic50 values of 20.3 nm and 90.6 nm, respectively. notably, its antitumor effects have been observed, making it a promising compound for targeted cancer therapy.
ALK-IN-13；ALK-IN-13ALK-IN-13 (2024/9/8)
簡(jiǎn)介：alk-in-13 is an alk inhibitor.
Azido-PEG8-propargyl；Azido-PEG8-propargylAzido-PEG8-propargyl；Azido-PEG8-propargyl (2024/9/8)
簡(jiǎn)介：azido-peg8-propargyl is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Antofloxacin；AntofloxacinAntofloxacin (2024/9/8)
簡(jiǎn)介：antofloxacin is a well-tolerated, orally active, and broad-spectrum 8-amino-fluoroquinolone compound that exhibits potent antibacterial properties. it demonstrates superior activity against gyra mutation-positive helicobacter pylori strains, particularly in strains with mutations in the asn87 position, when compared to levofloxacin. additionally, antofloxacin acts as a weak but reversible inhibitor of cyp1a2 and is clinically used to treat infections caused by various bacterial species.
Azido-PEG4-propargyl；Azido-PEG4-propargylAzido-PEG4-propargyl；Azido-PEG4-propargyl (2024/9/8)
簡(jiǎn)介：azido-peg4-propargyl is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
macranthoidin A灰氈毛忍冬皂苷甲灰氈毛忍冬皂苷甲|||金銀花 (2024/9/8)
簡(jiǎn)介：macranthoidin a has anti-inflammation activity.
Rutarensin；RutarensinRutarensin (2024/9/8)
簡(jiǎn)介：rutarensin is a phenolic compound found in ruta chalepensis cell culture.
(R)-8-Azido-2-(Fmoc-amino)octanoic acid；(R)-8-Azido-2-(Fmoc-amino)octanoic acid(R)-8-Azido-2-(Fmoc-a (2024/9/8)
簡(jiǎn)介：(r)-8-azido-2-(fmoc-amino)octanoic acid, a non-cleavable adc linker, is employed in the synthesis of antibody-drug conjugates (adcs).
Remdesivir O-desphosphate acetonide impurity；Remdesivir O-desphosphate acetonide impurityRemdesivir (2024/9/8)
簡(jiǎn)介：remdesivir o-desphosphate acetonide impurity is a contaminant found in remdesivir. remdesivir (gs-5734) is a nucleoside analogue known for its potent antiviral properties, particularly in inhibiting sars-cov-2 (covid-19) infection in vitro.
Propargyl-PEG1-THP；Propargyl-PEG1-THPPropargyl-PEG1-THP；Propargyl-PEG1-THP (2024/9/8)
簡(jiǎn)介：propargyl-peg1-thp is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Hydroxy-PEG3-ethyl acetate；Hydroxy-PEG3-ethyl acetateHydroxy-PEG3-ethyl acetate；Hydroxy-PEG3-ethyl a (2024/9/8)
簡(jiǎn)介：hydroxy-peg3-ethyl acetate is a polyethylene glycol (peg)-based linker compound employed in protac synthesis.
Trt-PEG4-C2-acid hydrate；Trt-PEG4-C2-acid hydrateTrt-PEG4-C2-acid hydrate；Trt-PEG4-C2-acid hydrate (2024/9/8)
簡(jiǎn)介：trt-peg4-c2-acid (hydrate) is a polyethylene glycol (peg)-derived linking moiety, specifically designed for the synthesis of proteolysis targeting chimeras (protacs).
Biotin-PEG3-CH2COOH；Biotin-PEG3-CH2COOHBiotin-PEG3-CH2COOH；Biotin-PEG3-CH2COOH (2024/9/8)
簡(jiǎn)介：biotin-peg3-ch2cooh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Testosterone buciclate；Testosterone buciclateTestosterone buciclate (2024/9/8)
簡(jiǎn)介：testosterone buciclate, a long-acting androgen ester, shows promise as a research agent for male hypogonadism.
Ilunocitinib；IlunocitinibIlunocitinib (2024/9/8)
簡(jiǎn)介：ilunocitinib (compound 27) is a jak inhibitor.
DMAPP triammonium；DMAPP三銨鹽Dimethylallyl diphosphate triammonium|||Dimethylallyl Pyrophosphate triamm (2024/9/8)
簡(jiǎn)介：dmapp triammonium (dimethylallyl diphosphate triammonium) is one of the prerequisite substances for an isoprenoid involved in the mevalonate (mva) pathway, which can be used in the study of metabolism-related diseases.
magnolin；木蘭苷(+)-Magnolin；木蘭脂素|||(+)-Magnolin|||木蘭苷 (2024/9/8)
簡(jiǎn)介：magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases bcl-2 expression in vivo and in vitro. magnolin has anti-inflammatory and antioxidative effects.
Tos-PEG2-OH；Tos-PEG2-OHTos-PEG2-OH；Tos-PEG2-OH (2024/9/8)
簡(jiǎn)介：tos-peg2-oh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Dibromochloronitromethane；DibromochloronitromethaneDibromochloronitromethane (2024/9/8)
簡(jiǎn)介：dibromochloronitromethane is a member of the class of halonitromethanes, which has been recently identified as a group of disinfection by-products (dbps) found in drinking water.
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